{"id":"https://openalex.org/W7222917481","doi":"https://doi.org/10.1186/s12874-026-03058-x","title":"A pragmatic workflow for handling missing PROM data in registry studies: a methodological scoping review and simulated worked example","display_name":"A pragmatic workflow for handling missing PROM data in registry studies: a methodological scoping review and simulated worked example","publication_year":2026,"publication_date":"2026-10-19","ids":{"openalex":"https://openalex.org/W7222917481","doi":"https://doi.org/10.1186/s12874-026-03058-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/42897463","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13682039"},"language":"en","primary_location":{"id":"doi:10.1186/s12874-026-03058-x","doi":"https://doi.org/10.1186/s12874-026-03058-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12874-026-03058-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12874-026-03058-x.pdf","source":{"id":"https://openalex.org/S185874209","display_name":"BMC Medical Research Methodology","issn_l":"1471-2288","issn":["1471-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Research Methodology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12874-026-03058-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072337768","display_name":"Johan Eriksson","orcid":"https://orcid.org/0000-0002-4653-2067","observed_orcids":["https://orcid.org/0000-0002-4653-2067"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Johan Eriksson","raw_affiliation_strings":["Department of Diagnostics and Intervention/Surgery, Ume\u00e5 University, Ume\u00e5, Sweden. johan.e.eriksson@umu.se"],"raw_orcid":"https://orcid.org/0000-0002-4653-2067","affiliations":[{"raw_affiliation_string":"Department of Diagnostics and Intervention/Surgery, Ume\u00e5 University, Ume\u00e5, Sweden. johan.e.eriksson@umu.se","institution_ids":["https://openalex.org/I90267481"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072337768"],"corresponding_institution_ids":["https://openalex.org/I90267481"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73272364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patient-reported-outcome-measures","display_name":"patient-reported outcome measures","score":0.925000011920929},{"id":"https://openalex.org/keywords/missing-data","display_name":"missing data","score":0.7710000276565552},{"id":"https://openalex.org/keywords/missing-not-at-random","display_name":"missing not at random","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tipping-point-analysis","display_name":"tipping point analysis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/inverse-probability-weighting","display_name":"inverse probability weighting","score":0.9929999709129333},{"id":"https://openalex.org/keywords/quality-registry","display_name":"quality register","score":0.5929999947547913},{"id":"https://openalex.org/keywords/complete-case-analysis","display_name":"complete case analysis","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2777364248","wikidata":"https://www.wikidata.org/wiki/Q1150737","display_name":"Prom","level":2,"score":0.7163000106811523},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.5878000259399414},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.48350000381469727},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.475600004196167},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.44999998807907104},{"id":"https://openalex.org/C199521495","wikidata":"https://www.wikidata.org/wiki/Q181487","display_name":"Audit","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36559998989105225},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.3564999997615814},{"id":"https://openalex.org/C24756922","wikidata":"https://www.wikidata.org/wiki/Q1757694","display_name":"Data quality","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3280999958515167},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31369999051094055},{"id":"https://openalex.org/C2779915747","wikidata":"https://www.wikidata.org/wiki/Q17058619","display_name":"Inverse probability weighting","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.28999999165534973},{"id":"https://openalex.org/C2779485042","wikidata":"https://www.wikidata.org/wiki/Q7268769","display_name":"Quality