{"id":"https://openalex.org/W7222966816","doi":"https://doi.org/10.5281/zenodo.23480846","title":"Human Spaceflight Transcriptomics: Radiation vs Simulated Microgravity \u2014 Locked Aggregate Pathway Results","display_name":"Human Spaceflight Transcriptomics: Radiation vs Simulated Microgravity \u2014 Locked Aggregate Pathway Results","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222966816","doi":"https://doi.org/10.5281/zenodo.23480846"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.23480846","doi":"https://doi.org/10.5281/zenodo.23480846","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23480846","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.23480846","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145049416","display_name":"Valeria Luz Maucaylli Campos","orcid":"https://orcid.org/0000-0003-4523-9392","observed_orcids":["https://orcid.org/0000-0003-4523-9392"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maucaylli Campos, Valeria Luz","raw_affiliation_strings":["Universidade Estadual do Cear\u00e1","Faculdade Unyleya","Liminal Research Group"],"raw_orcid":"https://orcid.org/0000-0003-4523-9392","affiliations":[{"raw_affiliation_string":"Universidade Estadual do Cear\u00e1","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Faculdade Unyleya","institution_ids":[]},{"raw_affiliation_string":"Liminal Research Group","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135589510","display_name":"Claudia Andrea Maucaylli Campos","orcid":"https://orcid.org/0009-0002-6604-798X","observed_orcids":["https://orcid.org/0009-0002-6604-798X","https://orcid.org/0000-0001-5909-4388"]},"institutions":[{"id":"https://openalex.org/I4210148428","display_name":"Universidad Tecnol\u00f3gica del Per\u00fa","ror":"https://ror.org/0406pmf58","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210148428"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Maucaylli Campos, Claudia Andrea","raw_affiliation_strings":["Universidad Tecnol\u00f3gica del Per\u00fa","Liminal Research Group"],"raw_orcid":"https://orcid.org/0009-0002-6604-798X","affiliations":[{"raw_affiliation_string":"Universidad Tecnol\u00f3gica del Per\u00fa","institution_ids":["https://openalex.org/I4210148428"]},{"raw_affiliation_string":"Liminal Research Group","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5139859609","display_name":"Jos\u00e9 Santos Herrada-Torres","orcid":"https://orcid.org/0009-0009-1302-8049","observed_orcids":["https://orcid.org/0009-0009-1302-8049"]},"institutions":[{"id":"https://openalex.org/I4210114822","display_name":"Universidad de Hu\u00e1nuco","ror":"https://ror.org/01fgscm92","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210114822"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Herrada-Torres, Jos\u00e9 Santos","raw_affiliation_strings":["Universidad de Hu\u00e1nuco"],"raw_orcid":"https://orcid.org/0009-0009-1302-8049","affiliations":[{"raw_affiliation_string":"Universidad de Hu\u00e1nuco","institution_ids":["https://openalex.org/I4210114822"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-spaceflight","display_name":"human spaceflight","score":0.8830000162124634},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.7390000224113464},{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/simulated-microgravity","display_name":"simulated microgravity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reactive-oxygen-species-response","display_name":"reactive oxygen species response","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":1.0},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pathway-enrichment-analysis","display_name":"pathway enrichment","score":0.6200000047683716},{"id":"https://openalex.org/keywords/holm-correction","display_name":"Holm correction","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.7059000134468079},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6596999764442444},{"id":"https://openalex.org/C4679612","wikidata":"https://www.wikidata.org/wiki/Q866298","display_name":"Aggregate (composite)","level":2,"score":0.5425999760627747},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5109000205993652},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.45350000262260437},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4293000102043152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39890000224113464},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.387800008058548},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36010000109672546},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.34850001335144043},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C3020437955","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Human