{"id":"https://openalex.org/W7222904834","doi":"https://doi.org/10.7150/ijms.127785","title":"A naturally occurring polyphenolic compound for liver cancer treatment","display_name":"A naturally occurring polyphenolic compound for liver cancer treatment","publication_year":2026,"publication_date":"2026-10-02","ids":{"openalex":"https://openalex.org/W7222904834","doi":"https://doi.org/10.7150/ijms.127785","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910117","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13685437"},"language":"en","primary_location":{"id":"doi:10.7150/ijms.127785","doi":"https://doi.org/10.7150/ijms.127785","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijms.127785","pdf_url":"https://www.medsci.org/v23p3531.pdf","source":{"id":"https://openalex.org/S46225466","display_name":"International Journal of Medical Sciences","issn_l":"1449-1907","issn":["1449-1907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.medsci.org/v23p3531.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159006516","display_name":"Ming-Hui Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ming-Hui Yang","raw_affiliation_strings":["Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066730226","display_name":"Tyan Yu-Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I16566446","display_name":"National Pingtung University of Science and Technology","ror":"https://ror.org/01y6ccj36","country_code":"TW","type":"education","lineage":["https://openalex.org/I16566446"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]},{"id":"https://openalex.org/I4210145822","display_name":"Kaohsiung Municipal Hsiao-Kang Hospital","ror":"https://ror.org/04gn22j10","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210145822"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chang Tyan","raw_affiliation_strings":["Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan","Center of Teaching and Research, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan","Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan","Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan","Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Tropical Medicine and Infectious Disease Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Center of Teaching and Research, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 812, Taiwan","institution_ids":["https://openalex.org/I4210145822"]},{"raw_affiliation_string":"Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Graduate Institute of Animal Vaccine Technology, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung 912, Taiwan","institution_ids":["https://openalex.org/I16566446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159022017","display_name":"Hsin-Rou Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsin-Rou Liang","raw_affiliation_strings":["Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159024935","display_name":"Chia-Yen Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Yen Dai","raw_affiliation_strings":["Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159021075","display_name":"Yung-Jen Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091198","display_name":"E-Da Hospital","ror":"https://ror.org/00eh7f421","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091198"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yung-Jen Chuang","raw_affiliation_strings":["Department of Neurosurgery, E-Da Hospital, Kaohsiung 824, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, E-Da Hospital, Kaohsiung 824, Taiwan","institution_ids":["https://openalex.org/I4210091198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159013434","display_name":"Cheng-Hui Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Cheng-Hui Yuan","raw_affiliation_strings":["Mass Spectrometry Laboratory, Department of Chemistry, National University of Singapore, Singapore 119077, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass Spectrometry Laboratory, Department of Chemistry, National University of Singapore, Singapore 119077, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159011044","display_name":"Shih-Chang Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]},{"id":"https://openalex.org/I2802587341","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802587341"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shih-Chang Chuang","raw_affiliation_strings":["Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"]},{"raw_affiliation_string":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan","institution_ids":["https://openalex.org/I152743029"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5159011044"],"corresponding_institution_ids":["https://openalex.org/I152743029","https://openalex.org/I2802587341"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.7705782,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"11","first_page":"3531","last_page":"3546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":1.0},{"id":"https://openalex.org/keywords/resveratrol-metabolites","display_name":"resveratrol metabolites","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.640999972820282},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6880000233650208},{"id":"https://openalex.org/keywords/colony-formation","display_name":"colony