{"id":"https://openalex.org/W7223043467","doi":"https://doi.org/10.3389/fimmu.2026.1982870","title":"Peri-transplant eculizumab for preventing antibody-mediated rejection in kidney transplant recipients at high immunologic risk: a systematic review with design-stratified evidence synthesis","display_name":"Peri-transplant eculizumab for preventing antibody-mediated rejection in kidney transplant recipients at high immunologic risk: a systematic review with design-stratified evidence synthesis","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223043467","doi":"https://doi.org/10.3389/fimmu.2026.1982870","pmid":"https://pubmed.ncbi.nlm.nih.gov/42978583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13727399"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1982870","doi":"https://doi.org/10.3389/fimmu.2026.1982870","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1982870","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1982870/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1982870/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023205956","display_name":"Chengze Liang","orcid":"https://orcid.org/0009-0002-8896-1967","observed_orcids":["https://orcid.org/0009-0002-8896-1967"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengze Liang","raw_affiliation_strings":["Department of Urology/Institute of Urology, West China Hospital, Sichuan University","Kidney Transplantation Center, West China Hospital, Sichuan University","Organ Transplantation Center, West China Hospital, Sichuan University","West China Medical School, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology/Institute of Urology, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Kidney Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Organ Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"West China Medical School, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159113639","display_name":"Rong Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Bao","raw_affiliation_strings":["Department of Urology/Institute of Urology, West China Hospital, Sichuan University","Kidney Transplantation Center, West China Hospital, Sichuan University","Organ Transplantation Center, West China Hospital, Sichuan University","West China Medical School, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology/Institute of Urology, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Kidney Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Organ Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"West China Medical School, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091902498","display_name":"Saifu Yin","orcid":"https://orcid.org/0000-0001-9710-7872","observed_orcids":["https://orcid.org/0000-0001-9710-7872"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Saifu Yin","raw_affiliation_strings":["Department of Urology/Institute of Urology, West China Hospital, Sichuan University","Kidney Transplantation Center, West China Hospital, Sichuan University","Organ Transplantation Center, West China Hospital, Sichuan University","West China Medical School, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology/Institute of Urology, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Kidney Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Organ Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"West China Medical School, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100834273","display_name":"Turun Song","orcid":"https://orcid.org/0000-0001-6594-2531","observed_orcids":["https://orcid.org/0000-0001-6594-2531"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Turun Song","raw_affiliation_strings":["Department of Urology/Institute of Urology, West China Hospital, Sichuan University","Kidney Transplantation Center, West China Hospital, Sichuan University","Organ Transplantation Center, West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology/Institute of Urology, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Kidney Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Organ Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159157299","display_name":"Tao Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Lin","raw_affiliation_strings":["Department of Urology/Institute of Urology, West China Hospital, Sichuan University","Kidney Transplantation Center, West China Hospital, Sichuan University","Organ Transplantation Center, West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology/Institute of Urology, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Kidney Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]},{"raw_affiliation_string":"Organ Transplantation Center, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100834273","https://openalex.org/A5159157299"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65079365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1982870","last_page":"1982870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eculizumab","display_name":"eculizumab","score":1.0},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.9100000262260437},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/complement-inhibition","display_name":"complement inhibition","score":0.6129999756813049},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.7129999995231628},{"id":"https://openalex.org/keywords/abo-incompatibility","display_name":"ABO incompatibility","score":0.8429999947547913},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.7179999947547913},{"id":"https://openalex.org/keywords/graft-survival","display_name":"graft survival","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9070000052452087},{"id":"https://openalex.org/C2777991916","wikidata":"https://www.wikidata.org/wiki/Q421617","display_name":"Eculizumab","level":4,"score":0.7989000082015991},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5365999937057495},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.5091000199317932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4749999940395355},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.447299987077713},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.436599999666214},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4350000023841858},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.42399999499320984},{"id":"https://openalex.org/C176080213","wikidata":"https://www.wikidata.org/wiki/Q188010","display_name":"ABO blood group system","level":2,"score":0.3720000088214874},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.3671000003814697},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35269999504089355},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C2910652704","wikidata":"https://www.wikidata.org/wiki/Q17002910","display_name":"ABO incompatibility","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C3019514911","wikidata":"https://www.wikidata.org/wiki/Q48928650","display_name":"Donor