{"id":"https://openalex.org/W7222931084","doi":"https://doi.org/10.3389/fphar.2026.1919037","title":"From sepsis to necrotizing enterocolitis with appendiceal perforation: a case report of successful salvage therapy with aztreonam\u2013avibactam in an extremely preterm infant with NDM-producing Klebsiella pneumoniae","display_name":"From sepsis to necrotizing enterocolitis with appendiceal perforation: a case report of successful salvage therapy with aztreonam\u2013avibactam in an extremely preterm infant with NDM-producing Klebsiella pneumoniae","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222931084","doi":"https://doi.org/10.3389/fphar.2026.1919037","pmid":"https://pubmed.ncbi.nlm.nih.gov/42974142","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13725202"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1919037","doi":"https://doi.org/10.3389/fphar.2026.1919037","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1919037","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1919037/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1919037/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062190790","display_name":"Yang He","orcid":"https://orcid.org/0000-0003-0952-2465","observed_orcids":["https://orcid.org/0000-0003-0952-2465"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang He","raw_affiliation_strings":["Department of Pediatrics, West China Second University Hospital, Sichuan University","Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159056895","display_name":"Jichong Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jichong Huang","raw_affiliation_strings":["Department of Pediatrics, West China Second University Hospital, Sichuan University","Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667892","display_name":"Bin Du","orcid":"https://orcid.org/0000-0002-2814-0406","observed_orcids":["https://orcid.org/0000-0002-2814-0406"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Du","raw_affiliation_strings":["Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159057782","display_name":"Zhe Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Chen","raw_affiliation_strings":["Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147878404","display_name":"Liang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Huang","raw_affiliation_strings":["Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116618613","display_name":"Jing Shi","orcid":"https://orcid.org/0009-0004-9767-3486","observed_orcids":["https://orcid.org/0009-0004-9767-3486"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Shi","raw_affiliation_strings":["Department of Pediatrics, West China Second University Hospital, Sichuan University","Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159037066","display_name":"Min Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhang","raw_affiliation_strings":["Department of Pediatric General Surgery, West China Second University Hospital, Sichuan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric General Surgery, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159089268","display_name":"Li Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Department of Pediatrics, West China Second University Hospital, Sichuan University","Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078707641","display_name":"Jun Tang","orcid":"https://orcid.org/0009-0009-8156-4580","observed_orcids":["https://orcid.org/0009-0009-8156-4580","https://orcid.org/0000-0003-3177-8926"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210089228","display_name":"West China Second University Hospital of Sichuan University","ror":"https://ror.org/00726et14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089228"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Tang","raw_affiliation_strings":["Department of Pediatrics, West China Second University Hospital, Sichuan University","Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, West China Second University Hospital, Sichuan University","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"]},{"raw_affiliation_string":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education","institution_ids":["https://openalex.org/I24185976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078707641","https://openalex.org/A5159089268"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210089228"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74501563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1919037","last_page":"1919037"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9146000146865845,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aztreonam-avibactam","display_name":"aztreonam-avibactam","score":0.9390000104904175},{"id":"https://openalex.org/keywords/new-delhi-metallo-beta-lactamase","display_name":"New Delhi metallo-beta-lactamase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9629999995231628},{"id":"https://openalex.org/keywords/extremely-preterm-infants","display_name":"extremely preterm infants","score":0.781000018119812},{"id":"https://openalex.org/keywords/neonatal-sepsis","display_name":"neonatal sepsis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/necrotizing-enterocolitis","display_name":"necrotizing enterocolitis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/appendiceal-perforation","display_name":"appendiceal perforation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/necrotizing-fasciitis","display_name":"necrotizing fasciitis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.8790000081062317},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.859000027179718},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.7710000276565552},{"id":"https://openalex.org/keywords/metagenomic-next-generation-sequencing","display_name":"metagenomic next-generation sequencing","score":0.9110000133514404},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.7960000038146973},{"id":"https://openalex.org/keywords/pulmonary-hemorrhage","display_name":"pulmonary