{"id":"https://openalex.org/W7222933928","doi":"https://doi.org/10.1038/s41422-026-01306-9","title":"Metabolic hallmarks of regulated cell death","display_name":"Metabolic hallmarks of regulated cell death","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222933928","doi":"https://doi.org/10.1038/s41422-026-01306-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/42897232","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13737170"},"language":"en","primary_location":{"id":"doi:10.1038/s41422-026-01306-9","doi":"https://doi.org/10.1038/s41422-026-01306-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41422-026-01306-9","pdf_url":"https://www.nature.com/articles/s41422-026-01306-9.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41422-026-01306-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112904481","display_name":"Rui Kang","orcid":"https://orcid.org/0000-0003-2725-1574","observed_orcids":["https://orcid.org/0000-0003-2725-1574"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rui Kang","raw_affiliation_strings":["Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA. rui.kang@utsouthwestern.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA. rui.kang@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100363126","display_name":"Xin Chen","orcid":"https://orcid.org/0000-0003-3668-4830","observed_orcids":["https://orcid.org/0000-0003-3668-4830"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Chen","raw_affiliation_strings":["Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China. chenxin@gzhmu.edu.cn","Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China. chenxin@gzhmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-3668-4830","affiliations":[{"raw_affiliation_string":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, China. chenxin@gzhmu.edu.cn","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China. chenxin@gzhmu.edu.cn","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210095243","display_name":"La Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210095243"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210102325","display_name":"H\u00f4pital Europ\u00e9en Georges-Pompidou","ror":"https://ror.org/016vx5156","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I4405255799","display_name":"Analyse mol\u00e9culaire, mod\u00e9lisation et imagerie de la maladie canc\u00e9reuse","ror":"https://ror.org/03ef0j886","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":["Centre de Recherche des Cordeliers, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm, Paris, France. kroemer@orange.fr","Centre de Recherche des Cordeliers, \u00c9quipe labellis\u00e9e par la Ligue contre le cancer, Paris, France. kroemer@orange.fr","Institut Gustave Roussy, Universit\u00e9 Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, UMS AMMICa, Villejuif Cedex, France. kroemer@orange.fr","Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges-Pompidou, AP-HP, Paris, France. kroemer@orange.fr"],"raw_orcid":"https://orcid.org/0000-0002-9334-4405","affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, Inserm, Paris, France. kroemer@orange.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Centre de Recherche des Cordeliers, \u00c9quipe labellis\u00e9e par la Ligue contre le cancer, Paris, France. kroemer@orange.fr","institution_ids":["https://openalex.org/I4210092322","https://openalex.org/I4210095243"]},{"raw_affiliation_string":"Institut Gustave Roussy, Universit\u00e9 Paris-Saclay, INSERM US23/CNRS UAR 3655, Metabolomics and Cell Biology Platforms, UMS AMMICa, Villejuif Cedex, France. kroemer@orange.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I4405255799"]},{"raw_affiliation_string":"Institut du Cancer Paris CARPEM, Department of Biology, H\u00f4pital Europ\u00e9en Georges-Pompidou, AP-HP, Paris, France. kroemer@orange.fr","institution_ids":["https://openalex.org/I4210097159","https://openalex.org/I4210102325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055468442","display_name":"Daolin Tang","orcid":"https://orcid.org/0000-0002-1903-6180","observed_orcids":["https://orcid.org/0000-0002-1903-6180","https://orcid.org/0000-0002-2650-3816"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daolin