formation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9509999752044678},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":1.0},{"id":"https://openalex.org/keywords/hspd1","display_name":"HSPD1","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8970000147819519},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6050000190734863},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.6990000009536743},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5827999711036682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.539900004863739},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4278999865055084},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36320000886917114},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35569998621940613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35339999198913574},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.22130000591278076}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7150/ijms.127785","doi":"https://doi.org/10.7150/ijms.127785","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijms.127785","pdf_url":"https://www.medsci.org/v23p3531.pdf","source":{"id":"https://openalex.org/S46225466","display_name":"International Journal of Medical Sciences","issn_l":"1449-1907","issn":["1449-1907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13685437","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685437/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13685437/pdf/ijmsv23p3531.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Med Sci","raw_type":"Text"},{"id":"pmid:42910117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of medical sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/ijms.127785","doi":"https://doi.org/10.7150/ijms.127785","is_oa":true,"landing_page_url":"https://doi.org/10.7150/ijms.127785","pdf_url":"https://www.medsci.org/v23p3531.pdf","source":{"id":"https://openalex.org/S46225466","display_name":"International Journal of Medical Sciences","issn_l":"1449-1907","issn":["1449-1907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G854130790","display_name":null,"funder_award_id":"KMU-TC114B01","funder_id":"https://openalex.org/F4320322811","funder_display_name":"Kaohsiung Medical University"}],"funders":[{"id":"https://openalex.org/F4320318457","display_name":"National Pingtung University of Science and Technology","ror":"https://ror.org/01y6ccj36"},{"id":"https://openalex.org/F4320322811","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96"},{"id":"https://openalex.org/F4320327176","display_name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","ror":"https://ror.org/02xmkec90"},{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222904834.pdf","grobid_xml":"https://content.openalex.org/works/W7222904834.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097527483","https://openalex.org/W2116725599","https://openalex.org/W4306786732","https://openalex.org/W1571535988","https://openalex.org/W2039507504","https://openalex.org/W2236820427","https://openalex.org/W2158034359","https://openalex.org/W2069901047","https://openalex.org/W2070129815","https://openalex.org/W2484478267"],"abstract_inverted_index":{"As":[0],"a":[1,16,89,170,180],"polyphenolic":[2],"compound":[3,184],"naturally":[4],"found":[5],"in":[6,79,88,130],"nature,":[7],"piceatannol":[8,47,167,177],"is":[9],"an":[10,157],"analogue":[11],"of":[12,33,46,58,97,118,122,140,154,188],"resveratrol.These":[13],"compounds":[14],"share":[15],"common":[17],"structural":[18],"motif":[19],"but":[20,29],"have":[21],"various":[22],"substituents.Resveratrol":[23],"shows":[24],"antiinflammation":[25],"and":[26,63,76,103,120,142,163],"anti-tumor":[27,44],"properties,":[28],"such":[30],"biological":[31],"activities":[32],"the":[34,43,116,152,186],"active":[35],"resveratrol":[36],"metabolite":[37,153],"-piceatannol":[38],"are":[39],"unclear.In":[40],"this":[41],"study,":[42],"properties":[45],"were":[48,106],"investigated":[49],"through":[50],"cell":[51,83,86,128,165],"viability,":[52],"colony":[53],"formation,":[54],"migration":[55,121],"assay,":[56],"detection":[57],"reactive":[59],"oxygen":[60],"species":[61],"(ROS)":[62],"mitochondrial":[64],"membrane":[65],"potential":[66],"(MMP)":[67],"change,":[68],"reverse":[69],"transcription":[70],"quantitative":[71],"polymerase":[72],"chain":[73],"reaction":[74],"(RT-qPCR),":[75],"Western":[77],"blotting":[78],"human":[80],"hepatocellular":[81,131],"carcinoma":[82,132],"lines.Piceatannol":[84],"decreased":[85],"viability":[87],"dose-dependent":[90],"manner.These":[91],"concentrations":[92],"required":[93],"to":[94,127],"inhibit":[95],"50%":[96],"activity":[98],"(IC50)":[99],"for":[100,182,185],"Huh7,":[101],"HepG2,":[102],"Hep3B":[104],"cells":[105],"76.1-99.7,17.0-19.6,and":[107],"57.0-83.7":[108],"\u03bcM":[109],"after":[110],"24-72":[111],"hour":[112],"treatment,":[113],"respectively.Piceatannol":[114],"inhibited":[115],"abilities":[117],"colony-forming":[119],"HCC":[123],"cells.Piceatannol":[124],"may":[125,168],"contribute":[126],"death":[129],"cells,":[133],"accompanied":[134],"by":[135,160],"altered":[136],"MMP,":[137],"reduced":[138],"expression":[139],"HSPD1":[141],"increased":[143],"DNA":[144],"double":[145],"strand":[146],"breaks.Our":[147],"results":[148],"show":[149],"that":[150],"piceatannol,":[151],"resveratrol,":[155],"supports":[156],"anti-cancerogenic":[158],"effect":[159],"inhibiting":[161],"proliferation":[162],"promoting":[164],"death.Moreover,":[166],"be":[169,179],"more":[171],"potent":[172],"anticancer":[173],"agent":[174],"than":[175],"resveratrol.Hence,":[176],"could":[178],"candidate":[181],"anti-cancer":[183],"management":[187],"liver":[189],"cancer.":[190]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-19T00:00:00"}