{"id":"https://openalex.org/W7223010692","doi":"https://doi.org/10.1098/rsos.261278","title":"Information-geometric optimization of transient dynamics in gene regulatory networks","display_name":"Information-geometric optimization of transient dynamics in gene regulatory networks","publication_year":2026,"publication_date":"2026-10-07","ids":{"openalex":"https://openalex.org/W7223010692","doi":"https://doi.org/10.1098/rsos.261278","pmid":"https://pubmed.ncbi.nlm.nih.gov/42904300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682892"},"language":"en","primary_location":{"id":"doi:10.1098/rsos.261278","doi":"https://doi.org/10.1098/rsos.261278","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsos.261278","pdf_url":null,"source":{"id":"https://openalex.org/S2737558550","display_name":"Royal Society Open Science","issn_l":"2054-5703","issn":["2054-5703"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society Open Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1098/rsos.261278","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068173467","display_name":"Alessandro Bravetti","orcid":"https://orcid.org/0000-0001-5348-9215","observed_orcids":["https://orcid.org/0000-0001-5348-9215"]},"institutions":[{"id":"https://openalex.org/I112859197","display_name":"Universit\u00e0 di Camerino","ror":"https://ror.org/0005w8d69","country_code":"IT","type":"education","lineage":["https://openalex.org/I112859197"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Bravetti","raw_affiliation_strings":["School of Science and Technology, University of Camerino 1 , Camerino, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5348-9215","affiliations":[{"raw_affiliation_string":"School of Science and Technology, University of Camerino 1 , Camerino, Italy","institution_ids":["https://openalex.org/I112859197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071499460","display_name":"Miguel \u00c1ngel Garc\u00eda-Ariza","orcid":"https://orcid.org/0000-0003-4567-1484","observed_orcids":["https://orcid.org/0000-0003-4567-1484"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Miguel \u00c1ngel Garc\u00eda Ariza","raw_affiliation_strings":["IIMAS, Universidad Nacional Aut\u00f3noma de M\u00e9xico 2 , Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-4567-1484","affiliations":[{"raw_affiliation_string":"IIMAS, Universidad Nacional Aut\u00f3noma de M\u00e9xico 2 , Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078031180","display_name":"Pablo Padilla-Longoria","orcid":"https://orcid.org/0000-0003-3457-6289","observed_orcids":["https://orcid.org/0000-0003-3457-6289"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Pablo Padilla","raw_affiliation_strings":["IIMAS, Universidad Nacional Aut\u00f3noma de M\u00e9xico 2 , Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-3457-6289","affiliations":[{"raw_affiliation_string":"IIMAS, Universidad Nacional Aut\u00f3noma de M\u00e9xico 2 , Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076434198","display_name":"J. Roberto Romero-Arias","orcid":"https://orcid.org/0000-0002-3423-6455","observed_orcids":["https://orcid.org/0000-0002-3423-6455"]},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Roberto Romero-Arias","raw_affiliation_strings":["IIMAS, Universidad Nacional Aut\u00f3noma de M\u00e9xico 2 , Mexico City, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-3423-6455","affiliations":[{"raw_affiliation_string":"IIMAS, Universidad Nacional Aut\u00f3noma de M\u00e9xico 2 , Mexico City, Mexico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071499460"],"corresponding_institution_ids":["https://openalex.org/I8961855"],"apc_list":{"value":1200,"currency":"GBP","value_usd":1471},"apc_paid":{"value":1200,"currency":"GBP","value_usd":1471},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6746396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"10","first_page":"261278","last_page":"261278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14299","display_name":"Complex Systems and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-networks","display_name":"gene regulatory networks","score":0.996999979019165},{"id":"https://openalex.org/keywords/information-geometry","display_name":"information geometry","score":0.6959999799728394},{"id":"https://openalex.org/keywords/fisher-information-metric","display_name":"Fisher information metric","score":0.9589999914169312},{"id":"https://openalex.org/keywords/boolean-networks","display_name":"Boolean networks","score":0.5730000138282776},{"id":"https://openalex.org/keywords/stochastic-gene-expression","display_name":"stochastic gene expression","score":0.6759999990463257},{"id":"https://openalex.org/keywords/molecular-noise","display_name":"molecular noise","score":0.7239999771118164},{"id":"https://openalex.org/keywords/kullback-leibler-divergence","display_name":"Kullback-Leibler divergence","score":0.8830000162124634},{"id":"https://openalex.org/keywords/attractor-dynamics","display_name":"attractor dynamics","score":0.5709999799728394},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gradient-flow","display_name":"gradient flow","score":0.49000000953674316},{"id":"https://openalex.org/keywords/synthetic-gene-networks","display_name":"synthetic gene