{"id":"https://openalex.org/W7222840481","doi":"https://doi.org/10.1016/j.jiph.2026.103385","title":"HIV resistance in patients with virological failure to single tablet regimen: Roles of second generation integrase strand transfer inhibitors (INSTIs)","display_name":"HIV resistance in patients with virological failure to single tablet regimen: Roles of second generation integrase strand transfer inhibitors (INSTIs)","publication_year":2026,"publication_date":"2026-10-17","ids":{"openalex":"https://openalex.org/W7222840481","doi":"https://doi.org/10.1016/j.jiph.2026.103385","pmid":"https://pubmed.ncbi.nlm.nih.gov/42913056"},"language":"en","primary_location":{"id":"doi:10.1016/j.jiph.2026.103385","doi":"https://doi.org/10.1016/j.jiph.2026.103385","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jiph.2026.103385","pdf_url":null,"source":{"id":"https://openalex.org/S53706017","display_name":"Journal of Infection and Public Health","issn_l":"1876-0341","issn":["1876-0341","1876-035X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infection and Public Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jiph.2026.103385","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018530414","display_name":"Hung\u2010Chin Tsai","orcid":"https://orcid.org/0000-0002-5441-4386","observed_orcids":["https://orcid.org/0000-0002-5441-4386"]},"institutions":[{"id":"https://openalex.org/I142974352","display_name":"National Sun Yat-sen University","ror":"https://ror.org/00mjawt10","country_code":"TW","type":"education","lineage":["https://openalex.org/I142974352"]},{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]},{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hung-Chin Tsai","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan. Electronic address: shamina@vghks.gov.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan; Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan. Electronic address: shamina@vghks.gov.tw","institution_ids":["https://openalex.org/I142974352","https://openalex.org/I148366613","https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058012657","display_name":"I\u2010Tzu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Tzu Chen","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address: itchen@vghks.gov.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Electronic address: itchen@vghks.gov.tw","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109299113","display_name":"Huimin Chang","orcid":"https://orcid.org/0000-0002-0129-3592","observed_orcids":["https://orcid.org/0000-0002-0129-3592"]},"institutions":[{"id":"https://openalex.org/I32303042","display_name":"Tajen University","ror":"https://ror.org/01fvf0d84","country_code":"TW","type":"education","lineage":["https://openalex.org/I32303042"]},{"id":"https://openalex.org/I4405272440","display_name":"Pingtung Veterans General Hospital","ror":"https://ror.org/045xv9g95","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4405272440"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Min Chang","raw_affiliation_strings":["Department of Pharmacy, Pingtung Veterans General Hospital, Pingtung, Taiwan; Pharmacy Department, Longquan Branch, Pingtung Veterans General Hospital, Pingtung, Taiwan; Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung, Taiwan; Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: p356@ptvgh.gov.tw"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Pingtung Veterans General Hospital, Pingtung, Taiwan; Pharmacy Department, Longquan Branch, Pingtung Veterans General Hospital, Pingtung, Taiwan; Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung, Taiwan; Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: p356@ptvgh.gov.tw","institution_ids":["https://openalex.org/I32303042","https://openalex.org/I4405272440","https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018530414"],"corresponding_institution_ids":["https://openalex.org/I142974352","https://openalex.org/I148366613","https://openalex.org/I4210152230"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":{"value":2310,"currency":"USD","value_usd":2310},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.79654884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"12","first_page":"103385","last_page":"103385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.9449999928474426},{"id":"https://openalex.org/keywords/integrase-strand-transfer-inhibitors","display_name":"integrase strand transfer inhibitors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/single-tablet-regimen","display_name":"single-tablet regimen","score":0.6480000019073486},{"id":"https://openalex.org/keywords/virologic-failure","display_name":"virological failure","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bictegravir","display_name":"bictegravir","score":0.8769999742507935},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.7170000076293945},{"id":"https://openalex.org/keywords/treatment-naive-patients","display_name":"treatment-naive patients","score":0.5320000052452087},{"id":"https://openalex.org/keywords/transmission-routes","display_name":"transmission routes","score":0.5529999732971191},{"id":"https://openalex.org/keywords/taiwan","display_name":"Taiwan","score":0.453000009059906},{"id":"https://openalex.org/keywords/genotypic-resistance-testing","display_name":"genotypic resistance testing","score":0.7860000133514404},{"id":"https://openalex.org/keywords/integrase-inhibitors","display_name":"integrase