{"id":"https://openalex.org/W7222997944","doi":"https://doi.org/10.3390/cancers18203396","title":"The SP4\u2013NUPR1\u2013SELM Axis Promotes Glycolytic Reprogramming and Stemness-Associated Phenotypes in Bladder Cancer","display_name":"The SP4\u2013NUPR1\u2013SELM Axis Promotes Glycolytic Reprogramming and Stemness-Associated Phenotypes in Bladder Cancer","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7222997944","doi":"https://doi.org/10.3390/cancers18203396","pmid":"https://pubmed.ncbi.nlm.nih.gov/42938928","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13702499"},"language":"en","primary_location":{"id":"doi:10.3390/cancers18203396","doi":"https://doi.org/10.3390/cancers18203396","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18203396","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers18203396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133957707","display_name":"Hannuo Deng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannuo Deng","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159117190","display_name":"Rui Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Sun","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152525097","display_name":"Guangming He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangming He","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026725390","display_name":"Yuchen Tan","orcid":"https://orcid.org/0009-0002-6577-5475","observed_orcids":["https://orcid.org/0009-0002-6577-5475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuchen Tan","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159136884","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0002-7988-7585","observed_orcids":["https://orcid.org/0000-0002-7988-7585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":"https://orcid.org/0000-0002-7988-7585","affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157868119","display_name":"Shenglin Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shenglin Gao","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032773676","display_name":"Yichao Zhu","orcid":"https://orcid.org/0000-0003-3499-8510","observed_orcids":["https://orcid.org/0000-0003-3499-8510"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yichao Zhu","raw_affiliation_strings":["Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China"],"raw_orcid":"https://orcid.org/0000-0003-3499-8510","affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133927485","display_name":"Lifeng Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lifeng Zhang","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100723743","display_name":"Li Zuo","orcid":"https://orcid.org/0000-0002-3668-004X","observed_orcids":["https://orcid.org/0000-0002-3668-004X","https://orcid.org/0000-0003-2933-9561"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Li Zuo","raw_affiliation_strings":["Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology & Urology Laboratory, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159099436","display_name":"Zhiqi Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098580","display_name":"Nanjing Traditional Chinese Medicine Hospital","ror":"https://ror.org/016k98t76","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098580"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiqi Tang","raw_affiliation_strings":["Department of Radiology, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Third Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China","institution_ids":["https://openalex.org/I4210098580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100723743","https://openalex.org/A5159099436"],"corresponding_institution_ids":["https://openalex.org/I4210098580"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7288246,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"20","first_page":"3396","last_page":"3396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9125999808311462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sp4","display_name":"Sp4","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nupr1","display_name":"NUPR1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/selenoprotein-m","display_name":"selenoprotein M","score":0.9350000023841858},{"id":"https://openalex.org/keywords/glycolytic-reprogramming","display_name":"glycolytic reprogramming","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5576000213623047},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5568000078201294},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5475000143051147},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5274999737739563},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5087000131607056},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5078999996185303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5059000253677368},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4523000121116638},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.39079999923706055},{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.3716999888420105},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.36340001225471497},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3531000018119812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34700000286102295},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3440999984741211},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.337799996137619},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3197999894618988},