networks","score":0.6930000185966492},{"id":"https://openalex.org/keywords/noise-intensity","display_name":"noise intensity","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6563000082969666},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.6226000189781189},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.54830002784729},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.5419999957084656},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.5407999753952026},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.5404999852180481},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5224000215530396},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5077000260353088},{"id":"https://openalex.org/C123757187","wikidata":"https://www.wikidata.org/wiki/Q9195957","display_name":"Network dynamics","level":2,"score":0.4763000011444092},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.46309998631477356},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.45890000462532043},{"id":"https://openalex.org/C73586568","wikidata":"https://www.wikidata.org/wiki/Q2600211","display_name":"Parameter space","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C29406490","wikidata":"https://www.wikidata.org/wiki/Q1420659","display_name":"Fisher information","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C61326573","wikidata":"https://www.wikidata.org/wiki/Q1496376","display_name":"Gaussian process","level":3,"score":0.40950000286102295},{"id":"https://openalex.org/C72434380","wikidata":"https://www.wikidata.org/wiki/Q230930","display_name":"State space","level":2,"score":0.40619999170303345},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C159886148","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov process","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C4199805","wikidata":"https://www.wikidata.org/wiki/Q2725903","display_name":"Gaussian noise","level":2,"score":0.3693000078201294},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.36579999327659607},{"id":"https://openalex.org/C184050105","wikidata":"https://www.wikidata.org/wiki/Q273163","display_name":"Isotropy","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C2984125019","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic dynamics","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.32409998774528503},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29919999837875366},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2973000109195709},{"id":"https://openalex.org/C171752962","wikidata":"https://www.wikidata.org/wiki/Q255166","display_name":"Kullback\u2013Leibler divergence","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C77405623","wikidata":"https://www.wikidata.org/wiki/Q598451","display_name":"System dynamics","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.2743000090122223},{"id":"https://openalex.org/C52622258","wikidata":"https://www.wikidata.org/wiki/Q131222","display_name":"Information theory","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.25459998846054077},{"id":"https://openalex.org/C2777317252","wikidata":"https://www.wikidata.org/wiki/Q18393516","display_name":"Rare events","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1098/rsos.261278","doi":"https://doi.org/10.1098/rsos.261278","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsos.261278","pdf_url":null,"source":{"id":"https://openalex.org/S2737558550","display_name":"Royal Society Open Science","issn_l":"2054-5703","issn":["2054-5703"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society Open Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682892","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682892/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682892/pdf/rsos.261278.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"R Soc Open Sci","raw_type":"Text"},{"id":"pmid:42904300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42904300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society open science","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:2509.08167","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2509.08167","pdf_url":"https://arxiv.org/pdf/2509.08167","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pubblicazioni.unicam.it:11581/505825","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11581/505825","pdf_url":"https://royalsocietypublishing.org/rsos/article-pdf/doi/10.1098/rsos.261278/6172870/rsos.261278.pdf","source":{"id":"https://openalex.org/S4306400819","display_name":"Unicam Scientific Publications (University of Camerino)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I112859197","host_organization_name":"Universit\u00e0 di Camerino","host_organization_lineage":["https://openalex.org/I112859197"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:32e022183aca4c74a54e3174e91f2a0c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/32e022183aca4c74a54e3174e91f2a0c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Royal Society Open Science, Vol 13, Iss 10, Pp - (2026)","raw_type":"article"},{"id":"doi:10.48550/arxiv.2509.08167","doi":"https://doi.org/10.48550/arxiv.2509.08167","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2509.08167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1098/rsos.261278","doi":"https://doi.org/10.1098/rsos.261278","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsos.261278","pdf_url":null,"source":{"id":"https://openalex.org/S2737558550","display_name":"Royal Society Open Science","issn_l":"2054-5703","issn":["2054-5703"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Royal Society Open Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7223010692.pdf","grobid_xml":"https://content.openalex.org/works/W7223010692.