{"id":"https://openalex.org/W7222995007","doi":"https://doi.org/10.1099/jmm.0.002210","title":"Evaluation of the Hologic Aptima\u00ae Vaginitis and Seegene Allplex\u2122 assays for microbiological diagnosis of bacterial vaginosis and Candida vaginitis in women in France, relative to Nugent score and culture","display_name":"Evaluation of the Hologic Aptima\u00ae Vaginitis and Seegene Allplex\u2122 assays for microbiological diagnosis of bacterial vaginosis and Candida vaginitis in women in France, relative to Nugent score and culture","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7222995007","doi":"https://doi.org/10.1099/jmm.0.002210","pmid":"https://pubmed.ncbi.nlm.nih.gov/42900509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682698"},"language":"en","primary_location":{"id":"doi:10.1099/jmm.0.002210","doi":"https://doi.org/10.1099/jmm.0.002210","is_oa":true,"landing_page_url":"https://doi.org/10.1099/jmm.0.002210","pdf_url":null,"source":{"id":"https://openalex.org/S154078021","display_name":"Journal of Medical Microbiology","issn_l":"0022-2615","issn":["0022-2615","1473-5644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1099/jmm.0.002210","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098066685","display_name":"C\u00e9cile Martaresche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C\u00e9cile Martaresche","raw_affiliation_strings":["Clinical Laboratory, INOVIE Barla, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, INOVIE Barla, Nice, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022212727","display_name":"Florian Scherrer","orcid":"https://orcid.org/0000-0001-8066-7320","observed_orcids":["https://orcid.org/0000-0001-8066-7320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florian Scherrer","raw_affiliation_strings":["Clinical Laboratory, INOVIE Barla, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Laboratory, INOVIE Barla, Nice, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5098066685"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.77616964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-vaginosis","display_name":"bacterial vaginosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/candida-vaginitis","display_name":"Candida vaginitis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/trichomoniasis","display_name":"trichomoniasis","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vaginitis","display_name":"vaginal infection","score":0.6940000057220459},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.625},{"id":"https://openalex.org/keywords/nugent-score","display_name":"Nugent score","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vaginal-culture","display_name":"vaginal culture","score":0.5740000009536743},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6990000009536743},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.574999988079071},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.7360000014305115},{"id":"https://openalex.org/keywords/multiplex-pcr","display_name":"multiplex PCR","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.8210999965667725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7883999943733215},{"id":"https://openalex.org/C2777617518","wikidata":"https://www.wikidata.org/wiki/Q676191","display_name":"Vaginitis","level":2,"score":0.7731999754905701},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5636000037193298},{"id":"https://openalex.org/C2781114625","wikidata":"https://www.wikidata.org/wiki/Q132595","display_name":"Trichomonas vaginalis","level":2,"score":0.46309998631477356},{"id":"https://openalex.org/C2910222780","wikidata":"https://www.wikidata.org/wiki/Q745865","display_name":"Trichomonas Vaginitis","level":3,"score":0.45170000195503235},{"id":"https://openalex.org/C2777023796","wikidata":"https://www.wikidata.org/wiki/Q745865","display_name":"Trichomoniasis","level":2,"score":0.3824000060558319},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.32409998774528503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3061000108718872},{"id":"https://openalex.org/C2777700855","wikidata":"https://www.wikidata.org/wiki/Q18211693","display_name":"Vaginal disease","level":3,"score":0.295199990272522},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.29269999265670776},{"id":"https://openalex.org/C2779397712","wikidata":"https://www.wikidata.org/wiki/Q309497","display_name":"Trichomonas","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25360000133514404}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002175","descriptor_name":"Candida","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D002181","descriptor_name":"Candidiasis, Vulvovaginal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002181","descriptor_name":"Candidiasis, Vulvovaginal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005602","descriptor_name":"France","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011933","descriptor_name":"Reagent Kits, Diagnostic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014247","descriptor_name":"Trichomonas Vaginitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014247","descriptor_name":"Trichomonas Vaginitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D016585","descriptor_name":"Vaginosis, Bacterial","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016585","descriptor_name":"Vaginosis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1099/jmm.0.002210","doi":"https://doi.org/10.1099/jmm.0.002210","is_oa":true,"landing_page_url":"https://doi.org/10.1099/jmm.0.002210","pdf_url":null,"source":{"id":"https://openalex.org/S154078021","display_name":"Journal of Medical Microbiology","issn_l":"0022-2615","issn":["0022-2615","1473-5644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682698","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682698/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682698/pdf/jmm-75-02210.