{"id":"https://openalex.org/W7222932943","doi":"https://doi.org/10.3390/ijms27209270","title":"The Interplay Between Pediatric Atopic Dermatitis and Neurodevelopmental Disorders: Emerging Evidence, Mechanistic Insights, and Clinical Implications","display_name":"The Interplay Between Pediatric Atopic Dermatitis and Neurodevelopmental Disorders: Emerging Evidence, Mechanistic Insights, and Clinical Implications","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222932943","doi":"https://doi.org/10.3390/ijms27209270","pmid":"https://pubmed.ncbi.nlm.nih.gov/42942038","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13705164"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27209270","doi":"https://doi.org/10.3390/ijms27209270","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209270","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27209270","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120789738","display_name":"Xiaoya Ma","orcid":"https://orcid.org/0009-0000-9427-7462","observed_orcids":["https://orcid.org/0009-0000-9427-7462"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoya Ma","raw_affiliation_strings":["Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine"],"raw_orcid":"https://orcid.org/0009-0000-9427-7462","affiliations":[{"raw_affiliation_string":"Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159072196","display_name":"Zhuo Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo Chen","raw_affiliation_strings":["Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064694639","display_name":"Pengjie Wan","orcid":"https://orcid.org/0000-0001-8384-7407","observed_orcids":["https://orcid.org/0000-0001-8384-7407"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengjie Wan","raw_affiliation_strings":["Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101666767","display_name":"Dan Deng","orcid":"https://orcid.org/0000-0001-7317-283X","observed_orcids":["https://orcid.org/0000-0001-7317-283X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Deng","raw_affiliation_strings":["Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-7317-283X","affiliations":[{"raw_affiliation_string":"Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5118666764","display_name":"Alexander Anstey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800820451","display_name":"Musgrove Park Hospital","ror":"https://ror.org/042fv2404","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800820451"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander Anstey","raw_affiliation_strings":["Musgrove Park Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musgrove Park Hospital","institution_ids":["https://openalex.org/I2800820451"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61067111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"20","first_page":"9270","last_page":"9270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-atopic-dermatitis","display_name":"pediatric atopic dermatitis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/neurodevelopmental-disorders","display_name":"neurodevelopmental disorders","score":0.9980000257492065},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":1.0},{"id":"https://openalex.org/keywords/skin-brain-axis","display_name":"skin-brain axis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sleep-disruption","display_name":"sleep disruption","score":0.9390000104904175},{"id":"https://openalex.org/keywords/psychosocial-stress","display_name":"psychosocial stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/atopic-comorbidities","display_name":"atopic comorbidities","score":0.8519999980926514},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/developmental-surveillance","display_name":"child development monitoring","score":0.7689999938011169},{"id":"https://openalex.org/keywords/multidisciplinary-management","display_name":"multidisciplinary management","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.7573999762535095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6913999915122986},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6092000007629395},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.5659999847412109},{"id":"https://openalex.org/C2779388368","wikidata":"https://www.wikidata.org/wiki/Q3450985","display_name":"Neurodevelopmental disorder","level":3,"score":0.5152000188827515},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.5067999958992004},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.4715000092983246},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.39640000462532043},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.38260000944137573},{"id":"https://openalex.org/C78635009","wikidata":"https://www.wikidata.org/wiki/Q2109172","display_name":"Hygiene