{"id":"https://openalex.org/W7222960906","doi":"https://doi.org/10.64898/2026.10.16.759562","title":"Elevated cortical tension triggers precocious ectopic polarization in mammalian oocytes, associated with lower developmental potential","display_name":"Elevated cortical tension triggers precocious ectopic polarization in mammalian oocytes, associated with lower developmental potential","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222960906","doi":"https://doi.org/10.64898/2026.10.16.759562"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.16.759562","doi":"https://doi.org/10.64898/2026.10.16.759562","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.10.16.759562","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093972250","display_name":"Anastasia Shihabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A. Shihabi","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146615529","display_name":"Eric Neiva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]},{"id":"https://openalex.org/I9617848","display_name":"Universitat Polit\u00e8cnica de Catalunya","ror":"https://ror.org/03mb6wj31","country_code":"ES","type":"education","lineage":["https://openalex.org/I9617848"]}],"countries":["ES","FR"],"is_corresponding":false,"raw_author_name":"E. Neiva","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","Departament de Mec\u00e0nica de Fluids (MF), Escola Polit\u00e8cnica Superior d\u2019Enginyeria de Vilanova i la Geltr\u00fa (EPSEVG), Universitat Polit\u00e8cnica de Catalunya \u00b7 BarcelonaTech (UPC), 08800 Vilanova i la Geltr\u00fa, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]},{"raw_affiliation_string":"Departament de Mec\u00e0nica de Fluids (MF), Escola Polit\u00e8cnica Superior d\u2019Enginyeria de Vilanova i la Geltr\u00fa (EPSEVG), Universitat Polit\u00e8cnica de Catalunya \u00b7 BarcelonaTech (UPC), 08800 Vilanova i la Geltr\u00fa, Spain","institution_ids":["https://openalex.org/I9617848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017317489","display_name":"Ga\u00eblle Letort","orcid":"https://orcid.org/0000-0002-5866-0322","observed_orcids":["https://orcid.org/0000-0002-5866-0322"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4387153797","display_name":"Biologie du D\u00e9veloppement et Cellules Souches","ror":"https://ror.org/02af93v77","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I4387153797"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G. Letort","raw_affiliation_strings":["Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR 3738, Universit\u00e9 Paris Cit\u00e9, 25 rue du Dr. Roux, 75015 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR 3738, Universit\u00e9 Paris Cit\u00e9, 25 rue du Dr. Roux, 75015 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4387153797"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032198182","display_name":"Elvira Nikalayevich","orcid":"https://orcid.org/0000-0001-7841-544X","observed_orcids":["https://orcid.org/0000-0001-7841-544X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Nikalayevich","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159048659","display_name":"Sajjad Madhavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Madhavi","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005836015","display_name":"Mohamed Yahiatene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Yahiatene","raw_affiliation_strings":["Centre Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation Nataliance, Groupe Mlab, P\u00f4le Sant\u00e9 Or\u00e9liance, Saran, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation Nataliance, Groupe Mlab, P\u00f4le Sant\u00e9 Or\u00e9liance, Saran, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032030858","display_name":"Xavier Pollet\u2010Villard","orcid":"https://orcid.org/0000-0001-9473-4408","observed_orcids":["https://orcid.org/0000-0001-9473-4408"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X. Pollet-Villard","raw_affiliation_strings":["Centre Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation Nataliance, Groupe Mlab, P\u00f4le Sant\u00e9 Or\u00e9liance, Saran, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Assistance M\u00e9dicale \u00e0 la Procr\u00e9ation Nataliance, Groupe Mlab, P\u00f4le Sant\u00e9 Or\u00e9liance, Saran, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159078621","display_name":"Herve Turlier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405266242","display_name":"Centre de Biologie Int\u00e9grative de Toulouse","ror":"https://ror.org/01f4pb571","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H. Turlier","raw_affiliation_strings":["Center for Integrative Biology (CBI), University of Toulouse, CNRS, Toulouse, France","Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Biology (CBI), University of Toulouse, CNRS, Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4405258862","https://openalex.org/I4405266242"]},{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062039839","display_name":"Marie\u2010H\u00e9l\u00e8ne