{"id":"https://openalex.org/W7222961745","doi":"https://doi.org/10.1155/jamc/9609425","title":"Tracing Hydrazine in Pharmaceuticals: Toxicological Concerns, Extraction Approaches, and Analytical Method Development","display_name":"Tracing Hydrazine in Pharmaceuticals: Toxicological Concerns, Extraction Approaches, and Analytical Method Development","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7222961745","doi":"https://doi.org/10.1155/jamc/9609425","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898726","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678575"},"language":"en","primary_location":{"id":"doi:10.1155/jamc/9609425","doi":"https://doi.org/10.1155/jamc/9609425","is_oa":true,"landing_page_url":"https://doi.org/10.1155/jamc/9609425","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/jamc/9609425","source":{"id":"https://openalex.org/S4210240219","display_name":"Journal of Analytical Methods in Chemistry","issn_l":"2090-8865","issn":["2090-8865","2090-8873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Methods in Chemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/jamc/9609425","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159078913","display_name":"Buhlebenkosi Mercy Donga","orcid":"https://orcid.org/0009-0008-1611-9547","observed_orcids":["https://orcid.org/0009-0008-1611-9547"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Buhlebenkosi Mercy Donga","raw_affiliation_strings":["Department of Pharmaceutical Analysis and Medicinal Chemistry Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia","Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia"],"raw_orcid":"https://orcid.org/0009-0008-1611-9547","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analysis and Medicinal Chemistry Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia","institution_ids":["https://openalex.org/I91819753"]},{"raw_affiliation_string":"Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036332642","display_name":"Rimadani Pratiwi","orcid":"https://orcid.org/0000-0001-8753-6868","observed_orcids":["https://orcid.org/0000-0001-8753-6868"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Rimadani Pratiwi","raw_affiliation_strings":["Department of Pharmaceutical Analysis and Medicinal Chemistry Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-8753-6868","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analysis and Medicinal Chemistry Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016753330","display_name":"Aliya Nur Hasanah","orcid":"https://orcid.org/0000-0002-4085-7872","observed_orcids":["https://orcid.org/0000-0002-4085-7872"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aliya Nur Hasanah","raw_affiliation_strings":["Department of Pharmaceutical Analysis and Medicinal Chemistry Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-4085-7872","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Analysis and Medicinal Chemistry Faculty of Pharmacy University Padjadjaran  Jl. Raya Bandung Sumedang KM 21 Sumedang 45363 West Java Indonesia","institution_ids":["https://openalex.org/I91819753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036332642"],"corresponding_institution_ids":["https://openalex.org/I91819753"],"apc_list":{"value":2160,"currency":"USD","value_usd":2160},"apc_paid":{"value":2160,"currency":"USD","value_usd":2160},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46471372,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"1","first_page":"9609425","last_page":"9609425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrazine","display_name":"hydrazine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/genotoxic-impurities","display_name":"genotoxic impurities","score":0.8650000095367432},{"id":"https://openalex.org/keywords/threshold-of-toxicological-concern","display_name":"threshold of toxicological concern","score":0.9100000262260437},{"id":"https://openalex.org/keywords/degradation-products","display_name":"degradation products","score":0.7549999952316284},{"id":"https://openalex.org/keywords/derivatization","display_name":"derivatization","score":0.6710000038146973},{"id":"https://openalex.org/keywords/hyphenated-analytical-techniques","display_name":"hyphenated analytical techniques","score":0.6110000014305115},{"id":"https://openalex.org/keywords/gc-ms-ms","display_name":"GC-MS/MS","score":0.9440000057220459},{"id":"https://openalex.org/keywords/method-harmonization","display_name":"method harmonization","score":0.5899999737739563},{"id":"https://openalex.org/keywords/reference-materials","display_name":"reference materials","score":0.6169999837875366},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.5040000081062317},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":0.6880000233650208},{"id":"https://openalex.org/keywords/hydralazine","display_name":"hydralazine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/carbidopa","display_name":"carbidopa","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2776597398","wikidata":"https://www.wikidata.org/wiki/Q5954496","display_name":"Hydrazine (antidepressant)","level":2,"score":0.7447999715805054},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.6119999885559082},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.597599983215332},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5965999960899353},{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.5091000199317932},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5063999891281128},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.4884999990463257},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.3919000029563904},{"id":"https://openalex.org/C3018395757","wikidata":"https://www.wikidata.org/wiki/Q1379672","display_name":"Evaluation methods","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3449000120162964},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3188000023365021},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.30480000376701355},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.29330000281333923},{"id":"https://openalex.org/C71987851","wikidata":"https://www.wikidata.org/wiki/Q7216430","display_name":"Impurity","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C75291252","wikidata":"https://www.wikidata.org/wiki/Q1315756","display_name":"TRACE (psycholinguistics)","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C106186310","wikidata":"https://www.wikidata.org/wiki/Q1437823","display_name":"Pharmaceutical formulation","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C155512373","wikidata":"https://www.wikidata.org/wiki/Q287450","display_name":"Residual","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C170814935","wikidata":"https://www.wikidata.org/wiki/Q4751159","display_name":"Analytical technique","level":2,"score":0.2606000006198883}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/jamc/9609425","doi":"https://doi.org/10.1155/jamc/9609425","is_oa":true,"landing_page_url":"https://doi.org/10.1155/jamc/9609425","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/jamc/9609425","source":{"id":"https://openalex.org/S4210240219","display_name":"Journal of Analytical Methods in Chemistry","issn_l":"2090-8865","issn":["2090-8865","2090-8873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Methods in Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678575","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678575/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678575/pdf/JAMC-2026-9609425.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anal Methods Chem","raw_type":"Text"},{"id":"pmid:42898726","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898726","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of analytical methods in chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b1c4f28e7c824f2d9d227b37bd323464","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b1c4f28e7c824f2d9d227b37bd323464","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Analytical Methods in Chemistry, Vol 2026 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/jamc/9609425","doi":"https://doi.org/10.1155/jamc/9609425","is_oa":true,"landing_page_url":"https://doi.org/10.1155/jamc/9609425","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/jamc/9609425","source":{"id":"https://openalex.org/S4210240219","display_name":"Journal of Analytical Methods in Chemistry","issn_l":"2090-8865","issn":["2090-8865","2090-8873"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Methods in Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1089955028","display_name":null,"funder_award_id":"3927/UN6.RKT/HK.07.00/2025","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G1150945012","display_name":null,"funder_award_id":"3927/UN6.RKT/HK","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G233117845","display_name":null,"funder_award_id":"RKT/HK.07.00/2025","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G3068747324","display_name":null,"funder_award_id":"4303/ B3/DT.03.08/2025","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G3766506783","display_name":null,"funder_award_id":"3927/UN6. RKT/HK.07.00/2025","funder_id":"https://openalex.org/F4320328515","funder_display_name":"Lembaga Pengelola Dana Pendidikan"},{"id":"https://openalex.org/G5735835454","display_name":null,"funder_award_id":"3927/UN6","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"},{"id":"https://openalex.org/G91409571","display_name":null,"funder_award_id":"3927/UN6.RKT/HK.07.00","funder_id":"https://openalex.org/F4320329092","funder_display_name":"Universitas Padjadjaran"}],"funders":[{"id":"https://openalex.org/F4320327264","display_name":"Ministrstvo za visoko \u0161olstvo, znanost in tehnologijo","ror":"https://ror.org/0452h9305"},{"id":"https://openalex.org/F4320328515","display_name":"Lembaga Pengelola Dana Pendidikan","ror":"https://ror.org/05p2xef58"},{"id":"https://openalex.org/F4320329092","display_name":"Universitas Padjadjaran","ror":"https://ror.org/00xqf8t64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222961745.pdf","grobid_xml":"https://content.openalex.org/works/W7222961745.