hypothesis","level":3,"score":0.3544999957084656},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.35260000824928284},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.34369999170303345},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3314000070095062},{"id":"https://openalex.org/C190684412","wikidata":"https://www.wikidata.org/wiki/Q21201832","display_name":"Filaggrin","level":3,"score":0.31859999895095825},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.3149999976158142},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C2778338976","wikidata":"https://www.wikidata.org/wiki/Q517104","display_name":"Wheeze","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29019999504089355},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C3017743773","wikidata":"https://www.wikidata.org/wiki/Q159979","display_name":"Monozygotic twin","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C2778594975","wikidata":"https://www.wikidata.org/wiki/Q3087172","display_name":"Developmental disorder","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2524999976158142},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.2522999942302704}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065886","descriptor_name":"Neurodevelopmental Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms27209270","doi":"https://doi.org/10.3390/ijms27209270","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209270","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.22541/au.176559136.67431898/v1","doi":"https://doi.org/10.22541/au.176559136.67431898/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.176559136.67431898/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.176559136.67431898/v1","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13705164","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705164/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13705164/pdf/ijms-27-09270.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42942038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42942038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27209270","doi":"https://doi.org/10.3390/ijms27209270","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27209270","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5582055711","display_name":null,"funder_award_id":"82203910","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320330670","display_name":"Shanghai Pudong New Area Health Commission","ror":"https://ror.org/041s47w50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222932943.pdf","grobid_xml":"https://content.openalex.org/works/W7222932943.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W1606922774","https://openalex.org/W1798688674","https://openalex.org/W1904997767","https://openalex.org/W1967827041","https://openalex.org/W1975121282","https://openalex.org/W1976164385","https://openalex.org/W1979466963","https://openalex.org/W1998000193","https://openalex.org/W2017542850","https://openalex.org/W2022600227","https://openalex.org/W2025345772","https://openalex.org/W2025802167","https://openalex.org/W2026942296","https://openalex.org/W2050040086","https://openalex.org/W2051840885","https://openalex.org/W2056518522","https://openalex.org/W2057393070","https://openalex.org/W2067255906","https://openalex.org/W2070769297","https://openalex.org/W2088552013","https://openalex.org/W2089176003","https://openalex.org/W2091427002","https://openalex.org/W2091921019","https://openalex.org/W2110370692","https://openalex.org/W2116570550","https://openalex.org/W2121095822","https://openalex.org/W2126742635","https://openalex.org/W2137207936","https://openalex.org/W2141857876","https://openalex.org/W2153298564","https://openalex.org/W2168301089","https://openalex.org/W2186214466","https://openalex.org/W2260904522","https://openalex.org/W2295001406","https://openalex.org/W2307068968","https://openalex.org/W2345736995","https://openalex.org/W2466729104","https://openalex.org/W2469957454","https://openalex.org/W2470735313","https://openalex.org/W2505649614","https://openalex.org/W2519925888","https://openalex.org/W2529680825","https://openalex.org/W2553830639","https://openalex.org/W2556036718","https://openalex.org/W2572080179","https://openalex.org/W2600345547","https://openalex.org/W2604697269","https://openalex.org/W2741189881","https://openalex.org/W2762361114","https://openalex.org/W2765965774","https://openalex.org/W2789024274","https://openalex.org/W2789533527","https://openalex.org/W2885934404","https://openalex.org/W2885967118","https://openalex.org/W2891904864","https://openalex.org/W2897204831","https://openalex.org/W2903939799","https://openalex.org/W2904371741","https://openalex.org/W2905507067","https://openalex.org/W2918395485","https://openalex.org/W2956862886","https://openalex.org/W2968064626","https://openalex.org/W2981035082","https://openalex.org/W2981330976","https://openalex.org/W2989651886","https://openalex.org/W2999725632","https://openalex.org/W3014352885","https://openalex.org/W3025251467","https://openalex.org/W3026952914","https://openalex.org/W3036562415","https://openalex.org/W3037648206","https://openalex.org/W3040875857","https://openalex.org/W3091989788","https://openalex.org/W3114335419","https://openalex.org/W3120289132","https://openalex.org/W3124764718","