{"id":"https://openalex.org/W7222932785","doi":"https://doi.org/10.64898/2026.10.16.759547","title":"A Computational Framework for Understanding HCV Infection and Associated Lipid Dynamics","display_name":"A Computational Framework for Understanding HCV Infection and Associated Lipid Dynamics","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222932785","doi":"https://doi.org/10.64898/2026.10.16.759547"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.16.759547","doi":"https://doi.org/10.64898/2026.10.16.759547","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.16.759547","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.16.759547.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.16.759547.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159026615","display_name":"Andrew Jacoby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Jacoby","raw_affiliation_strings":["MIT, Department of Mathematics, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT, Department of Mathematics, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159043209","display_name":"Samiran Ghosh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samiran Ghosh","raw_affiliation_strings":["CSIR National Institute of Data Science and AI, Wind Tunnel Road, Bangalore, 560037, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR National Institute of Data Science and AI, Wind Tunnel Road, Bangalore, 560037, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062102948","display_name":"Malay Banerjee","orcid":"https://orcid.org/0000-0003-4327-5904","observed_orcids":["https://orcid.org/0000-0003-4327-5904"]},"institutions":[{"id":"https://openalex.org/I94234084","display_name":"Indian Institute of Technology Kanpur","ror":"https://ror.org/05pjsgx75","country_code":"IN","type":"education","lineage":["https://openalex.org/I94234084"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Malay Banerjee","raw_affiliation_strings":["Indian Institute of Technology Kanpur; Department of Mathematics, Kanpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Technology Kanpur; Department of Mathematics, Kanpur, India","institution_ids":["https://openalex.org/I94234084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010879040","display_name":"Aditi Ghosh","orcid":"https://orcid.org/0000-0003-4239-0038","observed_orcids":["https://orcid.org/0000-0003-4239-0038"]},"institutions":[{"id":"https://openalex.org/I2801014300","display_name":"Florida Gulf Coast University","ror":"https://ror.org/05tc5bm31","country_code":"US","type":"education","lineage":["https://openalex.org/I2801014300"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Aditi Ghosh","raw_affiliation_strings":["Florida Gulf Coast University, Department of Mathematics, Fort Myers,, USA"],"raw_orcid":"https://orcid.org/0000-0003-4239-0038","affiliations":[{"raw_affiliation_string":"Florida Gulf Coast University, Department of Mathematics, Fort Myers,, USA","institution_ids":["https://openalex.org/I2801014300"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045766768","display_name":"Vitaly A Volpert","orcid":"https://orcid.org/0000-0002-5323-9934","observed_orcids":["https://orcid.org/0000-0002-5323-9934"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210104796","display_name":"Institut Camille Jordan","ror":"https://ror.org/01ekw7f87","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210104796","https://openalex.org/I4405259976","https://openalex.org/I48430043"]},{"id":"https://openalex.org/I4210119410","display_name":"Institute of Fundamental Technological Research","ror":"https://ror.org/03fs4aq04","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["FR","PL"],"is_corresponding":false,"raw_author_name":"Vitaly Volpert","raw_affiliation_strings":["Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, France","Institute of Fundamental Technological Research, Polish Academy of Sciences, 5B Pawinskiego St., 02-106 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I4210104796"]},{"raw_affiliation_string":"Institute of Fundamental Technological Research, Polish Academy of Sciences, 5B Pawinskiego St., 02-106 Warsaw, Poland","institution_ids":["https://openalex.org/I4210119410","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010879040"],"corresponding_institution_ids":["https://openalex.org/I2801014300"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/host-lipid-metabolism","display_name":"host lipid metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reaction-diffusion-systems","display_name":"reaction-diffusion systems","score":0.8880000114440918},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.6330000162124634},{"id":"https://openalex.org/keywords/immunological-memory","display_name":"immunological