{"id":"https://openalex.org/W7222946522","doi":"https://doi.org/10.64898/2026.10.13.744538","title":"Droplet-based organoid screens enable high-throughput identification of cancer vulnerabilities","display_name":"Droplet-based organoid screens enable high-throughput identification of cancer vulnerabilities","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222946522","doi":"https://doi.org/10.64898/2026.10.13.744538"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.13.744538","doi":"https://doi.org/10.64898/2026.10.13.744538","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.744538","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.13.744538.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.13.744538.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111206455","display_name":"Yanan Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya-Nan Xia","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310030, China","Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159072876","display_name":"Yuting Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Sun","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141140799","display_name":"Yimin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yimin Wang","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140950179","display_name":"Mingyang Zhang","orcid":"https://orcid.org/0009-0006-4277-871X","observed_orcids":["https://orcid.org/0009-0006-4277-871X"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingyang Zhang","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159035192","display_name":"Guangyue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangyue Li","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030714587","display_name":"Xinyi Dai","orcid":"https://orcid.org/0009-0007-8616-2893","observed_orcids":["https://orcid.org/0009-0007-8616-2893"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Dai","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152542830","display_name":"Xinyue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Li","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129830404","display_name":"Can Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Can Hu","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103159223","display_name":"Zhiyuan Xu","orcid":"https://orcid.org/0000-0003-0289-5947","observed_orcids":["https://orcid.org/0000-0003-0289-5947"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyuan Xu","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102706488","display_name":"Li Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yuan","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159035098","display_name":"Zhiguo Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiguo Zheng","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159041924","display_name":"Xiangdong Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangdong Cheng","raw_affiliation_strings":["Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210098734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083114703","display_name":"Xin Jin","orcid":"https://orcid.org/0000-0001-7554-4975","observed_orcids":["https://orcid.org/0000-0001-7554-4975","https://orcid.org/0009-0000-2151-9619"]},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Jin","raw_affiliation_strings":["School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]},{"raw_affiliation_string":"Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang 310030, China","institution_ids":["https://openalex.org/I3133055985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083114703"],"corresponding_institution_ids":["https://openalex.org/I3133055985"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.13019999861717224,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-organoids","display_name":"tumor organoids","score":0.9369999766349792},{"id":"https://openalex.org/keywords/high-throughput-drug-screening","display_name":"high-throughput drug screening","score":0.8650000095367432},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cancer-vulnerability","display_name":"cancer vulnerability","score":0.6169999837875366},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.9330000281333923},{"id":"https://openalex.org/keywords/uxs1","display_name":"UXS1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.875}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8945000171661377},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6654000282287598},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.6628999710083008},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5404000282287598},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5063999891281128},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4970000088214874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44279998540878296},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3862999975681305},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.32499998807907104},{"id":"https://openalex.org/C163688615","wikidata":"https://www.wikidata.org/wiki/Q15883629","display_name":"3D cell culture","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.3183000087738037},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.31200000643730164},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3107999861240387},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C124978682","wikidata":"https://www.wikidata.org/wiki/Q1201019","display_name":"Proof of concept","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C6555983","wikidata":"https://www.wikidata.org/wiki/Q7181398","display_name":"Phenotypic screening","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.26080000400543213},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2540000081062317},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.2533999979496002}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.13.744538","doi":"https://doi.org/10.64898/2026.10.13.744538","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.744538","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.13.744538.