{"id":"https://openalex.org/W7222897889","doi":"https://doi.org/10.21608/zumj.2026.523497.4779","title":"Hematological Biomarkers in Sepsis-Associated Acute Kidney Injury","display_name":"Hematological Biomarkers in Sepsis-Associated Acute Kidney Injury","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7222897889","doi":"https://doi.org/10.21608/zumj.2026.523497.4779"},"language":"en","primary_location":{"id":"doi:10.21608/zumj.2026.523497.4779","doi":"https://doi.org/10.21608/zumj.2026.523497.4779","is_oa":true,"landing_page_url":"https://doi.org/10.21608/zumj.2026.523497.4779","pdf_url":null,"source":{"id":"https://openalex.org/S2764698744","display_name":"Zagazig University Medical Journal","issn_l":"1110-1431","issn":["1110-1431","2357-0717"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-1"],"host_organization":"https://openalex.org/P4365384376","host_organization_name":"Zagazig University","host_organization_lineage":["https://openalex.org/P4365384376"],"host_organization_lineage_names":["Zagazig University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zagazig University Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21608/zumj.2026.523497.4779","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033413803","display_name":"Tamer Mohamed Goda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamer Mohamed Goda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088513331","display_name":"Adel Ghorab","orcid":"https://orcid.org/0000-0002-7712-1172","observed_orcids":["https://orcid.org/0000-0002-7712-1172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adel A.M Ghorab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035308445","display_name":"Nafesa M. Kamal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nafesa Mohammed Kamal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159023423","display_name":"Moaaz Mohamed Attia Asker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moaaz Mohamed Attia Asker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109666066","display_name":"Fatma M. Attia Elsayed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatma M. Attia Elsayed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.80028493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"0","issue":"0","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0649000033736229,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis-associated-acute-kidney-injury","display_name":"sepsis-associated acute kidney injury","score":0.9769999980926514},{"id":"https://openalex.org/keywords/monocyte-distribution-width","display_name":"monocyte distribution width","score":0.9319999814033508},{"id":"https://openalex.org/keywords/red-blood-cell-distribution-width","display_name":"red cell distribution width","score":0.8700000047683716},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/hematological-biomarkers","display_name":"hematological biomarkers","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sepsis-severity","display_name":"sepsis severity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sofa-score","display_name":"SOFA score","score":0.8320000171661377},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9810000061988831},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.761900007724762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5300999879837036},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3880999982357025},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3849000036716461},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2833000123500824},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.26460000872612},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.2572999894618988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24379999935626984}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21608/zumj.2026.523497.4779","doi":"https://doi.org/10.21608/zumj.2026.523497.4779","is_oa":true,"landing_page_url":"https://doi.org/10.21608/zumj.2026.523497.4779","pdf_url":null,"source":{"id":"https://openalex.org/S2764698744","display_name":"Zagazig University Medical Journal","issn_l":"1110-1431","issn":["1110-1431","2357-0717"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-1"],"host_organization":"https://openalex.org/P4365384376","host_organization_name":"Zagazig