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W2343377814","https://openalex.org/W2974375624","https://openalex.org/W3012405573","https://openalex.org/W3014486626","https://openalex.org/W3022694661","https://openalex.org/W3035536639","https://openalex.org/W3042193490","https://openalex.org/W3091162812","https://openalex.org/W3091852887","https://openalex.org/W3151867313","https://openalex.org/W3175212906","https://openalex.org/W3181109755","https://openalex.org/W3188364038","https://openalex.org/W3202409002","https://openalex.org/W4206405851","https://openalex.org/W4221064495","https://openalex.org/W4252695538","https://openalex.org/W4285079184","https://openalex.org/W4285387341","https://openalex.org/W4288739685","https://openalex.org/W4302013369","https://openalex.org/W4313222804","https://openalex.org/W4313464380","https://openalex.org/W4382896658","https://openalex.org/W4386236356","https://openalex.org/W4386492856","https://openalex.org/W4390102686","https://openalex.org/W4391378661","https://openalex.org/W4392404021","https://openalex.org/W4393487936","https://openalex.org/W4393854554","https://openalex.org/W4394983570","https://openalex.org/W4396524248","https://openalex.org/W4396590836","https://openalex.org/W4396905639","https://openalex.org/W4398177436","https://openalex.org/W4400425352","https://openalex.org/W4403139131","https://openalex.org/W4403356931","https://openalex.org/W4406962295","https://openalex.org/W4412783456","https://openalex.org/W4415787453","https://openalex.org/W4417058584","https://openalex.org/W6931007414","https://openalex.org/W7164753591"],"related_works":["https://openalex.org/W2343377814","https://openalex.org/W2089140292","https://openalex.org/W2078133575","https://openalex.org/W153179086","https://openalex.org/W1965536376","https://openalex.org/W2078581324","https://openalex.org/W4205625046","https://openalex.org/W2488024349","https://openalex.org/W3014486626","https://openalex.org/W2918411507"],"abstract_inverted_index":{")":[0],"is":[1,6,101],"a":[2,33,121],"synthetic":[3],"reagent":[4,35],"that":[5,170],"used":[7],"in":[8,30,98,154,215],"the":[9,46,67,86,140,167,178,185,194],"manufacturing":[10],"of":[11,41,89,104,112,146,166,239,242,248],"various":[12],"active":[13],"pharmaceutical":[14,155],"ingredients":[15],"(APIs)":[16],"such":[17],"as":[18,32,184,205,244,246],"isoniazid,":[19],"hydralazine,":[20],"and":[21,51,77,114,134,143,152,200,221],"carbidopa.":[22],"The":[23],"major":[24],"concerns":[25],"associated":[26],"with":[27,85,174,197,208],"its":[28,42,105,150],"presence":[29],"medications":[31],"residual":[34],"or":[36],"degradation":[37],"product":[38],"arise":[39],"because":[40,103],"ability":[43],"to":[44,81,119,148,160],"damage":[45],"genetic":[47],"material,":[48],"cause":[49],"mutations,":[50],"potentially":[52],"trigger":[53],"cancer.":[54],"It":[55],"has":[56],"been":[57],"classified":[58],"under":[59],"Class":[60],"2":[61],"genotoxic":[62],"impurity":[63,125],"(GTI),":[64],"based":[65],"on":[66,139,234],"ICH":[68],"M7":[69],"guideline.":[70],"Its":[71],"multitissue":[72],"toxicities":[73],"including":[74],"hepatotoxicity,":[75],"neurotoxicity,":[76],"hematotoxicity":[78],"have":[79],"led":[80],"tight":[82],"regulatory":[83],"limits":[84,192],"EMA":[87],"threshold":[88],"toxicological":[90,130],"concern":[91],"(TTC)":[92],"at":[93,193],"1.5":[94],"\u00b5g/day.":[95],"Detecting":[96],"hydrazine":[97,147],"trace":[99],"concentrations":[100],"challenging":[102],"low":[106,190],"molecular":[107],"weight,":[108],"high":[109,198],"polarity,":[110],"absence":[111],"chromophores,":[113],"chemical":[115,172],"instability.":[116],"In":[117],"order":[118],"provide":[120],"unified":[122],"framework":[123],"for":[124,211,223],"profiling,":[126],"we":[127],"combine":[128],"hydrazine's":[129],"profiles,":[131],"formation":[132],"pathways,":[133],"analytical":[135,144,236],"advancements.":[136],"Recent":[137],"advances":[138],"extraction,":[141],"derivatization,":[142,243],"determination":[145],"improve":[149],"stability":[151],"detectability":[153],"matrices":[156],"ranging":[157],"from":[158],"2020":[159],"2025":[161],"were":[162],"collected.":[163],"Comparative":[164],"evaluation":[165],"methodologies":[168],"reveals":[169],"combining":[171],"derivatization":[173],"hyphenated":[175],"techniques":[176],"delivers":[177],"highest":[179],"sensitivity.":[180],"GC-MS/MS":[181],"stands":[182],"out":[183],"gold":[186],"standard,":[187],"providing":[188],"exceptionally":[189],"detection":[191,250],"sub-ppm":[195],"level":[196],"precision":[199],"reliability,":[201],"while":[202],"UHPLC-fluorescence":[203],"serves":[204],"an":[206],"alternative":[207],"considerable":[209],"sensitivity":[210],"detecting":[212],"hydrazine.":[213],"Gaps":[214],"method":[216],"harmonization,":[217],"reference":[218],"standard":[219],"availability,":[220],"validation":[222],"complex":[224],"formulations":[225],"still":[226],"remain":[227],"therefore":[228],"future":[229],"work":[230],"should":[231],"focus":[232],"more":[233],"standardized":[235],"methods,":[237],"development":[238],"greener":[240],"methods":[241],"well":[245],"use":[247],"high-resolution":[249],"systems.":[251]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-20T00:00:00"}