memory","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6664999723434448},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5782999992370605},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5770000219345093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5271000266075134},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.49480000138282776},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.45969998836517334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43970000743865967},{"id":"https://openalex.org/C2781463415","wikidata":"https://www.wikidata.org/wiki/Q2082778","display_name":"Hepacivirus","level":4,"score":0.4341999888420105},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4115999937057495},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.34860000014305115},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.32109999656677246},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C144464004","wikidata":"https://www.wikidata.org/wiki/Q3077338","display_name":"Lipid A","level":3,"score":0.2978000044822693},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.29339998960494995},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.28769999742507935},{"id":"https://openalex.org/C3019983190","wikidata":"https://www.wikidata.org/wiki/Q157661","display_name":"Hepatitis a virus","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C2779174946","wikidata":"https://www.wikidata.org/wiki/Q751911","display_name":"RNA virus","level":4,"score":0.27410000562667847},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2702000141143799},{"id":"https://openalex.org/C2777072776","wikidata":"https://www.wikidata.org/wiki/Q1983841","display_name":"Viral hepatitis","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2574999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.16.759547","doi":"https://doi.org/10.64898/2026.10.16.759547","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.16.759547","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.16.759547.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.16.759547","doi":"https://doi.org/10.64898/2026.10.16.759547","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.16.759547","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/19/2026.10.16.759547.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222932785.pdf","grobid_xml":"https://content.openalex.org/works/W7222932785.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1481102184","https://openalex.org/W1961705168","https://openalex.org/W1997579187","https://openalex.org/W2027030357","https://openalex.org/W2032840033","https://openalex.org/W2047028523","https://openalex.org/W2123724780","https://openalex.org/W2126205829","https://openalex.org/W2158489341","https://openalex.org/W2315879504","https://openalex.org/W2401321240","https://openalex.org/W2518843464","https://openalex.org/W2519616155","https://openalex.org/W2741576343","https://openalex.org/W4282932107"],"related_works":["https://openalex.org/W7168034352","https://openalex.org/W2123724780","https://openalex.org/W4365509059","https://openalex.org/W3090155597","https://openalex.org/W4389115128","https://openalex.org/W2047384841","https://openalex.org/W2013018952","https://openalex.org/W2047028523","https://openalex.org/W4319600819","https://openalex.org/W2130463797"],"abstract_inverted_index":{"Abstract":[0],"Hepatitis":[1],"C":[2],"virus":[3,163],"(HCV)":[4],"infection":[5,69,104],"is":[6,14],"strongly":[7],"intertwined":[8],"with":[9,17,71,86],"host":[10,33],"lipid":[11,25,53,73,92,100,113],"metabolism":[12,54,164],"and":[13,39,52,108,136,139,155],"frequently":[15],"associated":[16],"hepatic":[18],"steatosis,":[19],"particularly":[20],"in":[21,102,166],"genotype-specific":[22],"cases":[23],"where":[24],"accumulation":[26,114],"reflects":[27],"direct":[28],"viral":[29,50,84,121,143],"effects":[30],"rather":[31],"than":[32],"metabolic":[34,89],"comorbidities.":[35],"Despite":[36],"extensive":[37],"clinical":[38],"experimental":[40],"evidence,":[41],"a":[42,62,78,87,117,157],"quantitative":[43],"framework":[44,76,148],"capturing":[45],"the":[46,97,127,147],"bidirectional":[47],"coupling":[48],"between":[49],"dynamics":[51,70,154],"remains":[55],"lacking.":[56],"In":[57],"this":[58],"work,":[59],"we":[60],"develop":[61],"comprehensive":[63],"mathematical":[64],"model":[65,124],"that":[66,112],"integrates":[67],"HCV":[68,153],"intracellular":[72],"regulation.":[74],"The":[75,123],"combines":[77],"reaction":[79],"diffusion":[80],"system":[81],"for":[82,161],"spatial":[83],"spread":[85],"coupled":[88],"module":[90],"describing":[91],"influx.":[93],"Numerical":[94],"simulations":[95],"highlight":[96],"role":[98,129],"of":[99,120,130],"feedback":[101],"shifting":[103],"outcomes":[105],"toward":[106],"persistence":[107],"recurrent":[109],"oscillations,":[110],"demonstrating":[111],"acts":[115],"as":[116],"critical":[118,128],"driver":[119],"amplification.":[122],"also":[125],"highlights":[126],"immune":[131],"memory":[132],"to":[133],"study":[134],"acute":[135],"chronic":[137],"phase":[138],"successfully":[140],"reproduces":[141],"observed":[142],"RNA":[144],"trajectories.":[145],"Overall,":[146],"provides":[149],"mechanistic":[150],"insights":[151],"into":[152],"offers":[156],"general":[158],"modeling":[159],"approach":[160],"studying":[162],"interactions":[165],"liver":[167],"disease.":[168]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-20T00:00:00"}