{"id":"https://openalex.org/W7223035818","doi":"https://doi.org/10.64898/2026.10.17.759359","title":"Developmental origins of thymic B-cell lymphomas","display_name":"Developmental origins of thymic B-cell lymphomas","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223035818","doi":"https://doi.org/10.64898/2026.10.17.759359"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.17.759359","doi":"https://doi.org/10.64898/2026.10.17.759359","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.17.759359","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.17.759359.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.17.759359.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004550999","display_name":"Shinya Rai","orcid":"https://orcid.org/0000-0003-3929-9751","observed_orcids":["https://orcid.org/0000-0003-3929-9751"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Shinya Rai","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Sakai, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Sakai, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159130508","display_name":"Yifan Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yifan Yin","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111514269","display_name":"Manabu Fujisawa","orcid":"https://orcid.org/0009-0007-1122-6549","observed_orcids":["https://orcid.org/0009-0007-1122-6549"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["CA","JP"],"is_corresponding":false,"raw_author_name":"Manabu Fujisawa","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Institute of Medicine, University of Tsukuba, Ibaraki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Institute of Medicine, University of Tsukuba, Ibaraki, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072324572","display_name":"Makoto Kishida","orcid":"https://orcid.org/0009-0009-3599-4643","observed_orcids":["https://orcid.org/0009-0009-3599-4643"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Makoto Kishida","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159136723","display_name":"Michael Yu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Yu Li","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017815916","display_name":"Jeffrey Niu","orcid":"https://orcid.org/0000-0002-5691-8238","observed_orcids":["https://orcid.org/0000-0002-5691-8238"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey Niu","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017830191","display_name":"Aixiang Jiang","orcid":"https://orcid.org/0000-0002-6153-7595","observed_orcids":["https://orcid.org/0000-0002-6153-7595"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aixiang Jiang","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013858831","display_name":"Laura K. Hilton","orcid":"https://orcid.org/0000-0002-6413-6586","observed_orcids":["https://orcid.org/0000-0002-6413-6586"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Laura K Hilton","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091462801","display_name":"Amos Fong","orcid":"https://orcid.org/0009-0005-3145-7382","observed_orcids":["https://orcid.org/0009-0005-3145-7382"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Amos Fong","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091240481","display_name":"Gerben Duns","orcid":"https://orcid.org/0000-0001-8060-694X","observed_orcids":["https://orcid.org/0000-0001-8060-694X"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerben Duns","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057411182","display_name":"Ad\u00e8le Telenius","orcid":"https://orcid.org/0000-0002-6901-5126","observed_orcids":["https://orcid.org/0000-0002-6901-5126"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ad\u00e8le Telenius","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103260929","display_name":"Barbara Meissner","orcid":"https://orcid.org/0000-0002-5242-5559","observed_orcids":["https://orcid.org/0000-0002-5242-5559"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Barbara Meissner","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088976997","display_name":"Merrill Boyle","orcid":"https://orcid.org/0000-0002-7618-0103","observed_orcids":["https://orcid.org/0000-0002-7618-0103"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Merrill Boyle","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009923873","display_name":"Hisae Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hisae Nakamura","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110079607","display_name":"Alexandra Roos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexandra Roos","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072918766","display_name":"Shiva Daryani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shiva Daryani","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138776192","display_name":"Luke O\u2019Brien","orcid":"https://orcid.org/0009-0003-3541-684X","observed_orcids":["https://orcid.org/0009-0003-3541-684X"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Luke \u00d2Brien","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023996340","display_name":"Claudia Cassidy","orcid":"https://orcid.org/0009-0006-1327-9639","observed_orcids":["https://orcid.org/0009-0006-1327-9639"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Claudia