{"id":"https://openalex.org/W7222964200","doi":"https://doi.org/10.64898/2026.10.17.759687","title":"Dynamic TET1 repression coordinates activation of macroH2A.2-poised bivalent genes during neuroectoderm differentiation","display_name":"Dynamic TET1 repression coordinates activation of macroH2A.2-poised bivalent genes during neuroectoderm differentiation","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222964200","doi":"https://doi.org/10.64898/2026.10.17.759687"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.17.759687","doi":"https://doi.org/10.64898/2026.10.17.759687","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.17.759687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.17.759687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.17.759687.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117011667","display_name":"Brendan Terry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Brendan Terry","raw_affiliation_strings":["Epigenetics Programme, Babraham Institute, Cambridge, UK","University of California, San Francisco School of Medicine, San Francisco, CA, USA","University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics Programme, Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"University of California, San Francisco School of Medicine, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095369224","display_name":"Carine Stapel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carine Stapel","raw_affiliation_strings":["Epigenetics Programme, Babraham Institute, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics Programme, Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045183489","display_name":"F\u00e1tima Santos","orcid":"https://orcid.org/0000-0002-6516-6189","observed_orcids":["https://orcid.org/0000-0002-6516-6189"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fatima Santos","raw_affiliation_strings":["Altos Labs, Institute of Science, Cambridge, UK","Epigenetics Programme, Babraham Institute, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altos Labs, Institute of Science, Cambridge, UK","institution_ids":[]},{"raw_affiliation_string":"Epigenetics Programme, Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159067132","display_name":"Joshua Kent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joshua Kent","raw_affiliation_strings":["Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","Oncology R&D, AstraZeneca, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]},{"raw_affiliation_string":"Oncology R&D, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045178955","display_name":"Kamal Kishore","orcid":"https://orcid.org/0000-0002-4650-8745","observed_orcids":["https://orcid.org/0000-0002-4650-8745"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kamal Kishore","raw_affiliation_strings":["Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089597821","display_name":"Clive S. D\u2019Santos","orcid":"https://orcid.org/0000-0003-4592-0487","observed_orcids":["https://orcid.org/0000-0003-4592-0487","https://orcid.org/0000-0003-3425-7288"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2801316944","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801316944"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clive D\u2019Santos","raw_affiliation_strings":["Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I2801316944"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085359324","display_name":"Ian Chambers","orcid":"https://orcid.org/0000-0003-2605-1597","observed_orcids":["https://orcid.org/0000-0003-2605-1597"]},"institutions":[{"id":"https://openalex.org/I4210108209","display_name":"MRC Centre for Regenerative Medicine","ror":"https://ror.org/01x802g65","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210108209","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian Chambers","raw_affiliation_strings":["Centre for Regenerative Medicine, Institute for Regeneration and Repair, Edinburgh, Scotland","Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Regenerative Medicine, Institute for Regeneration and Repair, Edinburgh, Scotland","institution_ids":["https://openalex.org/I4210108209"]},{"raw_affiliation_string":"Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, Scotland","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034705836","display_name":"Aled Parry","orcid":"https://orcid.org/0000-0001-5192-3727","observed_orcids":["https://orcid.org/0000-0001-5192-3727"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aled Parry","raw_affiliation_strings":["Altos Labs, Institute of Science, Cambridge, UK","Epigenetics Programme, Babraham