and Outcomes Framework","level":3,"score":0.2874999940395355},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.2727000117301941}],"mesh":[{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012042","descriptor_name":"Registries","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064887","descriptor_name":"Observational Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12874-026-03058-x","doi":"https://doi.org/10.1186/s12874-026-03058-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12874-026-03058-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12874-026-03058-x.pdf","source":{"id":"https://openalex.org/S185874209","display_name":"BMC Medical Research Methodology","issn_l":"1471-2288","issn":["1471-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Research Methodology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13682039","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682039/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13682039/pdf/12874_2026_Article_3058.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Med Res Methodol","raw_type":"Text"},{"id":"pmid:42897463","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42897463","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical research methodology","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:umu-261255","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-261255","pdf_url":null,"source":{"id":"https://openalex.org/S4306400653","display_name":"Diva portal (Dalarna University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:860da3b0193a45a589e9c1bde49b0e33","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/860da3b0193a45a589e9c1bde49b0e33","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Research Methodology, Vol 26, Iss 1 (2026)","raw_type":"article"},{"id":"doi:10.6084/m9.figshare.c.8783780","doi":"https://doi.org/10.6084/m9.figshare.c.8783780","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8783780","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"},{"id":"doi:10.6084/m9.figshare.c.8783780.v1","doi":"https://doi.org/10.6084/m9.figshare.c.8783780.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.c.8783780.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Collection"}],"best_oa_location":{"id":"doi:10.1186/s12874-026-03058-x","doi":"https://doi.org/10.1186/s12874-026-03058-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12874-026-03058-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12874-026-03058-x.pdf","source":{"id":"https://openalex.org/S185874209","display_name":"BMC Medical Research Methodology","issn_l":"1471-2288","issn":["1471-2288"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Research Methodology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222917481.pdf","grobid_xml":"https://content.openalex.org/works/W7222917481.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1500944114","https://openalex.org/W1968185435","https://openalex.org/W2057270012","https://openalex.org/W2065974896","https://openalex.org/W2099716808","https://openalex.org/W2110818436","https://openalex.org/W2163278718","https://openalex.org/W2312836362","https://openalex.org/W2480680997","https://openalex.org/W2891378911","https://openalex.org/W2953086467","https://openalex.org/W3043614504","https://openalex.org/W3048054692","https://openalex.org/W3092419658","https://openalex.org/W3185099007","https://openalex.org/W4323074651","https://openalex.org/W4381322801","https://openalex.org/W4393358139","https://openalex.org/W4399715737"],"related_works":["https://openalex.org/W7223049559","https://openalex.org/W7223037643","https://openalex.org/W7223070243","https://openalex.org/W7017325486","https://openalex.org/W2262134418","https://openalex.org/W2896731154","https://openalex.org/W3048054692","https://openalex.org/W2338934733","https://openalex.org/W4383956764","https://openalex.org/W2423702537"],"abstract_inverted_index":{"BACKGROUND:":[0],"Patient-reported":[1],"outcome":[2],"measures":[3],"(PROMs)":[4],"are":[5,45,369],"increasingly":[6],"integrated":[7],"into":[8],"clinical":[9],"quality":[10],"registries.":[11],"Registry-based":[12],"PROM":[13,82,