Tang","raw_affiliation_strings":["Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA. daolin.tang@utsouthwestern.edu"],"raw_orcid":"https://orcid.org/0000-0002-1903-6180","affiliations":[{"raw_affiliation_string":"Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA. daolin.tang@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5055468442","https://openalex.org/A5075296559","https://openalex.org/A5100363126","https://openalex.org/A5112904481"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I277688954","https://openalex.org/I2801843802","https://openalex.org/I39804081","https://openalex.org/I4210092322","https://openalex.org/I4210095243","https://openalex.org/I4210097159","https://openalex.org/I4210102325","https://openalex.org/I4405255799","https://openalex.org/I867280407","https://openalex.org/I92039509"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47102007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"11","first_page":"841","last_page":"873"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulated-cell-death","display_name":"regulated cell death","score":1.0},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bioenergetics","display_name":"bioenergetics","score":0.8650000095367432},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nutrient-availability","display_name":"nutrient availability","score":0.9150000214576721},{"id":"https://openalex.org/keywords/metal-ion-metabolism","display_name":"metal ion metabolism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/organelle-function","display_name":"organelle function","score":0.9599999785423279},{"id":"https://openalex.org/keywords/metabolic-homeostasis","display_name":"metabolic homeostasis","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8428000211715698},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6428999900817871},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5665000081062317},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.5590000152587891},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5586000084877014},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.5356000065803528},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4903999865055084},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4641999900341034},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.461899995803833},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4230000078678131},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.3968000113964081},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.37689998745918274},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.3686999976634979},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.3659999966621399},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3628999888896942},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.34040001034736633},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3305000066757202},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30160000920295715},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.258899986743927}],"mesh":[{"descriptor_ui":"D000079404","descriptor_name":"Regulated Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41422-026-01306-9","doi":"https://doi.org/10.1038/s41422-026-01306-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41422-026-01306-9","pdf_url":"https://www.nature.com/articles/s41422-026-01306-9.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13737170","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13737170/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13737170/pdf/41422_2026_Article_1306.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Res","raw_type":"Text"},{"id":"pmid:42897232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42897232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41422-026-01306-9","doi":"https://doi.org/10.1038/s41422-026-01306-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41422-026-01306-9","pdf_url":"https://www.nature.com/articles/s41422-026-01306-9.pdf","source":{"id":"https://openalex.org/S128296271","display_name":"Cell