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3174000084400177},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3109000027179718},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2964000105857849},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.26159998774528503}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers18203396","doi":"https://doi.org/10.3390/cancers18203396","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18203396","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:42938928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42938928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13702499","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13702499/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers18203396","doi":"https://doi.org/10.3390/cancers18203396","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18203396","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1559076667","https://openalex.org/W2011588132","https://openalex.org/W2019732936","https://openalex.org/W2026393494","https://openalex.org/W2035297454","https://openalex.org/W2045184660","https://openalex.org/W2072451938","https://openalex.org/W2073759231","https://openalex.org/W2074469807","https://openalex.org/W2075786756","https://openalex.org/W2083274861","https://openalex.org/W2084251083","https://openalex.org/W2091381282","https://openalex.org/W2092045059","https://openalex.org/W2097259163","https://openalex.org/W2161877652","https://openalex.org/W2167142486","https://openalex.org/W2223535266","https://openalex.org/W2234115940","https://openalex.org/W2345381093","https://openalex.org/W2495417528","https://openalex.org/W2763367287","https://openalex.org/W2763670669","https://openalex.org/W2791923388","https://openalex.org/W2923618138","https://openalex.org/W2991314738","https://openalex.org/W3003593776","https://openalex.org/W3015450697","https://openalex.org/W3028304854","https://openalex.org/W3136595794","https://openalex.org/W3185605253","https://openalex.org/W4294152366","https://openalex.org/W4295959293","https://openalex.org/W4306726347","https://openalex.org/W4323568226","https://openalex.org/W4385516270","https://openalex.org/W4391169343","https://openalex.org/W4401664244","https://openalex.org/W4404755824","https://openalex.org/W4405810865","https://openalex.org/W4408662609"],"related_works":["https://openalex.org/W4396886985","https://openalex.org/W4310710348","https://openalex.org/W4399028778","https://openalex.org/W7133481935","https://openalex.org/W2215528332","https://openalex.org/W3195745733","https://openalex.org/W3178840743","https://openalex.org/W4401641282","https://openalex.org/W4392558387","https://openalex.org/W7170107138"],"abstract_inverted_index":{"Background:":[0],"Metabolic":[1],"adaptation":[2],"and":[3,16,28,40,45,61,68,78,105,122,133,145,176,200],"stemness-associated":[4,106,207],"programs":[5],"contribute":[6],"to":[7],"bladder":[8,210],"cancer":[9,211,226],"growth.":[10],"This":[11],"study":[12],"investigated":[13],"the":[14,137,152,162],"regulatory":[15,223],"functional":[17,195],"relationships":[18,196],"among":[19,197],"specificity":[20],"protein":[21,25],"4":[22],"(SP4),":[23],"nuclear":[24],"1":[26],"(NUPR1),":[27],"selenoprotein":[29],"M":[30],"(SELM).":[31],"Methods:":[32],"TCGA-BLCA":[33,110],"analyses":[34],"were":[35,64,71],"combined":[36],"with":[37,91,102,131,148,206],"silencing,":[38],"overexpression,":[39],"rescue":[41],"experiments":[42,82],"in":[43,83,109,172,209,225],"5637":[44],"T24":[46],"cells.":[47],"Viability,":[48],"migration,":[49,174],"invasion,":[50,175],"colony":[51,177],"formation,":[52],"glucose":[53,118],"uptake,":[54,119],"lactate":[55,120],"production,":[56,121],"extracellular":[57],"acidification,":[58],"oxygen":[59,127],"consumption,":[60],"OCT4/SOX2":[62,123],"expression":[63,99,124,144],"assessed.":[65],"Protein":[66],"interactions":[67],"promoter-associated":[69],"regulation":[70],"examined":[72],"using":[73],"co-immunoprecipitation,":[74],"immunofluorescence,":[75],"chromatin":[76],"immunoprecipitation,":[77],"reporter":[79,146],"assays.":[80],"Xenograft":[81],"female":[84],"BALB/c":[85],"nude":[86],"mice":[87],"evaluated":[88],"NUPR1":[89,98,112,132,138,141,165,179],"depletion":[90,113,180],"or":[92,157],"without":[93],"SP4":[94,129,156,189],"overexpression.":[95,190],"Results:":[96],"Higher":[97],"was":[100,185],"associated":[101],"higher":[103],"glycolysis-":[104],"transcriptional":[107],"scores":[108],"tumors.":[111],"reduced":[114],"viability,":[115,173],"glycolytic":[116,204],"activity,":[117,147],"while":[125],"increasing":[126],"consumption.":[128],"interacted":[130],"showed":[134],"enrichment":[135,149],"at":[136,151],"promoter":[139,154],"region.":[140,155],"promoted":[142],"SELM":[143,153,158,167,201],"detected":[150],"overexpression":[159],"partially":[160,186],"rescued":[161,187],"effects":[163],"of":[164,221],"depletion.":[166],"silencing":[168],"attenuated":[169],"NUPR1-associated":[170],"increases":[171],"formation.":[178],"suppressed":[181],"xenograft":[182],"growth,":[183],"which":[184],"by":[188],"Conclusions:":[191],"These":[192],"findings":[193],"support":[194],"SP4,":[198],"NUPR1,":[199],"that":[202],"connect":[203],"activity":[205],"phenotypes":[208],"models.":[212],"The":[213],"results":[214],"provide":[215],"a":[216],"basis":[217],"for":[218],"further":[219],"investigation":[220],"this":[222],"network":[224],"metabolism.":[227]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-10-21T00:00:00"}