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Microbiol","raw_type":"Text"},{"id":"pmid:42900509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42900509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1099/jmm.0.002210","doi":"https://doi.org/10.1099/jmm.0.002210","is_oa":true,"landing_page_url":"https://doi.org/10.1099/jmm.0.002210","pdf_url":null,"source":{"id":"https://openalex.org/S154078021","display_name":"Journal of Medical Microbiology","issn_l":"0022-2615","issn":["0022-2615","1473-5644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222995007.pdf","grobid_xml":"https://content.openalex.org/works/W7222995007.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1868667984","https://openalex.org/W1970291896","https://openalex.org/W1989407809","https://openalex.org/W2015989259","https://openalex.org/W2055610891","https://openalex.org/W2120796351","https://openalex.org/W2167580471","https://openalex.org/W2259627284","https://openalex.org/W2558209517","https://openalex.org/W2767605447","https://openalex.org/W2803342654","https://openalex.org/W2882984619","https://openalex.org/W2912874780","https://openalex.org/W2972418731","https://openalex.org/W2982772917","https://openalex.org/W2990575861","https://openalex.org/W2991287676","https://openalex.org/W3007795453","https://openalex.org/W3014744244","https://openalex.org/W3123404149","https://openalex.org/W3129087706","https://openalex.org/W3141383887","https://openalex.org/W4200213196","https://openalex.org/W4205136760","https://openalex.org/W4210782876","https://openalex.org/W4282924061","https://openalex.org/W4292202448","https://openalex.org/W4312220834","https://openalex.org/W4322618003","https://openalex.org/W4367043069","https://openalex.org/W4377011840","https://openalex.org/W4387230395","https://openalex.org/W4390411820","https://openalex.org/W4390608498","https://openalex.org/W4404528435","https://openalex.org/W4413960247","https://openalex.org/W7161730719"],"related_works":["https://openalex.org/W7161730719","https://openalex.org/W4367043069","https://openalex.org/W3129087706","https://openalex.org/W7214765695","https://openalex.org/W4415896046","https://openalex.org/W2972418731","https://openalex.org/W4404528435","https://openalex.org/W4403416606","https://openalex.org/W3209972667","https://openalex.org/W4321503150"],"abstract_inverted_index":{"Introduction.":[0],"Molecular":[1],"assays":[2,74,131],"such":[3],"as":[4,48,163,165],"the":[5,24,30,39,62,66,81,129,194,238,247,291,304],"Hologic":[6],"Aptima":[7,43,67,72,108,119,130,166,195,248,292],"\u00ae":[8],"Vaginitis":[9,15,293],"Panel":[10,294],"and":[11,20,71,111,180,190,200,206,208,228,234,244,251,253,308],"Seegene":[12,45,82,211,226,256,301],"Allplex":[13,83,212,227,302],"\u2122":[14],"assay":[16,84,139,152,197,328],"offer":[17],"improved":[18],"sensitivity":[19,189],"multiplex":[21],"detection":[22,239,259,305],"for":[23,91,150,193,210,237,246,255,303,330],"diagnosis":[25],"of":[26,33,42,51,65,128,240,260,271,306],"vaginitis":[27,92,176],"compared":[28],"with":[29,54,281],"non-molecular":[31],"standard":[32],"care.":[34],"Gap":[35],"Statement.":[36],"Evidence":[37],"comparing":[38],"relative":[40,153,167,202,213],"performance":[41,64,127,283,299],"versus":[44],"is":[46,49],"limited,":[47],"knowledge":[50],"Aptima\u2019s":[52,282],"compatibility":[53],"non-proprietary":[55,113,185,313],"swabs.":[56],"Aim.":[57],"This":[58],"prospective":[59],"study":[60],"assessed":[61],"diagnostic":[63,298],"BV":[68,196,307],"(bacterial":[69],"vaginosis)":[70],"CV/TV":[73,249],"(":[75,221,274],"Candida":[76],"vaginitis/":[77],"Trichomonas":[78],"vaginitis)":[79],"alongside":[80],"in":[85,94,97,322],"symptomatic":[86],"women":[87,174],"(\u226518":[88],"years)":[89],"presenting":[90],"testing":[93,177],"primary":[95,138],"care":[96],"France.":[98],"Methodology.":[99],"Two":[100],"vaginal":[101],"swabs":[102],"were":[103,122,141,148,198,242,279],"taken":[104],"per":[105],"patient:":[106],"one":[107,112],"Multitest":[109],"Swab":[110],"\u03a3-TRANSWAB":[114,144,186],"liquid":[115],"Amies":[116],"collection":[117,187,287,315],"swab.":[118],"swab":[120],"data":[121],"used":[123],"solely":[124],"to":[125,154,168,203,214,267,300,325],"confirm":[126],"under":[132],"current":[133],"test":[134],"conditions,":[135],"while":[136],"all":[137],"comparisons":[140,147],"performed":[142,149],"using":[143,184,285,311],"samples.":[145],"These":[146,277],"each":[151],"Nugent":[155,204,215,229],"score":[156,230],"(for":[157,161],"BV)":[158],"or":[159],"culture":[160],"CV),":[162],"well":[164],"Seegene.":[169],"Results.":[170],"In":[171],"total,":[172],"500":[173],"underwent":[175],"between":[178,225],"July":[179],"August":[181],"2024.":[182],"When":[183],"methods,":[188],"specificity":[191,235],"values":[192,236],"96.7":[199],"89.7%":[201],"score,":[205],"89.9":[207],"90.6%":[209],"score.":[216],"Among":[217],"\u2018intermediate":[218],"BV\u2019":[219],"samples":[220,273],"n":[222,275],"=66),":[223],"agreement":[224],"was":[231,319],"1.5%.":[232],"Sensitivity":[233],"CV":[241,309],"88.6":[243],"90.8%":[245],"assay,":[250],"90.2":[252],"93.7%":[254],"Allplex.":[257],"Assay":[258],"TV":[261,317],"could":[262],"not":[263],"be":[264],"validated":[265],"due":[266],"an":[268],"insufficient":[269],"number":[270],"TV-positive":[272],"=1).":[276],"findings":[278],"consistent":[280],"when":[284,310],"proprietary":[286],"methods.":[288],"Conclusion.":[289],"Overall,":[290],"demonstrated":[295],"comparably":[296],"high":[297],"a":[312],"sample":[314],"method.":[316],"prevalence":[318],"too":[320],"low":[321],"this":[323,331],"cohort":[324],"permit":[326],"meaningful":[327],"evaluation":[329],"pathogen.":[332]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-21T00:00:00"}