Research","issn_l":"1001-0602","issn":["1001-0602","1748-7838"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222933928.pdf","grobid_xml":"https://content.openalex.org/works/W7222933928.grobid-xml"},"referenced_works_count":440,"referenced_works":["https://openalex.org/W1523845694","https://openalex.org/W1598875012","https://openalex.org/W1793488575","https://openalex.org/W1830803900","https://openalex.org/W1864325817","https://openalex.org/W1882905539","https://openalex.org/W1913879859","https://openalex.org/W1966928113","https://openalex.org/W1975593978","https://openalex.org/W1976881265","https://openalex.org/W1978259246","https://openalex.org/W1979032223","https://openalex.org/W1979995768","https://openalex.org/W1982219839","https://openalex.org/W1984145308","https://openalex.org/W1984547206","https://openalex.org/W1985538633","https://openalex.org/W1989051519","https://openalex.org/W1992724001","https://openalex.org/W1995878762","https://openalex.org/W1996568613","https://openalex.org/W1997183854","https://openalex.org/W1999998145","https://openalex.org/W2002057703","https://openalex.org/W2002490399","https://openalex.org/W2004018261","https://openalex.org/W2008772139","https://openalex.org/W2009004909","https://openalex.org/W2010953153","https://openalex.org/W2013969500","https://openalex.org/W2014678245","https://openalex.org/W2016612145","https://openalex.org/W2018917075","https://openalex.org/W2018951108","https://openalex.org/W2023947368","https://openalex.org/W2024876727","https://openalex.org/W2027468963","https://openalex.org/W2027705428","https://openalex.org/W2032417513","https://openalex.org/W2033615443","https://openalex.org/W2033958147","https://openalex.org/W2034213169","https://openalex.org/W2035339329","https://openalex.org/W2035849683","https://openalex.org/W2035898183","https://openalex.org/W2038691856","https://openalex.org/W2039386747","https://openalex.org/W2043133007","https://openalex.org/W2044247344","https://openalex.org/W2044256586","https://openalex.org/W2046353863","https://openalex.org/W2049028195","https://openalex.org/W2052605153","https://openalex.org/W2052853635","https://openalex.org/W2053047691","https://openalex.org/W2055793916","https://openalex.org/W2057632732","https://openalex.org/W2059122356","https://openalex.org/W2060204808","https://openalex.org/W2062853648","https://openalex.org/W2063250341","https://openalex.org/W2064111002","https://openalex.org/W2065934830","https://openalex.org/W2067107606","https://openalex.org/W2074161856","https://openalex.org/W2074331191","https://openalex.org/W2077317536","https://openalex.org/W2079882002","https://openalex.org/W2081251630","https://openalex.org/W2081826742","https://openalex.org/W2082812721","https://openalex.org/W2083560313","https://openalex.org/W2084092576","https://openalex.org/W2084414744","https://openalex.org/W2089532303","https://openalex.org/W2091363184","https://openalex.org/W2091903353","https://openalex.org/W2093424661","https://openalex.org/W2094334993","https://openalex.org/W2094557223","https://openalex.org/W2094728839","https://openalex.org/W2095061901","https://openalex.org/W2100347985","https://openalex.org/W2102601355","https://openalex.org/W2102694854","https://openalex.org/W2104682444","https://openalex.org/W2104934425","https://openalex.org/W2108086395","https://openalex.org/W2110443482","https://openalex.org/W2112329697","https://openalex.org/W2112497627","https://openalex.org/W2113010696","https://openalex.org/W2115273524","https://openalex.org/W2117275311","https://openalex.org/W2118621467","https://openalex.org/W2119239003","https://openalex.org/W2119683782","https://openalex.org/W2122545253","https://openalex.org/W2126384811","https://openalex.org/W2127848114","https://openalex.org/W2129917557","https://openalex.org/W2130153302","https://openalex.org/W2130866079","https://openalex.org/W2130904379","https://openalex.org/W2131357993","https://openalex.org/W2131632095","https://openalex.org/W2131651601","https://openalex.org/W2131874160","https://openalex.org/W2132161879","https://openalex.org/W2135325091","https://openalex.org/W2137426380","https://openalex.org/W2139360111","https://openalex.org/W2142153200","https://openalex.org/W2145084709","https://openalex.org/W2147494386","https://openalex.org/W2149967205","https://openalex.org/W2150146658","https://openalex.org/W2155015733","https://openalex.org/W2156144699","https://openalex.org/W2160095658","https://openalex.org/W2163005196","https://openalex.org/W2164455918","https://openalex.org/W2171487873","https://openalex.org/W2171864779","https://openalex.org/W2238799256","https://openalex.org/W2269336718","https://openalex.org/W2286515888","https://openalex.org/W2314001535","https://openalex.org/W2321171642","https://openalex.org/W2340046691","https://openalex.org/W2343193821","https://openalex.org/W2345350059","https://openalex.org/W2414659015","https://