{"id":"https://openalex.org/W7223028813","doi":"https://doi.org/10.3389/fphar.2026.1962620","title":"Hupehenine suppresses tumor cell phenotypes and modulates macrophage marker profiles in a diabeticmimetic colorectal cancer model","display_name":"Hupehenine suppresses tumor cell phenotypes and modulates macrophage marker profiles in a diabeticmimetic colorectal cancer model","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223028813","doi":"https://doi.org/10.3389/fphar.2026.1962620","pmid":"https://pubmed.ncbi.nlm.nih.gov/42978697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13727481"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1962620","doi":"https://doi.org/10.3389/fphar.2026.1962620","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1962620","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1962620/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1962620/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159127484","display_name":"Ming Qi Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Qi Zhu","raw_affiliation_strings":["Xuzhou Clinical College of Xuzhou Medical University, Xuzhou Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xuzhou Clinical College of Xuzhou Medical University, Xuzhou Central Hospital","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210132906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159109904","display_name":"Zi Tong Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zi Tong Shi","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041571923","display_name":"Hong Mei Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Mei Hu","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159153728","display_name":"Qi Dong Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Dong Xue","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159141405","display_name":"Xin Yu Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yu Gu","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007235790","display_name":"Xin Cheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Cheng Li","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159147444","display_name":"Qiu Yan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu Yan Wang","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159121767","display_name":"Yan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159115753","display_name":"You Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210132906","display_name":"Xuzhou Central Hospital","ror":"https://ror.org/048q23a93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132906"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"You Wei Zhang","raw_affiliation_strings":["Xuzhou Clinical College of Xuzhou Medical University, Xuzhou Central Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xuzhou Clinical College of Xuzhou Medical University, Xuzhou Central Hospital","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210132906"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003143168","display_name":"Ji Zhong Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118574674","display_name":"Jiangsu Normal University","ror":"https://ror.org/051hvcm98","country_code":"CN","type":"education","lineage":["https://openalex.org/I118574674"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ji Zhong Zhao","raw_affiliation_strings":["Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lab of Cell Biology, School of Life Sciences, Jiangsu Normal University","institution_ids":["https://openalex.org/I118574674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003143168","https://openalex.org/A5159115753"],"corresponding_institution_ids":["https://openalex.org/I118574674","https://openalex.org/I177388780","https://openalex.org/I4210132906"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73061899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1962620","last_page":"1962620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.5791000127792358,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.18359999358654022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.6169999837875366},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.875},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7850000262260437},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8519999980926514},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8059999942779541},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.8949999809265137},{"id":"https://openalex.org/keywords/multitarget-directed-ligands","display_name":"multi-target-directed ligands","score":0.765999972820282},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.7419999837875366},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.7059999704360962},{"id":"https://openalex.org/keywords/palmitic-acid","display_name":"palmitic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.8379999995231628},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.7739999890327454},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6581000089645386},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5752999782562256},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5418000221252441},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4853000044822693},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4440000057220459},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40540000796318054},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3605000078678131},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3601999878883362},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.3424000144004822},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33660000562667847},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.33480000495910645},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32280001044273376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3082999885082245},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2874999940395355},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.28519999980926514},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.28450000286102295},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2784999907016754},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2728999853134155},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.2572999894618988}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1962620","doi":"https://doi.org/10.3389/fphar.2026.1962620","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1962620","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1962620/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13727481","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727481/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13727481/pdf/fphar-17-1962620.