{"id":"https://openalex.org/W7222921082","doi":"https://doi.org/10.3389/fonc.2026.1923679","title":"Oral versus intravenous melphalan for autologous stem cell transplantation conditioning in lymphoma and multiple myeloma: a retrospective cohort study","display_name":"Oral versus intravenous melphalan for autologous stem cell transplantation conditioning in lymphoma and multiple myeloma: a retrospective cohort study","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222921082","doi":"https://doi.org/10.3389/fonc.2026.1923679","pmid":"https://pubmed.ncbi.nlm.nih.gov/42973770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13724488"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1923679","doi":"https://doi.org/10.3389/fonc.2026.1923679","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1923679","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1923679/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1923679/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159091670","display_name":"Jingrong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingrong Wang","raw_affiliation_strings":["Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102184136","display_name":"Yimeng Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yimeng Guo","raw_affiliation_strings":["Department of Pharmacy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124769883","display_name":"Jin Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhao","raw_affiliation_strings":["Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101081316","display_name":"Xiaolian Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolian Wen","raw_affiliation_strings":["Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103254652","display_name":"Liping Su","orcid":"https://orcid.org/0009-0006-6238-1234","observed_orcids":["https://orcid.org/0009-0006-6238-1234","https://orcid.org/0000-0002-2146-589X"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Su","raw_affiliation_strings":["Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100568082","display_name":"Zhiying Hao","orcid":"https://orcid.org/0009-0000-2121-0128","observed_orcids":["https://orcid.org/0009-0000-2121-0128","https://orcid.org/0009-0005-6836-6695"]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiying Hao","raw_affiliation_strings":["Department of Pharmacy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159094553","display_name":"Jing Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17721919","display_name":"Shanxi Medical University","ror":"https://ror.org/0265d1010","country_code":"CN","type":"education","lineage":["https://openalex.org/I17721919"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210102673","display_name":"Shanxi Provincial Cancer Hospital","ror":"https://ror.org/01790dx02","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210102673"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Department of Pharmacy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University","institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100568082","https://openalex.org/A5159094553"],"corresponding_institution_ids":["https://openalex.org/I17721919","https://openalex.org/I200296433","https://openalex.org/I4210102673"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76856046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1923679","last_page":"1923679"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-melphalan","display_name":"oral melphalan","score":0.9539999961853027},{"id":"https://openalex.org/keywords/autologous-stem-cell-transplantation","display_name":"autologous stem cell transplantation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/beam-conditioning","display_name":"BEAM conditioning","score":0.8939999938011169},{"id":"https://openalex.org/keywords/neutrophil-engraftment","display_name":"neutrophil engraftment","score":0.9020000100135803},{"id":"https://openalex.org/keywords/platelet-engraftment","display_name":"platelet engraftment","score":0.9980000257492065},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/oral-mucositis","display_name":"oral mucositis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.7919999957084656},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9319999814033508},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.7699999809265137},{"id":"https://openalex.org/keywords/drug-bioavailability","display_name":"drug bioavailability","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.9259999990463257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8889999985694885},{"id":"https://openalex.org/C2778496288","wikidata":"https://www.wikidata.org/wiki/Q6931269","display_name":"Mucositis","level":3,"score":0.8550000190734863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6252999901771545},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5059000253677368},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.4993000030517578},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.47609999775886536},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.47040000557899475},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.46810001134872437},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4537999927997589},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.45260000228881836},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4348999857902527},{"id":"https://openalex.org/C2779050716","wikidata":"https://www.wikidata.org/wiki/Q4826373","display_name":"Autologous stem-cell transplantation","level":3,"score":0.43160000443458557},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.42419999837875366},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.40700000524520874},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.39419999718666077},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.3682999908924103},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34610000252723694},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.3073999881744385},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C2778670039","wikidata":"https://www.wikidata.org/wiki/Q414004","display_name":"Nitrogen