inhibitors","score":0.3529999852180481},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8087999820709229},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6929000020027161},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6848000288009644},{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.6435999870300293},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6018000245094299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.545799970626831},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5210999846458435},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.44699999690055847},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.4359000027179718},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.4212999939918518},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.420199990272522},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.38960000872612},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3774999976158142},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.296999990940094},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.27379998564720154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jiph.2026.103385","doi":"https://doi.org/10.1016/j.jiph.2026.103385","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jiph.2026.103385","pdf_url":null,"source":{"id":"https://openalex.org/S53706017","display_name":"Journal of Infection and Public Health","issn_l":"1876-0341","issn":["1876-0341","1876-035X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infection and Public Health","raw_type":"journal-article"},{"id":"pmid:42913056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42913056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of infection and public health","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6a954ded6b3b4a01a0e71572daedb9af","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6a954ded6b3b4a01a0e71572daedb9af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Infection and Public Health, Vol 19, Iss 12, Pp 103385- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jiph.2026.103385","doi":"https://doi.org/10.1016/j.jiph.2026.103385","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jiph.2026.103385","pdf_url":null,"source":{"id":"https://openalex.org/S53706017","display_name":"Journal of Infection and Public Health","issn_l":"1876-0341","issn":["1876-0341","1876-035X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infection and Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327359","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1986803970","https://openalex.org/W2057784452","https://openalex.org/W2140123055","https://openalex.org/W2169433939","https://openalex.org/W2584986959","https://openalex.org/W2885221924","https://openalex.org/W3006611826","https://openalex.org/W3111444461","https://openalex.org/W4283795455","https://openalex.org/W4289346113","https://openalex.org/W4309572164","https://openalex.org/W4378799395","https://openalex.org/W4386814599","https://openalex.org/W4401553596","https://openalex.org/W4403636958","https://openalex.org/W4404337467"],"related_works":["https://openalex.org/W4401553596","https://openalex.org/W4311732876","https://openalex.org/W4391940516","https://openalex.org/W4396930190","https://openalex.org/W3093569914","https://openalex.org/W3206734804","https://openalex.org/W4404605141","https://openalex.org/W4213411987","https://openalex.org/W7163707412","https://openalex.org/W3034026100"],"abstract_inverted_index":{"BACKGROUND:":[0],"Limited":[1],"clinical":[2],"data":[3],"are":[4],"available":[5],"on":[6,112,244],"the":[7,36,93,140,200,260],"prevalence":[8],"of":[9,30,61,102,108,205,259],"HIV":[10],"resistance,":[11,272],"especially":[12],"for":[13,65,139],"patients":[14,58,104,263,279],"experiencing":[15,59],"virological":[16,128],"failure":[17,60,75,124,129,149,243,269],"with":[18,27,96,121,146,153,264],"integrase":[19],"strand":[20],"transfer":[21],"inhibitors":[22],"(INSTI)":[23],"in":[24,46,247,278],"an":[25],"area":[26],"universal":[28],"implementation":[29],"single":[31],"tablet":[32],"regimen":[33],"(STR)":[34],"as":[35,78,284],"first-line":[37],"therapy.":[38],"METHODS:":[39],"This":[40],"multicenter":[41],"retrospective":[42],"study":[43],"was":[44,76,89],"conducted":[45],"Taiwan":[47,248],"between":[48],"2015":[49],"and":[50,125,181],"2023.":[51],"Clinical":[52],"samples":[53],"were":[54,118,150,220],"obtained":[55],"nationwide":[56],"from":[57],"a":[62,79,168],"STR":[63,123,148,268],"requested":[64],"genotypic":[66,187],"drug":[67],"resistance":[68,188,210,227],"testing":[69,189],"at":[70,211],"our":[71],"reference":[72],"laboratory.":[73],"Virological":[74,242],"defined":[77],"plasma":[80],"viral":[81],"load":[82],"\u2267":[83],"1000":[84],"copies/ml.":[85],"Logistic":[86],"regression":[87,137],"analysis":[88,138,214],"used":[90],"to":[91,106,132,156,224,238,255],"identify":[92],"factors":[94],"associated":[95,152],"INSTI":[97,209,226,271],"failure.":[98,212],"RESULTS:":[99],"A":[100],"total":[101],"216":[103],"failed":[105,111],"STRs,":[107],"whom":[109],"99":[110],"INSTIs-based":[113],"STRs.":[114,134],"Among":[115],"these,":[116],"26":[117],"treatment":[119,261],"na\u00efve":[120,262],"INSTI-based":[122,133,147,245],"73":[126],"experienced":[127],"after":[130],"switching":[131],"Multivariable":[135,213],"logistic":[136],"primary":[141],"outcome":[142],"revealed":[143],"that":[144,216],"PLHIV":[145,207,217],"independently":[151],"previous":[154],"exposure":[155,254],"first-generation":[157,256,281],"INSTIs":[158],"(adjusted":[159,172,190,228],"OR":[160,173,191,229],"9.470,":[161],"95%":[162,175,193,231],"CI:":[163,176,194],"3.880-23.115,":[164],"p":[165,178,196,234],"<":[166],"0.001),":[167],"non-MSM":[169],"transmission":[170],"route":[171],"0.252,":[174],"0.098-0.649,":[177],"=":[179,197,235],"0.004)":[180],"current":[182],"regimen>":[183],"12":[184],"months":[185],"before":[186],"2.015,":[192],"1.067-3.805,":[195],"0.031).":[198],"For":[199],"secondary":[201],"outcomes,":[202],"24.4%":[203],"(19/78)":[204],"tested":[206],"exhibited":[208],"showed":[215],"failing":[218,280],"EVG/COBI/TAF/FTC":[219],"significantly":[221],"more":[222],"likely":[223],"develop":[225],"22.75,":[230],"CI":[232],"2.114-244.868,":[233],"0.01)":[236],"compared":[237],"BIC/TAF/FTC":[239],"failures":[240],"CONCLUSIONS:":[241],"STRs":[246],"is":[249,275],"primarily":[250],"driven":[251],"by":[252],"prior":[253],"INSTIs.":[257],"None":[258],"DTG":[265],"or":[266],"BIC-based":[267],"developed":[270],"but":[273],"it":[274],"highly":[276],"prevalent":[277],"INSTIs,":[282],"such":[283],"EVG/COBI/TAF/FTC.":[285]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-10-18T00:00:00"}
