{"id":"https://openalex.org/W7223049282","doi":"https://doi.org/10.3390/ijms27209306","title":"Non-Canonical HIF2 Accumulation in Breast Cancer Cells","display_name":"Non-Canonical HIF2 Accumulation in Breast Cancer Cells","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223049282","doi":"https://doi.org/10.3390/ijms27209306","pmid":"https://pubmed.ncbi.nlm.nih.gov/42942075","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13705551"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27209306","doi":"https://doi.org/10.3390/ijms27209306","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209306","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27209306","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062741268","display_name":"Karolina Kozal","orcid":"https://orcid.org/0000-0001-6879-3674","observed_orcids":["https://orcid.org/0000-0001-6879-3674"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Karolina Kozal","raw_affiliation_strings":["Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","The BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Jana Matejki 21/23, 90-237 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-6879-3674","affiliations":[{"raw_affiliation_string":"Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]},{"raw_affiliation_string":"The BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Jana Matejki 21/23, 90-237 Lodz, Poland","institution_ids":["https://openalex.org/I34250744","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159131140","display_name":"Aleksandra Opitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Opitz","raw_affiliation_strings":["Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083474678","display_name":"Monika Jarosiewicz","orcid":"https://orcid.org/0000-0003-3104-4025","observed_orcids":["https://orcid.org/0000-0003-3104-4025"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Jarosiewicz","raw_affiliation_strings":["Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0003-3104-4025","affiliations":[{"raw_affiliation_string":"Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078745673","display_name":"Micha\u0142 Juszczak","orcid":"https://orcid.org/0000-0003-4055-6102","observed_orcids":["https://orcid.org/0000-0003-4055-6102"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Micha\u0142 Juszczak","raw_affiliation_strings":["Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036973071","display_name":"Anna Krze\u015blak","orcid":"https://orcid.org/0000-0002-4982-7901","observed_orcids":["https://orcid.org/0000-0002-4982-7901"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Anna Krze\u015blak","raw_affiliation_strings":["Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","The BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Jana Matejki 21/23, 90-237 Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0002-4982-7901","affiliations":[{"raw_affiliation_string":"Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland","institution_ids":["https://openalex.org/I34250744"]},{"raw_affiliation_string":"The BioMedChem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Jana Matejki 21/23, 90-237 Lodz, Poland","institution_ids":["https://openalex.org/I34250744","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036973071","https://openalex.org/A5062741268"],"corresponding_institution_ids":["https://openalex.org/I34250744","https://openalex.org/I99542240"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73115029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"20","first_page":"9306","last_page":"9306"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hif-2","display_name":"HIF-2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9509999752044678},{"id":"https://openalex.org/keywords/glucose-restriction","display_name":"glucose restriction","score":0.6589999794960022},{"id":"https://openalex.org/keywords/pdk1","display_name":"PDK1","score":0.7480000257492065},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6110000014305115},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7017999887466431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6019999980926514},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.5738999843597412},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5371999740600586},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.45989999175071716},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.436599999666214},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.414900004863739},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.41440001130104065},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.34060001373291016},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000092302","descriptor_name":"MDA-MB-231 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097784","descriptor_name":"Metabolic Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099162","descriptor_name":"Endothelial PAS Domain-Containing Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27209306","doi":"https://doi.org/10.3390/ijms27209306","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209306","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13705551","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705551/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705551/pdf/ijms-27-09306.