Cassidy","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021885562","display_name":"Shaocheng Wu","orcid":"https://orcid.org/0000-0002-1663-7132","observed_orcids":["https://orcid.org/0000-0002-1663-7132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaocheng Wu","raw_affiliation_strings":["Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159102052","display_name":"Eric Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Lee","raw_affiliation_strings":["Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112862272","display_name":"Andrew Lytle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Lytle","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008961404","display_name":"Pedro Farinha","orcid":"https://orcid.org/0000-0001-9364-9391","observed_orcids":["https://orcid.org/0000-0001-9364-9391"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pedro Farinha","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159107744","display_name":"Graham Slack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Graham Slack","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028957609","display_name":"Jonathan W. Bush","orcid":"https://orcid.org/0000-0001-9432-2390","observed_orcids":["https://orcid.org/0000-0001-9432-2390"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan W Bush","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081644676","display_name":"Ryan D. Morin","orcid":"https://orcid.org/0000-0003-2932-7800","observed_orcids":["https://orcid.org/0000-0003-2932-7800"]},"institutions":[{"id":"https://openalex.org/I18014758","display_name":"Simon Fraser University","ror":"https://ror.org/0213rcc28","country_code":"CA","type":"education","lineage":["https://openalex.org/I18014758"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ryan D Morin","raw_affiliation_strings":["Simon Fraser University, Burnaby, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Simon Fraser University, Burnaby, BC, Canada","institution_ids":["https://openalex.org/I18014758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011827252","display_name":"Leandro Venturutti","orcid":"https://orcid.org/0000-0002-7264-8370","observed_orcids":["https://orcid.org/0000-0002-7264-8370"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leandro Venturutti","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069512440","display_name":"Andrew P. Weng","orcid":"https://orcid.org/0000-0001-7394-5425","observed_orcids":["https://orcid.org/0000-0001-7394-5425"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew P Weng","raw_affiliation_strings":["Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Terry Fox Laboratory, British Columbia Cancer Research Institute, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066899464","display_name":"Andrew J. L. Roth","orcid":"https://orcid.org/0000-0003-3422-8823","observed_orcids":["https://orcid.org/0000-0003-3422-8823"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrew Roth","raw_affiliation_strings":["Department of Computer Science, University of British Columbia, Vancouver, BC, Canada","Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Molecular Oncology, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158489794","display_name":"Brad H Nelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286984","display_name":"BC Cancer \u2013 Victoria","ror":"https://ror.org/03rh4z082","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486","https://openalex.org/I4405286984"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Brad H Nelson","raw_affiliation_strings":["Deeley Research Centre, British Columbia Cancer, Victoria, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deeley Research Centre, British Columbia Cancer, Victoria, British Columbia, Canada","institution_ids":["https://openalex.org/I4405286984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017873196","display_name":"Kerry J. J. Savage","orcid":"https://orcid.org/0000-0002-5835-9863","observed_orcids":["https://orcid.org/0000-0002-5835-9863"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kerry J Savage","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077833764","display_name":"Tomohiro Aoki","orcid":"https://orcid.org/0000-0001-6782-8361","observed_orcids":["https://orcid.org/0000-0001-6782-8361"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tomohiro Aoki","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario, Canada","University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"raw_affiliation_string":"University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044269394","display_name":"Cl\u00e9mentine Sarkozy","orcid":"https://orcid.org/0000-0002-1942-9304","observed_orcids":["https://orcid.org/0000-0002-1942-9304"]},"institutions":[{"id":"https://openalex.org/I195731000","display_name":"Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines","ror":"https://ror.org/03mkjjy25","country_code":"FR","type":"education","lineage":["https://openalex.org/I195731000","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4405266781","display_name":"Imagerie, Radioth\u00e9rapie Innovante et m\u00e9decine des Syst\u00e8mes","ror":"https://ror.org/05h75s094","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I195731000","https://openalex.org/I277688954","https://openalex.org/I4405266781","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Clementine