{"id":"https://openalex.org/W7223055348","doi":"https://doi.org/10.1080/20415990.2026.2742651","title":"Preparation of artificial tears with in-situ gelling properties for the management of dry eye disease: efficient droplet administration by a 3D-printed device","display_name":"Preparation of artificial tears with in-situ gelling properties for the management of dry eye disease: efficient droplet administration by a 3D-printed device","publication_year":2026,"publication_date":"2026-09-02","ids":{"openalex":"https://openalex.org/W7223055348","doi":"https://doi.org/10.1080/20415990.2026.2742651","pmid":"https://pubmed.ncbi.nlm.nih.gov/42900245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13733146"},"language":"en","primary_location":{"id":"doi:10.1080/20415990.2026.2742651","doi":"https://doi.org/10.1080/20415990.2026.2742651","is_oa":false,"landing_page_url":"https://doi.org/10.1080/20415990.2026.2742651","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42900245/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123089571","display_name":"Sana Yousaf","orcid":"https://orcid.org/0009-0002-6673-4317","observed_orcids":["https://orcid.org/0009-0002-6673-4317"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Sana Yousaf","raw_affiliation_strings":["Bahauddin Zakariya University"],"raw_orcid":"https://orcid.org/0009-0002-6673-4317","affiliations":[{"raw_affiliation_string":"Bahauddin Zakariya University","institution_ids":["https://openalex.org/I127670440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072550829","display_name":"Saman Zafar","orcid":"https://orcid.org/0000-0003-3418-3039","observed_orcids":["https://orcid.org/0000-0003-3418-3039"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Saman Zafar","raw_affiliation_strings":["Bahauddin Zakariya University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bahauddin Zakariya University","institution_ids":["https://openalex.org/I127670440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066763668","display_name":"Muhammad Majid Bashir","orcid":"https://orcid.org/0009-0005-4412-9724","observed_orcids":["https://orcid.org/0009-0005-4412-9724"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Majid Bashir","raw_affiliation_strings":["Bahauddin Zakariya University"],"raw_orcid":"https://orcid.org/0009-0005-4412-9724","affiliations":[{"raw_affiliation_string":"Bahauddin Zakariya University","institution_ids":["https://openalex.org/I127670440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042511820","display_name":"Sadia Jafar Rana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadia Jafar Rana","raw_affiliation_strings":["The Next Institute of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Next Institute of Science and Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013804170","display_name":"Jahanzeb Mudassir","orcid":"https://orcid.org/0000-0002-7308-6509","observed_orcids":["https://orcid.org/0000-0002-7308-6509"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Jahanzeb Mudassir","raw_affiliation_strings":["Bahauddin Zakariya University"],"raw_orcid":"https://orcid.org/0000-0002-7308-6509","affiliations":[{"raw_affiliation_string":"Bahauddin Zakariya University","institution_ids":["https://openalex.org/I127670440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079230134","display_name":"Amjad Hussain","orcid":"https://orcid.org/0000-0002-9427-2677","observed_orcids":["https://orcid.org/0000-0002-9427-2677"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amjad Hussain","raw_affiliation_strings":["University College of Pharmacy, University of the Punjab"],"raw_orcid":"https://orcid.org/0000-0002-9427-2677","affiliations":[{"raw_affiliation_string":"University College of Pharmacy, University of the Punjab","institution_ids":["https://openalex.org/I172780181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055489849","display_name":"Nasir A. Abbas","orcid":"https://orcid.org/0000-0003-1862-1609","observed_orcids":["https://orcid.org/0000-0003-1862-1609"]},"institutions":[{"id":"https://openalex.org/I172780181","display_name":"University of the Punjab","ror":"https://ror.org/011maz450","country_code":"PK","type":"education","lineage":["https://openalex.org/I172780181"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nasir Abbas","raw_affiliation_strings":["University College of Pharmacy, University of the Punjab"],"raw_orcid":"https://orcid.org/0000-0003-1862-1609","affiliations":[{"raw_affiliation_string":"University College of Pharmacy, University of the Punjab","institution_ids":["https://openalex.org/I172780181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017483804","display_name":"Enas Al-Ani","orcid":"https://orcid.org/0000-0001-6254-8432","observed_orcids":["https://orcid.org/0000-0001-6254-8432"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Enas Al-Ani","raw_affiliation_strings":["University of Manchester"],"raw_orcid":"https://orcid.org/0000-0001-6254-8432","affiliations":[{"raw_affiliation_string":"University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019293364","display_name":"Muhammad Sohail Arshad","orcid":"https://orcid.org/0000-0001-9807-5841","observed_orcids":["https://orcid.org/0000-0001-9807-5841","https://orcid.org/0009-0007-4635-5797"]},"institutions":[{"id":"https://openalex.org/I127670440","display_name":"Bahauddin