blood","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26669999957084656},{"id":"https://openalex.org/C2987978230","wikidata":"https://www.wikidata.org/wiki/Q5691173","display_name":"Space radiation","level":3,"score":0.26019999384880066},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2547000050544739}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.23480846","doi":"https://doi.org/10.5281/zenodo.23480846","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23480846","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.23480847","doi":"https://doi.org/10.5281/zenodo.23480847","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23480847","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.23480846","doi":"https://doi.org/10.5281/zenodo.23480846","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23480846","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7222976146","https://openalex.org/W7221636681","https://openalex.org/W4328049131","https://openalex.org/W4398510883","https://openalex.org/W4390741060","https://openalex.org/W6889876041","https://openalex.org/W6944549217","https://openalex.org/W7212063244","https://openalex.org/W7201865737","https://openalex.org/W6996823847"],"abstract_inverted_index":{"This":[0,167,207],"dataset":[1,47,208],"provides":[2],"the":[3,59,81,164,173,214],"locked":[4,134],"aggregate":[5,50,170],"results":[6,132],"of":[7,58,77,95,120,213],"a":[8,220],"secondary,":[9],"reproducible":[10],"bioinformatics":[11],"study":[12],"comparing":[13],"human":[14,22,182],"transcriptomic":[15,122,183],"responses":[16,112],"across":[17,102],"spaceflight":[18],"missions":[19],"and":[20,24,43,90,108,115,177,187,199,216],"controlled":[21],"radiation":[23,114],"simulated":[25,116],"microgravity":[26,117],"models.":[27],"Four":[28],"molecular":[29],"pathways":[30],"were":[31,133],"prespecified:":[32],"reactive":[33],"oxygen":[34],"species":[35],"(ROS)":[36],"response,":[37],"DNA":[38],"repair,":[39],"oxidative":[40],"phosphorylation":[41],"(OXPHOS),":[42],"inflammatory":[44],"response.":[45],"The":[46,130,195],"contains":[48],"three":[49],"summary":[51],"tables":[52],"covering":[53],"60":[54,60,78,96],"context\u2013pathway":[55],"comparisons.":[56,97],"None":[57],"confirmatory":[61],"biological-unit-level":[62],"pathway":[63],"tests":[64],"remained":[65],"significant":[66],"after":[67,211],"within-context":[68],"Holm":[69],"correction.":[70],"Exploratory":[71],"gene-ranked":[72],"enrichment":[73],"analysis":[74],"identified":[75],"32":[76],"comparisons":[79],"meeting":[80],"reported":[82],"Holm-adjusted":[83],"threshold,":[84],"while":[85],"directional":[86],"concordance":[87],"between":[88],"preliminary":[89],"canonical":[91,149],"methods":[92],"was":[93,209],"50":[94],"These":[98],"findings":[99],"highlight":[100],"heterogeneity":[101],"missions,":[103],"sampling":[104],"phases,":[105],"biological":[106],"models,":[107],"exposure":[109],"contexts.":[110],"Overlapping":[111],"to":[113,127],"prevent":[118],"attribution":[119],"astronaut":[121],"signatures":[123],"specifically":[124],"or":[125],"causally":[126],"space":[128],"radiation.":[129],"primary":[131],"on":[135],"17":[136],"October":[137],"2026.":[138],"A":[139],"subsequent":[140],"archive":[141,168],"comparison":[142],"verified":[143],"byte-level":[144],"identity":[145],"for":[146],"all":[147],"40":[148],"R":[150,178],"output":[151],"files;":[152],"this":[153],"does":[154,217],"not":[155,193,218],"independently":[156],"establish":[157],"complete":[158],"regeneration":[159],"from":[160],"raw":[161],"inputs":[162],"during":[163],"latest":[165],"execution.":[166],"includes":[169],"pathway-level":[171],"tables,":[172],"Results":[174],"Lock":[175],"documentation,":[176],"environment":[179],"information.":[180],"Individual-level":[181],"matrices,":[184],"subject-level":[185],"results,":[186],"third-party":[188],"gene-set":[189],"membership":[190],"files":[191],"are":[192],"redistributed.":[194],"original":[196],"NASA":[197],"OSDR/GeneLab":[198],"NCBI":[200],"GEO":[201],"datasets":[202],"should":[203],"be":[204],"cited":[205],"independently.":[206],"deposited":[210],"completion":[212],"analyses":[215],"constitute":[219],"prospective":[221],"preregistration.":[222]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-20T00:00:00"}