Sarkozy","raw_affiliation_strings":["Hematological Department-IRIS Lab UMR9029/U1353, Institut Curie, Saint Cloud, France","Universit\u00e9 Versailles Saint Quentin en Yvelines, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematological Department-IRIS Lab UMR9029/U1353, Institut Curie, Saint Cloud, France","institution_ids":["https://openalex.org/I4405266781","https://openalex.org/I80043"]},{"raw_affiliation_string":"Universit\u00e9 Versailles Saint Quentin en Yvelines, France","institution_ids":["https://openalex.org/I195731000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159140729","display_name":"David W Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David W Scott","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048030695","display_name":"Christian Steidl","orcid":"https://orcid.org/0000-0001-9842-9750","observed_orcids":["https://orcid.org/0000-0001-9842-9750","https://orcid.org/0000-0003-2143-517X"]},"institutions":[{"id":"https://openalex.org/I1289530486","display_name":"BC Cancer Agency","ror":"https://ror.org/03sfybe47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1289530486"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Christian Steidl","raw_affiliation_strings":["Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Lymphoid Cancer, British Columbia Cancer, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I1289530486"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5048030695"],"corresponding_institution_ids":["https://openalex.org/I1289530486","https://openalex.org/I141945490"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-b-cells","display_name":"thymic B cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/primary-mediastinal-large-b-cell-lymphoma","display_name":"primary mediastinal B-cell lymphoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ccl17","display_name":"CCL17","score":0.9290000200271606},{"id":"https://openalex.org/keywords/thymic-medulla","display_name":"thymic medulla","score":0.9210000038146973},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.8496000170707703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7892000079154968},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5406000018119812},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47920000553131104},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.41760000586509705},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.39590001106262207},{"id":"https://openalex.org/C2781246680","wikidata":"https://www.wikidata.org/wiki/Q1052970","display_name":"Cell of origin","level":3,"score":0.38589999079704285},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34450000524520874},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32190001010894775},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.30320000648498535},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28790000081062317},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.2809999883174896},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.17.759359","doi":"https://doi.org/10.64898/2026.10.17.759359","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.17.759359","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.17.759359.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.17.759359","doi":"https://doi.org/10.64898/2026.10.17.759359","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.17.759359","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.17.759359.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1383039060","display_name":null,"funder_award_id":"271LYM","funder_id":"https://openalex.org/F4320310787","funder_display_name":"Genome Canada"},{"id":"https://openalex.org/G2045244154","display_name":null,"funder_award_id":"705288","funder_id":"https://openalex.org/F4320334576","funder_display_name":"Canadian Cancer Society Research Institute"},{"id":"https://openalex.org/G3177940809","display_name":null,"funder_award_id":"148393","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6027838516","display_name":null,"funder_award_id":"13124","funder_id":"https://openalex.org/F4320310787","funder_display_name":"Genome Canada"},{"id":"https://openalex.org/G6465546663","display_name":null,"funder_award_id":"12829","funder_id":"https://openalex.org/F4320329172","funder_display_name":"BC Cancer Foundation"},{"id":"https://openalex.org/G6914548128","display_name":"Deciphering the genome biology of relapsed lymphoid cancers to improve patient management","funder_award_id":"271LYM","funder_id":"https://openalex.org/F4320319973","funder_display_name":"Genome British Columbia"},{"id":"https://openalex.org/G848056422","display_name":null,"funder_award_id":"191809","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320310787","display_name":"Genome Canada","ror":"https://ror.org/029s29983"},{"id":"https://openalex.org/F4320311559","display_name":"Princess Margaret Cancer Foundation","ror":"https://ror.org/00ctsa544"},{"id":"https://openalex.org/F4320319973","display_name":"Genome British Columbia","ror":"https://ror.org/03gne5057"},{"id":"https://openalex.org/F4320329172","display_name":"BC Cancer Foundation","ror":"https://ror.org/03gqhbs95"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334576","display_name":"Canadian Cancer Society Research Institute","ror":"https://ror.org/017343w90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223035818.pdf","grobid_xml":"https://content.openalex.org/works/W7223035818.