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42978697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42978697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:fb87e2dde3ee4235b1209d8f6ab7a856","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fb87e2dde3ee4235b1209d8f6ab7a856","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1962620","doi":"https://doi.org/10.3389/fphar.2026.1962620","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1962620","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1962620/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223028813.pdf","grobid_xml":"https://content.openalex.org/works/W7223028813.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1994132423","https://openalex.org/W2578528809","https://openalex.org/W2885635355","https://openalex.org/W2953819571","https://openalex.org/W2983701642","https://openalex.org/W2993908729","https://openalex.org/W3106694177","https://openalex.org/W3127351741","https://openalex.org/W3162096748","https://openalex.org/W3173572567","https://openalex.org/W3193419934","https://openalex.org/W4200045218","https://openalex.org/W4205641863","https://openalex.org/W4206525638","https://openalex.org/W4224236626","https://openalex.org/W4318065100","https://openalex.org/W4318777402","https://openalex.org/W4320918075","https://openalex.org/W4364380738","https://openalex.org/W4365504834","https://openalex.org/W4388035189","https://openalex.org/W4388296544","https://openalex.org/W4396765663","https://openalex.org/W4401862604","https://openalex.org/W4403252192","https://openalex.org/W4404768843","https://openalex.org/W4404796491","https://openalex.org/W4408254070","https://openalex.org/W4408833150","https://openalex.org/W4410905300","https://openalex.org/W4411533978","https://openalex.org/W4412400278","https://openalex.org/W4416713298"],"related_works":["https://openalex.org/W4360619271","https://openalex.org/W4387003261","https://openalex.org/W4413475737","https://openalex.org/W3130207730","https://openalex.org/W4410819404","https://openalex.org/W4399501118","https://openalex.org/W4411849379","https://openalex.org/W3021488899","https://openalex.org/W3159887622","https://openalex.org/W4411533978"],"abstract_inverted_index":{"Background:":[0],"Diabetes":[1],"is":[2],"associated":[3,136,152],"with":[4,110,139,153,189],"increased":[5,232],"colorectal":[6],"cancer":[7],"(CRC)":[8],"risk":[9],"and":[10,28,30,51,61,68,88,104,113,132,142,171,187,202,231,245,254],"mortality,":[11],"but":[12],"the":[13,36,128],"molecular":[14,24,89],"links":[15],"remain":[16],"incompletely":[17],"understood.":[18],"We":[19],"aimed":[20],"to":[21,76,209],"characterize":[22],"shared":[23],"features":[25],"of":[26,34,59,260],"diabetes":[27],"CRC,":[29],"identify":[31],"compounds":[32],"capable":[33],"modulating":[35],"candidate":[37,124],"axis":[38,119,148],"at":[39,127],"this":[40],"interface.":[41,130],"Methods:":[42],"Shared":[43],"disease-associated":[44],"genes":[45],"were":[46,74,94,206],"identified":[47,163],"using":[48,100],"integrated":[49],"bioinformatics":[50],"protein-protein":[52],"interaction":[53],"network":[54],"analysis,":[55],"followed":[56],"by":[57,83],"analyses":[58,135],"TCGA":[60,131],"single-cell":[62,133],"RNA-sequencing":[63],"data.":[64],"Deep":[65],"learning-based":[66],"(DeepPurpose)":[67],"structure-based":[69],"(AutoDock":[70],"Vina)":[71],"virtual":[72],"screening":[73],"used":[75],"prioritize":[77],"multi-target":[78,166,237],"ligands.":[79],"Binding":[80],"was":[81,120,150,162,220],"assessed":[82],"surface":[84],"plasmon":[85],"resonance":[86],"(SPR)":[87],"dynamics":[90],"simulations.":[91],"Cellular":[92],"effects":[93],"evaluated":[95],"in":[96,218,242],"a":[97,123,159,165,193,215],"diabetic-mimetic":[98,194,249],"model":[99],"high":[101],"glucose,":[102],"insulin,":[103],"palmitic":[105],"acid":[106],"(three":[107],"factors;":[108],"TF),":[109],"HCT116":[111,198],"cells":[112,205],"THP-1-derived":[114],"macrophages.":[115],"Results:":[116],"The":[117,239],"IL1\u03b2-CXCL8-CXCR2":[118],"prioritized":[121],"as":[122,164],"inflammatory":[125],"module":[126],"diabetes-CRC":[129],"RNA-seq":[134],"axis-related":[137],"expression":[138,149],"immune":[140],"infiltration":[141],"macrophage":[143,234,243,261],"polarization-related":[144],"transcriptional":[145],"signatures;":[146],"higher":[147],"also":[151,228],"longer":[154],"overall":[155],"survival.":[156],"Hupehenine":[157],"(HU),":[158],"steroidal":[160],"alkaloid,":[161],"ligand":[167],"engaging":[168],"IL1\u03b2,":[169,184],"CXCL8,":[170,181],"CXCR2.":[172],"SPR":[173],"showed":[174],"concentration-dependent":[175],"binding":[176],"(KD:":[177],"CXCR2,":[178],"505":[179],"nM;":[180],"2.2":[182],"\u03bcM;":[183],"12.7":[185],"\u03bcM)":[186],"interference":[188],"CXCL8-CXCR2":[190],"binding.":[191],"In":[192],"model,":[195],"HU":[196,210,227],"reduced":[197],"cell":[199],"viability,":[200],"migration,":[201],"invasion.":[203],"TF-conditioned":[204],"more":[207],"sensitive":[208],"than":[211],"non-TF":[212],"cells,":[213],"whereas":[214],"corresponding":[216],"increase":[217],"sensitivity":[219,247],"not":[221],"observed":[222,240],"for":[223],"5-fluorouracil":[224],"or":[225],"oxaliplatin.":[226],"decreased":[229],"M2-associated":[230],"M1-associated":[233],"markers.":[235],"Conclusion:":[236],"ligand.":[238],"changes":[241],"markers":[244],"differential":[246],"under":[248],"conditions":[250],"warrant":[251],"further":[252],"mechanistic":[253],"preclinical":[255],"evaluation,":[256],"including":[257],"direct":[258],"assessment":[259],"function.":[262]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}
