{"id":"https://openalex.org/W7222992912","doi":"https://doi.org/10.1002/acn3.70552","title":"Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke","display_name":"Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke","publication_year":2026,"publication_date":"2026-10-20","ids":{"openalex":"https://openalex.org/W7222992912","doi":"https://doi.org/10.1002/acn3.70552","pmid":"https://pubmed.ncbi.nlm.nih.gov/42899785","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682409"},"language":"en","primary_location":{"id":"doi:10.1002/acn3.70552","doi":"https://doi.org/10.1002/acn3.70552","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.70552","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.70552","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.70552","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159117249","display_name":"Jie Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhou","raw_affiliation_strings":["Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035320843","display_name":"Yang Qu","orcid":"https://orcid.org/0000-0001-8598-3517","observed_orcids":["https://orcid.org/0000-0001-8598-3517"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Qu","raw_affiliation_strings":["Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021096695","display_name":"Reziya Abuduxukuer","orcid":"https://orcid.org/0009-0009-6780-4947","observed_orcids":["https://orcid.org/0009-0009-6780-4947"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Reziya Abuduxukuer","raw_affiliation_strings":["Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364012","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0001-5536-0255","observed_orcids":["https://orcid.org/0000-0001-5536-0255"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":"https://orcid.org/0000-0001-5536-0255","affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159157344","display_name":"Ting Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Wang","raw_affiliation_strings":["Department of Neurology Songyuan Central Hospital  Songyuan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Songyuan Central Hospital  Songyuan China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159113851","display_name":"Jian\u2010Hua Gao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian\u2010Hua Gao","raw_affiliation_strings":["Department of Neurology Jilin Neuropsychiatric Hospital  Siping China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin Neuropsychiatric Hospital  Siping China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138669326","display_name":"De-Wang Pan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De\u2010Wang Pan","raw_affiliation_strings":["Stroke Center, Department of Neurology Siping Central People's Hospital  Siping China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology Siping Central People's Hospital  Siping China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159103473","display_name":"Zhi\u2010Mei Yuan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi\u2010Mei Yuan","raw_affiliation_strings":["Department of Neurology Tonghua City Vascular Disease Hospital and Dongchang District People's Hospital  Tonghua China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Tonghua City Vascular Disease Hospital and Dongchang District People's Hospital  Tonghua China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159100987","display_name":"Chun\u2010Ying Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun\u2010Ying Li","raw_affiliation_strings":["Department of Neurology Songyuan Jilin Oilfield Hospital  Songyuan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Songyuan Jilin Oilfield Hospital  Songyuan China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101973312","display_name":"Liping Chen","orcid":"https://orcid.org/0000-0002-5801-7791","observed_orcids":["https://orcid.org/0000-0002-5801-7791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li\u2010Ping Chen","raw_affiliation_strings":["Stroke Center, Department of Neurology Dehuishi People's Hospital  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology Dehuishi People's Hospital  Changchun China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159112295","display_name":"Jin\u2010Hua Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin\u2010Hua Chen","raw_affiliation_strings":["Department of Neurology Affiliated Hospital of Jilin Medical College  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Affiliated Hospital of Jilin Medical College  Jilin China","institution_ids":["https://openalex.org/I4210136497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159139939","display_name":"Ji\u2010Liang Gu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji\u2010Liang Gu","raw_affiliation_strings":["Department of Neurology Songyuan Hospital of Integrated Traditional Chinese and Western Medicine  Songyuan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Songyuan Hospital of Integrated Traditional Chinese and Western Medicine  Songyuan China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159141746","display_name":"An\u2010Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"An\u2010Ying Wang","raw_affiliation_strings":["Stroke Center, Department of Neurology Qianguoerros Mongolian Autonomous County Hospital  Songyuan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology Qianguoerros Mongolian Autonomous County Hospital  Songyuan China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159156929","display_name":"Li\u2010Gang Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136497","display_name":"Jilin Medical University","ror":"https://ror.org/03mzw7781","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210136497"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li\u2010Gang Jiang","raw_affiliation_strings":["Department of Neurology Affiliated Hospital of Jilin Medical College  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Affiliated Hospital of Jilin Medical College  Jilin China","institution_ids":["https://openalex.org/I4210136497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111183274","display_name":"Liang Liu","orcid":"https://orcid.org/0000-0003-3817-1756","observed_orcids":["https://orcid.org/0000-0003-3817-1756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang Liu","raw_affiliation_strings":["Department of Neurology Jilin City Hospital of Chemical Industry  