{"id":"https://openalex.org/W7223054497","doi":"https://doi.org/10.64898/2026.10.14.759110","title":"Roles of Interstitial Albumin in the Subcutaneous Delivery of Therapeutic Peptides","display_name":"Roles of Interstitial Albumin in the Subcutaneous Delivery of Therapeutic Peptides","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223054497","doi":"https://doi.org/10.64898/2026.10.14.759110"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.14.759110","doi":"https://doi.org/10.64898/2026.10.14.759110","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.759110","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.14.759110.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.14.759110.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043688702","display_name":"D\u00e1vid Juriga","orcid":"https://orcid.org/0000-0003-2655-5584","observed_orcids":["https://orcid.org/0000-0003-2655-5584"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"David Juriga","raw_affiliation_strings":["Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-2655-5584","affiliations":[{"raw_affiliation_string":"Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046074810","display_name":"Anton Norberg","orcid":"https://orcid.org/0000-0001-9142-1879","observed_orcids":["https://orcid.org/0000-0001-9142-1879"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anton Norberg","raw_affiliation_strings":["Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9142-1879","affiliations":[{"raw_affiliation_string":"Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106519435","display_name":"Esther Olaniran H\u00e5kansson","orcid":"https://orcid.org/0009-0008-6737-0336","observed_orcids":["https://orcid.org/0009-0008-6737-0336"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Esther Olaniran H\u00e5kansson","raw_affiliation_strings":["Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0009-0008-6737-0336","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159108709","display_name":"Jeroen Wilco van den Heuvel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jeroen Wilco van den Heuvel","raw_affiliation_strings":["Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053696627","display_name":"Johan Gr\u00e5sj\u00f6","orcid":"https://orcid.org/0000-0002-0080-3714","observed_orcids":["https://orcid.org/0000-0002-0080-3714"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Gr\u00e5sj\u00f6","raw_affiliation_strings":["Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0080-3714","affiliations":[{"raw_affiliation_string":"Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072386497","display_name":"Luke R. Odell","orcid":"https://orcid.org/0000-0001-7658-5103","observed_orcids":["https://orcid.org/0000-0001-7658-5103"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Luke R. Odell","raw_affiliation_strings":["Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-7658-5103","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014071440","display_name":"Anna Orlova","orcid":"https://orcid.org/0000-0001-6120-2683","observed_orcids":["https://orcid.org/0000-0001-6120-2683"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna Orlova","raw_affiliation_strings":["Theranostics Group, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0001-6120-2683","affiliations":[{"raw_affiliation_string":"Theranostics Group, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088941318","display_name":"Per Hansson","orcid":"https://orcid.org/0000-0002-0895-1180","observed_orcids":["https://orcid.org/0000-0002-0895-1180"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Per Hansson","raw_affiliation_strings":["Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-0895-1180","affiliations":[{"raw_affiliation_string":"Pharmaceutical Physical Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Biomedicinskt Centrum BMC, Husargatan 3, 751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088941318"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcutaneous-drug-delivery","display_name":"subcutaneous drug delivery","score":0.8629999756813049},{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.902999997138977},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9539999961853027},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6840000152587891},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cationic-peptides","display_name":"cationic peptides","score":0.953000009059906},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.859000027179718},{"id":"https://openalex.org/keywords/in-vitro-skin-model","display_name":"in vitro skin model","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.703499972820282},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6549999713897705},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5776000022888184},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5604000091552734},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5600000023841858},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48579999804496765},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.47589999437332153},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4415000081062317},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4350999891757965},{"id":"https://openalex.org/C37668627","wikidata":"https://www.wikidata.org/wiki/Q3381809","display_name":"Thermal diffusivity","level":2,"score":0.40779998898506165},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.4052000045776367},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.39419999718666077},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.387800008058548},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.3614000082015991},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.3427000045776367},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3046000003814697},{"id":"https://openalex.org/C2779822359","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Interstitial fluid","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.14.759110","doi":"https://doi.org/10.64898/2026.10.14.759110","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.759110","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.14.759110.