{"id":"https://openalex.org/W7222978436","doi":"https://doi.org/10.3389/fvets.2026.1967863","title":"First report of polymorphisms and genetic characteristics of the prion-like protein gene (PRND) in bats","display_name":"First report of polymorphisms and genetic characteristics of the prion-like protein gene (PRND) in bats","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222978436","doi":"https://doi.org/10.3389/fvets.2026.1967863","pmid":"https://pubmed.ncbi.nlm.nih.gov/42974130","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13725429"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2026.1967863","doi":"https://doi.org/10.3389/fvets.2026.1967863","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1967863","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1967863/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1967863/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101353631","display_name":"Da-In Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Da-In Choi","raw_affiliation_strings":["Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University","Korea Zoonosis Research Institute, Jeonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Korea Zoonosis Research Institute, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023728655","display_name":"Min\u2010Ju Jeong","orcid":"https://orcid.org/0000-0002-8734-4732","observed_orcids":["https://orcid.org/0000-0002-8734-4732"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min-Ju Jeong","raw_affiliation_strings":["Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University","Korea Zoonosis Research Institute, Jeonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Korea Zoonosis Research Institute, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066277755","display_name":"Eun\u2010Jee Na","orcid":"https://orcid.org/0000-0003-1685-3721","observed_orcids":["https://orcid.org/0000-0003-1685-3721"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun-Jee Na","raw_affiliation_strings":["Laboratory of Veterinary Infectious Diseases, College of Veterinary Medicine, Jeonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Infectious Diseases, College of Veterinary Medicine, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072527149","display_name":"Jae\u2010Ku Oem","orcid":"https://orcid.org/0000-0002-1598-4343","observed_orcids":["https://orcid.org/0000-0002-1598-4343","https://orcid.org/0000-0002-4298-0604"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Ku Oem","raw_affiliation_strings":["Laboratory of Veterinary Infectious Diseases, College of Veterinary Medicine, Jeonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Veterinary Infectious Diseases, College of Veterinary Medicine, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090580336","display_name":"Byung\u2010Hoon Jeong","orcid":"https://orcid.org/0000-0002-4525-9994","observed_orcids":["https://orcid.org/0000-0002-4525-9994"]},"institutions":[{"id":"https://openalex.org/I80611190","display_name":"Jeonbuk National University","ror":"https://ror.org/05q92br09","country_code":"KR","type":"education","lineage":["https://openalex.org/I80611190"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byung-Hoon Jeong","raw_affiliation_strings":["Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University","Korea Zoonosis Research Institute, Jeonbuk National University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]},{"raw_affiliation_string":"Korea Zoonosis Research Institute, Jeonbuk National University","institution_ids":["https://openalex.org/I80611190"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090580336"],"corresponding_institution_ids":["https://openalex.org/I80611190"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67375101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1967863","last_page":"1967863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doppel-protein","display_name":"doppel protein","score":0.8220000267028809},{"id":"https://openalex.org/keywords/prion-like-proteins","display_name":"prion-like proteins","score":0.7770000100135803},{"id":"https://openalex.org/keywords/bats","display_name":"bats","score":0.8830000162124634},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9430000185966492},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.9039999842643738},{"id":"https://openalex.org/keywords/prnp","display_name":"prion protein gene","score":0.7630000114440918},{"id":"https://openalex.org/keywords/prion-disease-susceptibility","display_name":"prion disease susceptibility","score":0.7699999809265137},{"id":"https://openalex.org/keywords/nonsynonymous-snps","display_name":"non-synonymous SNPs","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2778147599","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"PRNP","level":4,"score":0.8916000127792358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7396000027656555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6869999766349792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6284999847412109},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6202999949455261},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.48829999566078186},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.4535999894142151},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.43540000915527344},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.3986999988555908},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.3889999985694885},{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.3880999982357025},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.3700999915599823},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.3684999942779541},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.3578999936580658},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.3384999930858612},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.3382999897003174},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C81566733","wikidata":"https://www.wikidata.org/wiki/Q1047544","display_name":"Hypervariable region","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C163691529","wikidata":"https://www.wikidata.org/wiki/Q7391886","display_name":"SNP genotyping","level":5,"score":0.27639999985694885},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.2572999894618988},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.25540000200271606},{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2524000108242035},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.25099998712539673}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2026.1967863","doi":"https://doi.org/10.3389/fvets.2026.1967863","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1967863","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1967863/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13725429","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725429/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725429/pdf/fvets-13-1967863.