{"id":"https://openalex.org/W7223015955","doi":"https://doi.org/10.1084/jem.20260507","title":"A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration","display_name":"A genetically regulated SKAP2 switch modulates human T lymphocyte adhesion and migration","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223015955","doi":"https://doi.org/10.1084/jem.20260507","pmid":"https://pubmed.ncbi.nlm.nih.gov/42900686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682646"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20260507","doi":"https://doi.org/10.1084/jem.20260507","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20260507","pdf_url":"https://rupress.org/jem/article-pdf/223/12/e20260507/2042471/jem_20260507.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://rupress.org/jem/article-pdf/223/12/e20260507/2042471/jem_20260507.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029196026","display_name":"Mara Cetty Spinella","orcid":"https://orcid.org/0000-0002-2363-3295","observed_orcids":["https://orcid.org/0000-0002-2363-3295"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]},{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Mara Cetty Spinella","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0002-2363-3295","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]},{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084739414","display_name":"Francesco Gualdrini","orcid":"https://orcid.org/0000-0002-6180-7292","observed_orcids":["https://orcid.org/0000-0002-6180-7292"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Gualdrini","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-6180-7292","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003491885","display_name":"Cristina Leoni","orcid":"https://orcid.org/0000-0002-4458-1121","observed_orcids":["https://orcid.org/0000-0002-4458-1121"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Cristina Leoni","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0002-4458-1121","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087362989","display_name":"Jun Siong Low","orcid":"https://orcid.org/0000-0002-1775-0778","observed_orcids":["https://orcid.org/0000-0002-1775-0778"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I4405257335","display_name":"Institute of Microbiology","ror":"https://ror.org/0556as610","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257335"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jun Siong Low","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","Institute of Microbiology, ETH Z\u00fcrich 3 , Zurich,"],"raw_orcid":"https://orcid.org/0000-0002-1775-0778","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Microbiology, ETH Z\u00fcrich 3 , Zurich,","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059545456","display_name":"Sara Polletti","orcid":"https://orcid.org/0000-0002-5433-0502","observed_orcids":["https://orcid.org/0000-0002-5433-0502"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Polletti","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-5433-0502","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062317546","display_name":"Amy Kenyon","orcid":"https://orcid.org/0000-0001-9248-576X","observed_orcids":["https://orcid.org/0000-0001-9248-576X"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Amy Kenyon","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0001-9248-576X","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159124360","display_name":"Samuele Mauri","orcid":"https://orcid.org/0009-0009-0488-3107","observed_orcids":["https://orcid.org/0009-0009-0488-3107"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Samuele Mauri","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0009-0009-0488-3107","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071102504","display_name":"Veronica Vallelonga","orcid":"https://orcid.org/0009-0004-2285-2711","observed_orcids":["https://orcid.org/0009-0004-2285-2711"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Veronica Vallelonga","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0009-0004-2285-2711","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119565594","display_name":"Mehrpouya Mostanfar","orcid":"https://orcid.org/0000-0003-2624-7063","observed_orcids":["https://orcid.org/0000-0003-2624-7063"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mehrpouya Mostanfar","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0003-2624-7063","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016102303","display_name":"Matteo Pecoraro","orcid":"https://orcid.org/0009-0002-8105-9671","observed_orcids":["https://orcid.org/0009-0002-8105-9671"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matteo Pecoraro","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0009-0002-8105-9671","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044631143","display_name":"Chiara Soriani","orcid":"https://orcid.org/0000-0003-4363-6597","observed_orcids":["https://orcid.org/0000-0003-4363-6597"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Soriani","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0003-4363-6597","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103026984","display_name":"Roberta Marzi","orcid":"https://orcid.org/0000-0002-3501-4168","observed_orcids":["https://orcid.org/0000-0002-3501-4168"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roberta