Zakariya University","ror":"https://ror.org/05x817c41","country_code":"PK","type":"education","lineage":["https://openalex.org/I127670440"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Muhammad Sohail Arshad","raw_affiliation_strings":["Bahauddin Zakariya University"],"raw_orcid":"https://orcid.org/0000-0001-9807-5841","affiliations":[{"raw_affiliation_string":"Bahauddin Zakariya University","institution_ids":["https://openalex.org/I127670440"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029000704","display_name":"Zeeshan Ahmad","orcid":"https://orcid.org/0000-0001-8863-6211","observed_orcids":["https://orcid.org/0000-0001-8863-6211"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zeeshan Ahmad","raw_affiliation_strings":["University of Manchester"],"raw_orcid":"https://orcid.org/0000-0001-8863-6211","affiliations":[{"raw_affiliation_string":"University of Manchester","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019293364","https://openalex.org/A5029000704"],"corresponding_institution_ids":["https://openalex.org/I127670440","https://openalex.org/I28407311"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77129416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"9","first_page":"985","last_page":"997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.11590000241994858,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-tears","display_name":"artificial tears","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dry-eye-disease","display_name":"dry eye","score":0.8870000243186951},{"id":"https://openalex.org/keywords/in-situ-gelling","display_name":"in situ gelling","score":0.8870000243186951},{"id":"https://openalex.org/keywords/gellan-gum","display_name":"gellan gum","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":1.0},{"id":"https://openalex.org/keywords/fused-deposition-modeling","display_name":"fused deposition modeling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/eye-irritation","display_name":"eye irritation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/schirmer-test","display_name":"Schirmer test","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2778837293","wikidata":"https://www.wikidata.org/wiki/Q3320636","display_name":"Artificial tears","level":2,"score":0.7961999773979187},{"id":"https://openalex.org/C2781220964","wikidata":"https://www.wikidata.org/wiki/Q416694","display_name":"Gellan gum","level":2,"score":0.7537999749183655},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.557699978351593},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.47119998931884766},{"id":"https://openalex.org/C2778275304","wikidata":"https://www.wikidata.org/wiki/Q76469","display_name":"Tears","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C2775984611","wikidata":"https://www.wikidata.org/wiki/Q273554","display_name":"Conjunctiva","level":2,"score":0.414000004529953},{"id":"https://openalex.org/C2994251472","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Eye irritation","level":3,"score":0.37770000100135803},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.36239999532699585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3587000072002411},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3407999873161316},{"id":"https://openalex.org/C2777339698","wikidata":"https://www.wikidata.org/wiki/Q423123","display_name":"Dextran","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3070000112056732},{"id":"https://openalex.org/C2908964346","wikidata":"https://www.wikidata.org/wiki/Q1891053","display_name":"Schirmer test","level":3,"score":0.27239999175071716},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2676999866962433}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011135","descriptor_name":"Polysaccharides, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015352","descriptor_name":"Dry Eye Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D060433","descriptor_name":"Administration, Ophthalmic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065346","descriptor_name":"Lubricant Eye Drops","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D065346","descriptor_name":"Lubricant Eye Drops","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065347","descriptor_name":"Hypromellose Derivatives","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D066330","descriptor_name":"Printing, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/20415990.2026.2742651","doi":"https://doi.org/10.1080/20415990.2026.2742651","is_oa":false,"landing_page_url":"https://doi.org/10.1080/20415990.2026.2742651","pdf_url":null,"source":{"id":"https://openalex.org/S89829989","display_name":"Therapeutic Delivery","issn_l":"2041-5990","issn":["2041-5990","2041-6008"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320316","host_organization_name":"Future Science Ltd","host_organization_lineage":["https://openalex.org/P4310320316"],"host_organization_lineage_names":["Future Science Ltd"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Delivery","raw_type":"journal-article"},{"id":"pmid:42900245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42900245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic