{"id":"https://openalex.org/W7223046343","doi":"https://doi.org/10.3389/fnins.2026.1898605","title":"Domain-specific associations of metabolomic features with cognition and neural networks among cognitively normal adults","display_name":"Domain-specific associations of metabolomic features with cognition and neural networks among cognitively normal adults","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223046343","doi":"https://doi.org/10.3389/fnins.2026.1898605","pmid":"https://pubmed.ncbi.nlm.nih.gov/42978722","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13727718"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2026.1898605","doi":"https://doi.org/10.3389/fnins.2026.1898605","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1898605","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1898605/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1898605/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081495152","display_name":"Brandi L. Vollmer","orcid":"https://orcid.org/0000-0002-0593-9012","observed_orcids":["https://orcid.org/0000-0002-0593-9012"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi L. Vollmer","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049228057","display_name":"Christian Georg Habeck","orcid":"https://orcid.org/0000-0001-9961-7446","observed_orcids":["https://orcid.org/0000-0001-9961-7446"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Habeck","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038713311","display_name":"Vrinda Kalia","orcid":"https://orcid.org/0000-0003-2244-6663","observed_orcids":["https://orcid.org/0000-0003-2244-6663"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vrinda Kalia","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091023924","display_name":"Badri Narayan Vardarajan","orcid":"https://orcid.org/0000-0002-5560-4085","observed_orcids":["https://orcid.org/0000-0002-5560-4085"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Badri N. Vardarajan","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078079034","display_name":"Nikolaos Scarmeas","orcid":"https://orcid.org/0000-0001-6453-8908","observed_orcids":["https://orcid.org/0000-0001-6453-8908"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["GR","US"],"is_corresponding":false,"raw_author_name":"Nikolaos Scarmeas","raw_affiliation_strings":["Department of Neurology, Columbia University","Department of Neurology, National and Kapodistrian University of Athens"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Neurology, National and Kapodistrian University of Athens","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069002204","display_name":"Gary W. Miller","orcid":"https://orcid.org/0000-0001-8984-1284","observed_orcids":["https://orcid.org/0000-0001-8984-1284"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary W. Miller","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032025339","display_name":"Yaakov Stern","orcid":"https://orcid.org/0000-0001-7542-3241","observed_orcids":["https://orcid.org/0000-0001-7542-3241"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaakov Stern","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159114946","display_name":"Yian Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yian Gu","raw_affiliation_strings":["Department of Neurology, Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5159114946"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80489959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":"1898605","last_page":"1898605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6488999724388123,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.33500000834465027,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-metabolites","display_name":"circulating metabolites","score":0.8899999856948853},{"id":"https://openalex.org/keywords/plasma-metabolomics","display_name":"plasma metabolomics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cognitive-domain","display_name":"cognitive domain","score":0.7129999995231628},{"id":"https://openalex.org/keywords/reasoning","display_name":"reasoning","score":0.5389999747276306},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.8579999804496765},{"id":"https://openalex.org/keywords/processing-speed","display_name":"processing speed","score":0.9800000190734863},{"id":"https://openalex.org/keywords/language","display_name":"language","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cognitively-normal-adults","display_name":"cognitively normal adults","score":0.7870000004768372},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cofactor-and-vitamin-metabolism","display_name":"cofactor and vitamin metabolism","score":0.8980000019073486},{"id":"https://openalex.org/keywords/energy-production","display_name":"energy