Institute, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altos Labs, Institute of Science, Cambridge, UK","institution_ids":[]},{"raw_affiliation_string":"Epigenetics Programme, Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052074743","display_name":"Wolf Reik","orcid":"https://orcid.org/0000-0003-0216-9881","observed_orcids":["https://orcid.org/0000-0003-0216-9881"]},"institutions":[{"id":"https://openalex.org/I1302113299","display_name":"Babraham Institute","ror":"https://ror.org/01d5qpn59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1302113299","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Wolf Reik","raw_affiliation_strings":["Altos Labs, Institute of Science, Cambridge, UK","Epigenetics Programme, Babraham Institute, Cambridge, UK","University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Altos Labs, Institute of Science, Cambridge, UK","institution_ids":[]},{"raw_affiliation_string":"Epigenetics Programme, Babraham Institute, Cambridge, UK","institution_ids":["https://openalex.org/I1302113299"]},{"raw_affiliation_string":"University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5117011667"],"corresponding_institution_ids":["https://openalex.org/I1302113299","https://openalex.org/I180670191","https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.4731000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tet1","display_name":"TET1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bivalent-chromatin","display_name":"bivalent chromatin","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neuroectoderm-differentiation","display_name":"neuroectoderm differentiation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pluripotency-exit","display_name":"pluripotency exit","score":0.7590000033378601},{"id":"https://openalex.org/keywords/h2ax","display_name":"H2AX","score":0.8820000290870667},{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.8519999980926514},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.40299999713897705},{"id":"https://openalex.org/keywords/cell-state-transitions","display_name":"cell state transitions","score":0.5720000267028809},{"id":"https://openalex.org/keywords/neural-specification","display_name":"neural specification","score":0.3529999852180481},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C137338518","wikidata":"https://www.wikidata.org/wiki/Q4919210","display_name":"Bivalent chromatin","level":5,"score":0.8174999952316284},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8104000091552734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7182000279426575},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.6811000108718872},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.6614000201225281},{"id":"https://openalex.org/C135073763","wikidata":"https://www.wikidata.org/wiki/Q1271432","display_name":"Neuroectoderm","level":5,"score":0.6277999877929688},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5343999862670898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5318999886512756},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5040000081062317},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.4569999873638153},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.42800000309944153},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4163999855518341},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38510000705718994},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.35659998655319214},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3422999978065491},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3393000066280365},{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.3021000027656555},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.28049999475479126},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2791999876499176},{"id":"https://openalex.org/C67258246","wikidata":"https://www.wikidata.org/wiki/Q5065897","display_name":"ChIA-PET","level":5,"score":0.27140000462532043},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.17.759687","doi":"https://doi.org/10.64898/2026.10.17.759687","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.17.759687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.17.759687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.17.759687","doi":"https://doi.org/10.64898/2026.10.17.759687","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.17.759687","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.17.759687.