263],"data":[14],"frequently":[15],"exhibit":[16],"structural":[17],"non-response,":[18],"including":[19],"patients":[20],"who":[21],"never":[22],"return":[23],"PROMs":[24],"(\"never-responders\"),":[25],"and":[26,42,67,77,109,127,152,163,252,277,364,381],"longitudinal":[27],"attrition,":[28],"making":[29],"missing-not-at-random":[30],"(MNAR)":[31],"mechanisms":[32],"plausible.":[33],"Although":[34],"MNAR":[35,154,196,206,354],"sensitivity":[36,155,197,349],"methods":[37,87,327,358],"such":[38],"as":[39,91,104,146,296,316,347],"delta":[40,157,228,339],"adjustment":[41,158,229,340],"tipping-point":[43,161,215,382],"analysis":[44,150,198,216,320,383],"methodologically":[46],"well-described,":[47],"their":[48],"uptake":[49],"in":[50,111,172,201,210,220,232,241,324,343,372],"registry-PROM":[51,337],"practice":[52],"is":[53,125,170],"unknown.":[54],"METHODS:":[55],"A":[56,121,376],"structured":[57],"search":[58],"of":[59,222,331,333],"PubMed":[60,63],"(Nordic-specific":[61],"terms),":[62,65],"(global":[64],"Embase":[66],"CINAHL":[68],"was":[69,102,199,217,230,250,261,272,282,290,310,321,341],"conducted":[70,103],"(2018-2024),":[71],"yielding":[72],"425":[73],"records.":[74],"After":[75],"deduplication":[76],"screening,":[78],"61":[79,224,335],"registry-based":[80],"observational":[81],"studies":[83,190,226],"with":[84,113,136,159],"explicit":[85,160],"missing-data":[86,194],"discussion":[88],"were":[89,208,237],"included":[90,225,336],"the":[92,114,182,223,246,255,258,268,278,299,303,306,325,334],"primary":[93,149,183,256],"analytic":[94,184],"sample":[95,185],"(17":[96],"Nordic,":[97],"44":[98],"global).":[99],"The":[100,168,287,351],"audit":[101],"a":[105,147,164,173,348],"methodological":[106],"scoping":[107,118],"review":[108],"reported":[110,200,219,231,323,342],"accordance":[112],"PRISMA":[115],"extension":[116],"for":[117],"reviews":[119],"(PRISMA-ScR).":[120],"three-step":[122],"pragmatic":[123,377],"workflow":[124,169,378],"proposed":[126],"demonstrated:":[128],"(1)":[129],"non-response":[130,249],"diagnostics":[131],"separating":[132],"never-responders":[133],"from":[134,239],"dropout,":[135],"standardized":[137],"mean":[138],"differences":[139],"(SMD);":[140],"(2)":[141],"inverse":[142],"probability":[143],"weighting":[144],"(IPW)":[145],"default":[148],"strategy;":[151],"(3)":[153],"via":[156],"identification":[162],"simple":[165],"robustness":[166],"classification.":[167],"demonstrated":[171],"simulated":[174,247],"registry-like":[175],"cohort":[176],"(N":[177],"=":[178,187,292,312],"8,000).":[179],"RESULTS:":[180],"In":[181,245,254,302],"(n":[186],"61),":[188],"24":[189],"(39%)":[191],"stated":[192],"no":[193],"strategy.":[195],"18/61":[202],"(30%),":[203],"but":[204],"formal":[205,353],"models":[207],"used":[209,357],"only":[211,233,242,344],"5/61":[212],"(8%).":[213],"Critically,":[214],"not":[218,322],"any":[221,332],"(0%);":[227],"1/61":[234],"(2%).":[235],"Never-responders":[236],"distinguished":[238],"dropout":[240],"17/61":[243],"(28%).":[244],"cohort,":[248],"substantial":[251],"selective.":[253],"scenario,":[257,305],"complete-case":[259],"estimate":[260,271,281],"1.21":[262],"points":[264,294,314],"(95%":[265,274,284],"CI:":[266,275,285],"0.69-1.72),":[267],"single-stage":[269],"IPW":[270,280,380],"1.22":[273],"0.69-1.74),":[276],"two-stage":[279],"1.23":[283],"0.67-1.79).":[286],"tipping":[288,308],"point":[289,309],"\u03b4*":[291,311],"7.2":[293],"(classified":[295,315],"sensitive":[297],"under":[298],"illustrative":[300],"thresholds).":[301],"secondary":[304],"corresponding":[307],"30.5":[313],"stable).":[317],"CONCLUSIONS:":[318],"Tipping-point":[319],"accessible":[326],"or":[328],"supplementary":[329],"material":[330],"studies;":[338],"one":[345],"study":[346],"check.":[350],"five":[352],"analyses":[355],"identified":[356],"that":[359],"typically":[360],"require":[361],"specialist":[362,389],"expertise":[363],"stronger":[365],"modeling":[366],"assumptions":[367],"than":[368],"routinely":[370],"feasible":[371],"many":[373],"registry":[374],"settings.":[375],"using":[379],"can":[384],"close":[385],"this":[386],"gap":[387],"without":[388],"infrastructure.":[390]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-20T00:00:00"}