Verlhac","orcid":"https://orcid.org/0000-0001-8377-9010","observed_orcids":["https://orcid.org/0000-0001-8377-9010"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"MH. Verlhac","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054027067","display_name":"Marie\u2010Emilie Terret","orcid":"https://orcid.org/0000-0001-5843-925X","observed_orcids":["https://orcid.org/0000-0001-5843-925X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"ME. Terret","raw_affiliation_strings":["Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France"],"raw_orcid":"https://orcid.org/0000-0001-5843-925X","affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Biology (CIRB), Coll\u00e8ge de France, Universit\u00e9 PSL, CNRS, INSERM, 75005 Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I2746051580","https://openalex.org/I4210113621"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.6650000214576721,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.2964000105857849,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cortical-tension","display_name":"cortical tension","score":0.9660000205039978},{"id":"https://openalex.org/keywords/actomyosin-contractility","display_name":"actomyosin contractility","score":0.9800000190734863},{"id":"https://openalex.org/keywords/meiosis-i","display_name":"meiosis I","score":0.7089999914169312},{"id":"https://openalex.org/keywords/spindle-orientation","display_name":"spindle orientation","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cytoplasmic-flow","display_name":"cytoplasmic flow","score":0.8790000081062317},{"id":"https://openalex.org/keywords/hydrodynamic-model","display_name":"hydrodynamic model","score":0.8930000066757202},{"id":"https://openalex.org/keywords/polyspermy","display_name":"polyspermy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/oocyte-developmental-competence","display_name":"oocyte developmental competence","score":0.7910000085830688},{"id":"https://openalex.org/keywords/oocyte-quality","display_name":"oocyte quality","score":0.8130000233650208},{"id":"https://openalex.org/keywords/cortical-architecture","display_name":"cortical architecture","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.6164000034332275},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.51910001039505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5166000127792358},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5080000162124634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47099998593330383},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.42559999227523804},{"id":"https://openalex.org/C148196450","wikidata":"https://www.wikidata.org/wiki/Q21100485","display_name":"Meiosis","level":3,"score":0.4214000105857849},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37299999594688416},{"id":"https://openalex.org/C120691718","wikidata":"https://www.wikidata.org/wiki/Q2477534","display_name":"Cytoplasmic streaming","level":3,"score":0.37229999899864197},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.35580000281333923},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3402999937534332},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.33340001106262207},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3199000060558319},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2897999882698059},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2777000069618225},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C194058213","wikidata":"https://www.wikidata.org/wiki/Q7209147","display_name":"Polarity in embryogenesis","level":5,"score":0.26840001344680786},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2662000060081482},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.16.759562","doi":"https://doi.org/10.64898/2026.10.16.759562","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.10.16.759562","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W1585160083","https://openalex.org/W1974708640","https://openalex.org/W1975353477","https://openalex.org/W1982103775","https://openalex.org/W1983611278","https://openalex.org/W1984426476","https://openalex.org/W1984474513","https://openalex.org/W1988876420","https://openalex.org/W1999411716","https://openalex.org/W2001412060","https://openalex.org/W2001686036","https://openalex.org/W2006810261","https://openalex.org/W2010932551","https://openalex.org/W2015010151","https://openalex.org/W2034073944","https://openalex.org/W2036932956","https://openalex.org/W2037570047","https://openalex.org/W2039402113","https://openalex.org/W2046522273","https://openalex.org/W2046963960","https://openalex.org/W2047361983","https://openalex.org/W2059190326","https://openalex.org/W2061167268","https://openalex.org/W2065305930","https://openalex.org/W2065429801","https://openalex.org/W2066422187","https://openalex.org/W2066574156","https://openalex.org/W2075204347","https://openalex.org/W2077603983","https://openalex.org/W2084344228","https://openalex.org/W2087941042","https://openalex.org