{"id":"https://openalex.org/W7222934992","doi":"https://doi.org/10.3389/fimmu.2026.1996626","title":"Antigen specificity and inflammatory amplification in autoimmune hepatitis","display_name":"Antigen specificity and inflammatory amplification in autoimmune hepatitis","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222934992","doi":"https://doi.org/10.3389/fimmu.2026.1996626","pmid":"https://pubmed.ncbi.nlm.nih.gov/42974240","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13725687"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1996626","doi":"https://doi.org/10.3389/fimmu.2026.1996626","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1996626","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1996626/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1996626/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108105189","display_name":"Zihao Xu","orcid":"https://orcid.org/0009-0006-7120-9321","observed_orcids":["https://orcid.org/0009-0006-7120-9321","https://orcid.org/0009-0007-5230-6633"]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihao Xu","raw_affiliation_strings":["School of Chinese Medicine, Hubei University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157365950","display_name":"Yifan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Liu","raw_affiliation_strings":["School of Chinese Medicine, Hubei University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113921816","display_name":"Haoyang Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyang Zou","raw_affiliation_strings":["School of Chinese Medicine, Hubei University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Medicine, Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159028285","display_name":"Sheng Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205016115","display_name":"Hubei University of Chinese Medicine","ror":"https://ror.org/02my3bx32","country_code":"CN","type":"education","lineage":["https://openalex.org/I205016115"]},{"id":"https://openalex.org/I4210099122","display_name":"Hubei Provincial Hospital of Traditional Chinese Medicine","ror":"https://ror.org/00xabh388","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099122"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sheng Guo","raw_affiliation_strings":["Affiliated Hospital of Hubei University of Chinese Medicine","Hubei Provincial Clinical Research Center of Traditional Chinese Medicine for Liver Diseases","Hubei Shizhen Laboratory","Institute of Liver Diseases, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Hubei University of Chinese Medicine","institution_ids":["https://openalex.org/I205016115"]},{"raw_affiliation_string":"Hubei Provincial Clinical Research Center of Traditional Chinese Medicine for Liver Diseases","institution_ids":[]},{"raw_affiliation_string":"Hubei Shizhen Laboratory","institution_ids":[]},{"raw_affiliation_string":"Institute of Liver Diseases, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210099122"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5159028285"],"corresponding_institution_ids":["https://openalex.org/I205016115","https://openalex.org/I4210099122"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54254796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1996626","last_page":"1996626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":1.0},{"id":"https://openalex.org/keywords/hla-association","display_name":"HLA association","score":0.8730000257492065},{"id":"https://openalex.org/keywords/antigen-specificity","display_name":"antigen specificity","score":0.699999988079071},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.4230000078678131},{"id":"https://openalex.org/keywords/autoreactive-t-cells","display_name":"autoreactive T cells","score":0.8240000009536743},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.8970000147819519},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.875},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.6330000162124634},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7330999970436096},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.656499981880188},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.6449000239372253},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5823000073432922},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5447999835014343},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.5321000218391418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4408999979496002},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38519999384880066},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.3458000123500824},{"id":"https://openalex.org/C83464605","wikidata":"https://www.wikidata.org/wiki/Q575296","display_name":"Antigen presentation","level":4,"score":0.3321000039577484},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.3303999900817871},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.3237000107765198},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.322299987077713},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.25369998812675476}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017951","descriptor_name":"Antigen Presentation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1996626","doi":"https://doi.org/10.3389/fimmu.2026.1996626","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1996626","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1996626/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13725687","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725687/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725687/pdf/fimmu-17-1996626.