{"id":"https://openalex.org/W7222949947","doi":"https://doi.org/10.3390/jcm15208118","title":"Drug Therapies and Incident Heart Failure in Atrial Fibrillation: A Systematic Review","display_name":"Drug Therapies and Incident Heart Failure in Atrial Fibrillation: A Systematic Review","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222949947","doi":"https://doi.org/10.3390/jcm15208118","pmid":"https://pubmed.ncbi.nlm.nih.gov/42941631","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13706031"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15208118","doi":"https://doi.org/10.3390/jcm15208118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15208118","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/jcm15208118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093052226","display_name":"Amirreza Zobdeh","orcid":"https://orcid.org/0000-0001-6975-5426","observed_orcids":["https://orcid.org/0000-0001-6975-5426"]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Amirreza Zobdeh","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia"],"raw_orcid":"https://orcid.org/0000-0001-6975-5426","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006038504","display_name":"Gregory Mark Peterson","orcid":"https://orcid.org/0000-0002-6764-3882","observed_orcids":["https://orcid.org/0000-0002-6764-3882"]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Gregory M. Peterson","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia"],"raw_orcid":"https://orcid.org/0000-0002-6764-3882","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074193099","display_name":"Woldesellassie M Mequanint Bezabhe","orcid":"https://orcid.org/0000-0002-3028-6949","observed_orcids":["https://orcid.org/0000-0002-3028-6949"]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Woldesellassie M. Bezabhe","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3028-6949","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159092397","display_name":"Pankti Shastri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Pankti Shastri","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008662212","display_name":"Daniel Jake Hoyle","orcid":"https://orcid.org/0000-0003-2867-3736","observed_orcids":["https://orcid.org/0000-0003-2867-3736"]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel J. Hoyle","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia"],"raw_orcid":"https://orcid.org/0000-0003-2867-3736","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, Australia","institution_ids":["https://openalex.org/I129801699"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5093052226"],"corresponding_institution_ids":["https://openalex.org/I129801699"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60441176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"20","first_page":"8118","last_page":"8118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0674000009894371,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9259999990463257},{"id":"https://openalex.org/keywords/incident-heart-failure","display_name":"incident heart failure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/irbesartan","display_name":"irbesartan","score":0.949999988079071},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9610000252723694},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9760000109672546},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor-antagonists","display_name":"mineralocorticoid receptor antagonists","score":0.9990000128746033},{"id":"https://openalex.org/keywords/digoxin","display_name":"digoxin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/renin-angiotensin-system-inhibitors","display_name":"renin-angiotensin system inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/confounding-by-indication","display_name":"confounding by indication","score":0.8820000290870667},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9843999743461609},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6464999914169312},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.6464999914169312},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6449999809265137},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5913000106811523},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5540000200271606},{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.5103999972343445},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.47200000286102295},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4587000012397766},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45320001244544983},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4198000133037567},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.41519999504089355},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3813000023365021},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3472000062465668},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.32179999351501465},{"id":"https://openalex.org/C2776379505","wikidata":"https://www.wikidata.org/wiki/Q422188","display_name":"Spironolactone","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.30300000309944153},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2976999878883362},{"id":"https://openalex.org/C2780259554","wikidata":"https://www.wikidata.org/wiki/Q947266","display_name":"Irbesartan","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C2778176773","wikidata":"https://www.wikidata.org/wiki/Q2976049","display_name":"Drug class","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2761000096797943},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.2651999890804291}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/jcm15208118","doi":"https://doi.org/10.3390/jcm15208118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15208118","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13706031","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13706031/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13706031/pdf/jcm-15-08118.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmid:42941631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42941631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/jcm15208118","doi":"https://doi.org/10.3390/jcm15208118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15208118","pdf_url":null,"source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222949947.pdf","grobid_xml":"https://content.openalex.org/works/W7222949947.