{"id":"https://openalex.org/W7222962687","doi":"https://doi.org/10.64898/2026.10.14.759024","title":"Protein Crowding Buffers Membrane Fluidity","display_name":"Protein Crowding Buffers Membrane Fluidity","publication_year":2026,"publication_date":"2026-10-18","ids":{"openalex":"https://openalex.org/W7222962687","doi":"https://doi.org/10.64898/2026.10.14.759024"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.14.759024","doi":"https://doi.org/10.64898/2026.10.14.759024","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.759024","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/18/2026.10.14.759024.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/18/2026.10.14.759024.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043852758","display_name":"Matti Javanainen","orcid":"https://orcid.org/0000-0003-4858-364X","observed_orcids":["https://orcid.org/0000-0003-4858-364X"]},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Matti Javanainen","raw_affiliation_strings":["Tampere University;"],"raw_orcid":"https://orcid.org/0000-0003-4858-364X","affiliations":[{"raw_affiliation_string":"Tampere University;","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025294516","display_name":"Bal\u00e1zs F\u00e1bi\u00e1n","orcid":"https://orcid.org/0000-0002-6881-716X","observed_orcids":["https://orcid.org/0000-0002-6881-716X"]},"institutions":[{"id":"https://openalex.org/I4210124035","display_name":"Max Planck Institute of Biophysics","ror":"https://ror.org/02panr271","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210124035"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Balazs Fabian","raw_affiliation_strings":["Max Planck Institute of Biophysics;"],"raw_orcid":"https://orcid.org/0000-0002-6881-716X","affiliations":[{"raw_affiliation_string":"Max Planck Institute of Biophysics;","institution_ids":["https://openalex.org/I4210124035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060189850","display_name":"Jorge Bernardino de la Serna","orcid":"https://orcid.org/0000-0002-1396-3338","observed_orcids":["https://orcid.org/0000-0002-1396-3338"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jorge Bernardino de la Serna","raw_affiliation_strings":["Imperial College London;"],"raw_orcid":"https://orcid.org/0000-0002-1396-3338","affiliations":[{"raw_affiliation_string":"Imperial College London;","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075124865","display_name":"Hector Martinez\u2010Seara","orcid":"https://orcid.org/0000-0001-9716-1713","observed_orcids":["https://orcid.org/0000-0001-9716-1713"]},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210145889","display_name":"Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry","ror":"https://ror.org/04nfjn472","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Hector Martinez-Seara","raw_affiliation_strings":["Institute of organic chemistry and biochemistry of the Czech academy of sciences"],"raw_orcid":"https://orcid.org/0000-0001-9716-1713","affiliations":[{"raw_affiliation_string":"Institute of organic chemistry and biochemistry of the Czech academy of sciences","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210145889"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043852758"],"corresponding_institution_ids":["https://openalex.org/I166825849"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-crowding","display_name":"protein crowding","score":0.9850000143051147},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phosphatidylcholine-bilayers","display_name":"phosphatidylcholine bilayers","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.6489999890327454},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.5899999737739563},{"id":"https://openalex.org/keywords/lipid-order","display_name":"lipid ordering","score":0.7260000109672546},{"id":"https://openalex.org/keywords/lateral-diffusion","display_name":"lateral diffusion","score":0.7960000038146973},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.8669999837875366},{"id":"https://openalex.org/keywords/coarse-grained-simulation","display_name":"coarse-grained simulation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/atomistic-simulation","display_name":"atomistic simulation","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6761000156402588},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.6656000018119812},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6107000112533569},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.5738000273704529},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5371999740600586},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.498199999332428},{"id":"https://openalex.org/C166311969","wikidata":"https://www.wikidata.org/wiki/Q11036250","display_name":"Protein\u2013lipid interaction","level":5,"score":0.47189998626708984},{"id":"https://openalex.org/C149288129","wikidata":"https://www.wikidata.org/wiki/Q185357","display_name":"Phase transition","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.412200003862381},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.3921000063419342},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.391400009393692},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C149333683","wikidata":"https://www.wikidata.org/wiki/Q5189188","display_name":"Crowding","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C181990884","wikidata":"https://www.wikidata.org/wiki/Q11396092","display_name":"Macromolecular crowding","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C76564549","wikidata":"https://www.wikidata.org/wiki/Q17154515","display_name":"Lipid bilayer phase behavior","level":4,"score":0.2978000044822693},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C2780727160","wikidata":"https://www.wikidata.org/wiki/Q1500907","display_name":"Membrane structure","level":3,"score":0.2784999907016754},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C96347405","wikidata":"https://www.wikidata.org/wiki/Q16863771","display_name":"Membrane biophysics","level":4,"score":0.2540999948978424},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.250900000333786},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.14.759024","doi":"https://doi.org/10.64898/2026.10.14.759024","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.759024","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/18/2026.10.14.759024.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.14.759024","doi":"https://doi.org/10.64898/2026.10.14.759024","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.759024","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/18/2026.10.14.759024.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222962687.pdf","grobid_xml":"https://content.openalex.org/works/W7222962687.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004564635","https://openalex.org/W2079204245","https://openalex.org/W1549318323","https://openalex.org/W2056408911","https://openalex.org/W4366241621","https://openalex.org/W7027820665","https://openalex.org/W2076243860","https://openalex.org/W4414549518","https://openalex.org/W2216529200","https://openalex.org/W1977157146"],"abstract_inverted_index":{"Like":[0],"cholesterol,":[1,59],"protein":[2,32,132],"crowding":[3],"has":[4],"been":[5],"shown":[6],"to":[7,46,63,127,144],"alter":[8],"the":[9,19,27,55,75,100,106,109,117],"temperature":[10,145],"dependence":[11],"of":[12,30,39,54,105],"lateral":[13],"diffusion":[14],"in":[15,125],"biomembranes,":[16],"eventually":[17],"eliminating":[18],"distinct":[20],"liquid-gel":[21],"phase":[22,69],"transition.":[23],"Here,":[24],"we":[25,78],"resolve":[26],"molecular":[28],"origin":[29],"this":[31],"effect":[33],"with":[34],"coarse-grained":[35],"and":[36,49,111,116,140],"all-atom":[37],"simulations":[38],"protein-crowded":[40],"phosphatidylcholine":[41],"bilayers,":[42],"which":[43,60],"give":[44],"access":[45],"lipid":[47,84],"structure":[48],"dynamics":[50],"on":[51,74],"both":[52],"sides":[53],"transition":[56,118],"temperature.":[57],"Unlike":[58],"is":[61,92,119],"known":[62],"induce":[64],"a":[65],"continuous":[66],"liquid":[67],"ordered":[68],"by":[70],"having":[71],"opposite":[72],"effects":[73],"two":[76],"phases,":[77],"find":[79],"that":[80,98,124],"membrane":[81,107,138],"proteins":[82,101],"decrease":[83],"order":[85],"at":[86,94],"all":[87],"temperatures":[88],"studied.":[89],"The":[90],"disordering":[91],"stronger":[93],"low":[95],"temperatures,":[96],"so":[97],"once":[99],"cover":[102],"roughly":[103],"half":[104],"area":[108],"low-":[110],"high-temperature":[112],"phases":[113],"become":[114],"alike":[115],"lost.":[120],"Our":[121],"results":[122],"suggest":[123],"addition":[126],"local":[128,131],"cholesterol":[129],"concentration,":[130],"concentration":[133],"may":[134],"also":[135],"help":[136],"dictate":[137],"fluidity":[139],"especially":[141],"its":[142],"response":[143],"change.":[146]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-20T00:00:00"}