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W595145996","https://openalex.org/W1566877408","https://openalex.org/W1970779075","https://openalex.org/W1983121418","https://openalex.org/W1986041196","https://openalex.org/W1990314284","https://openalex.org/W2006877085","https://openalex.org/W2036632921","https://openalex.org/W2044692345","https://openalex.org/W2044788682","https://openalex.org/W2071048859","https://openalex.org/W2077998526","https://openalex.org/W2112296120","https://openalex.org/W2112326910","https://openalex.org/W2112540303","https://openalex.org/W2121633536","https://openalex.org/W2124098876","https://openalex.org/W2149242848","https://openalex.org/W2190001876","https://openalex.org/W2296679604","https://openalex.org/W2314143613","https://openalex.org/W2331030820","https://openalex.org/W2467711497","https://openalex.org/W2479661392","https://openalex.org/W2485135680","https://openalex.org/W2528271650","https://openalex.org/W2587641917","https://openalex.org/W2771262442","https://openalex.org/W2782588114","https://openalex.org/W2885291172","https://openalex.org/W2912185173","https://openalex.org/W2963645788","https://openalex.org/W3010093582","https://openalex.org/W3025326584","https://openalex.org/W3025478249","https://openalex.org/W3048745573","https://openalex.org/W3092838074","https://openalex.org/W3095627698","https://openalex.org/W3100494228","https://openalex.org/W3130910473","https://openalex.org/W3194068170","https://openalex.org/W3208616929","https://openalex.org/W3210503352","https://openalex.org/W4220706748","https://openalex.org/W4220751272","https://openalex.org/W4221149956","https://openalex.org/W4236324035","https://openalex.org/W4246954948","https://openalex.org/W4251529871","https://openalex.org/W4283724581","https://openalex.org/W4293483406","https://openalex.org/W4300432631","https://openalex.org/W4307282757","https://openalex.org/W4323537242","https://openalex.org/W4381929620","https://openalex.org/W4385724955","https://openalex.org/W4385873015","https://openalex.org/W4388902335","https://openalex.org/W4388975180","https://openalex.org/W4390571774","https://openalex.org/W4396809801","https://openalex.org/W4399122997","https://openalex.org/W4403135410","https://openalex.org/W4403894452","https://openalex.org/W4407310951","https://openalex.org/W4408435422","https://openalex.org/W4411384349","https://openalex.org/W7118172657","https://openalex.org/W7168358071"],"related_works":["https://openalex.org/W4416068968","https://openalex.org/W2141316905","https://openalex.org/W116304031","https://openalex.org/W134141952","https://openalex.org/W1966954598","https://openalex.org/W4287674459","https://openalex.org/W2025860033","https://openalex.org/W7165461854","https://openalex.org/W7096930076","https://openalex.org/W2523640714"],"abstract_inverted_index":{"The":[0],"dynamics":[1,32,68,124],"of":[2,46,73,118,162],"gene":[3],"regulatory":[4],"networks":[5],"(GRNs)":[6],"is":[7,137],"governed":[8],"by":[9],"the":[10,43,51,70,74,87,92,96,105,116,158],"interaction":[11],"between":[12,95],"deterministic":[13,123],"biochemical":[14],"reactions":[15],"and":[16,85,98,120,146,160],"molecular":[17],"noise.":[18],"To":[19],"understand":[20],"how":[21],"GRNs":[22],"process":[23],"information":[24,53],"during":[25],"cell":[26,140],"state":[27],"transitions,":[28],"we":[29,102],"study":[30],"stochastic":[31],"derived":[33],"from":[34,134],"a":[35,61,154],"Boolean":[36],"network":[37],"model":[38],"via":[39],"its":[40],"representation":[41],"on":[42],"parameter":[44],"space":[45],"Gaussian":[47],"distributions,":[48],"equipped":[49],"with":[50,110],"Fisher":[52,106],"metric.":[54],"Restricting":[55],"our":[56],"analysis":[57,159],"to":[58,122],"transitions":[59],"towards":[60],"single":[62],"attractor,":[63],"this":[64],"reformulation":[65],"reveals":[66],"that":[67,86,104,125,131],"along":[69],"gradient":[71],"flows":[72],"Kullback-Leibler":[75],"(KL)":[76],"divergence":[77],"requires":[78],"isotropic":[79],"decay":[80,147],"rates":[81,148],"across":[82],"all":[83],"nodes,":[84],"noise":[88,119,145],"intensity":[89],"quantitatively":[90],"determines":[91],"potential":[93],"differentiation":[94],"initial":[97],"final":[99],"states.":[100],"Furthermore,":[101],"show":[103],"geodesics,":[107],"previously":[108],"identified":[109],"minimal":[111,135],"biological":[112,127],"cost,":[113],"would":[114],"require":[115],"suppression":[117],"lead":[121],"lacks":[126],"relevance.":[128],"This":[129],"suggests":[130],"some":[132],"departure":[133],"cost":[136],"necessary":[138],"for":[139,157],"differentiation.":[141],"Our":[142],"approach":[143],"frames":[144],"as":[149],"fundamental":[150],"control":[151],"parameters,":[152],"providing":[153],"geometric":[155],"principle":[156],"design":[161],"synthetic":[163],"networks.":[164]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-21T00:00:00"}