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311098","display_name":"Jack Kent Cooke Foundation","ror":"https://ror.org/003thv661"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323264","display_name":"Gates Cambridge Trust","ror":"https://ror.org/033sn5p83"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320337195","display_name":"Cancer Research UK Cambridge Institute, University of Cambridge","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222964200.pdf","grobid_xml":"https://content.openalex.org/works/W7222964200.grobid-xml"},"referenced_works_count":174,"referenced_works":["https://openalex.org/W1567515623","https://openalex.org/W1598350571","https://openalex.org/W1669125802","https://openalex.org/W1852828105","https://openalex.org/W1967835379","https://openalex.org/W1968426850","https://openalex.org/W1968931043","https://openalex.org/W1968983678","https://openalex.org/W1978107331","https://openalex.org/W1979556178","https://openalex.org/W1981059575","https://openalex.org/W1982742545","https://openalex.org/W1983329574","https://openalex.org/W1984783883","https://openalex.org/W1989920563","https://openalex.org/W1992949513","https://openalex.org/W1995366461","https://openalex.org/W1995765993","https://openalex.org/W1997698058","https://openalex.org/W1999168854","https://openalex.org/W2001036497","https://openalex.org/W2014623973","https://openalex.org/W2025860724","https://openalex.org/W2028456873","https://openalex.org/W2030523067","https://openalex.org/W2031366529","https://openalex.org/W2035222904","https://openalex.org/W2038761741","https://openalex.org/W2039288739","https://openalex.org/W2045740132","https://openalex.org/W2046355022","https://openalex.org/W2047835204","https://openalex.org/W2048627992","https://openalex.org/W2048786084","https://openalex.org/W2049598074","https://openalex.org/W2054771785","https://openalex.org/W2060816347","https://openalex.org/W2060924735","https://openalex.org/W2062118486","https://openalex.org/W2069112909","https://openalex.org/W2072713007","https://openalex.org/W2077359452","https://openalex.org/W2078589960","https://openalex.org/W2083308605","https://openalex.org/W2084699632","https://openalex.org/W2085379799","https://openalex.org/W2087476954","https://openalex.org/W2092315684","https://openalex.org/W2095649629","https://openalex.org/W2096968356","https://openalex.org/W2102182015","https://openalex.org/W2108078422","https://openalex.org/W2109017100","https://openalex.org/W2118397540","https://openalex.org/W2122813253","https://openalex.org/W2126235341","https://openalex.org/W2130193649","https://openalex.org/W2131478115","https://openalex.org/W2134440878","https://openalex.org/W2138472595","https://openalex.org/W2140909735","https://openalex.org/W2145534945","https://openalex.org/W2146111983","https://openalex.org/W2146512944","https://openalex.org/W2147350988","https://openalex.org/W2147393421","https://openalex.org/W2152478160","https://openalex.org/W2153091158","https://openalex.org/W2154962310","https://openalex.org/W2158151314","https://openalex.org/W2158887873","https://openalex.org/W2161614747","https://openalex.org/W2170520831","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2239846723","https://openalex.org/W2252568502","https://openalex.org/W2259938310","https://openalex.org/W2269247182","https://openalex.org/W2276045700","https://openalex.org/W2406250479","https://openalex.org/W2408159682","https://openalex.org/W2460218004","https://openalex.org/W2519449049","https://openalex.org/W2523244706","https://openalex.org/W2532812479","https://openalex.org/W2559543273","https://openalex.org/W2594685900","https://openalex.org/W2613161265","https://openalex.org/W2738015524","https://openalex.org/W2766763178","https://openalex.org/W2790626243","https://openalex.org/W2794707737","https://openalex.org/W2806700712","https://openalex.org/W2808525707","https://openalex.org/W2809496840","https://openalex.org/W2888440394","https://openalex.org/W2889323361","https://openalex.org/W2891423862","https://openalex.org/W2892943554","https://openalex.org/W2894168445","https://openalex.org/W2897716354","https://openalex.org/W2904226822","https://openalex.org/W2906567604","https://openalex.org/W2912272542","https://openalex.org/W2938635896","https://openalex.org/W2944090517","https://openalex.org/W2950221693","https://openalex.org/W2950425598","https://openalex.org/W2972254987","https://openalex.org/W2978504885","https://openalex.org/W2991819357","https://openalex.org/W2992957227","https://openalex.org/W2996429202","https://openalex.org/W2999259130","https://openalex.org/W3004109420","https://openalex.org/W3006859307","https://openalex.org/W3008992447","https://openalex.org/W3012638023","https://openalex.org/W3023115352","https://openalex.org/W3027897906","https://openalex.org/W3030944609","https