{"id":"https://openalex.org/W7222905656","doi":"https://doi.org/10.1111/aji.70335","title":"BeWo\u2010Derived Extracellular Vesicles Downregulate IL\u20106R \u03b1 Expression via miRNAs on CD4+ T Lymphocytes","display_name":"BeWo\u2010Derived Extracellular Vesicles Downregulate IL\u20106R \u03b1 Expression via miRNAs on CD4+ T Lymphocytes","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7222905656","doi":"https://doi.org/10.1111/aji.70335","pmid":"https://pubmed.ncbi.nlm.nih.gov/42893527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13677083"},"language":"en","primary_location":{"id":"doi:10.1111/aji.70335","doi":"https://doi.org/10.1111/aji.70335","is_oa":true,"landing_page_url":"https://doi.org/10.1111/aji.70335","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/aji.70335","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026786487","display_name":"G\u00e1bor Sereg\u00e9lyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"G\u00e1bor Sereg\u00e9lyes","raw_affiliation_strings":["Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139081162","display_name":"Bence Nagy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Bence Nagy","raw_affiliation_strings":["Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048773415","display_name":"\u00c1rp\u00e1d Ferenc Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-7742-160X","observed_orcids":["https://orcid.org/0000-0002-7742-160X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c1rp\u00e1d Ferenc Kov\u00e1cs","raw_affiliation_strings":["Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary","Heart and Vascular Center, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Heart and Vascular Center, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123444845","display_name":"Nora Fekete","orcid":"https://orcid.org/0000-0001-9721-765X","observed_orcids":["https://orcid.org/0000-0001-9721-765X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"N\u00f3ra Fekete","raw_affiliation_strings":["Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086107375","display_name":"Edit I. Buz\u00e1s","orcid":"https://orcid.org/0000-0002-3744-206X","observed_orcids":["https://orcid.org/0000-0002-3744-206X"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Edit I Buz\u00e1s","raw_affiliation_strings":["HCEMM-SE Extracellular Vesicle Research Group","Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary","MTA-SE Immune-Proteogenomics Extracellular Vesicle Research Group, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HCEMM-SE Extracellular Vesicle Research Group","institution_ids":[]},{"raw_affiliation_string":"Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"MTA-SE Immune-Proteogenomics Extracellular Vesicle Research Group, Budapest, Hungary","institution_ids":["https://openalex.org/I7597260"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069889713","display_name":"\u00c9va P\u00e1llinger","orcid":"https://orcid.org/0000-0002-5789-0951","observed_orcids":["https://orcid.org/0000-0002-5789-0951"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c9va P\u00e1llinger","raw_affiliation_strings":["Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026786487"],"corresponding_institution_ids":["https://openalex.org/I101202996"],"apc_list":{"value":4460,"currency":"USD","value_usd":4460},"apc_paid":{"value":4460,"currency":"USD","value_usd":4460},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67054162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":"4","first_page":"e70335","last_page":"e70335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bewo-cells","display_name":"BeWo cells","score":0.9480000138282776},{"id":"https://openalex.org/keywords/il-6-receptor-alpha","display_name":"IL-6 receptor alpha","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7239999771118164},{"id":"https://openalex.org/keywords/il-6-signaling","display_name":"IL-6 signaling","score":0.7580000162124634},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7319999933242798},{"id":"https://openalex.org/keywords/maternal-fetal-immune-tolerance","display_name":"maternal-fetal immune tolerance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.6639999747276306},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pias3","display_name":"PIAS3","score":0.8759999871253967},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.8989999890327454},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8220000267028809},{"id":"https://openalex.org/keywords/t-cell-polarization","display_name":"T cell polarization","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7681000232696533},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7214999794960022},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.667900025844574},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.656499981880188},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.6083999872207642},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5371000170707703},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5365999937057495},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5253999829292297},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.4763999879360199},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4537000060081482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43369999527931213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4242999851703644},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3741999864578247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36629998683929443},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.36000001430511475},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.34369999170303345},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.32659998536109924},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.32019999623298645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31290000677108765},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30979999899864197},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2750999927520752},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25440001487731934},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/aji.70335","doi":"https://doi.org/10.1111/aji.70335","is_oa":true,"landing_page_url":"https://doi.org/10.1111/aji.70335","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},{"id":"doi:10.1101/2025.09.08.674438","doi":"https://doi.org/10.1101/2025.09.08.674438","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.08.674438","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/12/2025.09.08.674438.