{"id":"https://openalex.org/W7223012002","doi":"https://doi.org/10.1186/s12962-026-00846-6","title":"Cost-effectiveness of iStent-based trabecular micro-bypass stenting combined with cataract surgery in mild-to-moderate open-angle glaucoma: a systematic review of analytic perspectives and time horizons","display_name":"Cost-effectiveness of iStent-based trabecular micro-bypass stenting combined with cataract surgery in mild-to-moderate open-angle glaucoma: a systematic review of analytic perspectives and time horizons","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7223012002","doi":"https://doi.org/10.1186/s12962-026-00846-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42902356","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685196"},"language":"en","primary_location":{"id":"doi:10.1186/s12962-026-00846-6","doi":"https://doi.org/10.1186/s12962-026-00846-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12962-026-00846-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12962-026-00846-6.pdf","source":{"id":"https://openalex.org/S22361854","display_name":"Cost Effectiveness and Resource Allocation","issn_l":"1478-7547","issn":["1478-7547"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cost Effectiveness and Resource Allocation","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12962-026-00846-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027840591","display_name":"Dan Drobin","orcid":"https://orcid.org/0009-0004-4490-5263","observed_orcids":["https://orcid.org/0009-0004-4490-5263"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Dan Drobin","raw_affiliation_strings":["Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. dan.drobin@ki.se"],"raw_orcid":"https://orcid.org/0009-0004-4490-5263","affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. dan.drobin@ki.se","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027840591"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62560839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/istent","display_name":"iStent","score":0.8960000276565552},{"id":"https://openalex.org/keywords/minimally-invasive-glaucoma-surgery","display_name":"minimally invasive glaucoma surgery","score":0.9470000267028809},{"id":"https://openalex.org/keywords/open-angle-glaucoma","display_name":"open-angle glaucoma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cataract-surgery","display_name":"cataract surgery","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9430000185966492},{"id":"https://openalex.org/keywords/time-horizon","display_name":"time horizon","score":0.9850000143051147},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.906000018119812},{"id":"https://openalex.org/keywords/incremental-cost-effectiveness-ratio","display_name":"incremental cost-effectiveness ratio","score":0.796999990940094},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.5910000205039978},{"id":"https://openalex.org/keywords/microsimulation","display_name":"microsimulation","score":0.5230000019073486},{"id":"https://openalex.org/keywords/reimbursement","display_name":"reimbursement","score":0.45100000500679016},{"id":"https://openalex.org/keywords/healthcare-system-perspective","display_name":"healthcare system perspective","score":0.34200000762939453},{"id":"https://openalex.org/keywords/societal-perspective","display_name":"societal perspective","score":0.7310000061988831},{"id":"https://openalex.org/keywords/discount-rate","display_name":"discount rate","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9352999925613403},{"id":"https://openalex.org/C2775888743","wikidata":"https://www.wikidata.org/wiki/Q1818260","display_name":"Cataract surgery","level":2,"score":0.7429999709129333},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.5209000110626221},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3991999924182892},{"id":"https://openalex.org/C2776125615","wikidata":"https://www.wikidata.org/wiki/Q18391886","display_name":"Economic evaluation","level":2,"score":0.37290000915527344},{"id":"https://openalex.org/C524218345","wikidata":"https://www.wikidata.org/wiki/Q31218","display_name":"Health economics","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.3596000075340271},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3425000011920929},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3319999873638153},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C2780877353","wikidata":"https://www.wikidata.org/wiki/Q2518253","display_name":"Health services research","level":3,"score":0.30480000376701355},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.2928999960422516},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C3020256872","wikidata":"https://www.wikidata.org/wiki/Q1818260","display_name":"Cataract extraction","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C2776766258","wikidata":"https://www.wikidata.org/wiki/Q5567291","display_name":"Glaucoma surgery","level":3,"score":0.27480000257492065},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C2778091340","wikidata":"https://www.wikidata.org/wiki/Q15749950","display_name":"Quality of Life Research","level":3,"score":0.2624000012874603},{"id":"https://openalex.org/C2779231881","wikidata":"https://www.wikidata.org/wiki/Q5977147","display_name":"Medical