{"id":"https://openalex.org/W7223060732","doi":"https://doi.org/10.1039/d6ra05893k","title":"1,2,3-Triazolyl indole-piperazine hybrids as potential anti-tubercular agents: design, synthesis, in vitro , and in silico evaluation","display_name":"1,2,3-Triazolyl indole-piperazine hybrids as potential anti-tubercular agents: design, synthesis, in vitro , and in silico evaluation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7223060732","doi":"https://doi.org/10.1039/d6ra05893k","pmid":"https://pubmed.ncbi.nlm.nih.gov/42903586","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13681189"},"language":"en","primary_location":{"id":"doi:10.1039/d6ra05893k","doi":"https://doi.org/10.1039/d6ra05893k","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra05893k","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra05893k/14916909/d6ra05893k.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra05893k/14916909/d6ra05893k.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026786101","display_name":"Rajkumar Reddyrajula","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rajkumar Reddyrajula","raw_affiliation_strings":["Department of Chemistry, School of Technology & School of Sciences, Woxsen University, Hyderabad-502345, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Technology & School of Sciences, Woxsen University, Hyderabad-502345, Telangana, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093623976","display_name":"Umadevi Etikyala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Umadevi Etikyala","raw_affiliation_strings":["Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500 076, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500 076, Telangana, India","institution_ids":["https://openalex.org/I8975392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113331341","display_name":"Mohammed Muzaffar-Ur-Rehman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohammed Muzaffar-Ur-Rehman","raw_affiliation_strings":["Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani-333031, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Pilani-333031, Rajasthan, India","institution_ids":["https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159127040","display_name":"Sampat Parayya Vibhutimath","orcid":"https://orcid.org/0009-0008-7493-9738","observed_orcids":["https://orcid.org/0009-0008-7493-9738"]},"institutions":[{"id":"https://openalex.org/I11880225","display_name":"National Institute of Technology Karnataka","ror":"https://ror.org/01hz4v948","country_code":"IN","type":"education","lineage":["https://openalex.org/I11880225"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sampat Parayya Vibhutimath","raw_affiliation_strings":["Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India"],"raw_orcid":"https://orcid.org/0009-0008-7493-9738","affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India","institution_ids":["https://openalex.org/I11880225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070434867","display_name":"Udayakumar Dalimba","orcid":"https://orcid.org/0000-0002-0493-878X","observed_orcids":["https://orcid.org/0000-0002-0493-878X"]},"institutions":[{"id":"https://openalex.org/I11880225","display_name":"National Institute of Technology Karnataka","ror":"https://ror.org/01hz4v948","country_code":"IN","type":"education","lineage":["https://openalex.org/I11880225"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Udayakumar Dalimba","raw_affiliation_strings":["Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0002-0493-878X","affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India","institution_ids":["https://openalex.org/I11880225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037149776","display_name":"Shreeganesh Subraya Hegde","orcid":"https://orcid.org/0000-0003-2678-7481","observed_orcids":["https://orcid.org/0000-0003-2678-7481"]},"institutions":[{"id":"https://openalex.org/I11880225","display_name":"National Institute of Technology Karnataka","ror":"https://ror.org/01hz4v948","country_code":"IN","type":"education","lineage":["https://openalex.org/I11880225"]},{"id":"https://openalex.org/I4400573291","display_name":"Dayananda Sagar University","ror":"https://ror.org/033f7da12","country_code":"IN","type":"education","lineage":["https://openalex.org/I4400573291"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shreeganesh Subraya Hegde","raw_affiliation_strings":["Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India","Department of Chemistry, School of Engineering, Dayananda Sagar University, Harohalli, Bengaluru-562112, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0003-2678-7481","affiliations":[{"raw_affiliation_string":"Department of Chemistry, National Institute of Technology Karnataka, Surathkal-575025, Mangalore, Karnataka, India","institution_ids":["https://openalex.org/I11880225"]},{"raw_affiliation_string":"Department of Chemistry, School of Engineering, Dayananda Sagar University, Harohalli, Bengaluru-562112, Karnataka, India","institution_ids":["https://openalex.org/I4400573291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129694914","display_name":"Chandra Sekhar Kondapalli Venkata Gowri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandra Sekhar Kondapalli Venkata Gowri","raw_affiliation_strings":["Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India"],"raw_orcid":"https://orcid.org/0000-0002-2319-8297","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad 500078, Telangana, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061528499","display_name":"Vijjulatha Manga","orcid":"https://orcid.org/0000-0001-9056-8385","observed_orcids":["https://orcid.org/0000-0001-9056-8385"]},"institutions":[{"id":"https://openalex.org/I8975392","display_name":"Osmania University","ror":"https://ror.org/030sjb889","country_code":"IN","type":"education","lineage":["https://openalex.org/I8975392"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vijjulatha