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin City Hospital of Chemical Industry  Jilin China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159110552","display_name":"Yong\u2010Fei Jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yong\u2010Fei Jiang","raw_affiliation_strings":["Department of Neurology Changchun People's Hospital  Changchun China","Department of Neurology Changchun Second Hospital  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Changchun People's Hospital  Changchun China","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology Changchun Second Hospital  Changchun China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159149383","display_name":"Chun\u2010Fei Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun\u2010Fei Wang","raw_affiliation_strings":["Department of Neurology Dongliao First People's Hospital  Liaoyuan China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Dongliao First People's Hospital  Liaoyuan China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040081599","display_name":"Yan Jia","orcid":"https://orcid.org/0000-0003-1048-9842","observed_orcids":["https://orcid.org/0000-0003-1048-9842"]},"institutions":[{"id":"https://openalex.org/I4210094094","display_name":"People 's Hospital of Jilin Province","ror":"https://ror.org/00n5w1596","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094094"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Jia","raw_affiliation_strings":["Department of Neurology Jilin People's Hospital  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin People's Hospital  Jilin China","institution_ids":["https://openalex.org/I4210094094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159128688","display_name":"Hong Xin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Xin","raw_affiliation_strings":["Department of Neurology Jilin City Hospital of Chemical Industry  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin City Hospital of Chemical Industry  Jilin China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159109354","display_name":"Chun\u2010Li Jiang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun\u2010Li Jiang","raw_affiliation_strings":["Department of Neurology Jilin City Hospital of Chemical Industry  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin City Hospital of Chemical Industry  Jilin China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159114398","display_name":"Ying\u2010Bin Qi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094094","display_name":"People 's Hospital of Jilin Province","ror":"https://ror.org/00n5w1596","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094094"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying\u2010Bin Qi","raw_affiliation_strings":["Department of Neurology Jilin Province People's Hospital  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin Province People's Hospital  Changchun China","institution_ids":["https://openalex.org/I4210094094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159095327","display_name":"Xue\u2010Feng Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xue\u2010Feng Hu","raw_affiliation_strings":["Stroke Center, Department of Neurology Jilin Central General Hospital  Jilin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology Jilin Central General Hospital  Jilin China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159142090","display_name":"Song Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094094","display_name":"People 's Hospital of Jilin Province","ror":"https://ror.org/00n5w1596","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210094094"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Li","raw_affiliation_strings":["Department of Neurology Jilin Province People's Hospital  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Jilin Province People's Hospital  Changchun China","institution_ids":["https://openalex.org/I4210094094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101646456","display_name":"Hang Jin","orcid":"https://orcid.org/0000-0003-0300-5918","observed_orcids":["https://orcid.org/0000-0003-0300-5918"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hang Jin","raw_affiliation_strings":["Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":"https://orcid.org/0000-0003-0300-5918","affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159106662","display_name":"Zhen\u2010Ni Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen\u2010Ni Guo","raw_affiliation_strings":["Neuroscience Research Center, Department of Neurology The First Hospital of Jilin University  Changchun China","Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]},{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061580592","display_name":"Yi Yang","orcid":"https://orcid.org/0000-0002-9729-8522","observed_orcids":["https://orcid.org/0000-0002-9729-8522"]},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Yang","raw_affiliation_strings":["Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China"],"raw_orcid":"https://orcid.org/0000-0002-9729-8522","affiliations":[{"raw_affiliation_string":"Stroke Center, Department of Neurology The First Hospital of Jilin University  Changchun China","institution_ids":["https://openalex.org/I4210125137"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159132378","display_name":"the Biomarkers of Brain Injury Investigator Study Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the Biomarkers of Brain Injury Investigator Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061580592","https://openalex.org/A5101646456","https://openalex.org/A5159106662"],"corresponding_institution_ids":["https://openalex.org/I4210125137"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79700532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/early-neurological-deterioration","display_name":"early neurological deterioration","score":0.8100000023841858},{"id":"https://openalex.org/keywords/minor-stroke","display_name":"minor stroke","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intravenous-thrombolysis","display_name":"intravenous thrombolysis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8960000276565552},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.8550000190734863},{"id":"https://openalex.org/keywords/nihss-score","display_name":"NIHSS