production","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.5770000219345093},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.832099974155426},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.6438000202178955},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5515000224113464},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5421000123023987},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5212000012397766},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.4968000054359436},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48089998960494995},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4733999967575073},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.46399998664855957},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C119653847","wikidata":"https://www.wikidata.org/wiki/Q1327780","display_name":"Elementary cognitive task","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.3240000009536743},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.31450000405311584},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3098999857902527},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.30730000138282776},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.3059000074863434},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.2962000072002411},{"id":"https://openalex.org/C536788834","wikidata":"https://www.wikidata.org/wiki/Q7002588","display_name":"Neuropsychological assessment","level":4,"score":0.28459998965263367},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.25679999589920044},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.25429999828338623},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2508000135421753}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2026.1898605","doi":"https://doi.org/10.3389/fnins.2026.1898605","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1898605","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1898605/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13727718","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727718/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727718/pdf/fnins-20-1898605.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:42978722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42978722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5b729189570b4c41a90043bdf498edb8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/5b729189570b4c41a90043bdf498edb8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 20 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2026.1898605","doi":"https://doi.org/10.3389/fnins.2026.1898605","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1898605","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1898605/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223046343.pdf","grobid_xml":"https://content.openalex.org/works/W7223046343.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W1607421054","https://openalex.org/W1872912399","https://openalex.org/W1964321058","https://openalex.org/W1972195252","https://openalex.org/W1985113736","https://openalex.org/W1985579937","https://openalex.org/W2006096283","https://openalex.org/W2006500696","https://openalex.org/W2008591007","https://openalex.org/W2012660994","https://openalex.org/W2016224362","https://openalex.org/W2018527646","https://openalex.org/W2025944550","https://openalex.org/W2062453566","https://openalex.org/W2075420402","https://openalex.org/W2081432693","https://openalex.org/W2094248542","https://openalex.org/W2117731638","https://openalex.org/W2129497119","https://openalex.org/W2130319566","https://openalex.org/W2132647859","https://openalex.org/W2159124202","https://openalex.org/W2159529587","https://openalex.org/W2161493176","https://openalex.org/W2162234541","https://openalex.org/W2169353806","https://openalex.org/W2321987850","https://openalex.org/W2322580831","https://openalex.org/W2520784563","https://openalex.org/W2526986571","https://openalex.org/W2561291010","https://openalex.org/W2614874662","https://openalex.org/W2789268291","https://openalex.org/W2939298434","https://openalex.org/W2968003786","https://openalex.org/W3047253193","https://openalex.org/W3123085888","https://openalex.org/W3127319292","https://openalex.org/W3198174135","https://openalex.org/W3201595862","https://openalex.org/W3211901466","https://openalex.org/W4205633393","https://openalex.org/W4206055706","https://openalex.org/W4206447491","https://openalex.org/W4210493947","https://openalex.org/W4214522814","https://openalex.org/W4214725397","https://openalex.org/W4283017342","https://openalex.org/W4283078447","https://openalex.org/W4297250769","https://openalex.org/W4307958530","https://openalex.org/W4385827917","https://openalex.org/W4386098040","https://openalex.org