{"id":"https://openalex.org/W7223065841","doi":"https://doi.org/10.1038/s41467-026-77684-w","title":"Nutrient stress-driven ACSS1 controls metabolic flexibility and bone formation","display_name":"Nutrient stress-driven ACSS1 controls metabolic flexibility and bone formation","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223065841","doi":"https://doi.org/10.1038/s41467-026-77684-w"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-77684-w","doi":"https://doi.org/10.1038/s41467-026-77684-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77684-w","pdf_url":"https://www.nature.com/articles/s41467-026-77684-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-77684-w_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101468550","display_name":"Lu Gao","orcid":"https://orcid.org/0009-0002-1549-4018","observed_orcids":["https://orcid.org/0009-0002-1549-4018"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Gao","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0002-1549-4018","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059816884","display_name":"Zhuolei Yuan","orcid":"https://orcid.org/0009-0002-1771-407X","observed_orcids":["https://orcid.org/0009-0002-1771-407X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuolei Yuan","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0002-1771-407X","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050446399","display_name":"Tongling Huang","orcid":"https://orcid.org/0009-0007-1512-4822","observed_orcids":["https://orcid.org/0009-0007-1512-4822"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tongling Huang","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0007-1512-4822","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101980475","display_name":"Pengda Li","orcid":"https://orcid.org/0000-0001-9968-1560","observed_orcids":["https://orcid.org/0000-0001-9968-1560"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengda Li","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0001-9968-1560","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134901937","display_name":"Yanting Zhong","orcid":"https://orcid.org/0009-0008-5336-4103","observed_orcids":["https://orcid.org/0009-0008-5336-4103"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanting Zhong","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0009-0008-5336-4103","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008565704","display_name":"Jun Gao","orcid":"https://orcid.org/0009-0001-1315-7248","observed_orcids":["https://orcid.org/0009-0001-1315-7248"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Gao","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0001-1315-7248","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101436615","display_name":"Yifan Luo","orcid":"https://orcid.org/0009-0001-8224-5081","observed_orcids":["https://orcid.org/0009-0001-8224-5081","https://orcid.org/0000-0003-2338-3836"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Luo","raw_affiliation_strings":["Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0001-8224-5081","affiliations":[{"raw_affiliation_string":"Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100365127","display_name":"Bin Li","orcid":"https://orcid.org/0000-0001-8516-9953","observed_orcids":["https://orcid.org/0000-0001-8516-9953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Li","raw_affiliation_strings":["Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-8516-9953","affiliations":[{"raw_affiliation_string":"Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112307515","display_name":"Haobo Pan","orcid":"https://orcid.org/0000-0002-8775-8572","observed_orcids":["https://orcid.org/0000-0002-8775-8572"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haobo Pan","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","Shenzhen Key Laboratory of Marine Biomaterials, Shenzhen Institutes of Advanced Technology, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-8775-8572","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Marine Biomaterials, Shenzhen Institutes of Advanced Technology, Shenzhen, China","institution_ids":["https://openalex.org/I4210145761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073266870","display_name":"Keqiang Ye","orcid":"https://orcid.org/0000-0002-7657-8154","observed_orcids":["https://orcid.org/0000-0002-7657-8154"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4405255904","display_name":"Shenzhen University of Advanced Technology","ror":"https://ror.org/03hz5th67","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405255904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keqiang Ye","raw_affiliation_strings":["Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, China"],"raw_orcid":"https://orcid.org/0000-0002-7657-8154","affiliations":[{"raw_affiliation_string":"Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"raw_affiliation_string":"Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, China","institution_ids":["https://openalex.org/I4405255904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041988083","display_name":"Min Guan","orcid":"https://orcid.org/0000-0003-3851-8553","observed_orcids":["https://orcid.org/0000-0003-3851-8553"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Min Guan","raw_affiliation_strings":["Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","Shenzhen Key Laboratory of Marine Biomaterials, Shenzhen Institutes of Advanced Technology, Shenzhen, China","University of Chinese Academy of Sciences, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3851-8553","affiliations":[{"raw_affiliation_string":"Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]},{"raw_affiliation_string":"Shenzhen Key Laboratory of Marine Biomaterials, Shenzhen Institutes of Advanced Technology, Shenzhen, China","institution_ids":["https://openalex.org/I4210145761"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5041988083"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210145761","https://openalex.org/I4210165038"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.68541295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetyl-coa-synthetase","display_name":"acetyl-CoA synthetase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/acetate-metabolism","display_name":"acetate