score","score":0.9049999713897705},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.4869999885559082},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.91839998960495},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.6909999847412109},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6769999861717224},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.6714000105857849},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.6600000262260437},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.6262000203132629},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5979999899864197},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5241000056266785},{"id":"https://openalex.org/C3020581612","wikidata":"https://www.wikidata.org/wiki/Q593958","display_name":"Minor stroke","level":3,"score":0.4932999908924103},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49160000681877136},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34599998593330383},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.335999995470047},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C2775965419","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter trial","level":4,"score":0.26499998569488525},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2621000111103058},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/acn3.70552","doi":"https://doi.org/10.1002/acn3.70552","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.70552","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.70552","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682409","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682409/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682409/pdf/ACN3-9999-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Clin Transl Neurol","raw_type":"Text"},{"id":"pmid:42899785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42899785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and translational neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/acn3.70552","doi":"https://doi.org/10.1002/acn3.70552","is_oa":true,"landing_page_url":"https://doi.org/10.1002/acn3.70552","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.70552","source":{"id":"https://openalex.org/S2764382054","display_name":"Annals of Clinical and Translational Neurology","issn_l":"2328-9503","issn":["2328-9503"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical and Translational Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320327282","display_name":"Department of Science and Technology of Jilin Province","ror":"https://ror.org/049x38272"},{"id":"https://openalex.org/F4320336564","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222992912.pdf","grobid_xml":"https://content.openalex.org/works/W7222992912.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1496642521","https://openalex.org/W1999357998","https://openalex.org/W2026616100","https://openalex.org/W2107181967","https://openalex.org/W2138595885","https://openalex.org/W2144588257","https://openalex.org/W2152140063","https://openalex.org/W2328176404","https://openalex.org/W2469958479","https://openalex.org/W2870184972","https://openalex.org/W2956490955","https://openalex.org/W3034842320","https://openalex.org/W3045697132","https://openalex.org/W3120463483","https://openalex.org/W4210566758","https://openalex.org/W4310643633","https://openalex.org/W4380883538","https://openalex.org/W4382182719","https://openalex.org/W4392661031","https://openalex.org/W4400745883","https://openalex.org/W4403042333","https://openalex.org/W4405107228","https://openalex.org/W4405195668","https://openalex.org/W4406678411","https://openalex.org/W4410282063","https://openalex.org/W4411093430","https://openalex.org/W4417492651"],"related_works":["https://openalex.org/W4416412141","https://openalex.org/W2946129327","https://openalex.org/W3155159118","https://openalex.org/W7126022479","https://openalex.org/W2782930559","https://openalex.org/W7160374634","https://openalex.org/W4410485015","https://openalex.org/W7203468491","https://openalex.org/W4396685152","https://openalex.org/W3044669723"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Minor":[1],"strokes":[2],"may":[3],"be":[4],"associated":[5,105],"with":[6,93,106,177],"early":[7],"neurological":[8],"deterioration":[9],"(END)":[10],"and":[11,57,71,73,140,183],"disabilities.":[12],"The":[13],"objective":[14],"was":[15,42,76,103],"to":[16,53,65,78,113,129,164],"investigate":[17],"the":[18,45,67,90],"role":[19],"of":[20,47,89,143,173],"serum":[21],"glial":[22],"fibrillary":[23],"acidic":[24],"protein":[25],"(GFAP)":[26],"levels":[27],"in":[28,86,175,191],"predicting":[29,197],"END.":[30,198],"METHODS:":[31],"Data":[32],"originated":[33],"from":[34],"a":[35,74,135,152,169,187,192],"multicenter":[36],"cohort":[37],"study":[38],"conducted":[39],"prospectively.":[40],"\u0394GFAP":[41],"calculated":[43],"as":[44],"ratio":[46],"post-thrombolysis":[48],"GFAP":[49],"at":[50,149],"24":[51],"h":[52],"baseline":[54],"GFAP.":[55],"Univariable":[56],"multivariable":[58],"binary":[59],"logistic":[60],"regression":[61],"analyses":[62],"were":[63],"performed":[64],"assess":[66],"association":[68],"between":[69],"\u2206GFAP":[70,102,167],"END,":[72],"nomogram":[75],"established":[77],"illustrate":[79],"its":[80],"predictive":[81,154],"value.":[82],"RESULTS:":[83],"END":[84,107,157,174],"occurred":[85],"20":[87],"(7.35%)":[88],"272":[91],"patients":[92,176],"minor":[94,178],"stroke":[95],"who":[96],"underwent":[97],"intravenous":[98],"thrombolysis":[99],"(IVT).":[100],"Elevated":[101],"independently":[104],"(OR,":[108],"3.50;":[109],"95%":[110,126,161],"CI,":[111,127,162],"1.67":[112],"7.31;":[114],"p":[115,131],"<":[116,132],"0.001),":[117],"even":[118],"after":[119],"adjusting":[120],"for":[121,156,196],"confounders":[122],"(adjusted":[123],"OR,":[124],"4.64;":[125],"1.86":[128],"11.54;":[130],"0.001).":[133],"Furthermore,":[134],"model":[136,189],"combining":[137],"\u2206GFAP,":[138,181],"age,":[139,182],"National":[141],"Institutes":[142],"Health":[144],"Stroke":[145],"Scale":[146],"(NIHSS)":[147],"score":[148,185],"admission":[150],"demonstrated":[151],"good":[153,193],"value":[155],"(AUC":[158],"=":[159],"0.77;":[160],"0.67":[163],"0.89).":[165],"INTERPRETATION:":[166],"is":[168],"strong,":[170],"independent":[171],"predictor":[172],"strokes.":[179],"Integrating":[180],"NIHSS":[184],"into":[186],"prognostic":[188],"results":[190],"discriminative":[194],"ability":[195]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-21T00:00:00"}