specific antibodies","level":4,"score":0.2809000015258789},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2777637130","wikidata":"https://www.wikidata.org/wiki/Q17165460","display_name":"Atypical hemolytic uremic syndrome","level":4,"score":0.26579999923706055},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C2776016174","wikidata":"https://www.wikidata.org/wiki/Q28502965","display_name":"Vascular access","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.2522999942302704},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007518","descriptor_name":"Isoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1982870","doi":"https://doi.org/10.3389/fimmu.2026.1982870","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1982870","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1982870/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13727399","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727399/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727399/pdf/fimmu-17-1982870.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42978583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42978583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a1f5b3d9f9094fb3b566efc52eb802d6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a1f5b3d9f9094fb3b566efc52eb802d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1982870","doi":"https://doi.org/10.3389/fimmu.2026.1982870","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1982870","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1982870/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223043467.pdf","grobid_xml":"https://content.openalex.org/works/W7223043467.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1533163737","https://openalex.org/W1923404879","https://openalex.org/W1970972988","https://openalex.org/W1999458479","https://openalex.org/W2296398718","https://openalex.org/W2314032891","https://openalex.org/W2408706680","https://openalex.org/W2418381055","https://openalex.org/W2765650810","https://openalex.org/W2767353164","https://openalex.org/W2773423507","https://openalex.org/W2783888490","https://openalex.org/W2791636184","https://openalex.org/W2807992825","https://openalex.org/W2892130773","https://openalex.org/W2899746149","https://openalex.org/W2923970214","https://openalex.org/W2942193435","https://openalex.org/W2982807444","https://openalex.org/W2990648940","https://openalex.org/W3015680166","https://openalex.org/W3034227906","https://openalex.org/W3093541446","https://openalex.org/W3118615836","https://openalex.org/W4243933449","https://openalex.org/W4290723728","https://openalex.org/W4292448914","https://openalex.org/W4378801513","https://openalex.org/W4384120698","https://openalex.org/W4385237772","https://openalex.org/W4389685526","https://openalex.org/W4392860164","https://openalex.org/W4394724136","https://openalex.org/W4397024304","https://openalex.org/W4403806885","https://openalex.org/W4403812417","https://openalex.org/W4408052616","https://openalex.org/W4412851194","https://openalex.org/W7119484279","https://openalex.org/W7128793592","https://openalex.org/W7128959005","https://openalex.org/W7133928496"],"related_works":["https://openalex.org/W2942193435","https://openalex.org/W2923970214","https://openalex.org/W1533163737","https://openalex.org/W4298626038","https://openalex.org/W4408052616","https://openalex.org/W4391532674","https://openalex.org/W2791636184","https://openalex.org/W1576168827","https://openalex.org/W2094308013","https://openalex.org/W4380626402"],"abstract_inverted_index":{"Introduction:":[0],"Highly":[1],"sensitized":[2],"candidates,":[3],"preformed":[4],"donor-specific":[5,165],"antibodies,":[6],"and":[7,15,49,58,82,105,138,167,206],"ABO":[8],"incompatibility":[9],"restrict":[10],"access":[11],"to":[12,76],"kidney":[13,29],"transplantation":[14],"increase":[16],"antibody-mediated":[17],"rejection":[18],"(AMR)":[19],"risk.":[20],"We":[21,32],"systematically":[22],"evaluated":[23],"peri-transplant":[24],"eculizumab-containing":[25],"prophylaxis":[26],"in":[27,98,101,122,193,214],"high-immunologic-risk":[28],"transplantation.":[30],"Methods:":[31],"searched":[33],"PubMed,":[34],"Europe":[35],"PMC,":[36],"Ovid":[37,44],"Embase,":[38],"Web":[39],"of":[40,68],"Science":[41],"Core":[42],"Collection,":[43],"CENTRAL,":[45],"ClinicalTrials.gov,":[46],"WHO":[47],"ICTRP,":[48],"supplementary":[50],"sources;":[51],"database":[52],"searches":[53,60],"ended":[54,61],"10":[55],"June":[56],"2026,":[57],"registry":[59,80],"20":[62],"August":[63],"2026.":[64],"Results:":[65],"A":[66,117],"total":[67],"31":[69],"reports":[70],"were":[71,74],"included;":[72],"30":[73],"linked":[75],"14":[77],"studies":[78],"or":[79,160],"projects,":[81],"one":[83],"pathology":[84],"report":[85],"was":[86,212],"retained":[87],"qualitatively.":[88],"In":[89],"the":[90,103],"only":[91],"randomized":[92,185],"trial,":[93],"centrally":[94],"confirmed":[95],"AMR":[96,121,149],"occurred":[97],"5/51":[99],"recipients":[100,126],"both":[102],"eculizumab":[104],"standard-desensitization":[106],"groups":[107],"[risk":[108],"ratio":[109],"(RR)":[110],"1.00,":[111],"95%":[112,129],"confidence":[113],"interval":[114],"(CI)":[115],"0.31-3.25].":[116],"historical":[118],"comparison":[119],"reported":[120,147],"2/26":[123],"versus":[124],"21/51":[125],"(RR":[127],"0.19,":[128],"CI":[130],"0.05-0.74),":[131],"but":[132,184],"treatment":[133],"era,":[134],"post-transplant":[135],"plasma":[136],"exchange,":[137],"clinical":[139],"management":[140],"changed":[141],"concurrently.":[142],"An":[143],"80-recipient":[144],"single-arm":[145],"study":[146],"three":[148],"events":[150],"by":[151],"week":[152],"9.":[153],"Long-term":[154],"follow-up":[155],"showed":[156],"no":[157],"consistent":[158],"graft-survival":[159],"kidney-function":[161],"advantage,":[162],"while":[163],"persistent":[164],"antibodies":[166],"chronic":[168],"microvascular":[169],"injury":[170],"remained":[171],"evident.":[172],"Discussion:":[173],"Eculizumab":[174],"can":[175],"provide":[176],"terminal":[177],"complement":[178],"blockade":[179],"within":[180],"selected":[181],"combination":[182],"prophylaxis,":[183],"evidence":[186],"does":[187],"not":[188],"establish":[189],"an":[190],"incremental":[191],"reduction":[192],"AMR.":[194],"Definitive":[195],"trials":[196],"require":[197],"standardized":[198],"background":[199],"therapy,":[200],"rescue":[201],"criteria,":[202],"long-term":[203],"graft":[204],"outcomes,":[205],"infection":[207],"surveillance.":[208],"This":[209],"systematic":[210],"review":[211,218],"registered":[213],"PROSPERO":[215],"(CRD420261484542).":[216],"Systematic":[217],"registration:":[219],"https://www.crd.york.ac.uk/PROSPERO/,":[220],"identifier":[221],"CRD420261484542.":[222]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-10-21T00:00:00"}