/W4390571844","https://openalex.org/W4391107710","https://openalex.org/W4392002283","https://openalex.org/W4393901220","https://openalex.org/W4401467805","https://openalex.org/W4406329437","https://openalex.org/W4407954114","https://openalex.org/W4410522455","https://openalex.org/W4411639560","https://openalex.org/W4413494998","https://openalex.org/W4414645410","https://openalex.org/W4415626376"],"related_works":["https://openalex.org/W7116978621","https://openalex.org/W7212905344","https://openalex.org/W7212352734","https://openalex.org/W2962716259","https://openalex.org/W4404246620","https://openalex.org/W4407389931","https://openalex.org/W7165125620","https://openalex.org/W2950517764","https://openalex.org/W4207082501","https://openalex.org/W7164339666"],"abstract_inverted_index":{"Background":[0],"Alterations":[1],"in":[2,244,311,346],"systemic":[3],"metabolism":[4],"may":[5,324,334],"reflect":[6,325],"biological":[7,339],"processes":[8,340],"relevant":[9],"to":[10,19,24,98,130,138],"brain":[11],"function":[12],"and":[13,28,58,86,144,148,174,252,298,301,319],"cognitive":[14,26,79,223,250,275,317,347],"aging,":[15],"yet":[16],"the":[17,45,77,175,186],"extent":[18],"which":[20,323],"circulating":[21],"metabolites":[22],"relate":[23],"both":[25,316],"performance":[27,251,318],"underlying":[29,338],"neural":[30,101,149,196,253,263,320],"network":[31,102,150,197,254,264,321,332],"activity":[32],"remains":[33],"unclear.":[34],"Methods":[35],"The":[36],"current":[37],"study":[38,50],"included":[39],"112":[40],"cognitively":[41],"normal":[42],"participants":[43,117],"of":[44,76,81,160,225,289,328,337],"Reference":[46],"Abilities":[47],"Neural":[48,331],"Network":[49],"at":[51,62],"Columbia":[52],"University":[53],"who":[54],"had":[55,156],"metabolomic,":[56],"cognitive,":[57],"imaging":[59],"data":[60],"available":[61],"baseline.":[63],"Cognition":[64],"was":[65,136,179,271],"measured":[66],"using":[67,120,237],"a":[68,157],"neuropsychological":[69],"battery":[70],"including":[71,146],"three":[72],"tests":[73],"for":[74,201],"each":[75],"four":[78],"domains":[80,206,224],"memory,":[82,226],"reasoning,":[83,202,227],"processing":[84,228],"speed,":[85],"language.":[87],"Participants":[88,155],"underwent":[89],"fMRI":[90],"while":[91],"performing":[92],"12":[93],"tasks,":[94],"3":[95],"per":[96],"domain,":[97],"derive":[99],"domain-specific":[100,249],"activation":[103,151,198],"pattern":[104,152,199],"scores":[105,200],"such":[106],"that":[107,341],"patterns":[108],"correlated":[109],"positively":[110],"with":[111,195,221,248,261,273],"behavioral":[112],"performance.":[113,349],"Plasma":[114],"collected":[115],"from":[116],"were":[118,169,172,192,218,259],"analyzed":[119],"an":[121],"untargeted":[122],"liquid":[123],"chromatography":[124],"coupled":[125],"high-resolution":[126],"mass":[127],"spectrometry-metabolomics":[128],"assay":[129],"generate":[131],"metabolic":[132],"profiles.":[133],"Linear":[134],"regression":[135],"used":[137],"explore":[139],"associations":[140,314],"between":[141],"metabolite":[142,188,216,245,257,269,313],"features":[143,189,217,246,258],"outcomes":[145],"cognition":[147],"scores.":[153],"Results":[154],"mean":[158,176],"age":[159],"56.6":[161],"years":[162,181],"(standard":[163],"deviation":[164],"(SD)":[165],"=":[166,183],"15.6),":[167],"50.0%":[168],"female,":[170],"71.4%":[171],"white,":[173],"education":[177],"level":[178],"15.8":[180],"(SD":[182],"2.2).":[184],"Of":[185],"4,286":[187],"analyzed,":[190],"8":[191],"significantly":[193,219],"associated":[194,220,247,260,272],"but":[203,286],"no":[204,215],"other":[205],"after":[207,232],"false":[208],"discovery":[209],"rate":[210],"(FDR)":[211],"adjustment.":[212,234],"In":[213],"contrast,":[214],"any":[222],"speed":[229],"or":[230],"language":[231],"FDR":[233],"Exploratory":[235],"analyses":[236,278],"nominal":[238],"p":[239],"-values":[240],"revealed":[241],"minimal":[242],"overlap":[243,310],"measures.":[255],"Six":[256],"all":[262,274],"domains,":[265,285],"whereas":[266],"only":[267],"one":[268],"feature":[270],"domains.":[276],"Pathway-level":[277],"did":[279],"not":[280,343],"demonstrate":[281],"consistent":[282],"enrichment":[283],"across":[284,315],"suggested":[287],"involvement":[288],"amino":[290],"acid":[291],"metabolism,":[292,294,300],"lipid":[293],"energy":[295],"production,":[296],"cofactor":[297],"vitamin":[299],"nitrogen":[302],"handling":[303],"pathways.":[304],"Conclusion":[305],"Our":[306],"findings":[307],"suggest":[308],"limited":[309],"significant":[312],"activity,":[322],"some":[326],"degree":[327],"domain":[329],"specificity.":[330],"measures":[333],"capture":[335],"aspects":[336],"are":[342],"fully":[344],"reflected":[345],"test":[348]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-21T00:00:00"}