Marzi","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0002-3501-4168","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049648750","display_name":"Elena Grassi","orcid":"https://orcid.org/0000-0003-1066-927X","observed_orcids":["https://orcid.org/0000-0003-1066-927X"]},"institutions":[{"id":"https://openalex.org/I4210151091","display_name":"Candiolo Cancer Institute","ror":"https://ror.org/04wadq306","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210151091","https://openalex.org/I4210153126","https://openalex.org/I4210167100"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Grassi","raw_affiliation_strings":["5Department of Oncology, University of Turin, Turin, Italy","INOC \u2013 Istituto Nazionale Oncologico Candiolo, IRCCS 4 , Candiolo,"],"raw_orcid":"https://orcid.org/0000-0003-1066-927X","affiliations":[{"raw_affiliation_string":"5Department of Oncology, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"INOC \u2013 Istituto Nazionale Oncologico Candiolo, IRCCS 4 , Candiolo,","institution_ids":["https://openalex.org/I4210151091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049038356","display_name":"Fabio Bedin","orcid":"https://orcid.org/0009-0006-4313-7762","observed_orcids":["https://orcid.org/0009-0006-4313-7762"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Bedin","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0009-0006-4313-7762","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064602227","display_name":"Elena Foli","orcid":"https://orcid.org/0009-0003-3916-1653","observed_orcids":["https://orcid.org/0009-0003-3916-1653"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elena Foli","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0009-0003-3916-1653","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056134137","display_name":"Niccol\u00f2 Bianchi","orcid":"https://orcid.org/0000-0001-5605-3425","observed_orcids":["https://orcid.org/0000-0001-5605-3425"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Niccol\u00f2 Bianchi","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0001-5605-3425","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020476749","display_name":"Emina D\u017eafo","orcid":"https://orcid.org/0000-0001-8276-858X","observed_orcids":["https://orcid.org/0000-0001-8276-858X"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Emina D\u017eafo","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0001-8276-858X","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066872389","display_name":"Sandra Jovic","orcid":"https://orcid.org/0000-0001-6871-8690","observed_orcids":["https://orcid.org/0000-0001-6871-8690"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sandra Jovic","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0001-6871-8690","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041711959","display_name":"Alessandro Cuomo","orcid":"https://orcid.org/0000-0002-9778-7190","observed_orcids":["https://orcid.org/0000-0002-9778-7190"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Cuomo","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0002-9778-7190","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065130211","display_name":"Simona Rodighiero","orcid":"https://orcid.org/0000-0003-4236-7823","observed_orcids":["https://orcid.org/0000-0003-4236-7823"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Rodighiero","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0003-4236-7823","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006902186","display_name":"David Jarrossay","orcid":"https://orcid.org/0000-0002-0924-6395","observed_orcids":["https://orcid.org/0000-0002-0924-6395"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David Jarrossay","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0002-0924-6395","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047171254","display_name":"Federica Sallusto","orcid":"https://orcid.org/0000-0003-3750-2752","observed_orcids":["https://orcid.org/0000-0003-3750-2752"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I4405257335","display_name":"Institute of Microbiology","ror":"https://ror.org/0556as610","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405257335"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Federica Sallusto","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","Institute of Microbiology, ETH Z\u00fcrich 3 , Zurich,"],"raw_orcid":"https://orcid.org/0000-0003-3750-2752","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"raw_affiliation_string":"Institute of Microbiology, ETH Z\u00fcrich 3 , Zurich,","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405257335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076459388","display_name":"Gioacchino Natoli","orcid":"https://orcid.org/0000-0003-0711-2411","observed_orcids":["https://orcid.org/0000-0003-0711-2411"]},"institutions":[{"id":"https://openalex.org/I6141010","display_name":"European Institute of Oncology","ror":"https://ror.org/02vr0ne26","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I6141010"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gioacchino Natoli","raw_affiliation_strings":["IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,"],"raw_orcid":"https://orcid.org/0000-0003-0711-2411","affiliations":[{"raw_affiliation_string":"IEO, European