{"id":"https://openalex.org/W7223031609","doi":"https://doi.org/10.64898/2026.10.19.760162","title":"Odad1 is Required for Deployment of Axonemal Outer Arm Dyneins and Embryonic Left-Right Patterning","display_name":"Odad1 is Required for Deployment of Axonemal Outer Arm Dyneins and Embryonic Left-Right Patterning","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223031609","doi":"https://doi.org/10.64898/2026.10.19.760162"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.19.760162","doi":"https://doi.org/10.64898/2026.10.19.760162","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760162","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.19.760162.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.19.760162.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078730967","display_name":"Nayeli G. Reyes\u2010Nava","orcid":"https://orcid.org/0000-0002-3412-3792","observed_orcids":["https://orcid.org/0000-0002-3412-3792"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nayeli G. Reyes-Nava","raw_affiliation_strings":["Dept. of Molecular Biosciences, University of Texas at Austin, USA"],"raw_orcid":"https://orcid.org/0000-0002-3412-3792","affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biosciences, University of Texas at Austin, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010049810","display_name":"Indrani Basu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Indrani Basu","raw_affiliation_strings":["Dept. of Molecular Biosciences, University of Texas at Austin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biosciences, University of Texas at Austin, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159120690","display_name":"Kristen R. Holladay","orcid":"https://orcid.org/0009-0008-4839-456X","observed_orcids":["https://orcid.org/0009-0008-4839-456X"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen R. Holladay","raw_affiliation_strings":["Dept. of Molecular Biosciences, University of Texas at Austin, USA"],"raw_orcid":"https://orcid.org/0009-0008-4839-456X","affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biosciences, University of Texas at Austin, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054294894","display_name":"John B. Wallingford","orcid":"https://orcid.org/0000-0002-6280-8625","observed_orcids":["https://orcid.org/0000-0002-6280-8625","https://orcid.org/0000-0001-8701-4293"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John B. Wallingford","raw_affiliation_strings":["Dept. of Molecular Biosciences, University of Texas at Austin, USA"],"raw_orcid":"https://orcid.org/0000-0002-6280-8625","affiliations":[{"raw_affiliation_string":"Dept. of Molecular Biosciences, University of Texas at Austin, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054294894"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/outer-dynein-arm","display_name":"outer dynein arm","score":0.8479999899864197},{"id":"https://openalex.org/keywords/primary-ciliary-dyskinesia","display_name":"primary ciliary dyskinesia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/left-right-asymmetry","display_name":"left-right asymmetry","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nodal-cilia","display_name":"nodal cilia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ciliary-motility","display_name":"ciliary motility","score":0.8050000071525574},{"id":"https://openalex.org/keywords/situs-inversus","display_name":"situs inversus","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pitx2","display_name":"PITX2","score":0.8809999823570251},{"id":"https://openalex.org/keywords/truncating-variants","display_name":"truncating mutations","score":0.6370000243186951},{"id":"https://openalex.org/keywords/ciliopathy","display_name":"ciliopathies","score":0.6909999847412109},{"id":"https://openalex.org/keywords/xenopus","display_name":"Xenopus","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.9375},{"id":"https://openalex.org/C2778206077","wikidata":"https://www.wikidata.org/wiki/Q1690779","display_name":"Primary ciliary dyskinesia","level":4,"score":0.9365000128746033},{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.8180000185966492},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7263000011444092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6992999911308289},{"id":"https://openalex.org/C2910722709","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Motile cilium","level":3,"score":0.6891000270843506},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6190000176429749},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.5462999939918518},{"id":"https://openalex.org/C24870808","wikidata":"https://www.wikidata.org/wiki/Q792605","display_name":"Axoneme","level":4,"score":0.49160000681877136},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.46790000796318054},{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.4609000086784363},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4327000081539154},{"id":"https://openalex.org/C37590093","wikidata":"https://www.wikidata.org/wiki/Q978456","display_name":"Intraflagellar transport","level":4,"score":0.4043000042438507},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.39980000257492065},{"id":"https://openalex.org/C115811362","wikidata":"https://www.wikidata.org/wiki/Q189998","display_name":"Flagellum","level":3,"score":0.39879998564720154},{"id":"https://openalex.org/C195267511","wikidata":"https://www.wikidata.org/wiki/Q5119969","display_name":"Ciliogenesis","level":3,"score":0.3792000114917755},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.36980000138282776},{"id":"https://openalex.org/C2779104077","wikidata":"https://www.wikidata.org/wiki/Q1456383","display_name":"Situs