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1994231358","https://openalex.org/W2001159349","https://openalex.org/W2034561289","https://openalex.org/W2034814979","https://openalex.org/W2069444518","https://openalex.org/W2070237852","https://openalex.org/W2085424146","https://openalex.org/W2091911010","https://openalex.org/W2097730487","https://openalex.org/W2100224535","https://openalex.org/W2104553590","https://openalex.org/W2104657845","https://openalex.org/W2125435699","https://openalex.org/W2140384764","https://openalex.org/W2154449833","https://openalex.org/W2162586165","https://openalex.org/W2268480244","https://openalex.org/W2323458614","https://openalex.org/W2464924628","https://openalex.org/W2513430955","https://openalex.org/W2560726162","https://openalex.org/W2588672988","https://openalex.org/W2727421390","https://openalex.org/W2749861182","https://openalex.org/W2805417982","https://openalex.org/W2806140515","https://openalex.org/W2899259164","https://openalex.org/W2903752723","https://openalex.org/W2905303519","https://openalex.org/W2914227111","https://openalex.org/W2968633786","https://openalex.org/W2970684805","https://openalex.org/W2982404359","https://openalex.org/W2989627761","https://openalex.org/W2998851712","https://openalex.org/W3000776376","https://openalex.org/W3043749388","https://openalex.org/W3046794749","https://openalex.org/W3082794714","https://openalex.org/W3090865931","https://openalex.org/W3098781229","https://openalex.org/W3107243156","https://openalex.org/W3118615836","https://openalex.org/W3121606972","https://openalex.org/W3134726506","https://openalex.org/W3191652905","https://openalex.org/W3193598686","https://openalex.org/W3200838867","https://openalex.org/W4200007332","https://openalex.org/W4220884194","https://openalex.org/W4229066296","https://openalex.org/W4239943088","https://openalex.org/W4280608908","https://openalex.org/W4284708558","https://openalex.org/W4288968168","https://openalex.org/W4292636079","https://openalex.org/W4295925641","https://openalex.org/W4307831606","https://openalex.org/W4310220122","https://openalex.org/W4313650054","https://openalex.org/W4323653534","https://openalex.org/W4365146541","https://openalex.org/W4366603702","https://openalex.org/W4372218808","https://openalex.org/W4376613310","https://openalex.org/W4379094968","https://openalex.org/W4384819572","https://openalex.org/W4387121751","https://openalex.org/W4387954115","https://openalex.org/W4389088320","https://openalex.org/W4389166035","https://openalex.org/W4391447712","https://openalex.org/W4391785511","https://openalex.org/W4392716259","https://openalex.org/W4394676160","https://openalex.org/W4402049769","https://openalex.org/W4403805995","https://openalex.org/W4404276742","https://openalex.org/W4404658230","https://openalex.org/W4405520090","https://openalex.org/W4406269985","https://openalex.org/W4406919048","https://openalex.org/W4408606135","https://openalex.org/W4408812564","https://openalex.org/W4410237291","https://openalex.org/W4412406455","https://openalex.org/W4413116354","https://openalex.org/W4414283174","https://openalex.org/W7134034908","https://openalex.org/W7135190396","https://openalex.org/W7139035945","https://openalex.org/W7143403231","https://openalex.org/W7160767860","https://openalex.org/W7167898423"],"related_works":["https://openalex.org/W4387121751","https://openalex.org/W2806140515","https://openalex.org/W4306290975","https://openalex.org/W3043749388","https://openalex.org/W4377197326","https://openalex.org/W4407998014","https://openalex.org/W7125947221","https://openalex.org/W4389940453","https://openalex.org/W4404363803","https://openalex.org/W2624056855"],"abstract_inverted_index":{"Background/Objectives:":[0],"Atrial":[1],"fibrillation":[2],"(AF),":[3],"the":[4,11,84,98],"most":[5],"common":[6],"cardiac":[7],"arrhythmia,":[8],"significantly":[9],"elevates":[10],"risk":[12],"of":[13,45,62,83,181],"new-onset":[14],"heart":[15],"failure":[16],"(HF).":[17],"We":[18,38],"aimed":[19],"to":[20,51,205,212],"systematically":[21],"map":[22],"and":[23,30,48,64,139,187],"appraise":[24],"available":[25],"evidence":[26,161],"on":[27,202],"drug":[28,168,203],"therapies":[29,204],"incident":[31,141],"HF":[32,95,115,142,177,207],"in":[33,87,123,144,208,233],"patients":[34,124,150],"with":[35,92,112,125,193],"AF.":[36],"Methods:":[37],"searched":[39],"Medline,":[40],"Embase,":[41],"Cochrane":[42],"Central":[43],"Register":[44],"Controlled":[46],"Trials,":[47],"Scopus":[49],"up":[50],"16":[52],"September":[53],"2026":[54],"for":[55,117,217],"relevant":[56],"randomized":[57,76,214],"controlled":[58],"trials":[59],"(RCTs),":[60],"sub-analyses":[61],"RCTs,":[63],"observational/cohort":[65],"studies.":[66],"Results:":[67],"Seventeen":[68],"studies":[69,108],"(397,991":[70],"participants)":[71],"were":[72,222],"included.":[73],"The":[74,158,175,219],"only":[75],"signal":[77,216],"came":[78],"from":[79],"a":[80,145],"prespecified":[81],"subgroup":[82,215],"ACTIVE-I":[85],"trial,":[86],"which":[88],"irbesartan":[89],"was":[90,191],"associated":[91],"fewer":[93],"first":[94,114],"hospitalizations":[96],"than":[97,167,225],"placebo":[99],"(HR":[100,153],"0.81,":[101],"95%":[102,132,155],"CI":[103,133,156],"0.69\u20130.96;":[104],"moderate":[105],"certainty).":[106,199],"Observational":[107],"showed":[109,171],"an":[110,172],"association":[111],"lower":[113,140],"hospitalization":[116],"sodium-glucose":[118],"cotransporter":[119],"2":[120,127],"(SGLT2)":[121],"inhibitors":[122,190],"type":[126],"diabetes":[128,152],"(pooled":[129],"HR":[130],"0.68,":[131],"0.48\u20130.95;":[134],"two":[135],"studies;":[136],"low":[137,198],"certainty)":[138],"diagnosis":[143],"larger":[146],"cohort":[147,160],"that":[148],"included":[149],"without":[151],"0.86,":[154],"0.82\u20130.89).":[157],"remaining":[159,220],"largely":[162],"reflected":[163],"prescribing":[164],"patterns":[165],"rather":[166,224],"effects.":[169,228],"Statins":[170],"inconsistent":[173],"association.":[174],"higher":[176],"incidence":[178],"among":[179],"users":[180],"diuretics,":[182],"mineralocorticoid":[183],"receptor":[184],"antagonists,":[185],"digoxin":[186],"renin-angiotensin":[188],"system":[189],"consistent":[192],"confounding":[194],"by":[195],"indication":[196],"(very":[197],"Conclusions:":[200],"Evidence":[201],"prevent":[206],"AF":[209,235],"is":[210,237],"limited":[211],"one":[213],"irbesartan.":[218],"findings":[221],"associations":[223],"demonstrated":[226],"treatment":[227],"High-quality":[229],"research,":[230],"including":[231],"RCTs":[232],"broader":[234],"populations,":[236],"needed.":[238],"PROSPERO":[239],"Registration:":[240],"CRD42024587926.":[241]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-20T00:00:00"}