openalex.org/W2418806051","https://openalex.org/W2462773201","https://openalex.org/W2507605260","https://openalex.org/W2513656923","https://openalex.org/W2517200974","https://openalex.org/W2518357275","https://openalex.org/W2529744299","https://openalex.org/W2549188196","https://openalex.org/W2550324626","https://openalex.org/W2554740475","https://openalex.org/W2554956457","https://openalex.org/W2567141944","https://openalex.org/W2586088194","https://openalex.org/W2600098707","https://openalex.org/W2604229956","https://openalex.org/W2605757478","https://openalex.org/W2610662698","https://openalex.org/W2724720631","https://openalex.org/W2727828415","https://openalex.org/W2731058674","https://openalex.org/W2745157077","https://openalex.org/W2745520112","https://openalex.org/W2752949400","https://openalex.org/W2767055857","https://openalex.org/W2768102094","https://openalex.org/W2773684309","https://openalex.org/W2774311191","https://openalex.org/W2775328130","https://openalex.org/W2783101187","https://openalex.org/W2788640168","https://openalex.org/W2793937397","https://openalex.org/W2794844698","https://openalex.org/W2796110207","https://openalex.org/W2797967513","https://openalex.org/W2799138908","https://openalex.org/W2808965517","https://openalex.org/W2810311636","https://openalex.org/W2883276664","https://openalex.org/W2883979293","https://openalex.org/W2898743739","https://openalex.org/W2901585624","https://openalex.org/W2904913900","https://openalex.org/W2905399276","https://openalex.org/W2906319220","https://openalex.org/W2913137771","https://openalex.org/W2925187261","https://openalex.org/W2932111434","https://openalex.org/W2935369648","https://openalex.org/W2951032968","https://openalex.org/W2964024721","https://openalex.org/W2964813970","https://openalex.org/W2971114720","https://openalex.org/W2976190258","https://openalex.org/W2980472864","https://openalex.org/W2981147011","https://openalex.org/W2981179816","https://openalex.org/W2990517669","https://openalex.org/W2991204446","https://openalex.org/W2995084623","https://openalex.org/W2995538608","https://openalex.org/W2997323331","https://openalex.org/W2998764961","https://openalex.org/W2998839829","https://openalex.org/W3001558881","https://openalex.org/W3005253578","https://openalex.org/W3010189141","https://openalex.org/W3010985052","https://openalex.org/W3011113661","https://openalex.org/W3013042853","https://openalex.org/W3013796529","https://openalex.org/W3015020891","https://openalex.org/W3016811071","https://openalex.org/W3017229457","https://openalex.org/W3021782974","https://openalex.org/W3031137362","https://openalex.org/W3033596777","https://openalex.org/W3035955336","https://openalex.org/W3047495533","https://openalex.org/W3047876262","https://openalex.org/W3048446878","https://openalex.org/W3048885175","https://openalex.org/W3079197556","https://openalex.org/W3080259742","https://openalex.org/W3080481237","https://openalex.org/W3080868475","https://openalex.org/W3082740036","https://openalex.org/W3085463956","https://openalex.org/W3087176574","https://openalex.org/W3093180754","https://openalex.org/W3094153900","https://openalex.org/W3095977572","https://openalex.org/W3096272935","https://openalex.org/W3100758850","https://openalex.org/W3105908160","https://openalex.org/W3109926818","https://openalex.org/W3110985405","https://openalex.org/W3112599058","https://openalex.org/W3115667040","https://openalex.org/W3148063552","https://openalex.org/W3162306949","https://openalex.org/W3165696383","https://openalex.org/W3186137292","https://openalex.org/W3186520869","https://openalex.org/W3192038789","https://openalex.org/W3196868249","https://openalex.org/W3197986920","https://openalex.org/W3201654321","https://openalex.org/W3212729908","https://openalex.org/W3216398121","https://openalex.org/W3217112298","https://openalex.org/W4205510409","https://openalex.org/W4210362116","https://openalex.org/W4214769648","https://openalex.org/W4220874228","https://openalex.org/W4221115671","https://openalex.org/W4223452433","https://openalex.org/W4224438193","https://openalex.org/W4225137755","https://openalex.org/W4226171806","https://openalex.org/W4237937003","https://openalex.org/W4280500694","https://openalex.org/W4280576708","https://openalex.org/W4281661536","https://openalex.org/W4283740151","https://openalex.org/W4283757038","https://openalex.org/W4288075260","https://openalex