literature","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C160022790","wikidata":"https://www.wikidata.org/wiki/Q2964004","display_name":"Cardiothoracic surgery","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C2779703844","wikidata":"https://www.wikidata.org/wiki/Q760125","display_name":"Reimbursement","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.2556000053882599},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1186/s12962-026-00846-6","doi":"https://doi.org/10.1186/s12962-026-00846-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12962-026-00846-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12962-026-00846-6.pdf","source":{"id":"https://openalex.org/S22361854","display_name":"Cost Effectiveness and Resource Allocation","issn_l":"1478-7547","issn":["1478-7547"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cost Effectiveness and Resource Allocation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685196","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685196/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685196/pdf/12962_2026_Article_846.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cost Eff Resour Alloc","raw_type":"Text"},{"id":"pmid:42902356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42902356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cost effectiveness and resource allocation : C/E","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:552c85dd47314a2ea23e83bf0b1970be","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/552c85dd47314a2ea23e83bf0b1970be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cost Effectiveness and Resource Allocation, Vol 24, Iss 1 (2026)","raw_type":"article"},{"id":"doi:10.6084/m9.figshare.c.8786300","doi":"https://doi.org/10.6084/m9.figshare.c.8786300","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8786300","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.6084/m9.figshare.c.8786300.v1","doi":"https://doi.org/10.6084/m9.figshare.c.8786300.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8786300.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"}],"best_oa_location":{"id":"doi:10.1186/s12962-026-00846-6","doi":"https://doi.org/10.1186/s12962-026-00846-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12962-026-00846-6","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12962-026-00846-6.pdf","source":{"id":"https://openalex.org/S22361854","display_name":"Cost Effectiveness and Resource Allocation","issn_l":"1478-7547","issn":["1478-7547"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-c","anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cost Effectiveness and Resource Allocation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223012002.pdf","grobid_xml":"https://content.openalex.org/works/W7223012002.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2013329800","https://openalex.org/W2034742711","https://openalex.org/W2057266151","https://openalex.org/W2134263207","https://openalex.org/W2160605010","https://openalex.org/W2167256322","https://openalex.org/W2179102356","https://openalex.org/W2921397391","https://openalex.org/W2945203066","https://openalex.org/W2990842711","https://openalex.org/W3011260711","https://openalex.org/W3118615836","https://openalex.org/W3135368856","https://openalex.org/W3171718937","https://openalex.org/W3178502566","https://openalex.org/W3204394195","https://openalex.org/W4200304405","https://openalex.org/W4206121490","https://openalex.org/W4281986022"],"related_works":["https://openalex.org/W7223122753","https://openalex.org/W7223111931","https://openalex.org/W3178502566","https://openalex.org/W3135368856","https://openalex.org/W3171718937","https://openalex.org/W2990842711","https://openalex.org/W3204394195","https://openalex.org/W2800155023","https://openalex.org/W2906648483","https://openalex.org/W3082933730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Glaucoma":[1],"remains":[2,468],"a":[3,129,186,246,257,264,269,282,286,296,377,382,392,480,505,525,541,570],"major":[4],"cause":[5],"of":[6,24,50,76,121,155,336,339,479,523,573],"irreversible":[7],"blindness":[8],"and":[9,31,90,97,138,153,180,217,250,262,275,328,357,380,398,444,448,463,492,516],"was":[10,119,193,206,551,580,584],"estimated":[11],"to":[12,91,106,113,237,320,366,424,499,527,554],"affect":[13],"64.3":[14],"million":[15],"people":[16],"worldwide":[17],"in":[18,53,101,300,311,314,317,322,326,330,369,404,461,476,543,587],"2013.":[19],"Despite":[20],"growing":[21],"clinical":[22,457,577],"use":[23],"minimally":[25],"invasive":[26],"glaucoma":[27,442],"surgery":[28,52,85,239,242,426],"(MIGS),":[29],"reimbursement":[30],"uptake":[32],"remain":[33],"constrained":[34],"by":[35,344],"uncertainty":[36],"about":[37],"long-term":[38,401,456],"cost-effectiveness.":[39],"iStent-based":[40],"trabecular":[41,78],"micro-bypass":[42,79],"implantation":[43,80],"is":[44,111,459,473,532,540,569],"commonly":[45],"performed":[46,81,120],"at":[47],"the":[48,74,94,102,107,109,150,228,234,301,340,345,360,370,454,465,470,487,520,544,549],"time":[49,98,176],"cataract":[51,84,146,238,241,425,530],"patients":[54],"with":[55,83,145,185,333],"mild-to-moderate":[56,87,302],"open-angle":[57,88],"glaucoma,":[58,89],"yet":[59],"its