https://openalex.org/W3135504907","https://openalex.org/W3187226810","https://openalex.org/W3192687721","https://openalex.org/W4205208197","https://openalex.org/W4207002634","https://openalex.org/W4210592049","https://openalex.org/W4210708461","https://openalex.org/W4211013257","https://openalex.org/W4211026773","https://openalex.org/W4226154181","https://openalex.org/W4232712261","https://openalex.org/W4283692918","https://openalex.org/W4283832665","https://openalex.org/W4293125246","https://openalex.org/W4306399084","https://openalex.org/W4308147217","https://openalex.org/W4309742232","https://openalex.org/W4311864310","https://openalex.org/W4313622207","https://openalex.org/W4317492931","https://openalex.org/W4318831372","https://openalex.org/W4319985806","https://openalex.org/W4365135765","https://openalex.org/W4376113588","https://openalex.org/W4377094737","https://openalex.org/W4384819213","https://openalex.org/W4385308047","https://openalex.org/W4386402455","https://openalex.org/W4386979622","https://openalex.org/W4388074004","https://openalex.org/W4388129627","https://openalex.org/W4388484408","https://openalex.org/W4388665832","https://openalex.org/W4389231358","https://openalex.org/W4389564602","https://openalex.org/W4390508040","https://openalex.org/W4390743777","https://openalex.org/W4391036002","https://openalex.org/W4391543845","https://openalex.org/W4392509101","https://openalex.org/W4392654899","https://openalex.org/W4396592360","https://openalex.org/W4399355102","https://openalex.org/W4401113283","https://openalex.org/W4401384599","https://openalex.org/W4401494409","https://openalex.org/W4401504643","https://openalex.org/W4401639894","https://openalex.org/W4401728762","https://openalex.org/W4402927327","https://openalex.org/W4404135583","https://openalex.org/W4404504633","https://openalex.org/W4405515057","https://openalex.org/W4406422770","https://openalex.org/W4407110912","https://openalex.org/W4407460947","https://openalex.org/W4408991633","https://openalex.org/W4411132873","https://openalex.org/W4411134856","https://openalex.org/W4411895416","https://openalex.org/W4411927895","https://openalex.org/W7140297912","https://openalex.org/W7141032939"],"related_works":["https://openalex.org/W4417290243","https://openalex.org/W7204593884","https://openalex.org/W3091989788","https://openalex.org/W3109471010","https://openalex.org/W2305643977","https://openalex.org/W2559849158","https://openalex.org/W1767753605","https://openalex.org/W3036391521","https://openalex.org/W7166142031","https://openalex.org/W2985565832"],"abstract_inverted_index":{"Atopic":[0],"dermatitis":[1],"(AD)":[2],"is":[3,13],"a":[4,17],"common":[5],"chronic":[6],"inflammatory":[7],"skin":[8,81],"disease":[9,108],"in":[10,90,124],"children":[11,91],"and":[12,38,46,53,58,61,63,73,100,116,133,138,156,165],"increasingly":[14],"recognized":[15],"as":[16],"systemic":[18],"disorder":[19,36,41],"with":[20,83,92,127],"potential":[21,78],"consequences":[22],"beyond":[23],"the":[24,44,105,121],"skin.":[25],"Growing":[26],"evidence":[27,115,143],"links":[28],"pediatric":[29,125],"AD":[30,153,170],"to":[31,68,119,130,161],"neurodevelopmental":[32,157,175],"disorders,":[33],"particularly":[34],"attention-deficit/hyperactivity":[35],"(ADHD)":[37],"autism":[39],"spectrum":[40],"(ASD),":[42],"but":[43],"mechanisms":[45,118],"clinical":[47],"implications":[48,134],"remain":[49],"incompletely":[50],"understood.":[51],"Systemic":[52],"neuroimmune":[54],"inflammation,":[55],"altered":[56],"T-helper-cell":[57],"cytokine":[59],"signaling,":[60],"genetic":[62],"epigenetic":[64],"susceptibility":[65],"may":[66],"contribute":[67],"this":[69],"association.":[70],"Sleep":[71],"disruption":[72],"psychosocial":[74],"stress":[75],"represent":[76],"additional":[77],"pathways":[79],"linking":[80],"inflammation":[82],"neurodevelopment.":[84],"Stronger":[85],"associations":[86],"have":[87],"been":[88],"reported":[89],"severe":[93],"or":[94],"early-onset":[95],"AD,":[96,126],"multiple":[97],"atopic":[98],"comorbidities,":[99],"persistent":[101],"sleep":[102],"disturbance,":[103],"highlighting":[104],"importance":[106],"of":[107],"heterogeneity.":[109],"This":[110],"narrative":[111],"review":[112],"integrates":[113],"epidemiologic":[114],"proposed":[117],"examine":[120],"skin-brain":[122],"axis":[123],"particular":[128],"attention":[129],"high-risk":[131],"phenotypes":[132],"for":[135],"developmental":[136],"surveillance":[137],"multidisciplinary":[139],"management.":[140],"Although":[141],"current":[142],"supports":[144],"an":[145],"association,":[146],"causality":[147],"remains":[148],"uncertain.":[149],"Prospective":[150],"studies":[151],"integrating":[152],"phenotypes,":[154],"biomarkers,":[155],"assessments":[158],"are":[159],"needed":[160],"clarify":[162],"these":[163],"relationships":[164],"determine":[166],"whether":[167],"early":[168],"effective":[169],"treatment":[171],"can":[172],"modify":[173],"long-term":[174],"trajectories.":[176]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-20T00:00:00"}