.org/W4289638016","https://openalex.org/W4290673796","https://openalex.org/W4293102630","https://openalex.org/W4294011199","https://openalex.org/W4294904414","https://openalex.org/W4296663008","https://openalex.org/W4296733991","https://openalex.org/W4300980006","https://openalex.org/W4309511756","https://openalex.org/W4312114253","https://openalex.org/W4313251792","https://openalex.org/W4313334507","https://openalex.org/W4313560629","https://openalex.org/W4315435482","https://openalex.org/W4318225055","https://openalex.org/W4319310752","https://openalex.org/W4320725463","https://openalex.org/W4321187714","https://openalex.org/W4362555325","https://openalex.org/W4376878477","https://openalex.org/W4377010652","https://openalex.org/W4378980763","https://openalex.org/W4379054858","https://openalex.org/W4382520352","https://openalex.org/W4382655460","https://openalex.org/W4383217259","https://openalex.org/W4384156273","https://openalex.org/W4385725383","https://openalex.org/W4385851748","https://openalex.org/W4387711110","https://openalex.org/W4388125734","https://openalex.org/W4388224026","https://openalex.org/W4388966580","https://openalex.org/W4389883146","https://openalex.org/W4390972061","https://openalex.org/W4391383725","https://openalex.org/W4391383764","https://openalex.org/W4391849363","https://openalex.org/W4392096707","https://openalex.org/W4392168628","https://openalex.org/W4392294768","https://openalex.org/W4392560844","https://openalex.org/W4392757422","https://openalex.org/W4393191344","https://openalex.org/W4393305591","https://openalex.org/W4394676329","https://openalex.org/W4394749244","https://openalex.org/W4395071408","https://openalex.org/W4395668201","https://openalex.org/W4398132002","https://openalex.org/W4399011819","https://openalex.org/W4399391228","https://openalex.org/W4399670685","https://openalex.org/W4400038574","https://openalex.org/W4400491884","https://openalex.org/W4401015538","https://openalex.org/W4401211263","https://openalex.org/W4401281576","https://openalex.org/W4401428136","https://openalex.org/W4401461894","https://openalex.org/W4402459576","https://openalex.org/W4403433533","https://openalex.org/W4403718851","https://openalex.org/W4404166083","https://openalex.org/W4404692453","https://openalex.org/W4404798447","https://openalex.org/W4404828833","https://openalex.org/W4404993840","https://openalex.org/W4405038055","https://openalex.org/W4405288781","https://openalex.org/W4405720312","https://openalex.org/W4406098599","https://openalex.org/W4407175773","https://openalex.org/W4407189655","https://openalex.org/W4407303782","https://openalex.org/W4407680458","https://openalex.org/W4408023404","https://openalex.org/W4408171292","https://openalex.org/W4408187422","https://openalex.org/W4408311562","https://openalex.org/W4408945349","https://openalex.org/W4409288431","https://openalex.org/W4409329540","https://openalex.org/W4409340233","https://openalex.org/W4409412590","https://openalex.org/W4409412632","https://openalex.org/W4409565505","https://openalex.org/W4409571503","https://openalex.org/W4409710864","https://openalex.org/W4409737200","https://openalex.org/W4409864420","https://openalex.org/W4410189348","https://openalex.org/W4410399870","https://openalex.org/W4410523843","https://openalex.org/W4410754994","https://openalex.org/W4410973894","https://openalex.org/W4411117137","https://openalex.org/W4411148113","https://openalex.org/W4411284868","https://openalex.org/W4411291618","https://openalex.org/W4411949905","https://openalex.org/W4412044612","https://openalex.org/W4412111100","https://openalex.org/W4412472636","https://openalex.org/W4412708549","https://openalex.org/W4413345517","https://openalex.org/W4413386055","https://openalex.org/W4413395782","https://openalex.org/W4413780938","https://openalex.org/W4414249397","https://openalex.org/W4414452656","https://openalex.org/W4414776365","https://openalex.org/W4415082062","https://openalex.org/W4415190965","https://openalex.org/W4415256112","https://openalex.org/W4415407852","https://openalex.org/W4415655430","https://openalex.org/W4415671931","https://openalex.org/W4415972782","https://openalex.org/W4416154940","https://openalex.org/W4416372936","https://openalex.org/W4416534334","https://openalex.org/W4416593139","https://openalex.org/W4416795338","https://openalex.org/W4416829829","https://openalex.org/W4416996473","https://openalex.org/W4417