mustard","level":4,"score":0.25699999928474426},{"id":"https://openalex.org/C2779263901","wikidata":"https://www.wikidata.org/wiki/Q185916","display_name":"Fludarabine","level":4,"score":0.25380000472068787}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2026.1923679","doi":"https://doi.org/10.3389/fonc.2026.1923679","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1923679","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1923679/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13724488","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724488/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13724488/pdf/fonc-16-1923679.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:42973770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42973770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c2252bcf341e4960b80496669da6edeb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c2252bcf341e4960b80496669da6edeb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1923679","doi":"https://doi.org/10.3389/fonc.2026.1923679","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1923679","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1923679/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222921082.pdf","grobid_xml":"https://content.openalex.org/works/W7222921082.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1148123189","https://openalex.org/W1822252547","https://openalex.org/W2005929486","https://openalex.org/W2006996657","https://openalex.org/W2043353879","https://openalex.org/W2056472648","https://openalex.org/W2133676127","https://openalex.org/W2141082026","https://openalex.org/W2176620224","https://openalex.org/W2486629951","https://openalex.org/W2550257106","https://openalex.org/W2772193704","https://openalex.org/W3127065235","https://openalex.org/W3130827512","https://openalex.org/W3214100628","https://openalex.org/W4206581574","https://openalex.org/W4211191410","https://openalex.org/W4381715806","https://openalex.org/W4399134139","https://openalex.org/W4401266273","https://openalex.org/W4406807549","https://openalex.org/W7119503989"],"related_works":["https://openalex.org/W2005929486","https://openalex.org/W3097519386","https://openalex.org/W3037214851","https://openalex.org/W3156198912","https://openalex.org/W2001813071","https://openalex.org/W4223563416","https://openalex.org/W2163954716","https://openalex.org/W2887812219","https://openalex.org/W4417009496","https://openalex.org/W2554728082"],"abstract_inverted_index":{"Objective":[0],"To":[1],"compare":[2,45],"oral":[3,184,197],"(PO)":[4],"and":[5,38,50,54,71,81,153,196,231,255],"intravenous":[6],"(IV)":[7],"melphalan":[8,56,84,94,103,114,185,242,249],"as":[9,209],"conditioning":[10,77],"regimens":[11],"for":[12,79,87],"autologous":[13],"stem":[14],"cell":[15],"transplantation":[16],"in":[17,218,224],"patients":[18,34,90],"with":[19,36,40,91,97,117,169,180,188,202,252],"lymphoma":[20,37,80],"or":[21],"multiple":[22],"myeloma":[23],"(MM).":[24],"Methods":[25],"A":[26],"retrospective":[27],"propensity":[28],"score-matched":[29],"cohort":[30],"analysis":[31],"of":[32,191,216],"106":[33],"(76":[35],"30":[39],"MM)":[41],"was":[42,61,85,95,115,186],"conducted":[43],"to":[44,269,277],"engraftment":[46,100,121,172],"outcomes,":[47],"adverse":[48,214],"events,":[49],"survival":[51,233],"between":[52,237],"PO":[53,102,130,163,220],"IV":[55,93,113,181,226,248,270],"conditioning.":[57],"The":[58,66,129],"primary":[59],"endpoint":[60],"3-year":[62,232],"progression-free":[63],"survival.":[64],"Results":[65],"BEAM":[67],"(carmustine,":[68],"etoposide,":[69],"cytarabine,":[70],"melphalan)":[72],"regimen":[73,78],"is":[74,243,250],"the":[75,162,219,225,238],"standard":[76],"a":[82,244,256],"single-agent":[83],"administered":[86],"MM.":[88],"In":[89,111,161],"lymphoma,":[92],"associated":[96,116,187],"faster":[98,118],"neutrophil":[99],"than":[101],"(10":[104],"vs":[105,123,138,148,156,174,194,200],"12":[106],"days,":[107,125],"p":[108,126,140,150,158,176],"=":[109,127,141,151,159,177],"0.025).":[110],"MM,":[112],"platelet":[119],"(PLT)":[120],"(11":[122],"14":[124],"0.021).":[128],"group":[131,221],"had":[132],"higher":[133],"grade":[134,165],"3\u20134":[135,166],"anemia":[136,167],"(37.74%":[137],"18.87%,":[139],"0.031)":[142],"but":[143],"lower":[144,189],"febrile":[145],"neutropenia":[146],"(35.85%":[147],"56.60%,":[149],"0.032)":[152],"mucositis":[154,198],"(7.55%":[155,199],"33.96%,":[157],"0.001).":[160],"group,":[164],"correlated":[168],"delayed":[170],"PLT":[171],"(62.5%":[173],"21.4%,":[175],"0.008).":[178],"Compared":[179],"melphalan,":[182],"divided-dose":[183],"rates":[190,230],"diarrhea":[192],"(18.87%":[193],"37.74%)":[195],"33.96%),":[201],"an":[203],"overall":[204],"gastrointestinal":[205,213],"toxicity":[206,258],"rate":[207],"(defined":[208],"at":[210],"least":[211],"one":[212],"event)":[215],"21.7%":[217],"versus":[222],"56.60%":[223],"group.":[227],"Complete":[228],"response":[229],"outcomes":[234],"were":[235],"comparable":[236,253],"groups.":[239],"Conclusion":[240],"Oral":[241],"pragmatic":[245],"alternative":[246],"when":[247],"unavailable,":[251],"efficacy":[254],"distinct":[257],"profile.":[259],"Given":[260],"variable":[261],"bioavailability,":[262],"it":[263],"should":[264],"not":[265],"be":[266],"considered":[267],"bioequivalent":[268],"melphalan.":[271],"Prospective":[272],"pharmacokinetic":[273],"studies":[274],"are":[275],"warranted":[276],"validate":[278],"these":[279],"findings.":[280]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-20T00:00:00"}