{"id":"https://openalex.org/W7223028563","doi":"https://doi.org/10.1038/s41467-026-78778-1","title":"Peripheral glia drive the initiation of cutaneous squamous cell carcinoma","display_name":"Peripheral glia drive the initiation of cutaneous squamous cell carcinoma","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223028563","doi":"https://doi.org/10.1038/s41467-026-78778-1"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-78778-1","doi":"https://doi.org/10.1038/s41467-026-78778-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78778-1","pdf_url":"https://www.nature.com/articles/s41467-026-78778-1_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-026-78778-1_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111358820","display_name":"Sofia Micheli","orcid":"https://orcid.org/0009-0000-7426-4947","observed_orcids":["https://orcid.org/0009-0000-7426-4947"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sofia Micheli","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0009-0000-7426-4947","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060768997","display_name":"Adri\u00e1n Salas-Bastos","orcid":"https://orcid.org/0000-0001-9847-5562","observed_orcids":["https://orcid.org/0000-0001-9847-5562"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrian Salas-Bastos","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9847-5562","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057742836","display_name":"Khanh Hu\u1ef3nh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Khanh Hu\u1ef3nh","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005935176","display_name":"Virginia Cecconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Virginia Cecconi","raw_affiliation_strings":["Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053243248","display_name":"Isabel Kolm","orcid":"https://orcid.org/0000-0002-6550-9057","observed_orcids":["https://orcid.org/0000-0002-6550-9057"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Isabel Kolm","raw_affiliation_strings":["Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035364093","display_name":"Je\u013cena Vasi\u013cevska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jelena Vasilevska","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083811011","display_name":"Julien Debbache","orcid":"https://orcid.org/0000-0002-7308-9777","observed_orcids":["https://orcid.org/0000-0002-7308-9777"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julien Debbache","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-7308-9777","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015805841","display_name":"Peter F. Renz","orcid":"https://orcid.org/0009-0007-7259-5022","observed_orcids":["https://orcid.org/0009-0007-7259-5022"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter F. Renz","raw_affiliation_strings":["Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073113363","display_name":"Johanna Diener","orcid":"https://orcid.org/0000-0002-7733-5904","observed_orcids":["https://orcid.org/0000-0002-7733-5904"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Johanna Diener","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085430320","display_name":"Myriam Gwerder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Myriam Gwerder","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108176583","display_name":"Ravidu Nakandalage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ravidu Nakandalage","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111358819","display_name":"Janine Stadler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Janine Stadler","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046436556","display_name":"Phil Fang Cheng","orcid":"https://orcid.org/0000-0003-2940-006X","observed_orcids":["https://orcid.org/0000-0003-2940-006X"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Phil F. Cheng","raw_affiliation_strings":["Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016968396","display_name":"Gaetana Restivo","orcid":"https://orcid.org/0000-0003-4364-2364","observed_orcids":["https://orcid.org/0000-0003-4364-2364"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gaetana Restivo","raw_affiliation_strings":["Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4364-2364","affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074325274","display_name":"J\u00fcrg Hafner","orcid":"https://orcid.org/0000-0002-4571-1143","observed_orcids":["https://orcid.org/0000-0002-4571-1143"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00fcrg Hafner","raw_affiliation_strings":["Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-4571-1143","affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049220083","display_name":"Ataman Sendoel","orcid":"https://orcid.org/0000-0002-0381-9965","observed_orcids":["https://orcid.org/0000-0002-0381-9965"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ataman Sendoel","raw_affiliation_strings":["Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-0381-9965","affiliations":[{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015439827","display_name":"Maries F. van den Broek","orcid":"https://orcid.org/0000-0002-9489-3692","observed_orcids":["https://orcid.org/0000-0002-9489-3692"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maries van den Broek","raw_affiliation_strings":["Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9489-3692","affiliations":[{"raw_affiliation_string":"Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085361233","display_name":"Salome Stierli","orcid":"https://orcid.org/0000-0002-4981-4107","observed_orcids":["https://orcid.org/0000-0002-4981-4107"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Salome Stierli","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-4981-4107","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048139572","display_name":"Lukas Sommer","orcid":"https://orcid.org/0000-0002-1143-7908","observed_orcids":["https://orcid.org/0000-0002-1143-7908"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Lukas Sommer","raw_affiliation_strings":["Institute of Anatomy, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1143-7908","affiliations":[{"raw_affiliation_string":"Institute of