134430","https://openalex.org/W4417182048","https://openalex.org/W4417295650","https://openalex.org/W4417497903","https://openalex.org/W4417531200","https://openalex.org/W7117260246","https://openalex.org/W7117715914","https://openalex.org/W7118190624","https://openalex.org/W7126074734","https://openalex.org/W7127989426","https://openalex.org/W7128917239","https://openalex.org/W7129100804","https://openalex.org/W7129247800","https://openalex.org/W7129310075","https://openalex.org/W7130549407","https://openalex.org/W7130660923","https://openalex.org/W7131118164","https://openalex.org/W7133187847","https://openalex.org/W7133294021","https://openalex.org/W7133362722","https://openalex.org/W7133541954","https://openalex.org/W7133551335","https://openalex.org/W7134137438","https://openalex.org/W7134275623","https://openalex.org/W7135136636","https://openalex.org/W7135173101","https://openalex.org/W7135201355","https://openalex.org/W7138917030","https://openalex.org/W7139080857","https://openalex.org/W7140171844","https://openalex.org/W7141112055","https://openalex.org/W7149306168","https://openalex.org/W7149517005","https://openalex.org/W7149694632","https://openalex.org/W7151503954","https://openalex.org/W7154080874","https://openalex.org/W7155042677","https://openalex.org/W7155081907","https://openalex.org/W7155551913","https://openalex.org/W7156145118","https://openalex.org/W7156313586","https://openalex.org/W7160402473","https://openalex.org/W7160613425","https://openalex.org/W7160938501","https://openalex.org/W7161574345","https://openalex.org/W7161832647","https://openalex.org/W7162084019","https://openalex.org/W7162132883","https://openalex.org/W7163172393","https://openalex.org/W7163176989","https://openalex.org/W7163323865","https://openalex.org/W7165534218","https://openalex.org/W7165853267","https://openalex.org/W7171852209","https://openalex.org/W7202284665"],"related_works":["https://openalex.org/W7165853267","https://openalex.org/W7214353795","https://openalex.org/W4415390408","https://openalex.org/W2084092576","https://openalex.org/W170066957","https://openalex.org/W4414082589","https://openalex.org/W7137590011","https://openalex.org/W3155630646","https://openalex.org/W2935369648","https://openalex.org/W3030844453"],"abstract_inverted_index":{"Regulated":[0],"cell":[1,101,131],"death":[2,46,102],"(RCD)":[3],"is":[4],"characterized":[5],"by":[6,24,149],"distinct":[7],"molecular":[8],"execution":[9,52],"mechanisms,":[10],"but":[11,133],"its":[12],"initiation,":[13],"progression,":[14],"and":[15,38,47,51,69,80,95,107,122,141,153,156],"biological":[16],"consequences":[17,144],"are":[18],"increasingly":[19],"recognized":[20],"as":[21,127,134],"being":[22],"shaped":[23],"cellular":[25,43],"metabolism.":[26],"Bioenergetic":[27],"state,":[28],"redox":[29],"homeostasis,":[30],"nutrient":[31],"availability,":[32],"metal":[33],"ion":[34],"metabolism,":[35,37],"inflammatory":[36],"organelle":[39],"function":[40],"collectively":[41],"determine":[42],"susceptibility":[44],"to":[45,116],"influence":[48],"the":[49,62,88,117,162],"activation":[50],"of":[53,65,73,120,130,138,165],"diverse":[54],"RCD":[55,121],"programs.":[56],"In":[57],"this":[58],"review,":[59],"we":[60],"synthesize":[61],"metabolic":[63,83,93,118,163],"hallmarks":[64],"established,":[66],"independently":[67],"validated,":[68],"recently":[70],"proposed":[71],"forms":[72],"RCD,":[74],"highlighting":[75],"both":[76],"their":[77,81,98],"mechanistic":[78,154],"diversity":[79],"extensive":[82],"convergence.":[84],"We":[85,147],"then":[86],"examine":[87],"endogenous":[89],"mechanisms":[90],"that":[91],"maintain":[92],"homeostasis":[94],"discuss":[96],"how":[97],"disruption":[99],"reshapes":[100],"responses":[103],"in":[104],"human":[105],"disease":[106],"therapeutic":[108],"contexts.":[109],"Together,":[110],"these":[111],"insights":[112],"provide":[113],"a":[114,128,135],"guide":[115],"landscape":[119],"reveal":[123],"metabolism":[124],"not":[125],"only":[126],"modifier":[129],"death,":[132],"fundamental":[136],"determinant":[137],"when,":[139],"how,":[140],"with":[142],"what":[143],"cells":[145],"die.":[146],"conclude":[148],"discussing":[150],"key":[151],"conceptual":[152],"challenges":[155],"emerging":[157],"opportunities":[158],"for":[159],"therapeutically":[160],"exploiting":[161],"control":[164],"RCD.":[166]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-20T00:00:00"}