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.14.759110","doi":"https://doi.org/10.64898/2026.10.14.759110","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.759110","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.14.759110.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2023082088","display_name":"Combined targeted radionuclide imaging and targeted therapy \u2013 a way for precision treatment of prostate cancer","funder_award_id":"2022-00556","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G2319912484","display_name":null,"funder_award_id":"2022-00556","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G2878354728","display_name":null,"funder_award_id":"23 2645","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G3318081750","display_name":"Spatial Omics Enable Improved Pathophysiology-based Diagnosis of Parkinson\u00b4s Disease Dementia and Dementia with Lewy Bodies","funder_award_id":"2021-03293","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G3433214934","display_name":null,"funder_award_id":"2022-00556","funder_id":"https://openalex.org/F4320324119","funder_display_name":"Uppsala Universitet"},{"id":"https://openalex.org/G356405547","display_name":null,"funder_award_id":"23 2645 PjF 01H","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G4675316634","display_name":null,"funder_award_id":"24 3889 Pj","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G5744666124","display_name":null,"funder_award_id":"23 2645 PjF 01H","funder_id":"https://openalex.org/F4320324119","funder_display_name":"Uppsala Universitet"},{"id":"https://openalex.org/G6265702644","display_name":null,"funder_award_id":"2019-","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G6839690371","display_name":null,"funder_award_id":"3889 Pj","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G7995343556","display_name":"New and Enabling Chemical Tools for Molecular Imaging, Chemical Biology and Drug Discovery","funder_award_id":"2022-04831","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223054497.pdf","grobid_xml":"https://content.openalex.org/works/W7223054497.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7125466298","https://openalex.org/W4401739223","https://openalex.org/W4403668139","https://openalex.org/W4414030858","https://openalex.org/W6963965917","https://openalex.org/W7163551725","https://openalex.org/W2406983553","https://openalex.org/W4407972680","https://openalex.org/W4311930859","https://openalex.org/W4384663741"],"abstract_inverted_index":{"Abstract":[0],"Subcutaneous":[1],"administration":[2],"of":[3,26,67,96,100,110],"biotherapeutics":[4],"is":[5],"increasingly":[6],"favoured":[7],"for":[8,106,113,147,196],"better":[9],"safety":[10],"profile,":[11],"improved":[12],"stability,":[13],"and":[14,31,42,51,62,84,133,137,160,190],"patient":[15],"compliance":[16],"compared":[17],"with":[18,80,94,165],"intravenous":[19],"administration.":[20],"Despite":[21],"these":[22],"advantages,":[23],"the":[24,37,71,130,163],"roles":[25],"extracellular":[27],"matrix":[28,148],"(ECM)":[29],"components":[30],"interstitial":[32],"proteins,":[33],"particularly":[34],"albumin,":[35],"in":[36,58,70,162,171,179,182,198],"mechanisms":[38,69],"governing":[39],"therapeutic":[40],"pharmacokinetics":[41],"bioavailability":[43,124],"remain":[44],"poorly":[45],"understood.":[46],"We":[47,115],"present":[48],"a":[49,104,155,183],"versatile":[50],"customizable":[52],"hydrogel":[53],"platform":[54],"resembling":[55],"native":[56],"ECM":[57,131,188],"composition,":[59],"charge":[60],"density,":[61],"microstructure,":[63],"enabling":[64],"systematic":[65],"investigation":[66],"transport":[68,111],"subcutaneous":[72,200],"space.":[73],"Using":[74],"this":[75],"platform,":[76],"we":[77,102],"studied":[78],"peptides":[79,127],"different":[81],"net":[82],"charges":[83],"albumin":[85,107,140,153,191],"affinities.":[86],"Based":[87],"on":[88,158],"results":[89],"from":[90],"confocal":[91],"microscopy":[92],"combined":[93],"measurements":[95],"diffusivities":[97],"by":[98,125,177],"means":[99],"FRAP,":[101],"propose":[103],"role":[105],"beyond":[108],"that":[109,117],"vehicle":[112],"drugs.":[114],"show":[116],"reversible":[118],"peptide-albumin":[119],"binding":[120],"can":[121],"both":[122],"increase":[123],"removing":[126],"bound":[128],"to":[129,143],"biopolymers":[132],"modulate":[134],"peptide":[135],"diffusivity":[136,159],"distribution,":[138],"as":[139,193],"was":[141],"found":[142],"have":[144],"an":[145],"affinity":[146],"glycosaminoglycans.":[149],"For":[150],"cationic":[151],"peptides,":[152],"had":[154],"major":[156],"influence":[157],"distribution":[161],"matrix,":[164],"more":[166],"pronounced":[167],"effects":[168],"over":[169],"time":[170],"vitro":[172,199],".":[173],"These":[174],"findings,":[175],"complemented":[176],"exploratory":[178],"vivo":[180],"observations":[181],"limited":[184],"cohort,":[185],"highlight":[186],"realistic":[187],"structure":[189],"inclusion":[192],"key":[194],"considerations":[195],"predictive":[197],"models.":[201]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-21T00:00:00"}