University","host_organization_lineage":["https://openalex.org/P4365384376"],"host_organization_lineage_names":["Zagazig University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zagazig University Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7b777ed2c565470d842878371785d07c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7b777ed2c565470d842878371785d07c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Zagazig University Medical Journal (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.21608/zumj.2026.523497.4779","doi":"https://doi.org/10.21608/zumj.2026.523497.4779","is_oa":true,"landing_page_url":"https://doi.org/10.21608/zumj.2026.523497.4779","pdf_url":null,"source":{"id":"https://openalex.org/S2764698744","display_name":"Zagazig University Medical Journal","issn_l":"1110-1431","issn":["1110-1431","2357-0717"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-1"],"host_organization":"https://openalex.org/P4365384376","host_organization_name":"Zagazig University","host_organization_lineage":["https://openalex.org/P4365384376"],"host_organization_lineage_names":["Zagazig University"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zagazig University Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396761701","https://openalex.org/W4382564163","https://openalex.org/W4387464526","https://openalex.org/W4390987758","https://openalex.org/W4389790489","https://openalex.org/W4397012979","https://openalex.org/W2945141942","https://openalex.org/W4388015854","https://openalex.org/W7213906522","https://openalex.org/W2799521039"],"abstract_inverted_index":{"Background:":[0],"Sepsis-associated":[1,66],"acute":[2,67],"kidney":[3,46,68],"injury":[4,69],"(SA-AKI)":[5,70],"is":[6],"a":[7],"common":[8],"and":[9,24,48,63,103,126,133,182,190,198],"serious":[10],"complication":[11],"of":[12],"sepsis.":[13],"Monocyte":[14,83],"distribution":[15,21,84,89],"width":[16,22,85,90],"(MDW),":[17,86],"red":[18,87],"blood":[19,31,97],"cell":[20,88],"(RDW),":[23,91],"the":[25,74,168,204],"neutrophil-to-lymphocyte":[26,92],"ratio":[27,93],"(NLR)":[28],"are":[29],"simple":[30],"count":[32],"indices":[33,215],"that":[34],"may":[35,216],"help":[36],"identify":[37],"renal":[38,196,219],"risk.":[39],"This":[40,52],"study":[41,54],"assessed":[42,72],"their":[43,226],"association":[44],"with":[45,58,114,172,195,201,208,223],"deterioration":[47],"sepsis":[49,59,199],"severity.":[50],"Methods:":[51],"prospective":[53],"included":[55],"124":[56],"patients":[57,222],"admitted":[60],"between":[61],"April":[62],"September":[64],"2025.":[65],"was":[71],"by":[73,178],"Kidney":[75],"Disease:":[76],"Improving":[77],"Global":[78],"Outcomes":[79],"(KDIGO)":[80],"diagnostic":[81],"criteria.":[82],"(NLR),":[94],"serum":[95],"creatinine,":[96],"urea":[98],"nitrogen":[99],"(BUN),":[100],"inflammatory":[101],"markers,":[102],"Sequential":[104],"Organ":[105],"Failure":[106],"Assessment":[107],"(SOFA)":[108],"scores":[109,128],"were":[110,129,193],"evaluated":[111],"at":[112],"admission,":[113],"serial":[115],"measurements":[116],"performed":[117],"through":[118],"day":[119,144,151],"3.":[120],"Results:":[121],"Median":[122],"MDW,":[123,188],"RDW,":[124,189],"NLR,":[125],"SOFA":[127,173,209],"33.20,":[130],"15.36%,":[131],"21.75,":[132],"8.00,":[134],"respectively.":[135],"Serum":[136],"creatinine":[137],"increased":[138,156],"from":[139,157],"0.92":[140],"(0.80\u20131.04)":[141],"mg/dL":[142,149,163],"on":[143,150],"1":[145],"to":[146,160],"3.83":[147],"(3.21\u20134.32)":[148],"3":[152],"(P=0.001).":[153],"Similarly,":[154],"BUN":[155],"16.60":[158],"(13.47\u201320.55)":[159],"87.05":[161],"(56.15\u2013103.12)":[162],"(P<0.001).":[164],"Day-3":[165],"MDW":[166,202],"showed":[167],"strongest":[169,205],"reported":[170,206],"correlation":[171,207],"score":[174],"(r=0.650,":[175],"P=0.011),":[176],"followed":[177],"RDW":[179],"(r=0.540,":[180],"P=0.024)":[181],"NLR":[183,191],"(r=0.320,":[184],"P=0.024).":[185],"Conclusion:":[186],"Higher":[187],"values":[192],"associated":[194],"dysfunction":[197],"severity,":[200],"showing":[203],"score.":[210],"These":[211],"readily":[212],"available":[213],"hematological":[214],"complement":[217],"conventional":[218],"assessment":[220],"in":[221],"sepsis,":[224],"although":[225],"clinical":[227],"predictive":[228],"value":[229],"requires":[230],"further":[231],"validation.":[232]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-19T00:00:00"}