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.13.744538","doi":"https://doi.org/10.64898/2026.10.13.744538","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.13.744538","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.13.744538.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222946522.pdf","grobid_xml":"https://content.openalex.org/works/W7222946522.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1982024468","https://openalex.org/W1990197810","https://openalex.org/W1996506613","https://openalex.org/W1999574084","https://openalex.org/W2076311985","https://openalex.org/W2102212449","https://openalex.org/W2112241575","https://openalex.org/W2121424091","https://openalex.org/W2130410032","https://openalex.org/W2157828807","https://openalex.org/W2169456326","https://openalex.org/W2887506329","https://openalex.org/W2896450660","https://openalex.org/W2904226822","https://openalex.org/W2911986456","https://openalex.org/W2915459742","https://openalex.org/W2944727022","https://openalex.org/W3003119869","https://openalex.org/W3009694030","https://openalex.org/W3011410517","https://openalex.org/W3014731797","https://openalex.org/W3042690990","https://openalex.org/W3138516171","https://openalex.org/W3195543277","https://openalex.org/W4200519100","https://openalex.org/W4214876469","https://openalex.org/W4323320159","https://openalex.org/W4385493384","https://openalex.org/W4386195841","https://openalex.org/W4387661643","https://openalex.org/W4387935836","https://openalex.org/W4389427718","https://openalex.org/W4394564041","https://openalex.org/W4400060335","https://openalex.org/W4400414617","https://openalex.org/W4401324982","https://openalex.org/W4403810280","https://openalex.org/W4409283639","https://openalex.org/W4411918832","https://openalex.org/W4413139962","https://openalex.org/W4414090390","https://openalex.org/W4414146635","https://openalex.org/W4414321677","https://openalex.org/W4416132910","https://openalex.org/W4417471957","https://openalex.org/W4417472163","https://openalex.org/W7118266823","https://openalex.org/W7128378534","https://openalex.org/W7153213533","https://openalex.org/W7155506887","https://openalex.org/W7172493741","https://openalex.org/W7172515186"],"related_works":["https://openalex.org/W2897372172","https://openalex.org/W4226088025","https://openalex.org/W4381165487","https://openalex.org/W2740845931","https://openalex.org/W4409382808","https://openalex.org/W3042505563","https://openalex.org/W7117119392","https://openalex.org/W2951053164","https://openalex.org/W2794232533","https://openalex.org/W4403789158"],"abstract_inverted_index":{"Summary":[0],"Organoid":[1],"culture":[2,133,177],"is":[3],"a":[4,30,54,70,155,179],"powerful":[5],"platform":[6],"for":[7,184],"establishing":[8],"patient-derived":[9],"cancer":[10,160],"models,":[11],"yet":[12],"conventional":[13],"formats":[14],"are":[15],"difficult":[16],"to":[17,42],"scale,":[18],"limiting":[19],"their":[20],"impact":[21],"on":[22],"precision":[23],"oncology.":[24],"Here":[25],"we":[26,137],"introduce":[27],"droplet":[28,132,176],"culture,":[29],"method":[31],"that":[32,76,124],"encapsulates":[33],"tumor":[34,104,119,192],"cells":[35,161],"in":[36,44,143,191],"hundred-micrometer-sized":[37],"Matrigel":[38],"droplets,":[39,66],"allowing":[40],"organoids":[41,105],"grow":[43],"nanoliter":[45],"compartments":[46],"at":[47],"high":[48],"throughput.":[49],"Exploiting":[50],"an":[51,140,168],"emulsion":[52],"principle,":[53],"simple":[55],"vortex":[56],"step":[57],"with":[58,87,134],"standard":[59],"laboratory":[60],"equipment":[61],"produces":[62],"millions":[63],"of":[64,103,112,147,152],"monodisperse":[65],"each":[67],"serving":[68],"as":[69,178],"miniaturized,":[71],"independent,":[72],"quasi-physiological":[73],"culturing":[74],"unit":[75],"supports":[77],"uniform":[78],"organoid":[79],"growth.":[80],"The":[81],"system":[82],"can":[83],"be":[84],"seamlessly":[85],"integrated":[86],"high-throughput":[88],"drug":[89],"screening,":[90,136],"high-content":[91],"live":[92],"imaging,":[93],"and":[94,188],"large-scale":[95],"pooled":[96],"CRISPR":[97,135],"screens,":[98],"enabling":[99],"rich,":[100],"time-resolved":[101],"phenotyping":[102],"under":[106],"diverse":[107],"perturbations.":[108],"An":[109],"organoid-in-droplet":[110],"screen":[111],"over":[113],"5,000":[114],"clinical":[115],"compounds":[116],"across":[117],"multiple":[118],"models":[120],"uncovered":[121],"therapeutic":[122,189],"opportunities":[123],"were":[125],"undetectable":[126],"by":[127,150],"genomic":[128],"profiling":[129],"alone.":[130],"Coupling":[131],"further":[138],"identified":[139],"unanticipated":[141],"vulnerability":[142],"stomach":[144],"cancer:":[145],"disruption":[146],"nucleotide-sugar":[148],"homeostasis":[149],"loss":[151],"UXS1":[153],"drives":[154],"gastric-to-hepatic":[156],"trans-lineage":[157],"differentiation,":[158],"re-routing":[159],"away":[162],"from":[163],"the":[164],"malignant":[165],"program":[166],"toward":[167],"alternative":[169],"cell":[170],"fate.":[171],"Collectively,":[172],"these":[173],"capabilities":[174],"position":[175],"highly":[180],"versatile,":[181],"scalable":[182],"technology":[183],"discovering":[185],"actionable":[186],"dependencies":[187],"targets":[190],"organoids.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-20T00:00:00"}