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13677083","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677083/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13677083/pdf/AJI-96-e70335.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Reprod Immunol","raw_type":"Text"},{"id":"pmid:42893527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42893527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of reproductive immunology (New York, N.Y. : 1989)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/aji.70335","doi":"https://doi.org/10.1111/aji.70335","is_oa":true,"landing_page_url":"https://doi.org/10.1111/aji.70335","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320326762","display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","ror":null},{"id":"https://openalex.org/F4320336675","display_name":"National Research, Development and Innovation Office","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222905656.pdf","grobid_xml":"https://content.openalex.org/works/W7222905656.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1797058518","https://openalex.org/W1846781039","https://openalex.org/W1964380344","https://openalex.org/W1982180094","https://openalex.org/W1983761324","https://openalex.org/W1988940727","https://openalex.org/W1990404106","https://openalex.org/W1993965822","https://openalex.org/W1994645662","https://openalex.org/W1997791437","https://openalex.org/W2070068598","https://openalex.org/W2089943045","https://openalex.org/W2099703022","https://openalex.org/W2115070926","https://openalex.org/W2122445377","https://openalex.org/W2144320908","https://openalex.org/W2153095488","https://openalex.org/W2161720054","https://openalex.org/W2237743540","https://openalex.org/W2326532163","https://openalex.org/W2336792277","https://openalex.org/W2566488525","https://openalex.org/W2738232572","https://openalex.org/W2752229394","https://openalex.org/W2805286493","https://openalex.org/W2896958491","https://openalex.org/W2904780259","https://openalex.org/W2935024989","https://openalex.org/W2944545583","https://openalex.org/W2947982654","https://openalex.org/W2961131385","https://openalex.org/W3034147072","https://openalex.org/W3037718154","https://openalex.org/W3038112535","https://openalex.org/W3043211816","https://openalex.org/W3044354895","https://openalex.org/W3044367881","https://openalex.org/W3120356823","https://openalex.org/W3157812232","https://openalex.org/W3185619211","https://openalex.org/W3205952699","https://openalex.org/W4281872209","https://openalex.org/W4289836155","https://openalex.org/W4301187771","https://openalex.org/W4308286838","https://openalex.org/W4310938244","https://openalex.org/W4323971754","https://openalex.org/W4365452630","https://openalex.org/W4385235003","https://openalex.org/W4385879734","https://openalex.org/W4389045114","https://openalex.org/W4391649568","https://openalex.org/W4396557544","https://openalex.org/W4402023387","https://openalex.org/W7202075854"],"related_works":["https://openalex.org/W4415530542","https://openalex.org/W2961131385","https://openalex.org/W4416706393","https://openalex.org/W4414371754","https://openalex.org/W2950974530","https://openalex.org/W4281386118","https://openalex.org/W2299660349","https://openalex.org/W4320488395","https://openalex.org/W3024940552","https://openalex.org/W2742769620"],"abstract_inverted_index":{"PROBLEM:":[0],"A":[1],"balanced":[2],"Th1/Th2/Th17/Treg":[3],"status":[4],"is":[5],"necessary":[6],"for":[7],"a":[8],"successful":[9],"pregnancy.":[10],"T":[11,24,37,53,127,142,195,203,227,256],"cell":[12,54,60],"polarization":[13,42,253],"depends":[14],"on":[15,140,224],"the":[16,21,33,44,58,68,146,151,166,182,199,243,251,260],"local":[17,252],"cytokine":[18],"environment":[19],"and":[20,66,102,132,156,176,191,197],"responsiveness":[22,56],"of":[23,35,71,112,168,201,220,246,254],"lymphocytes":[25,82,128,257],"to":[26,40,77,165,234],"cytokines.":[27],"Trophoblast-derived":[28],"extracellular":[29],"vesicles":[30],"(EVs)":[31],"influence":[32],"function":[34],"maternal":[36,255],"lymphocytes,":[38],"contributing":[39],"their":[41],"into":[43],"Treg":[45],"phenotype.":[46],"We":[47,95],"examined":[48],"whether":[49],"BeWo-derived":[50],"EVs":[51,114,248],"affect":[52],"IL-6":[55,147,183],"using":[57],"BeWo":[59,72,93,113],"line":[61],"as":[62,173],"an":[63],"experimental":[64],"model":[65],"characterized":[67],"molecular":[69],"cargo":[70],"-EVs":[73],"that":[74,180,205,242],"may":[75,162],"contribute":[76],"this":[78],"process.":[79],"METHODS:":[80],"Circulating":[81],"from":[83,129],"non-pregnant":[84,133,236],"women":[85,232],"were":[86,222],"treated":[87],"with":[88,92,186],"BeWo-EVs":[89,136,179,187],"or":[90],"co-cultured":[91],"cells.":[94,143],"detected":[96,223],"IL-6R\u03b1":[97,122,138,209,221,261],"expression":[98,123,139],"by":[99,106,117,149,258],"flow":[100],"cytometry":[101],"IL6R":[103],"signaling":[104,262],"pathways":[105],"RT-PCR.":[107],"The":[108],"microRNA":[109,244],"(miRNA)":[110],"content":[111,245],"was":[115],"identified":[116],"sequencing.":[118],"Finally,":[119],"we":[120],"compared":[121,233],"levels":[124,219],"in":[125,178,194,214,229],"circulating":[126,225],"healthy":[130,230,235],"pregnant":[131,231],"women.":[134],"RESULTS:":[135],"reduced":[137],"CD4+":[141],"This":[144,161],"modifies":[145],"pathway":[148],"downregulating":[150],"transcription":[152],"factors":[153],"STAT3,":[154],"NFKB1,":[155],"PIAS3":[157],"while":[158],"upregulating":[159],"STAT1.":[160],"be":[163],"due":[164],"presence":[167],"specific":[169],"microRNAs":[170],"(miRNAs),":[171],"such":[172],"hsa-mir-92a-3p,":[174],"hsa-mir-520f-3p,":[175],"hsa-mir-25-3p,":[177],"target":[181],"pathway.":[184,263],"Treatment":[185],"also":[188],"induced":[189],"phenotypic":[190],"functional":[192],"changes":[193],"cells":[196,204,228],"enhanced":[198],"ratio":[200],"CD4+/CD25+":[202],"produce":[206],"IL-10.":[207],"Pregnancy-associated":[208],"downregulation":[210],"has":[211],"been":[212],"demonstrated":[213],"clinical":[215],"samples.":[216],"Significantly":[217],"lower":[218],"CD4+CD25+":[226],"individuals.":[237],"CONCLUSIONS:":[238],"Our":[239],"studies":[240],"suggest":[241],"trophoblast-derived":[247],"significantly":[249],"influences":[250],"modifying":[259]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-19T00:00:00"}