://openalex.org/W3031159512","https://openalex.org/W3033596656","https://openalex.org/W3033675475","https://openalex.org/W3035090529","https://openalex.org/W3036256258","https://openalex.org/W3036885479","https://openalex.org/W3042897759","https://openalex.org/W3044653739","https://openalex.org/W3092457640","https://openalex.org/W3094105865","https://openalex.org/W3121058674","https://openalex.org/W3129633320","https://openalex.org/W3134387853","https://openalex.org/W3152941255","https://openalex.org/W3156787165","https://openalex.org/W3177828909","https://openalex.org/W3193447048","https://openalex.org/W3202596707","https://openalex.org/W3215783423","https://openalex.org/W4206544575","https://openalex.org/W4206944599","https://openalex.org/W4210818953","https://openalex.org/W4210998775","https://openalex.org/W4254687493","https://openalex.org/W4281677190","https://openalex.org/W4281775207","https://openalex.org/W4288844208","https://openalex.org/W4293194990","https://openalex.org/W4294884846","https://openalex.org/W4297238434","https://openalex.org/W4303045394","https://openalex.org/W4307501395","https://openalex.org/W4315621830","https://openalex.org/W4315780562","https://openalex.org/W4362657691","https://openalex.org/W4362700505","https://openalex.org/W4383868339","https://openalex.org/W4383874999","https://openalex.org/W4384522416","https://openalex.org/W4388464011","https://openalex.org/W4391973315","https://openalex.org/W4400735087","https://openalex.org/W4400949467","https://openalex.org/W4401391379","https://openalex.org/W4401517664","https://openalex.org/W4401944752","https://openalex.org/W4404458588","https://openalex.org/W4406339163","https://openalex.org/W4408865330","https://openalex.org/W4411369718","https://openalex.org/W4413257752","https://openalex.org/W7160033285"],"related_works":["https://openalex.org/W4362657691","https://openalex.org/W7097606433","https://openalex.org/W4281677190","https://openalex.org/W4210818953","https://openalex.org/W7083298093","https://openalex.org/W2774170088","https://openalex.org/W7024956781","https://openalex.org/W7027349522","https://openalex.org/W2883620817","https://openalex.org/W2107368073"],"abstract_inverted_index":{"Cell":[0],"state":[1,120,156,188],"transitions":[2],"involve":[3],"changes":[4],"in":[5,9,15],"gene":[6,194],"expression":[7],"programs":[8],"conjunction":[10],"with":[11,88],"epigenetic":[12],"regulation":[13],"occurring":[14],"chromatin.":[16,93],"Bivalent":[17],"chromatin,":[18],"marked":[19],"by":[20],"overlapping":[21],"active":[22],"H3K4me3":[23],"and":[24,68,90,105,148,182,191],"repressive":[25],"H3K27me3,":[26],"poises":[27],"key":[28],"developmental":[29],"genes":[30,46,135,151],"during":[31,37,47,124,189,196],"pluripotency":[32,127,190],"for":[33,77],"cell":[34,155],"type-specific":[35],"activation":[36,195],"differentiation.":[38],"However,":[39],"the":[40,57,99,111],"molecular":[41],"mechanisms":[42],"that":[43,84,98,184],"activate":[44],"bivalent":[45,122,178],"lineage":[48],"commitment":[49],"remain":[50],"poorly":[51],"understood.":[52],"Here,":[53],"we":[54,82],"elucidate":[55],"how":[56],"cytosine":[58],"dioxygenase":[59],"TET1":[60,78,85,104,129,159,181],"promotes":[61],"neuroectoderm":[62,134,197],"differentiation":[63],"through":[64],"dynamic":[65],"chromatin":[66,79,123,179],"binding":[67],"a":[69,74,106,117,144,173,186],"non-catalytic":[70,100],"repressor":[71,101,145],"function.":[72],"Through":[73],"hypothesis-free":[75],"screen":[76],"complex":[80],"partners,":[81],"find":[83],"physically":[86],"interacts":[87],"macroH2A.2":[89,114,183],"H2A.X":[91],"on":[92],"Integrated":[94],"multi-omic":[95],"analyses":[96],"reveal":[97,172],"function":[102,109],"of":[103,110],"novel":[107],"activating":[108],"H2A":[112],"variant":[113],"together":[115],"promote":[116],"poised":[118,187],"transcriptional":[119],"within":[121,177],"pluripotency.":[125],"Upon":[126],"exit,":[128],"disengages":[130],"from":[131],"macroH2A.2-marked":[132],"early":[133],"to":[136,152],"permit":[137],"their":[138],"activation,":[139],"while":[140],"remaining":[141],"bound":[142],"as":[143],"at":[146,161],"mesoendoderm":[147],"late":[149],"neural":[150,166],"prevent":[153],"alternative":[154],"transitions.":[157],"Furthermore,":[158],"retention":[160],"accessible":[162],"primed":[163],"enhancers":[164],"supports":[165],"program":[167],"activation.":[168],"Together,":[169],"our":[170],"findings":[171],"noncanonical":[174],"functional":[175],"interplay":[176],"between":[180],"maintains":[185],"predicts":[192],"selective":[193],"specification.":[198]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-20T00:00:00"}