inversus","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.30079999566078186},{"id":"https://openalex.org/C2780301495","wikidata":"https://www.wikidata.org/wiki/Q13359588","display_name":"Dynein ATPase","level":4,"score":0.2971999943256378},{"id":"https://openalex.org/C134729014","wikidata":"https://www.wikidata.org/wiki/Q21105411","display_name":"Dynactin","level":4,"score":0.26589998602867126},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C105951970","wikidata":"https://www.wikidata.org/wiki/Q1036748","display_name":"Loss function","level":4,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.19.760162","doi":"https://doi.org/10.64898/2026.10.19.760162","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760162","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.19.760162.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.19.760162","doi":"https://doi.org/10.64898/2026.10.19.760162","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.19.760162","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/20/2026.10.19.760162.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223031609.pdf","grobid_xml":"https://content.openalex.org/works/W7223031609.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1518173022","https://openalex.org/W1693754698","https://openalex.org/W1897871655","https://openalex.org/W1963607937","https://openalex.org/W1965394252","https://openalex.org/W1965902274","https://openalex.org/W1969212379","https://openalex.org/W1980398966","https://openalex.org/W1982682976","https://openalex.org/W2006621251","https://openalex.org/W2033618759","https://openalex.org/W2053768951","https://openalex.org/W2063276998","https://openalex.org/W2093543973","https://openalex.org/W2114112320","https://openalex.org/W2119624567","https://openalex.org/W2133710187","https://openalex.org/W2134643909","https://openalex.org/W2136485352","https://openalex.org/W2157475494","https://openalex.org/W2416524868","https://openalex.org/W2493327039","https://openalex.org/W2514995173","https://openalex.org/W2735570916","https://openalex.org/W2895721934","https://openalex.org/W2904112041","https://openalex.org/W2950470037","https://openalex.org/W3036246898","https://openalex.org/W3107559716","https://openalex.org/W3108590102","https://openalex.org/W3114950737","https://openalex.org/W3209235624","https://openalex.org/W4210782494","https://openalex.org/W4211135382","https://openalex.org/W4220962740","https://openalex.org/W4318562027","https://openalex.org/W4365478924","https://openalex.org/W4378800731","https://openalex.org/W4388047175","https://openalex.org/W4400656018","https://openalex.org/W4411504277","https://openalex.org/W4414686835","https://openalex.org/W4416193659","https://openalex.org/W7143837415"],"related_works":["https://openalex.org/W1965394252","https://openalex.org/W2054470683","https://openalex.org/W2133710187","https://openalex.org/W1968625036","https://openalex.org/W2063276998","https://openalex.org/W4299619755","https://openalex.org/W7143837415","https://openalex.org/W2025073905","https://openalex.org/W1607956273","https://openalex.org/W2103652455"],"abstract_inverted_index":{"Abstract":[0],"Motile":[1],"cilia":[2,85,131],"generate":[3],"fluid":[4],"flow":[5],"required":[6,181],"for":[7,182],"development":[8],"and":[9,29,52,123,148,188,197],"tissue":[10],"homeostasis.":[11],"Defects":[12],"in":[13,87,115,167,185,201],"ciliary":[14,152,195],"motility":[15,196],"cause":[16],"Primary":[17],"Ciliary":[18,31],"Dyskinesia":[19],"(PCD),":[20],"presenting":[21],"with":[22,62,118],"situs":[23],"inversus,":[24],"infertility,":[25],"chronic":[26],"respiratory":[27],"disease,":[28],"hydrocephalus.":[30],"beating":[32],"requires":[33],"outer":[34],"dynein":[35],"arms":[36],"(ODAs),":[37],"anchored":[38],"to":[39,72,74,83,96,163,194],"microtubules":[40],"by":[41],"the":[42,88,93,97,133,173],"ODA":[43,146,165],"docking":[44,166],"complex":[45],"(ODA-DC).":[46],"ODAD1":[47,57,157,179],"is":[48,103,180],"an":[49],"ODA-DC":[50,149,183],"component":[51],"a":[53],"known":[54],"PCD":[55],"protein.":[56],"alleles":[58,158],"are":[59],"often":[60],"associated":[61],"human":[63],"laterality":[64],"defects,":[65],"however":[66],"Odad1":[67,109,141],"has":[68],"not":[69],"been":[70],"reported":[71],"localize":[73],"9+0":[75,129,187],"axonemes.":[76],"Here,":[77],"we":[78],"show":[79,178],"that":[80,108],"GFP-Odad1":[81],"localizes":[82],"nodal":[84,130],"(9+0)":[86],"gastrocoel":[89],"roof":[90],"plate":[91],"(GRP),":[92],"frog\u2019s":[94],"equivalent":[95],"mammalian":[98],"node":[99],"where":[100],"left-right":[101,113,170,198],"asymmetry":[102],"first":[104],"established.":[105],"We":[106],"found":[107],"knockdown":[110],"(KD)":[111],"disrupts":[112],"patterning":[114,171,199],"Xenopus":[116],",":[117],"loss":[119,142,193],"of":[120,145],"pitx2":[121],"expression":[122],"abnormal":[124],"gut":[125],"looping":[126],"reflecting":[127],"defective":[128],"at":[132,172],"GRP.":[134,174],"In":[135],"9+2":[136,189],"multiciliated":[137],"cells":[138],"(MCC)":[139],"axonemes,":[140],"impaired":[143],"deployment":[144],"motors":[147],"subunits,":[150],"disrupting":[151],"motility.":[153],"Two":[154],"patient-derived":[155],"truncating":[156],"were":[159],"similarly":[160],"unstable,":[161],"failing":[162],"rescue":[164],"MCCs":[168],"or":[169],"Together,":[175],"these":[176],"results":[177],"assembly":[184],"both":[186],"cilia,":[190],"linking":[191],"its":[192],"defects":[200],"ODAD1-associated":[202],"ciliopathy.":[203]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}