metabolism","score":0.9620000123977661},{"id":"https://openalex.org/keywords/metabolic-flexibility","display_name":"metabolic flexibility","score":0.722000002861023},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/integrated-stress-response","display_name":"integrated stress response","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cebpb","display_name":"CEBPB","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.6629999876022339},{"id":"https://openalex.org/keywords/protein-hyperacetylation","display_name":"protein hyperacetylation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/malate-aspartate-shuttle","display_name":"malate-aspartate shuttle","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8109999895095825},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/avascular-necrosis","display_name":"avascular necrosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chronic-alcohol-consumption","display_name":"chronic alcohol consumption","score":0.968999981880188},{"id":"https://openalex.org/keywords/osteoprogenitor-cells","display_name":"osteoprogenitor cells","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6575000286102295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5454000234603882},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5437999963760376},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.49630001187324524},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.46799999475479126},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45210000872612},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40529999136924744},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.35690000653266907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35420000553131104},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3463999927043915},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.3386000096797943},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.2549999952316284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41467-026-77684-w","doi":"https://doi.org/10.1038/s41467-026-77684-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77684-w","pdf_url":"https://www.nature.com/articles/s41467-026-77684-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-77684-w","doi":"https://doi.org/10.1038/s41467-026-77684-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-77684-w","pdf_url":"https://www.nature.com/articles/s41467-026-77684-w_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1208124273","display_name":null,"funder_award_id":"82072493","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2962229560","display_name":null,"funder_award_id":"82372464","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G936215137","display_name":null,"funder_award_id":"2023YFB3810200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223065841.pdf","grobid_xml":"https://content.openalex.org/works/W7223065841.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401980297","https://openalex.org/W1987440607","https://openalex.org/W1973971490","https://openalex.org/W7103755408","https://openalex.org/W2123758480","https://openalex.org/W4395108808","https://openalex.org/W4391810839","https://openalex.org/W7169492487","https://openalex.org/W1986449925","https://openalex.org/W7220695460"],"abstract_inverted_index":{"Metabolic":[0],"dysregulation":[1],"under":[2,202],"nutrient":[3,64,203],"stress":[4,38,79,125],"disrupts":[5],"bone":[6,45,152,195,213,222],"homeostasis.":[7],"Although":[8],"acetate":[9,53,70],"metabolism":[10,54],"is":[11],"linked":[12],"to":[13,116],"diabetes":[14,166],"and":[15,61,123,130,151,167,183,208,217],"alcoholism,":[16],"its":[17],"role":[18,176],"in":[19,44,143,159,179,215],"the":[20,112],"skeletal":[21,47],"complications":[22],"of":[23,52,120,136,163],"these":[24],"conditions":[25],"remains":[26],"unknown.":[27],"Here":[28],"we":[29],"identify":[30],"acetyl-CoA":[31,87],"synthetase":[32],"1":[33],"(ACSS1)":[34],"as":[35,187],"a":[36,74,117,188],"key":[37],"responder":[39],"that":[40,126],"mediates":[41,198],"mitonuclear":[42,200],"communication":[43,201],"marrow":[46],"stem":[48],"cells.":[49],"ACSS1-driven":[50],"rewiring":[51],"impairs":[55],"cellular":[56],"metabolic":[57,181,193,206],"flexibility,":[58],"mitochondrial":[59,75,97,128,147],"function,":[60],"osteogenesis.":[62,209],"Mechanistically,":[63],"excess":[65],"from":[66,89],"glucose,":[67],"alcohol":[68,169],"or":[69,92,138,157],"upregulates":[71],"ACSS1":[72,83,178,186,197,211],"via":[73,103],"ROS":[76],"activated":[77],"integrated":[78],"response-CEBPB":[80],"pathway.":[81],"Maladaptive":[82],"accumulation":[84],"enforces":[85],"excessive":[86],"production":[88],"either":[90],"exogenous":[91],"glucose/ethanol-derived":[93],"endogenous":[94],"acetate,":[95],"promoting":[96],"protein":[98],"hyperacetylation":[99],"specifically":[100],"inactivating":[101],"ME2":[102,109,141],"lysine":[104],"94":[105],"acetylation.":[106],"This":[107],"ACSS1-triggered":[108],"inactivation":[110],"disturbs":[111],"malate-aspartate":[113],"shuttle,":[114],"leading":[115],"self-perpetuating":[118],"cycle":[119],"redox":[121],"imbalance":[122],"oxidative":[124],"exacerbates":[127],"dysfunction":[129],"osteogenic":[131,149],"impairment.":[132],"Importantly,":[133],"genetic":[134],"deletion":[135],"Acss1":[137],"AAV-delivered":[139],"non-acetylatable":[140],"mutant":[142],"osteoprogenitor":[144],"cells":[145],"restores":[146],"resilience,":[148],"capacity,":[150],"formation,":[153],"protecting":[154],"against":[155],"osteoporosis":[156],"osteonecrosis":[158],"male":[160],"mouse":[161],"models":[162],"type":[164],"2":[165],"chronic":[168],"consumption.":[170],"These":[171],"results":[172],"unveil":[173],"an":[174],"essential":[175],"for":[177,192],"controlling":[180],"flexibility":[182,207],"osteogenesis,":[184],"identifying":[185],"potential":[189],"therapeutic":[190],"target":[191],"stress-related":[194],"disorders.":[196],"maladaptive":[199],"stress,":[204],"impairing":[205],"Targeting":[210],"preserves":[212],"integrity":[214],"diabetic":[216],"alcoholic":[218],"mice":[219],"by":[220],"sustaining":[221],"formation.":[223]},"counts_by_year":[],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2026-10-21T00:00:00"}