Anatomy, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048139572","https://openalex.org/A5085361233"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73058143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.475600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.2782999873161316,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.14229999482631683,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutaneous-squamous-cell-carcinoma","display_name":"cutaneous squamous cell carcinoma","score":0.9599999785423279},{"id":"https://openalex.org/keywords/peripheral-glia","display_name":"peripheral glia","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/premalignant-skin-lesions","display_name":"premalignant skin lesions","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9399999976158142},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.996999979019165},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6119999885559082},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5928000211715698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5685999989509583},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.535099983215332},{"id":"https://openalex.org/C2777004073","wikidata":"https://www.wikidata.org/wiki/Q465621","display_name":"Schwann cell","level":2,"score":0.49059998989105225},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4823000133037567},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4771000146865845},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4426000118255615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4399999976158142},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40560001134872437},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.37700000405311584},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.3492000102996826},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.34610000252723694},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3343000113964081},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.3280999958515167},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.30390000343322754},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2777620950","wikidata":"https://www.wikidata.org/wiki/Q189105","display_name":"Cell lineage","level":4,"score":0.28700000047683716},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.27459999918937683},{"id":"https://openalex.org/C2778342957","wikidata":"https://www.wikidata.org/wiki/Q1711744","display_name":"Merkel cell carcinoma","level":3,"score":0.25699999928474426},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41467-026-78778-1","doi":"https://doi.org/10.1038/s41467-026-78778-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78778-1","pdf_url":"https://www.nature.com/articles/s41467-026-78778-1_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-78778-1","doi":"https://doi.org/10.1038/s41467-026-78778-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-78778-1","pdf_url":"https://www.nature.com/articles/s41467-026-78778-1_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5231610606","display_name":null,"funder_award_id":"KLS-5391-08-2021","funder_id":"https://openalex.org/F4320327941","funder_display_name":"Swiss Cancer Research Foundation"},{"id":"https://openalex.org/G8114185634","display_name":null,"funder_award_id":"LF-OC-24-001634","funder_id":"https://openalex.org/F4320327561","funder_display_name":"LEO Fondet"},{"id":"https://openalex.org/G8754351091","display_name":null,"funder_award_id":"FK-22-056","funder_id":"https://openalex.org/F4320323874","funder_display_name":"Universit\u00e4t Z\u00fcrich"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320324811","display_name":"Universit\u00e4t zu K\u00f6ln","ror":"https://ror.org/00rcxh774"},{"id":"https://openalex.org/F4320327561","display_name":"LEO Fondet","ror":"https://ror.org/02rgsr590"},{"id":"https://openalex.org/F4320327730","display_name":"Universit\u00e4tsklinikum K\u00f6ln","ror":"https://ror.org/05mxhda18"},{"id":"https://openalex.org/F4320327941","display_name":"Swiss Cancer Research Foundation","ror":"https://ror.org/022wnsy59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223028563.pdf","grobid_xml":"https://content.openalex.org/works/W7223028563.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W7201867918"],"related_works":["https://openalex.org/W3043767252","https://openalex.org/W4412570277","https://openalex.org/W2993235783","https://openalex.org/W7140112434","https://openalex.org/W4415896159","https://openalex.org/W2221094617","https://openalex.org/W2606967300","https://openalex.org/W4366088159","https://openalex.org/W7171842681","https://openalex.org/W4386439593"],"abstract_inverted_index":{"Abstract":[0],"Although":[1],"tumor":[2,73,126,145],"innervation":[3],"is":[4,80],"known":[5],"to":[6,20],"promote":[7],"cancer":[8,42],"progression,":[9],"underlying":[10],"mechanisms":[11],"remain":[12],"poorly":[13],"understood":[14],"and":[15,63,66,69,111,134],"have":[16],"mostly":[17],"been":[18],"linked":[19],"axonal":[21],"signaling.":[22],"Here,":[23],"we":[24],"identify":[25],"peripheral":[26,136],"glia":[27],"as":[28,142],"critical":[29],"drivers":[30],"of":[31,60,99,144],"cutaneous":[32],"squamous":[33],"cell":[34,52],"carcinoma":[35],"(cSCC),":[36],"the":[37,58,100],"second":[38],"most":[39,129],"common":[40],"skin":[41,151],"in":[43,57,77,87,114],"humans.":[44],"Tumor-associated":[45],"glial":[46],"cells":[47],"(TAGs)":[48],"resemble":[49],"embryonic":[50],"Schwann":[51],"lineage":[53],"stages,":[54],"are":[55,70,89,132],"abundant":[56],"stroma":[59],"premalignant":[61,78],"lesions":[62,79],"established":[64],"murine":[65],"human":[67],"cSCC,":[68],"essential":[71],"for":[72,125],"formation.":[74],"TAG":[75,104],"activation":[76],"triggered":[81],"by":[82,91,120],"UV-induced":[83],"anti-inflammatory":[84],"macrophages,":[85,96,108],"which":[86],"turn":[88],"polarized":[90],"TAGs":[92,141],"into":[93],"pro-tumorigenic":[94],"Fc\u03b5RI\u03b1\u207a":[95,107],"key":[97],"components":[98],"cSCC":[101,118],"microenvironment.":[102],"Consequently,":[103],"depletion":[105],"reduces":[106],"cancer-associated":[109],"fibroblasts,":[110],"epithelial-mesenchymal":[112],"transition":[113],"keratinocytes,":[115],"thereby":[116],"impairing":[117],"initiation":[119,146],"disrupting":[121],"intercellular":[122],"communication":[123],"required":[124],"development.":[127],"As":[128],"solid":[130],"tumors":[131],"innervated":[133],"harbor":[135],"glia,":[137],"our":[138],"findings":[139],"reveal":[140],"regulators":[143],"with":[147],"potential":[148],"relevance":[149],"beyond":[150],"cancer.":[152]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-21T00:00:00"}