Institute of Oncology IRCCS 2 Department of Experimental Oncology, , Milan,","institution_ids":["https://openalex.org/I6141010"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020905419","display_name":"Silvia Monticelli","orcid":"https://orcid.org/0000-0002-5909-8802","observed_orcids":["https://orcid.org/0000-0002-5909-8802"]},"institutions":[{"id":"https://openalex.org/I4387152247","display_name":"Institute for Research in Biomedicine","ror":"https://ror.org/05gfswd81","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]},{"id":"https://openalex.org/I57201433","display_name":"Universit\u00e0 della Svizzera italiana","ror":"https://ror.org/03c4atk17","country_code":"CH","type":"education","lineage":["https://openalex.org/I57201433"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Silvia Monticelli","raw_affiliation_strings":["Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,"],"raw_orcid":"https://orcid.org/0000-0002-5909-8802","affiliations":[{"raw_affiliation_string":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera italiana 1 , Bellinzona,","institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5020905419"],"corresponding_institution_ids":["https://openalex.org/I4387152247","https://openalex.org/I57201433"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73764746,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"223","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5044000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5044000148773193,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.47360000014305115,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skap2","display_name":"SKAP2","score":1.0},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/t-cell-adhesion","display_name":"T cell adhesion","score":0.9350000023841858},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.9919999837875366},{"id":"https://openalex.org/keywords/caspase-cleavage","display_name":"caspase cleavage","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tcr-activation","display_name":"TCR activation","score":0.734000027179718},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.925000011920929},{"id":"https://openalex.org/keywords/adaptor-proteins","display_name":"adaptor proteins","score":0.6119999885559082},{"id":"https://openalex.org/keywords/autoimmune-disease-genetics","display_name":"autoimmune disease genetics","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5845999717712402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5697000026702881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5476999878883362},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5091999769210815},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48669999837875366},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.4350999891757965},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.41830000281333923},{"id":"https://openalex.org/C2777061661","wikidata":"https://www.wikidata.org/wiki/Q423934","display_name":"Phosphoprotein","level":3,"score":0.41179999709129333},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4097000062465668},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.4000999927520752},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.39320001006126404},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.3646000027656555},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3425999879837036},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.33059999346733093},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3138999938964844},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2777999937534332},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.27459999918937683},{"id":"https://openalex.org/C51456166","wikidata":"https://www.wikidata.org/wiki/Q182726","display_name":"Genetically modified organism","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2669000029563904},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C2778593620","wikidata":"https://www.wikidata.org/wiki/Q4042438","display_name":"Lymphocyte function-associated antigen 1","level":4,"score":0.26010000705718994},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.25940001010894775},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C47794810","wikidata":"https://www.wikidata.org/wiki/Q21122937","display_name":"TCIRG1","level":5,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1084/jem.20260507","doi":"https://doi.org/10.1084/jem.20260507","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20260507","pdf_url":"https://rupress.org/jem/article-pdf/223/12/e20260507/2042471/jem_20260507.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682646","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682646/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682646/pdf/jem_20260507.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:42900686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42900686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1084/jem.20260507","doi":"https://doi.org/10.1084/jem.20260507","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.20260507","pdf_url":"https://rupress.org/jem/article-pdf/223/12/e20260507/2042471/jem_20260507.