hemorrhage","score":0.7850000262260437},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8992999792098999},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.6887000203132629},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.6049000024795532},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5810999870300293},{"id":"https://openalex.org/C2776258884","wikidata":"https://www.wikidata.org/wiki/Q3055368","display_name":"Enterocolitis","level":2,"score":0.4943999946117401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47049999237060547},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46309998631477356},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4456000030040741},{"id":"https://openalex.org/C2780416669","wikidata":"https://www.wikidata.org/wiki/Q418546","display_name":"Aztreonam","level":5,"score":0.4068000018596649},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.38269999623298645},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3425999879837036},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.31949999928474426},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.31709998846054077},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.3107999861240387},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3086000084877014},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.26899999380111694}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2026.1919037","doi":"https://doi.org/10.3389/fphar.2026.1919037","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1919037","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1919037/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13725202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725202/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13725202/pdf/fphar-17-1919037.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:42974142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42974142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:823d7d6907274459bcac5b0aef55d3c5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/823d7d6907274459bcac5b0aef55d3c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1919037","doi":"https://doi.org/10.3389/fphar.2026.1919037","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1919037","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1919037/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[{"id":"https://openalex.org/G2649673857","display_name":null,"funder_award_id":"2025ZNSFSC0693","funder_id":"https://openalex.org/F4320329861","funder_display_name":"Natural Science Foundation of Sichuan Province"},{"id":"https://openalex.org/G4986530540","display_name":null,"funder_award_id":"2024YFC2707700","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7957276715","display_name":null,"funder_award_id":"GZC20241118","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320329861","display_name":"Natural Science Foundation of Sichuan Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222931084.pdf","grobid_xml":"https://content.openalex.org/works/W7222931084.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2911566892","https://openalex.org/W2939572893","https://openalex.org/W3040924159","https://openalex.org/W3113296698","https://openalex.org/W4381329199","https://openalex.org/W4386496928","https://openalex.org/W4392164284","https://openalex.org/W4400013149","https://openalex.org/W4401576847","https://openalex.org/W4402319060","https://openalex.org/W4416935946","https://openalex.org/W4417312486","https://openalex.org/W4417343584"],"related_works":["https://openalex.org/W7203464185","https://openalex.org/W2993614856","https://openalex.org/W7116054589","https://openalex.org/W7118069353","https://openalex.org/W2985769491","https://openalex.org/W3157588915","https://openalex.org/W3105062735","https://openalex.org/W7212072433","https://openalex.org/W2107642559","https://openalex.org/W4223595696"],"abstract_inverted_index":{"Infections":[0],"caused":[1],"by":[2,82,144],"New":[3],"Delhi":[4],"metallo-\u03b2-lactamase":[5],"(NDM)-producing":[6],"Klebsiella":[7,64],"pneumoniae":[8,65,108,183],"represent":[9],"a":[10,45,56,175],"major":[11],"therapeutic":[12],"challenge":[13],"in":[14,17,185,195],"neonatology,":[15],"particularly":[16],"extremely":[18,186],"preterm":[19,187],"infants,":[20,188],"for":[21,32,179],"whom":[22],"effective":[23,114],"options":[24],"are":[25,198],"limited":[26],"and":[27,29,92,97,116,147,149,158,192],"dosing":[28],"safety":[30,193],"data":[31,194],"last-resort":[33],"agents":[34],"such":[35],"as":[36,125],"aztreonam-avibactam":[37,122,137,165,172],"remain":[38],"scarce.":[39],"We":[40],"report":[41],"the":[42,111],"case":[43,169],"of":[44,53,59,113,156],"male":[46],"infants":[47],"born":[48],"at":[49],"24":[50],"+2":[51],"weeks":[52],"gestation":[54],"with":[55,67,74],"birth":[57],"weight":[58],"530":[60],"g":[61],"who":[62],"developed":[63],"sepsis":[66],"poor":[68],"clinical":[69,78,118,129],"response":[70],"to":[71,142,164],"aztreonam":[72],"combined":[73],"polymyxin":[75],"B.":[76],"His":[77],"course":[79],"was":[80,123,131],"complicated":[81],"pulmonary":[83],"hemorrhage,":[84],"disseminated":[85],"intravascular":[86],"coagulation,":[87],"necrotizing":[88,94],"enterocolitis,":[89],"appendiceal":[90],"perforation,":[91],"suspected":[93],"fasciitis.":[95],"Blood":[96],"ascitic":[98],"fluid":[99],"metagenomic":[100],"next-generation":[101],"sequencing":[102],"(mNGS)":[103],"identified":[104],"NDM-producing":[105,181],"carbapenem-resistant":[106],"K.":[107,182],".":[109],"Given":[110],"lack":[112],"alternatives":[115],"ongoing":[117],"deterioration,":[119],"off-label":[120],"intravenous":[121],"initiated":[124],"salvage":[126,177],"therapy.":[127],"Marked":[128],"improvement":[130],"observed":[132],"within":[133],"4":[134],"days":[135,155],"after":[136,153],"treatment,":[138,157],"blood":[139],"mNGS":[140],"converted":[141],"negative":[143],"day":[145],"6,":[146],"skin":[148],"gastrointestinal":[150],"manifestations":[151],"resolved":[152],"10":[154],"no":[159],"adverse":[160],"events":[161],"considered":[162],"attributable":[163],"were":[166],"identified.":[167],"This":[168],"suggests":[170],"that":[171],"may":[173],"be":[174],"viable":[176],"option":[178],"life-threatening":[180],"infections":[184],"though":[189],"prospective":[190],"pharmacokinetic":[191],"this":[196],"population":[197],"urgently":[199],"warranted.":[200]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-20T00:00:00"}