{"id":"https://openalex.org/W7222887329","doi":"https://doi.org/10.7150/jca.135818","title":"P-cadherin Overexpression Induces Partial Epithelial-to-Mesenchymal Transition and Confers Chemoresistance in Dysplastic Oral Epithelial Cells","display_name":"P-cadherin Overexpression Induces Partial Epithelial-to-Mesenchymal Transition and Confers Chemoresistance in Dysplastic Oral Epithelial Cells","publication_year":2026,"publication_date":"2026-10-16","ids":{"openalex":"https://openalex.org/W7222887329","doi":"https://doi.org/10.7150/jca.135818","pmid":"https://pubmed.ncbi.nlm.nih.gov/42910112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13686773"},"language":"en","primary_location":{"id":"doi:10.7150/jca.135818","doi":"https://doi.org/10.7150/jca.135818","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.135818","pdf_url":null,"source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7150/jca.135818","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159013663","display_name":"Aaron Suresh Mody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Suresh Mody","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159011808","display_name":"Christine Paulette Neal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Paulette Neal","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159013877","display_name":"Kristen Kim Drinkwater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Kim Drinkwater","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159000618","display_name":"Cassandra Lynn Decker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cassandra Lynn Decker","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA","institution_ids":["https://openalex.org/I128902783"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159001752","display_name":"Kathryn Rene Lawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I128902783","display_name":"Midwestern University","ror":"https://ror.org/046yatd98","country_code":"US","type":"education","lineage":["https://openalex.org/I128902783"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathryn Rene Lawson","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, College of Graduate Studies, Midwestern University, Department of Biochemistry, Glendale, AZ 85308, USA","institution_ids":["https://openalex.org/I128902783"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5159001752"],"corresponding_institution_ids":["https://openalex.org/I128902783"],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76634381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"11","first_page":"1841","last_page":"1852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0478999987244606,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.03150000050663948,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oral-epithelial-dysplasia","display_name":"oral dysplasia","score":0.9330000281333923},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mucin-1","display_name":"mucin 1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9559999704360962},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":1.0},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.921999990940094},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.609000027179718},{"id":"https://openalex.org/keywords/prosurvival-signaling","display_name":"survival signaling","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.7419999837875366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7271999716758728},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6255999803543091},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.478300005197525},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41269999742507935},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3671000003814697},{"id":"https://openalex.org/C2909289247","wikidata":"https://www.wikidata.org/wiki/Q1143025","display_name":"Oral Cancers","level":3,"score":0.35499998927116394},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.32330000400543213},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23119999468326569}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7150/jca.135818","doi":"https://doi.org/10.7150/jca.135818","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.135818","pdf_url":null,"source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:42910112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42910112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13686773","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13686773/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/jca.135818","doi":"https://doi.org/10.7150/jca.135818","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.135818","pdf_url":null,"source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2119185283","https://openalex.org/W2418673779","https://openalex.org/W2955343274"],"related_works":["https://openalex.org/W4393071772","https://openalex.org/W3174441793","https://openalex.org/W2002555948","https://openalex.org/W4417175534","https://openalex.org/W1604234431","https://openalex.org/W70936715","https://openalex.org/W2117133035","https://openalex.org/W2614648335","https://openalex.org/W2888791221","https://openalex.org/W7005008906"],"abstract_inverted_index":{"Chemoresistance":[0],"is":[1,21],"a":[2,59,69,95,110,182],"major":[3],"barrier":[4],"to":[5,46,72,118,199],"the":[6,32,56,74,87,102,121,126,135,209],"successful":[7],"treatment":[8,119],"of":[9,17,26,76,101,134,147,177,211],"oral":[10,18,51,61,194],"squamous":[11],"cell":[12,33,64],"carcinoma.":[13],"The":[14,39,151],"dysplasia":[15],"stage":[16],"tumor":[19,47],"progression":[20,48],"associated":[22],"with":[23,86,120,162],"increased":[24,99,132],"levels":[25,100,115,146],"antiapoptotic":[27],"mediators":[28],"as":[29,31,68,143,145,172],"well":[30,144],"adhesion":[34,149],"protein":[35,141],"placental":[36],"cadherin":[37,179],"(P-cadherin).":[38],"mechanisms":[40],"by":[41,157],"which":[42],"P-cadherin":[43,77,93,106,130,196],"may":[44,168,197],"contribute":[45],"in":[49,109,113,116,185,201],"dysplastic":[50,60],"epithelia":[52],"remain":[53],"unclear.":[54],"In":[55,125],"present":[57],"study,":[58],"keratinocyte":[62],"(DOK)":[63],"line":[65],"was":[66],"utilized":[67],"model":[70],"system":[71],"investigate":[73],"effects":[75],"overexpression":[78,107,131],"on":[79],"cellular":[80],"behavior":[81],"and":[82,98,139,154,180],"survival":[83,136,212],"signaling.":[84],"Compared":[85],"controls,":[88],"DOK":[89],"cells":[90,159,174],"that":[91,192],"overexpressed":[92],"displayed":[94,156],"mesenchymal":[96],"morphology":[97,152],"chemoresistance":[103,155,207],"modulator,":[104],"mucin-1.":[105],"resulted":[108],"2-fold":[111,183],"decrease":[112,184],"apoptosis":[114],"response":[117],"chemotherapeutic":[122],"agent":[123],"5-fluorouracil.":[124],"same":[127],"drug-treated":[128],"cells,":[129],"phosphorylation":[133],"kinases":[137],"Akt":[138],"mitogen-activated":[140],"kinase,":[142],"focal":[148],"kinase.":[150],"changes":[153],"P-cadherin-overexpressing":[158,173],"were":[160],"consistent":[161],"an":[163],"epithelial-to-mesenchymal":[164],"transition.":[165],"This":[166],"transition":[167],"be":[169],"partial,":[170],"however,":[171],"retained":[175],"expression":[176],"epithelial":[178],"exhibited":[181],"motility.":[186],"Taken":[187],"together,":[188],"these":[189],"data":[190],"suggest":[191],"during":[193],"dysplasia,":[195],"continue":[198],"participate":[200],"cell-to-cell":[202],"contacts":[203],"while":[204],"also":[205],"modulating":[206],"through":[208],"activation":[210],"signaling":[213],"pathways.":[214]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-19T00:00:00"}