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1539657684","https://openalex.org/W1898640512","https://openalex.org/W1964053262","https://openalex.org/W1976289621","https://openalex.org/W1980190478","https://openalex.org/W2029525307","https://openalex.org/W2083715503","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2112587694","https://openalex.org/W2113392525","https://openalex.org/W2117973542","https://openalex.org/W2131178345","https://openalex.org/W2135340773","https://openalex.org/W2138207763","https://openalex.org/W2159707944","https://openalex.org/W2161659059","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2287365612","https://openalex.org/W2410617016","https://openalex.org/W2594817103","https://openalex.org/W2750049634","https://openalex.org/W2806699208","https://openalex.org/W2808144819","https://openalex.org/W2892392661","https://openalex.org/W2904981155","https://openalex.org/W2923453543","https://openalex.org/W2943993922","https://openalex.org/W2951799803","https://openalex.org/W2953151710","https://openalex.org/W2959261838","https://openalex.org/W2971559821","https://openalex.org/W2979682945","https://openalex.org/W2984472267","https://openalex.org/W2988716798","https://openalex.org/W3002417351","https://openalex.org/W3008278692","https://openalex.org/W3017339438","https://openalex.org/W3024364746","https://openalex.org/W3036963192","https://openalex.org/W3114078084","https://openalex.org/W3135826314","https://openalex.org/W3154125530","https://openalex.org/W3164692211","https://openalex.org/W3175752499","https://openalex.org/W3197211115","https://openalex.org/W3202418805","https://openalex.org/W3210616983","https://openalex.org/W3210860076","https://openalex.org/W4200197309","https://openalex.org/W4225473684","https://openalex.org/W4281625438","https://openalex.org/W4283381496","https://openalex.org/W4308914942","https://openalex.org/W4312084077","https://openalex.org/W4317627602","https://openalex.org/W4324046169","https://openalex.org/W4389399485","https://openalex.org/W4389942753","https://openalex.org/W4390777310","https://openalex.org/W4396626528","https://openalex.org/W4401328272","https://openalex.org/W4401789626","https://openalex.org/W4403381644","https://openalex.org/W4404566936","https://openalex.org/W4408315374","https://openalex.org/W4408315770","https://openalex.org/W4409988818","https://openalex.org/W4411474622"],"related_works":["https://openalex.org/W2410617016","https://openalex.org/W7172343986","https://openalex.org/W2042384742","https://openalex.org/W7162399602","https://openalex.org/W1980190478","https://openalex.org/W2116736380","https://openalex.org/W2313208672","https://openalex.org/W2324641152","https://openalex.org/W2097225779","https://openalex.org/W1977580121"],"abstract_inverted_index":{"Abstract":[0],"The":[1,187],"thymus":[2,162],"provides":[3],"a":[4,42,62,137,178],"specialized":[5],"niche":[6],"for":[7],"lymphocyte":[8],"differentiation,":[9],"yet":[10],"the":[11,49,80,130,160],"developmental":[12],"trajectories":[13],"of":[14,181],"its":[15],"rare":[16],"B-cell":[17,24,43,59,88,120,142,149,154,175],"population":[18],"and":[19,34,56,70,102,123],"their":[20],"relationship":[21],"to":[22,40],"thymic":[23,81,107,131,148,183],"lymphomagenesis":[25],"remain":[26],"poorly":[27],"understood.":[28],"Here,":[29],"we":[30,90],"integrate":[31],"single-cell":[32],"multiomics":[33],"spatial":[35],"profiling":[36],"across":[37,86],"human":[38,50,87,161],"tissues":[39],"delineate":[41],"differentiation":[44,69,143,170],"program":[45,53],"selectively":[46,157],"represented":[47,158],"in":[48,74,79,97,118,139,159,193],"thymus.":[51],"This":[52,110],"links":[54],"CCL17\u207a":[55,106,153,182],"germinal":[57,67],"center-like":[58,169],"states":[60,155],"along":[61],"trajectory":[63],"distinct":[64,128],"from":[65,129],"canonical":[66],"center":[68],"can":[71],"be":[72],"recapitulated":[73],"vitro":[75],"by":[76],"signals":[77,166],"operating":[78],"medulla.":[82],"Extending":[83],"this":[84],"framework":[85],"lymphomas,":[89],"identify":[91],"an":[92],"inherent":[93],"malignant":[94,111,179,188],"cell":[95],"state":[96,112],"PMBCL":[98],"that":[99],"shares":[100],"transcriptional":[101],"epigenetic":[103],"features":[104],"with":[105,114],"B":[108,184],"cells.":[109],"associates":[113],"early":[115,191],"clonal":[116,194],"positions":[117],"reconstructed":[119],"receptor":[121],"phylogenies":[122,195],"persists":[124],"within":[125],"tumor":[126],"microenvironments":[127],"niche.":[132],"Together,":[133],"these":[134],"findings":[135],"support":[136],"model":[138],"which":[140],"thymus-specific":[141],"programs":[144],"are":[145,156],"redeployed":[146],"during":[147],"lymphomagenesis.":[150],"Highlights":[151],"\u2713":[152,163,171,186],"Thymic":[164],"medullary":[165],"recapitulate":[167],"CCL17\u207a-to-germinal":[168],"Primary":[172],"mediastinal":[173],"large":[174],"lymphomas":[176],"harbor":[177],"counterpart":[180,189],"cells":[185],"occupies":[190],"nodes":[192]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}