":[60],"economic":[61,124,222,395],"value":[62],"has":[63],"not":[64,375,386,552,585],"been":[65],"synthesised":[66,201],"systematically":[67],"across":[68],"healthcare":[69],"systems.":[70],"OBJECTIVE:":[71],"To":[72],"evaluate":[73],"cost-effectiveness":[75,170],"iStent":[77,141],"concurrently":[82,144],"for":[86,189,381],"examine":[92],"how":[93],"analytic":[95,174],"perspective":[96,261,284,510],"horizon":[99,288],"adopted":[100,256,281],"underlying":[103],"models":[104,416],"relate":[105],"decision":[108],"evidence":[110,452,471],"intended":[112],"inform.":[114],"METHODS:":[115],"A":[116],"systematic":[117,571],"review":[118,550,572,583],"published":[122,574],"model-based":[123],"evaluations.":[125],"Eligible":[126],"studies":[127],"used":[128,245,268],"formal":[130],"decision-analytic":[131],"model,":[132],"reported":[133,295,305,361,391],"quality-adjusted":[134],"life":[135],"years":[136,274,513],"(QALYs),":[137],"evaluated":[139],"an":[140,252,421,528,535],"device":[142,235,346,423,447,482],"implanted":[143],"surgery.":[147],"PubMed,":[148],"Embase,":[149],"Cochrane":[151],"Library":[152],"Web":[154],"Science":[156],"were":[157,183,200,342,351],"searched":[158],"on":[159,436,440,445,486,494],"27":[160],"July":[161],"2026":[162],"without":[163],"date,":[164],"language":[165],"or":[166,259,285,409,508,514],"publication-type":[167],"restriction.":[168],"Incremental":[169,348],"ratios":[171,306,362],"(ICERs),":[172],"QALYs,":[173],"perspectives,":[175],"horizons,":[177],"discount":[178],"rates":[179],"probabilistic":[181],"results":[182],"extracted":[184],"page":[187],"reference":[188],"each":[190],"value.":[191],"Reporting":[192,208],"appraised":[194],"item-by-item":[195],"against":[196,240],"CHEERS":[197],"2022.":[198],"Findings":[199],"narratively;":[202],"no":[203,389,576],"quantitative":[204],"pooling":[205],"attempted.":[207],"followed":[209],"PRISMA":[210],"2020.":[211],"RESULTS:":[212],"Of":[213],"418":[214],"records":[215],"identified":[216],"293":[218],"after":[219],"de-duplication,":[220],"eight":[221,225,232,294,341],"evaluations":[223,503],"from":[224],"countries":[226],"met":[227],"eligibility":[229,561],"criteria.":[230,562],"All":[231,293,501],"compared":[233],"added":[236],"alone;":[243],"seven":[244],"cohort":[247],"Markov":[248],"model":[249],"one":[251,272],"individual-patient":[253],"microsimulation.":[254],"Six":[255,338],"payer":[258],"health-system":[260,507],"two":[263,276,334],"societal":[265,509],"perspective;":[266],"five":[267],"lifetime":[270],"horizon,":[271],"35":[273],"15":[277,291,512],"years.":[278,292],"No":[279],"evaluation":[280],"provider":[283],"base-case":[287,298],"shorter":[289],"than":[290],"favourable":[297],"result":[299],"target":[303],"population:":[304],"included":[307,414,502,545],"\u20ac1,154":[308],"per":[309],"QALY":[310,349,496],"France,":[312],"\u20ac12,676":[313],"Spain,":[315],"\u20ac13,037":[316],"Italy,":[318],"\u20ac10,955":[319],"\u20ac15,673":[321],"Germany,":[323],"JPY":[324],"1,430,647":[325],"Japan":[327],"A$2,430":[329],"Australia,":[331],"together":[332],"instances":[335],"dominance.":[337],"funded":[343],"manufacturer.":[347],"gains":[350,497],"small":[352,367],"throughout,":[353],"between":[354],"approximately":[355],"0.005":[356],"0.17,":[358],"so":[359],"are":[363],"highly":[364],"sensitive":[365],"changes":[368],"denominator.":[371],"One":[372],"study":[373,390,568],"did":[374],"report":[376],"price":[378],"year":[379],"second":[383],"it":[384],"could":[385],"be":[387,428],"verified;":[388],"pre-specified":[393],"health":[394],"analysis":[396],"plan,":[397],"none":[399,517],"modelled":[400,455],"structural":[402],"change":[403],"medication":[405,438],"prices,":[406],"prescribing":[407],"practice":[408,462],"competing":[410],"alternatives.":[411],"CONCLUSIONS:":[412],"The":[413,582],"peer-reviewed":[415],"generally":[417],"project":[418],"that":[419,453],"adding":[420,524],"iStent-family":[422],"can":[427],"cost-effective":[429],"over":[430,511],"long":[431],"horizons.":[432],"That":[433],"projection":[434],"depends":[435],"sustained":[437],"reduction,":[439],"extrapolated":[441],"progression":[443],"local":[446],"treatment":[449],"costs.":[450],"Direct":[451],"benefit":[458],"realised":[460],"offsets":[464],"acquisition":[466],"cost":[467,522],"limited:":[469],"base":[472],"small,":[474],"concentrated":[475],"industry-funded":[477],"analyses":[478,558],"single":[481],"family":[483],"drawing":[484],"largely":[485],"same":[488],"two-year":[489],"pivotal":[490],"trial,":[491],"built":[493],"incremental":[495],"close":[498],"zero.":[500],"adopt":[504],"payer,":[506],"longer,":[515],"addresses":[518],"whether":[519],"marginal":[521],"stent":[526],"already-scheduled":[529],"procedure":[531],"justified":[533],"within":[534],"annual":[536],"operating":[537],"budget.":[538],"This":[539,567],"gap":[542],"QALY-based":[546],"cost-utility":[547],"literature;":[548],"designed":[553],"identify":[555],"provider-perspective":[556],"budget-impact":[557],"outside":[559],"these":[560],"TRIAL":[563],"REGISTRATION:":[564],"Not":[565],"applicable.":[566],"economicevaluations;":[575],"trial":[578],"registration":[579],"required.":[581],"registeredprospectively":[586],"PROSPERO.":[588]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}