/W2089121353","https://openalex.org/W2090115766","https://openalex.org/W2097073572","https://openalex.org/W2098602023","https://openalex.org/W2105299356","https://openalex.org/W2109461200","https://openalex.org/W2120575449","https://openalex.org/W2131728067","https://openalex.org/W2132762207","https://openalex.org/W2133059825","https://openalex.org/W2134728059","https://openalex.org/W2136070854","https://openalex.org/W2144534399","https://openalex.org/W2146412869","https://openalex.org/W2152900950","https://openalex.org/W2166254523","https://openalex.org/W2167279371","https://openalex.org/W2225259017","https://openalex.org/W2283883330","https://openalex.org/W2411171145","https://openalex.org/W2479489516","https://openalex.org/W2559617141","https://openalex.org/W2566759407","https://openalex.org/W2582192315","https://openalex.org/W2586973081","https://openalex.org/W2607960270","https://openalex.org/W2612527983","https://openalex.org/W2742756490","https://openalex.org/W2757762990","https://openalex.org/W2763522115","https://openalex.org/W2767895351","https://openalex.org/W2799407182","https://openalex.org/W2885411753","https://openalex.org/W2901768768","https://openalex.org/W2963486664","https://openalex.org/W2976430275","https://openalex.org/W2999583767","https://openalex.org/W3010232336","https://openalex.org/W3013564373","https://openalex.org/W3014436419","https://openalex.org/W3014806436","https://openalex.org/W3039256091","https://openalex.org/W3042338284","https://openalex.org/W3080566926","https://openalex.org/W3194782114","https://openalex.org/W3197310139","https://openalex.org/W3203610579","https://openalex.org/W4221085690","https://openalex.org/W4225164000","https://openalex.org/W4281734082","https://openalex.org/W4297879452","https://openalex.org/W4311357001","https://openalex.org/W4323534486","https://openalex.org/W4328089472","https://openalex.org/W4377041893","https://openalex.org/W4380369815","https://openalex.org/W4392005472","https://openalex.org/W4394572664","https://openalex.org/W4400190112","https://openalex.org/W4403067808","https://openalex.org/W4403456820","https://openalex.org/W4406933339","https://openalex.org/W4409038362","https://openalex.org/W4411299292","https://openalex.org/W4411917698","https://openalex.org/W4413114699","https://openalex.org/W4417085063","https://openalex.org/W6969112272","https://openalex.org/W7126443827","https://openalex.org/W7134966628","https://openalex.org/W7143462503","https://openalex.org/W7161557986","https://openalex.org/W7166170542","https://openalex.org/W7204201046","https://openalex.org/W7223182634"],"related_works":["https://openalex.org/W2170746782","https://openalex.org/W4392005472","https://openalex.org/W1969612920","https://openalex.org/W7095150613","https://openalex.org/W1975353477","https://openalex.org/W6887376886","https://openalex.org/W1964192572","https://openalex.org/W2102534728","https://openalex.org/W2068077831","https://openalex.org/W7130536097"],"abstract_inverted_index":{"Abstract":[0],"Oocytes":[1],"from":[2,139],"many":[3],"organisms":[4],"polarize":[5],"early":[6,108],"during":[7],"development,":[8],"unlike":[9],"mammalian":[10,140],"oocytes.":[11,123],"The":[12],"significance":[13],"of":[14,98,119],"maintaining":[15],"this":[16],"homogeneous":[17],"state":[18,136],"in":[19,90,117,147],"mammals":[20],"remains":[21],"unclear.":[22],"We":[23],"show":[24],"that":[25,59],"elevated":[26],"cortical":[27,35,39,128],"tension,":[28],"via":[29],"increased":[30,101],"actomyosin":[31],"contractility":[32],"or":[33],"disrupted":[34],"architecture,":[36],"induces":[37],"precocious":[38,127],"polarization":[40,54,88,129],"mid-meiosis":[41],"I,":[42],"with":[43,96],"an":[44],"ectopic":[45],"actomyosin-rich":[46],"domain":[47],"opposite":[48],"the":[49,63,76],"future":[50],"division":[51],"site.":[52],"This":[53],"generates":[55],"directional":[56],"cytoplasmic":[57],"flows":[58],"displace":[60],"organelles":[61],"and":[62,68,93,104,106,121],"spindle,":[64],"accelerating":[65],"its":[66,70],"migration":[67],"disrupting":[69],"orientation.":[71],"A":[72,111],"hydrodynamic":[73],"model":[74],"coupling":[75],"polarized":[77],"cortex":[78],"to":[79,145],"a":[80,131],"viscous":[81],"cytoplasm":[82],"accounts":[83],"for":[84],"these":[85],"rearrangements.":[86],"Ectopic":[87],"persists":[89],"meiosis":[91],"II":[92],"is":[94],"associated":[95],"mislocalization":[97],"fertilization":[99,102],"factors,":[100],"rates":[103],"polyspermy,":[105],"reduced":[107],"embryonic":[109],"development.":[110],"similar":[112],"morphological":[113],"signature":[114],"arises":[115],"spontaneously":[116],"subsets":[118],"mouse":[120],"human":[122],"These":[124],"results":[125],"reveal":[126],"as":[130],"previously":[132],"unrecognized,":[133],"mechanically":[134],"accessible":[135],"largely":[137],"absent":[138],"oocytes,":[141],"which":[142],"may":[143],"contribute":[144],"variability":[146],"oocyte":[148],"quality.":[149]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-20T00:00:00"}