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42974240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42974240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7e48adebfd8a406096422b1a80b04029","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7e48adebfd8a406096422b1a80b04029","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1996626","doi":"https://doi.org/10.3389/fimmu.2026.1996626","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1996626","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1996626/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222934992.pdf","grobid_xml":"https://content.openalex.org/works/W7222934992.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1608307860","https://openalex.org/W1971668390","https://openalex.org/W1998949806","https://openalex.org/W2008811593","https://openalex.org/W2009822430","https://openalex.org/W2020798067","https://openalex.org/W2048702747","https://openalex.org/W2055715897","https://openalex.org/W2149742106","https://openalex.org/W2151254896","https://openalex.org/W2152103678","https://openalex.org/W2153778621","https://openalex.org/W2618989410","https://openalex.org/W2767091540","https://openalex.org/W2987497707","https://openalex.org/W3041707911","https://openalex.org/W3043902401","https://openalex.org/W3124861943","https://openalex.org/W3144478225","https://openalex.org/W3185560091","https://openalex.org/W3213182232","https://openalex.org/W4212931002","https://openalex.org/W4298005902","https://openalex.org/W4304806288","https://openalex.org/W4385270787","https://openalex.org/W4387364234","https://openalex.org/W4391723450","https://openalex.org/W4401361289","https://openalex.org/W4405910881","https://openalex.org/W4406387259","https://openalex.org/W4406609583","https://openalex.org/W4406939471","https://openalex.org/W4408174239","https://openalex.org/W4417164590","https://openalex.org/W7133340342","https://openalex.org/W7134977962","https://openalex.org/W7139133867","https://openalex.org/W7167270785"],"related_works":["https://openalex.org/W1973636901","https://openalex.org/W2076327259","https://openalex.org/W2801152137","https://openalex.org/W2159764445","https://openalex.org/W2103509427","https://openalex.org/W2031820532","https://openalex.org/W2410278704","https://openalex.org/W2193978638","https://openalex.org/W7167270785","https://openalex.org/W2074504038"],"abstract_inverted_index":{"Human":[0],"leukocyte":[1],"antigen":[2,58,154,170],"(HLA)":[3],"associations":[4,82],"anchor":[5],"genetic":[6,150],"susceptibility":[7,14],"to":[8,15,108,152],"autoimmune":[9],"hepatitis":[10],"(AIH).":[11],"Connecting":[12],"this":[13],"the":[16,55,97,106],"immune":[17,52,90],"reactions":[18],"that":[19],"sustain":[20,109],"liver":[21,162],"injury":[22,111],"remains":[23],"a":[24,134],"central":[25],"challenge.":[26],"Recent":[27],"antigen-specific":[28,139,183],"experiments":[29,166],"and":[30,38,50,60,72,77,105,122,156,185],"tissue":[31,110,123],"analyses":[32],"provide":[33],"complementary":[34,89],"insights":[35],"into":[36],"recognition":[37,59,71],"injury.":[39,73,174],"This":[40],"Mini":[41],"Review":[42],"examines":[43],"how":[44],"population-specific":[45],"HLA":[46],"associations,":[47],"SepSecS-reactive":[48],"lymphocytes":[49],"intrahepatic":[51],"states":[53],"inform":[54],"relationship":[56],"between":[57,69],"inflammatory":[61,145,189],"amplification.":[62,190],"The":[63,131],"evidence":[64],"reveals":[65],"three":[66],"unresolved":[67],"relationships":[68],"susceptibility,":[70],"Class":[74],"II-restricted":[75],"autoreactivity":[76],"conditionally":[78],"independent":[79],"class":[80],"I":[81],"in":[83,136,161],"Han":[84],"Chinese":[85],"AIH":[86],"implicate":[87],"potentially":[88],"pathways.":[91],"Antigen-specific":[92],"T-cell":[93],"responses":[94,140],"extend":[95],"beyond":[96],"boundaries":[98],"defined":[99],"by":[100],"autoantibody":[101],"status.":[102],"Receptor":[103],"specificity":[104],"capacity":[107],"require":[112,182],"distinct":[113],"functional":[114],"tests.":[115],"We":[116],"evaluate":[117],"antigen-presentation":[118],"experiments,":[119],"receptor":[120],"studies":[121],"profiling,":[124],"distinguishing":[125],"human":[126],"observations":[127],"from":[128],"mechanistic":[129],"models.":[130],"synthesis":[132],"supports":[133],"model":[135],"which":[137,180,186],"heterogeneous":[138],"may":[141],"converge":[142],"on":[143],"shared":[144],"processes.":[146],"Priorities":[147],"include":[148],"linking":[149],"risk":[151],"natural":[153],"presentation":[155],"defining":[157],"autoreactive":[158],"clone":[159],"function":[160],"tissue.":[163],"Matched":[164],"perturbation":[165],"should":[167],"then":[168],"test":[169],"dependence":[171],"alongside":[172],"cytokine-dependent":[173],"Resolving":[175],"these":[176],"questions":[177],"would":[178],"clarify":[179],"mechanisms":[181],"intervention":[184],"reflect":[187],"downstream":[188]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-20T00:00:00"}