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42942075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42942075","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27209306","doi":"https://doi.org/10.3390/ijms27209306","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209306","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323344","display_name":"Uniwersytet \u0141\u00f3dzki","ror":"https://ror.org/05cq64r17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223049282.pdf","grobid_xml":"https://content.openalex.org/works/W7223049282.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1929533080","https://openalex.org/W1965154864","https://openalex.org/W1998664010","https://openalex.org/W2003670869","https://openalex.org/W2028897202","https://openalex.org/W2029255902","https://openalex.org/W2030587633","https://openalex.org/W2072141039","https://openalex.org/W2073560853","https://openalex.org/W2120483851","https://openalex.org/W2125350476","https://openalex.org/W2129469298","https://openalex.org/W2152488345","https://openalex.org/W2338352605","https://openalex.org/W2470067239","https://openalex.org/W2563689911","https://openalex.org/W2624068238","https://openalex.org/W2791034765","https://openalex.org/W2894385199","https://openalex.org/W2897659642","https://openalex.org/W2918097835","https://openalex.org/W2941222591","https://openalex.org/W2964416380","https://openalex.org/W2975185384","https://openalex.org/W2977099166","https://openalex.org/W2999288416","https://openalex.org/W3082891477","https://openalex.org/W3116557037","https://openalex.org/W3133286350","https://openalex.org/W3139507450","https://openalex.org/W3165667851","https://openalex.org/W3192535679","https://openalex.org/W3197266090","https://openalex.org/W3198945369","https://openalex.org/W4200095081","https://openalex.org/W4220868035","https://openalex.org/W4283204847","https://openalex.org/W4296251838","https://openalex.org/W4304092803","https://openalex.org/W4360942791","https://openalex.org/W4383737292","https://openalex.org/W4384408505","https://openalex.org/W4395076460","https://openalex.org/W4406781660","https://openalex.org/W4411682325","https://openalex.org/W4413003567","https://openalex.org/W7135063556"],"related_works":["https://openalex.org/W4250283355","https://openalex.org/W2059969789","https://openalex.org/W2791034765","https://openalex.org/W2942547274","https://openalex.org/W2975185384","https://openalex.org/W1985458442","https://openalex.org/W2096014622","https://openalex.org/W2149431653","https://openalex.org/W2326008812","https://openalex.org/W4296251838"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming":[1],"drives":[2],"cancer":[3,195],"aggressiveness.":[4],"While":[5],"hypoxia-inducible":[6],"factor":[7],"1":[8],"(HIF1)":[9],"is":[10],"commonly":[11],"associated":[12,91],"with":[13,51,92],"glycolysis":[14],"regulation,":[15],"the":[16,23,31,75,117,140,169,189],"under-investigated":[17],"HIF2":[18,35,62,87,120,146,154,166,190],"isoform":[19,191],"may":[20,148],"also":[21],"modulate":[22,168],"metabolic":[24,38,68,123,170],"profile":[25],"of":[26,33,86,172],"breast":[27,194,207],"cancer.":[28,208],"We":[29,80],"investigated":[30],"role":[32],"non-canonical":[34,84],"activation":[36],"in":[37,88,100,125,178],"adaptation":[39],"to":[40,150],"nutrient":[41,130],"availability":[42],"by":[43],"culturing":[44],"MDA-MB-231":[45,89,104,173],"and":[46,54,63,67,77,94,181,197],"MCF-7":[47,101],"cells":[48,90,174],"under":[49,108,129,159],"normoxia":[50],"varying":[52],"glucose":[53,93],"glutamine":[55,95],"concentrations.":[56],"Using":[57],"RNA":[58],"interference,":[59],"we":[60],"downregulated":[61],"analyzed":[64],"HIF":[65],"isoforms":[66],"targets":[69,124],"(GLUT1,":[70],"HK2,":[71],"PKM2,":[72],"PDK1)":[73],"at":[74],"transcriptional":[76],"protein":[78,118,141],"levels.":[79],"observed":[81],"a":[82,97,126,133,201],"new,":[83],"accumulation":[85,147],"restriction,":[96],"phenomenon":[98],"absent":[99],"cells.":[102],"In":[103],"cells,":[105],"silencing":[106],"HIF2A":[107],"standard":[109],"conditions":[110],"significantly":[111],"decreased":[112,156],"PDK1":[113],"mRNA":[114],"expression.":[115],"At":[116],"level,":[119],"downregulation":[121,155],"altered":[122],"context-dependent":[127,152],"manner":[128],"restriction.":[131],"Adding":[132],"hypoxia-mimetic":[134],"(CoCl2)":[135],"did":[136],"not":[137],"fully":[138],"restore":[139],"expression":[142,180],"patterns,":[143],"suggesting":[144],"that":[145,165],"contribute":[149],"these":[151],"shifts.":[153],"glycolytic":[157],"efficiency":[158],"low-glucose":[160],"conditions.":[161],"Our":[162],"findings":[163],"suggest":[164],"might":[167],"plasticity":[171],"through":[175],"distinct":[176],"changes":[177],"gene":[179],"post-translational":[182],"mechanisms.":[183],"This":[184],"provides":[185],"support":[186],"for":[187,204],"investigating":[188],"while":[192],"studying":[193],"metabolism":[196],"considering":[198],"it":[199],"as":[200],"potential":[202],"target":[203],"treating":[205],"triple-negative":[206]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-21T00:00:00"}