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmid:42974130","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42974130","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:046fbe11c2164d1e8945e96912a53917","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/046fbe11c2164d1e8945e96912a53917","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2026.1967863","doi":"https://doi.org/10.3389/fvets.2026.1967863","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1967863","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1967863/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1950801833","display_name":null,"funder_award_id":"RS-2021-NF000550","funder_id":"https://openalex.org/F4320322111","funder_display_name":"Korea Basic Science Institute"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322111","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222978436.pdf","grobid_xml":"https://content.openalex.org/works/W7222978436.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1535883711","https://openalex.org/W1977653419","https://openalex.org/W1979695510","https://openalex.org/W1984178897","https://openalex.org/W1990197397","https://openalex.org/W1990610956","https://openalex.org/W1996635503","https://openalex.org/W2015642465","https://openalex.org/W2018608889","https://openalex.org/W2020098545","https://openalex.org/W2027907160","https://openalex.org/W2064625507","https://openalex.org/W2071900098","https://openalex.org/W2076914359","https://openalex.org/W2089019621","https://openalex.org/W2103994885","https://openalex.org/W2120030908","https://openalex.org/W2121519777","https://openalex.org/W2135327444","https://openalex.org/W2143238378","https://openalex.org/W2152958744","https://openalex.org/W2171479567","https://openalex.org/W2314440764","https://openalex.org/W2431047374","https://openalex.org/W2598001119","https://openalex.org/W2613688952","https://openalex.org/W2794125549","https://openalex.org/W2898280909","https://openalex.org/W2924709018","https://openalex.org/W2954055434","https://openalex.org/W3021227418","https://openalex.org/W3031933942","https://openalex.org/W3035074698","https://openalex.org/W3084186874","https://openalex.org/W3104285666","https://openalex.org/W4283740949","https://openalex.org/W4389621661","https://openalex.org/W4398156450","https://openalex.org/W4399739152","https://openalex.org/W4404755755","https://openalex.org/W4405670661","https://openalex.org/W4406806715","https://openalex.org/W4410023476","https://openalex.org/W4414561474","https://openalex.org/W4415357692","https://openalex.org/W4416816090","https://openalex.org/W7131080383","https://openalex.org/W7135231131","https://openalex.org/W7161034496","https://openalex.org/W7202285789"],"related_works":["https://openalex.org/W7161034496","https://openalex.org/W7202285789","https://openalex.org/W2898280909","https://openalex.org/W4399739152","https://openalex.org/W2103994885","https://openalex.org/W2924709018","https://openalex.org/W7214950931","https://openalex.org/W4406390937","https://openalex.org/W4410023476","https://openalex.org/W4388522394"],"abstract_inverted_index":{"Background":[0],"Prion":[1],"diseases":[2],"are":[3,47],"fatal":[4],"brain":[5],"disorders":[6],"caused":[7],"by":[8],"the":[9,12,35,72,84,113,117,125,128,176,195,204,211],"misfolding":[10],"of":[11,62,71,93,116,178],"normal":[13],"cellular":[14],"prion":[15,43,63,153],"protein":[16,37,44,154,183],"(PrP":[17,24],"C":[18],")":[19,158],"into":[20],"its":[21],"infectious":[22],"isoform":[23],"Sc":[25],").":[26],"Previous":[27],"studies":[28],"have":[29,57,238],"reported":[30],"that":[31],"many":[32],"polymorphisms":[33,70,132,209],"within":[34],"prion-like":[36],"gene":[38,74,120,155],"(":[39,156,216],"PRND":[40,73,106,119,129,151,197,208],"),":[41],"a":[42,239],"family":[45],"member,":[46],"significantly":[48],"associated":[49],"with":[50,169],"disease":[51,64],"susceptibility":[52],"in":[53,66,75,79,87,185,194],"various":[54],"species.":[55],"There":[56],"been":[58],"no":[59],"natural":[60],"cases":[61],"found":[65,78,190],"bats.":[67],"The":[68,140],"genetic":[69,148],"bats":[76],"commonly":[77],"Korea":[80],"were":[81,97],"characterized":[82],"for":[83,213],"first":[85],"time":[86],"this":[88],"study.":[89],"Methods":[90],"A":[91],"total":[92],"98":[94],"bat":[95,105,118,196,244],"samples":[96],"used":[98],"to":[99,103,146,223,237],"extract":[100],"genomic":[101],"DNA":[102],"investigate":[104,147],"polymorphisms.":[107],"Next,":[108],"amplicon":[109],"sequencing":[110],"focusing":[111],"on":[112,181,243],"coding":[114],"region":[115],"was":[121,138,143,235],"conducted.":[122],"To":[123],"assess":[124],"linkage":[126,134],"among":[127],"single":[130],"nucleotide":[131],"(SNPs),":[133],"disequilibrium":[135],"(LD)":[136],"analysis":[137,142,168],"performed.":[139],"LD":[141,201,215],"also":[144],"conducted":[145,163],"associations":[149],"between":[150,203],"and":[152,166,171,174,207,228],"PRNP":[157,206],"SNPs.":[159],"In":[160],"addition,":[161],"we":[162],"sequence":[164],"alignment":[165],"evolutionary":[167],"ClustalW":[170],"MEGA":[172],"12.1,":[173],"assessed":[175],"effects":[177],"non-synonymous":[179,231],"SNPs":[180,193],"Doppel":[182,245],"using":[184],"silico":[186],"tools.":[187],"Results":[188],"We":[189],"7":[191],"novel":[192],"gene.":[198],"No":[199],"pairwise":[200],"value":[202],"analyzed":[205],"exceeded":[210],"threshold":[212],"strong":[214],"r":[217],"2":[218],">":[219],"0.333).":[220],"Furthermore,":[221],"according":[222],"preliminary":[224],"computational":[225],"analyses":[226],"(SIFT":[227],"MutPred2),":[229],"one":[230],"SNP,":[232],"c.392G>C":[233],"(R131T),":[234],"predicted":[236],"potentially":[240],"deleterious":[241],"effect":[242],"protein.":[246]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-20T00:00:00"}