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5716824486","display_name":null,"funder_award_id":"2020-2022","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G6170854158","display_name":"A Systems medicine approach to chronic inflammatory disease","funder_award_id":"733100","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320323329","display_name":"Universit\u00e9 de Li\u00e8ge","ror":"https://ror.org/00afp2z80"},{"id":"https://openalex.org/F4320332053","display_name":"Alleanza Contro il Cancro","ror":"https://ror.org/05y4mf750"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223015955.pdf","grobid_xml":"https://content.openalex.org/works/W7223015955.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1014257459","https://openalex.org/W1518815928","https://openalex.org/W1966286149","https://openalex.org/W1966732557","https://openalex.org/W1986656413","https://openalex.org/W1988952956","https://openalex.org/W2008144923","https://openalex.org/W2014776577","https://openalex.org/W2015776459","https://openalex.org/W2018057834","https://openalex.org/W2021341670","https://openalex.org/W2024108088","https://openalex.org/W2025065287","https://openalex.org/W2032335449","https://openalex.org/W2046175632","https://openalex.org/W2047977785","https://openalex.org/W2057359558","https://openalex.org/W2063330553","https://openalex.org/W2064636199","https://openalex.org/W2065840402","https://openalex.org/W2080752012","https://openalex.org/W2112635226","https://openalex.org/W2120139005","https://openalex.org/W2126654232","https://openalex.org/W2127862779","https://openalex.org/W2130503272","https://openalex.org/W2130947423","https://openalex.org/W2132279425","https://openalex.org/W2133964808","https://openalex.org/W2135403800","https://openalex.org/W2139075939","https://openalex.org/W2143625465","https://openalex.org/W2148187752","https://openalex.org/W2148270304","https://openalex.org/W2149468314","https://openalex.org/W2152365098","https://openalex.org/W2167279371","https://openalex.org/W2170776626","https://openalex.org/W2171622167","https://openalex.org/W2252568502","https://openalex.org/W2276196324","https://openalex.org/W2346951623","https://openalex.org/W2463195069","https://openalex.org/W2515435336","https://openalex.org/W2529052661","https://openalex.org/W2553059833","https://openalex.org/W2586847280","https://openalex.org/W2724938313","https://openalex.org/W2766922625","https://openalex.org/W2807901568","https://openalex.org/W2885096157","https://openalex.org/W2901765988","https://openalex.org/W2904226822","https://openalex.org/W2978261781","https://openalex.org/W2991016899","https://openalex.org/W3011105477","https://openalex.org/W3199815956","https://openalex.org/W4210396037","https://openalex.org/W4214763387","https://openalex.org/W4281555558","https://openalex.org/W4293475192","https://openalex.org/W4315796312","https://openalex.org/W4317904922","https://openalex.org/W4392028262","https://openalex.org/W4394694796","https://openalex.org/W4401417076","https://openalex.org/W4409906436","https://openalex.org/W4415243516"],"related_works":["https://openalex.org/W4387638245","https://openalex.org/W6964612404","https://openalex.org/W4378903215","https://openalex.org/W2130947423","https://openalex.org/W4313259214","https://openalex.org/W4310478451","https://openalex.org/W4313354980","https://openalex.org/W2148270304","https://openalex.org/W2032335449","https://openalex.org/W4396516913"],"abstract_inverted_index":{"Genome-wide":[0],"association":[1],"studies":[2],"investigating":[3],"autoimmune":[4],"disorders":[5],"may":[6],"reveal":[7],"previously":[8],"unrecognized":[9],"regulators":[10],"of":[11,28,109,127],"immune":[12],"cell":[13,69,129],"functions.":[14],"A":[15],"Crohn's":[16],"disease":[17],"risk":[18],"allele":[19],"was":[20],"associated":[21],"with":[22,76,81],"increased":[23],"expression":[24,132],"in":[25,40],"T":[26,47,68,128],"lymphocytes":[27],"the":[29,107,136],"adapter":[30],"protein":[31,96],"Src":[32],"kinase-associated":[33],"phosphoprotein":[34],"2":[35],"(SKAP2),":[36],"whose":[37,131],"functional":[38,83],"role":[39],"these":[41,118],"cells":[42,48],"is":[43],"unknown.":[44],"By":[45],"analyzing":[46],"from":[49],"individuals":[50],"homozygous":[51],"for":[52],"either":[53],"allelic":[54],"variant":[55],"or":[56],"engineered":[57],"to":[58,106],"modulate":[59],"SKAP2":[60,66,87,103,121],"endogenous":[61],"levels,":[62],"we":[63],"found":[64],"that":[65],"promotes":[67],"adhesion":[70,139],"while":[71],"restraining":[72],"migration,":[73],"acting":[74],"nonredundantly":[75],"its":[77,110],"homologue":[78],"SKAP1.":[79],"Consistent":[80],"such":[82],"differences,":[84],"SKAP1":[85],"and":[86,112,133,140],"displayed":[88],"distinct":[89],"activation-induced":[90],"regulation":[91],"as":[92,94,122],"well":[93],"unique":[95],"interactomes.":[97],"Prolonged":[98],"TCR":[99],"activation":[100],"triggered":[101],"caspase-mediated":[102],"cleavage,":[104],"leading":[105],"disassembly":[108],"interactome":[111],"enabling":[113],"a":[114,123],"migratory":[115],"program.":[116],"Together,":[117],"findings":[119],"identify":[120],"genetically":[124],"regulated":[125],"modulator":[126],"function":[130],"activity":[134],"control":[135],"balance":[137],"between":[138],"migration.":[141]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-10-21T00:00:00"}