{"id":"https://openalex.org/W7222928356","doi":"https://doi.org/10.1371/journal.pbio.3004032","title":"Oxidative signaling thresholds shape vulnerability in the central and peripheral nervous systems","display_name":"Oxidative signaling thresholds shape vulnerability in the central and peripheral nervous systems","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222928356","doi":"https://doi.org/10.1371/journal.pbio.3004032","pmid":"https://pubmed.ncbi.nlm.nih.gov/42895942","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13679830"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.3004032","doi":"https://doi.org/10.1371/journal.pbio.3004032","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3004032","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004032&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004032&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102979187","display_name":"Shuji Wakatsuki","orcid":"https://orcid.org/0000-0003-2403-5876","observed_orcids":["https://orcid.org/0000-0003-2403-5876"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]},{"id":"https://openalex.org/I4405287400","display_name":"National Institute of Neuroscience","ror":"https://ror.org/052fnx536","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shuji Wakatsuki","raw_affiliation_strings":["National Institute of Neuroscience, National Center of Neurology and Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Neuroscience, National Center of Neurology and Psychiatry","institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081349935","display_name":"Toshiyuki Araki","orcid":"https://orcid.org/0000-0003-3625-2042","observed_orcids":["https://orcid.org/0000-0003-3625-2042"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]},{"id":"https://openalex.org/I4405287400","display_name":"National Institute of Neuroscience","ror":"https://ror.org/052fnx536","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiyuki Araki","raw_affiliation_strings":["National Institute of Neuroscience, National Center of Neurology and Psychiatry"],"raw_orcid":"https://orcid.org/0000-0003-3625-2042","affiliations":[{"raw_affiliation_string":"National Institute of Neuroscience, National Center of Neurology and Psychiatry","institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081349935","https://openalex.org/A5102979187"],"corresponding_institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4405287400"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":1.4605,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86911362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"24","issue":"10","first_page":"e3004032","last_page":"e3004032"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8479999899864197},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.972000002861023},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neuronal-vulnerability","display_name":"neuronal vulnerability","score":0.9570000171661377},{"id":"https://openalex.org/keywords/signaling-threshold","display_name":"signal threshold","score":0.8579999804496765},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/selective-neuronal-vulnerability","display_name":"selective neuronal vulnerability","score":0.6190000176429749},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9340000152587891},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.7210000157356262},{"id":"https://openalex.org/keywords/peripheral-nervous-system","display_name":"peripheral nervous system","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8452000021934509},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.73089998960495},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7041000127792358},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6406999826431274},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6277999877929688},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5849000215530396},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.5570999979972839},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.4950000047683716},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4618000090122223},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4422999918460846},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.42649999260902405},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4032999873161316},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3625999987125397},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.31630000472068787},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C2993744773","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Neuronal damage","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.25200000405311584}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017933","descriptor_name":"Peripheral Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017933","descriptor_name":"Peripheral Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pbio.3004032","doi":"https://doi.org/10.1371/journal.pbio.3004032","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3004032","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004032&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13679830","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13679830/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13679830/pdf/pbio.3004032.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biol","raw_type":"Text"},{"id":"pmid:42895942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42895942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b2fbcb13a8714f9595768f3c9fc80a50","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b2fbcb13a8714f9595768f3c9fc80a50","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 24, Iss 10, p e3004032 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.3004032","doi":"https://doi.org/10.1371/journal.pbio.3004032","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.3004032","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3004032&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222928356.pdf","grobid_xml":"https://content.openalex.org/works/W7222928356.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1823204572","https://openalex.org/W1921965616","https://openalex.org/W1976599392","https://openalex.org/W1997288864","https://openalex.org/W2007636933","https://openalex.org/W2014880757","https://openalex.org/W2017275974","https://openalex.org/W2020583309","https://openalex.org/W2033007699","https://openalex.org/W2033448006","https://openalex.org/W2042776153","https://openalex.org/W2042991032","https://openalex.org/W2045497115","https://openalex.org/W2061076314","https://openalex.org/W2066218351","https://openalex.org/W2068539809","https://openalex.org/W2073168231","https://openalex.org/W2077351642","https://openalex.org/W2078184099","https://openalex.org/W2085203929","https://openalex.org/W2101861123","https://openalex.org/W2104968232","https://openalex.org/W2105970121","https://openalex.org/W2117800935","https://openalex.org/W2122341467","https://openalex.org/W2133451731","https://openalex.org/W2149745285","https://openalex.org/W2152165298","https://openalex.org/W2162305076","https://openalex.org/W2176436851","https://openalex.org/W2770446525","https://openalex.org/W2788048790","https://openalex.org/W2883441729","https://openalex.org/W2976277219","https://openalex.org/W2984519822","https://openalex.org/W3013352992","https://openalex.org/W3133905451","https://openalex.org/W3163504032","https://openalex.org/W3164329676","https://openalex.org/W3194459937","https://openalex.org/W3201742690","https://openalex.org/W4205131389","https://openalex.org/W4212860519","https://openalex.org/W4281491151","https://openalex.org/W4295027538","https://openalex.org/W4312128822","https://openalex.org/W4362665505","https://openalex.org/W4409152849","https://openalex.org/W7164517865"],"related_works":["https://openalex.org/W2081708414","https://openalex.org/W2155634762","https://openalex.org/W4407895111","https://openalex.org/W2174493934","https://openalex.org/W2945953380","https://openalex.org/W4220689352","https://openalex.org/W4401894152","https://openalex.org/W7099310095","https://openalex.org/W2030198251","https://openalex.org/W2970291323"],"abstract_inverted_index":{"Neurodegeneration":[0],"is":[1,60],"frequently":[2],"associated":[3],"with":[4],"oxidative":[5],"stress,":[6],"yet":[7],"the":[8,25],"mechanisms":[9],"that":[10,57],"convert":[11],"reactive":[12],"oxygen":[13],"species":[14],"(ROS)":[15],"into":[16],"irreversible":[17],"degenerative":[18],"signals":[19],"remain":[20],"incompletely":[21],"understood.":[22],"Neurons":[23],"in":[24,33,93],"central":[26],"and":[27,50,70,78,96],"peripheral":[28],"nervous":[29],"systems":[30],"often":[31],"differ":[32],"their":[34],"responses":[35],"to":[36,44,80],"injury,":[37],"but":[38],"these":[39],"differences":[40],"cannot":[41],"be":[42],"reduced":[43],"a":[45],"simple":[46],"contrast":[47],"between":[48],"weak":[49],"strong":[51],"antioxidant":[52,69],"capacity.":[53],"This":[54,85],"Essay":[55],"proposes":[56],"neuronal":[58,91],"vulnerability":[59,92],"shaped":[61],"by":[62],"multilayered":[63],"signaling":[64],"thresholds":[65],"comprising":[66],"ROS":[67,103],"production,":[68],"thiol":[71],"buffering,":[72],"redox-sensitive":[73],"signal":[74],"detection,":[75],"molecular":[76],"gating,":[77],"commitment":[79],"degeneration,":[81],"survival,":[82],"or":[83],"repair.":[84],"framework":[86],"may":[87],"help":[88],"explain":[89],"selective":[90],"neurodegenerative":[94],"diseases":[95],"identify":[97],"intervention":[98],"points":[99],"downstream":[100],"of":[101],"global":[102],"suppression.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-20T00:00:00"}