Manga","raw_affiliation_strings":["Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500 076, Telangana, India"],"raw_orcid":"https://orcid.org/0000-0001-9056-8385","affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad-500 076, Telangana, India","institution_ids":["https://openalex.org/I8975392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5026786101","https://openalex.org/A5061528499","https://openalex.org/A5070434867"],"corresponding_institution_ids":["https://openalex.org/I11880225","https://openalex.org/I8975392"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67703655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"48","first_page":"64610","last_page":"64625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-tubercular-agents","display_name":"anti-tubercular agents","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antitubercular-drug-design","display_name":"antitubercular drug design","score":0.7789999842643738},{"id":"https://openalex.org/keywords/lead-identification","display_name":"lead compound identification","score":0.48100000619888306},{"id":"https://openalex.org/keywords/in-silico-evaluation","display_name":"in silico evaluation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.9391000270843506},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.7620000243186951},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.7476000189781189},{"id":"https://openalex.org/C48189365","wikidata":"https://www.wikidata.org/wiki/Q42621","display_name":"Hybrid","level":2,"score":0.6690000295639038},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6668999791145325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4478999972343445},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33070001006126404},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2759000062942505},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2632000148296356},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1039/d6ra05893k","doi":"https://doi.org/10.1039/d6ra05893k","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra05893k","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra05893k/14916909/d6ra05893k.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13681189","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681189/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13681189/pdf/RA-OLF-D6RA05893K.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:42903586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42903586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:538e0a3939a14144a4434f424f81e16a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/538e0a3939a14144a4434f424f81e16a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"RSC Advances, Vol 16, Iss 48, Pp 64610-64610 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1039/d6ra05893k","doi":"https://doi.org/10.1039/d6ra05893k","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra05893k","pdf_url":"https://pubs.rsc.org/ra/article-pdf/doi/10.1039/d6ra05893k/14916909/d6ra05893k.pdf","source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6189000010490417,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322452","display_name":"Osmania University","ror":"https://ror.org/030sjb889"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223060732.pdf","grobid_xml":"https://content.openalex.org/works/W7223060732.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W567237283","https://openalex.org/W1973476287","https://openalex.org/W1988600626","https://openalex.org/W2003242056","https://openalex.org/W2009423060","https://openalex.org/W2071794983","https://openalex.org/W2093221728","https://openalex.org/W2095719702","https://openalex.org/W2134822873","https://openalex.org/W2136383016","https://openalex.org/W2158023121","https://openalex.org/W2160270692","https://openalex.org/W2160571788","https://openalex.org/W2165243436","https://openalex.org/W2192862478","https://openalex.org/W2298918770","https://openalex.org/W2615476494","https://openalex.org/W2947657280","https://openalex.org/W3097077145","https://openalex.org/W3117120008","https://openalex.org/W4200553976","https://openalex.org/W4286510150","https://openalex.org/W4293199754","https://openalex.org/W4307338130","https://openalex.org/W4317568756","https://openalex.org/W4322622712","https://openalex.org/W4387881054","https://openalex.org/W4390457822","https://openalex.org/W4391330319","https://openalex.org/W4391351637","https://openalex.org/W4396706385","https://openalex.org/W4399026047","https://openalex.org/W4399781502","https://openalex.org/W4404201306","https://openalex.org/W4405847378","https://openalex.org/W4410065411","https://openalex.org/W4410284832","https://openalex.org/W4410980089","https://openalex.org/W4414134161","https://openalex.org/W4414749686","https://openalex.org/W7083626803","https://openalex.org/W7128911220","https://openalex.org/W7160248027","https://openalex.org/W7163816212"],"related_works":["https://openalex.org/W4390457822","https://openalex.org/W7221196819","https://openalex.org/W3096419682","https://openalex.org/W4414039265","https://openalex.org/W4392741658","https://openalex.org/W2188301483","https://openalex.org/W2917780775","https://openalex.org/W4415726314","https://openalex.org/W4213026214","https://openalex.org/W3002418521"],"abstract_inverted_index":{"studies":[0],"identified":[1],"three":[2],"promising":[3],"lead":[4],"molecules":[5],"(R11,":[6],"R13":[7],"and":[8,14],"R15)":[9],"with":[10],"significant":[11],"antitubercular":[12],"activity":[13],"emphasizing":[15],"the":[16,19,24],"importance":[17],"of":[18,26],"1,2,3-triazolyl":[20],"indole-piperazine":[21],"scaffold":[22],"for":[23],"development":[25],"next-generation":[27],"anti-TB":[28],"therapeutics.":[29]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}