delivery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13733146","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42900245/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Deliv","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/6b9f1d58-e5ff-4194-aece-6f180e02f895","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/6b9f1d58-e5ff-4194-aece-6f180e02f895","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Yousaf, S, Zafar, S, Bashir, M M, Rana, S J, Mudassir, J, Hussain, A, Abbas, N, Al-Ani, E, Arshad, M S & Ahmad, Z 2026, 'Preparation of artificial tears with in-situ gelling properties for the management of dry eye disease : efficient droplet administration by a 3D-printed device', Therapeutic delivery, pp. 1-13. https://doi.org/10.1080/20415990.2026.2742651","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13733146","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42900245/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ther Deliv","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W796169222","https://openalex.org/W1587274562","https://openalex.org/W1995557581","https://openalex.org/W2012415721","https://openalex.org/W2057852734","https://openalex.org/W2125532747","https://openalex.org/W2141242845","https://openalex.org/W2144639656","https://openalex.org/W2169634958","https://openalex.org/W2196611084","https://openalex.org/W2286445807","https://openalex.org/W2343172066","https://openalex.org/W2399345654","https://openalex.org/W2472428533","https://openalex.org/W2564502977","https://openalex.org/W2608205014","https://openalex.org/W2626182649","https://openalex.org/W2651771062","https://openalex.org/W2774812666","https://openalex.org/W2890592868","https://openalex.org/W2980691871","https://openalex.org/W3001233275","https://openalex.org/W3083597173","https://openalex.org/W3091351497","https://openalex.org/W3099437660","https://openalex.org/W3123894004","https://openalex.org/W3135751630","https://openalex.org/W3136125550","https://openalex.org/W3167075662","https://openalex.org/W4200370166","https://openalex.org/W4207074865","https://openalex.org/W4221069075","https://openalex.org/W4280564097","https://openalex.org/W4294794246","https://openalex.org/W4310038878","https://openalex.org/W4323316822","https://openalex.org/W4360938314","https://openalex.org/W4383555603","https://openalex.org/W4385580250","https://openalex.org/W4386258711","https://openalex.org/W4389109033","https://openalex.org/W4389333811","https://openalex.org/W4394576732","https://openalex.org/W4404523818","https://openalex.org/W4410837106","https://openalex.org/W4414736553"],"related_works":["https://openalex.org/W2774812666","https://openalex.org/W2917241647","https://openalex.org/W4414736553","https://openalex.org/W2794711116","https://openalex.org/W2843275904","https://openalex.org/W7097229497","https://openalex.org/W2611635106","https://openalex.org/W852104085","https://openalex.org/W2795490010","https://openalex.org/W2587436937"],"abstract_inverted_index":{"Aims":[0],"The":[1],"present":[2],"study":[3],"was":[4,36,76,138,163,196],"aimed":[5],"at":[6],"developing":[7],"in-situ":[8],"gelling":[9,23],"artificial":[10],"tear":[11],"formulations":[12,24,93,147,187],"and":[13,20,30,64,87,99,114,129],"a":[14],"three-dimensional":[15],"(3D)":[16],"printed":[17,74,172],"administration":[18,169,194],"aid.Materials":[19],"methods":[21],"In-situ":[22],"were":[25,44],"prepared":[26,186,201],"using":[27],"gellan":[28,111],"gum":[29],"hydroxypropyl":[31],"methylcellulose":[32],"(HPMC).":[33],"Administration":[34],"aid":[35,173,195],"developed":[37],"by":[38,89],"fused":[39],"deposition":[40],"modeling":[41],"approach.":[42],"Formulations":[43,120],"evaluated":[45,77],"for":[46,78,199],"physicochemical":[47,96],"properties,":[48,97],"sterility,":[49],"in-vitro":[50],"erythrocyte":[51],"morphology":[52],"assessment,":[53],"disintegration,":[54],"in-silico":[55],"analysis,":[56],"ex-vivo":[57],"ocular":[58,62,115,123],"surface":[59],"retention,":[60],"in-vivo":[61],"irritation":[63],"efficacy":[65],"in":[66,71,140,159,165],"dry":[67],"eye":[68,150],"disease":[69],"model":[70],"rabbits.":[72],"3D":[73,171],"device":[75],"volume":[79,162],"of":[80,126,146,168,176],"dispensed":[81],"droplets,":[82],"usability,":[83],"instillation":[84,175],"success":[85],"rate":[86],"acceptance":[88],"human":[90],"participants.Results":[91],"Prepared":[92],"exhibited":[94],"acceptable":[95],"sterility":[98],"did":[100],"not":[101],"irritate":[102],"the":[103,132,141,152,160,166],"rabbit":[104,149],"eye.":[105],"In-silico":[106],"analysis":[107],"suggested":[108],"interactions":[109],"between":[110],"gum,":[112],"HPMC":[113],"proteins":[116],"(mucin,":[117],"p-glycoprotein,":[118],"OATP2A1).":[119],"showed":[121],"an":[122],"retention":[124],"time":[125],"~20\u201324":[127],"hours":[128],"disintegrated":[130],"within":[131],"same":[133],"timeframe.":[134],"A":[135,155],"two-fold":[136],"increase":[137,158],"recorded":[139],"Schirmer":[142,178],"1":[143,179],"test":[144,180],"score":[145],"treated":[148],"than":[151],"untreated":[153,191],"counterpart.":[154],"~":[156],"21%":[157],"droplet":[161],"observed":[164],"presence":[167],"aid.":[170],"facilitated":[174],"formulations.Conclusions":[177],"scores":[181],"increased":[182],"following":[183],"treatment":[184],"with":[185],"as":[188],"compared":[189],"to":[190],"counterparts.":[192],"An":[193],"successfully":[197],"engineered":[198],"dispensing":[200],"formulations.":[202]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}