{"id":"https://openalex.org/W7222835429","doi":"https://doi.org/10.1186/s12866-026-05590-8","title":"Statistical optimization of melanin-like pigment biosynthesis by marine Streptomyces isolate MOE3 and evaluation of its cytotoxic activity against A-431 cells","display_name":"Statistical optimization of melanin-like pigment biosynthesis by marine Streptomyces isolate MOE3 and evaluation of its cytotoxic activity against A-431 cells","publication_year":2026,"publication_date":"2026-10-17","ids":{"openalex":"https://openalex.org/W7222835429","doi":"https://doi.org/10.1186/s12866-026-05590-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42892683","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13675996"},"language":"en","primary_location":{"id":"doi:10.1186/s12866-026-05590-8","doi":"https://doi.org/10.1186/s12866-026-05590-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-026-05590-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12866-026-05590-8.pdf","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12866-026-05590-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049685660","display_name":"Moaz Mohamed Hamed","orcid":"https://orcid.org/0000-0002-2608-085X","observed_orcids":["https://orcid.org/0000-0002-2608-085X"]},"institutions":[{"id":"https://openalex.org/I3163904508","display_name":"National Institute of Oceanography and Fisheries","ror":"https://ror.org/052cjbe24","country_code":"EG","type":"facility","lineage":["https://openalex.org/I3163904508"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Moaz M. Hamed","raw_affiliation_strings":["National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt. moaz-micro@hotmail.com"],"raw_orcid":"https://orcid.org/0000-0002-2608-085X","affiliations":[{"raw_affiliation_string":"National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt. moaz-micro@hotmail.com","institution_ids":["https://openalex.org/I3163904508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102744601","display_name":"Sahar W. M. Hassan","orcid":"https://orcid.org/0000-0001-8556-5833","observed_orcids":["https://orcid.org/0000-0001-8556-5833"]},"institutions":[{"id":"https://openalex.org/I3163904508","display_name":"National Institute of Oceanography and Fisheries","ror":"https://ror.org/052cjbe24","country_code":"EG","type":"facility","lineage":["https://openalex.org/I3163904508"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sahar W. M. Hassan","raw_affiliation_strings":["National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt","institution_ids":["https://openalex.org/I3163904508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041742713","display_name":"Eman H. Zaghloul","orcid":"https://orcid.org/0000-0002-1048-8412","observed_orcids":["https://orcid.org/0000-0002-1048-8412"]},"institutions":[{"id":"https://openalex.org/I3163904508","display_name":"National Institute of Oceanography and Fisheries","ror":"https://ror.org/052cjbe24","country_code":"EG","type":"facility","lineage":["https://openalex.org/I3163904508"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eman H. Zaghloul","raw_affiliation_strings":["National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Oceanography and Fisheries (NIOF), Cairo, Egypt","institution_ids":["https://openalex.org/I3163904508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049685660"],"corresponding_institution_ids":["https://openalex.org/I3163904508"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72280786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanin-like-pigment","display_name":"melanin-like pigment","score":0.9860000014305115},{"id":"https://openalex.org/keywords/marine-actinomycetes","display_name":"marine actinomycetes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/plackett-burman-design","display_name":"Plackett-Burman design","score":0.8830000162124634},{"id":"https://openalex.org/keywords/box-behnken-design","display_name":"Box-Behnken design","score":1.0},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/a431-cells","display_name":"A431 cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.7879999876022339},{"id":"https://openalex.org/keywords/natural-pigments","display_name":"natural pigments","score":0.875},{"id":"https://openalex.org/keywords/16s-rrna-gene-identification","display_name":"16S rRNA identification","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8858000040054321},{"id":"https://openalex.org/C64584667","wikidata":"https://www.wikidata.org/wiki/Q161179","display_name":"Pigment","level":2,"score":0.7074999809265137},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6068999767303467},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5292999744415283},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.392300009727478},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3668999969959259},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3580000102519989},{"id":"https://openalex.org/C42062724","wikidata":"https://www.wikidata.org/wiki/Q1209205","display_name":"16S ribosomal RNA","level":3,"score":0.3544999957084656},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.35429999232292175},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3483000099658966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3237999975681305},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C2777915650","wikidata":"https://www.wikidata.org/wiki/Q1430556","display_name":"Streptomycetaceae","level":5,"score":0.2957000136375427},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.27090001106262207},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.26330000162124634}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010860","descriptor_name":"Pigments, Biological","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010860","descriptor_name":"Pigments, Biological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010860","descriptor_name":"Pigments, Biological","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12866-026-05590-8","doi":"https://doi.org/10.1186/s12866-026-05590-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-026-05590-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12866-026-05590-8.pdf","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13675996","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13675996/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13675996/pdf/12866_2026_Article_5590.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiol","raw_type":"Text"},{"id":"pmid:42892683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42892683","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:963646b5db734a668563d54ed700a9fd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/963646b5db734a668563d54ed700a9fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiology, Vol 26, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12866-026-05590-8","doi":"https://doi.org/10.1186/s12866-026-05590-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12866-026-05590-8","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12866-026-05590-8.pdf","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321655","display_name":"Science and Technology Development Fund","ror":"https://ror.org/044vr6g03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222835429.pdf","grobid_xml":"https://content.openalex.org/works/W7222835429.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1878781433","https://openalex.org/W1963506577","https://openalex.org/W1965258535","https://openalex.org/W1997892364","https://openalex.org/W2004798786","https://openalex.org/W2006901874","https://openalex.org/W2133371096","https://openalex.org/W2154401636","https://openalex.org/W2159008215","https://openalex.org/W2179722713","https://openalex.org/W2589012529","https://openalex.org/W2804440829","https://openalex.org/W2870363090","https://openalex.org/W2930532753","https://openalex.org/W2945589687","https://openalex.org/W2968325215","https://openalex.org/W2973880977","https://openalex.org/W2994724901","https://openalex.org/W3081189737","https://openalex.org/W4205303573","https://openalex.org/W4223609074","https://openalex.org/W4226145683","https://openalex.org/W4281570578","https://openalex.org/W4285678943","https://openalex.org/W4297997804","https://openalex.org/W4310397700","https://openalex.org/W4323842889","https://openalex.org/W4372333870","https://openalex.org/W4385615165","https://openalex.org/W4387078242","https://openalex.org/W4389304462","https://openalex.org/W4390952885","https://openalex.org/W4392471309","https://openalex.org/W4406327729","https://openalex.org/W7118569833","https://openalex.org/W7124271798"],"related_works":["https://openalex.org/W4390952885","https://openalex.org/W7124271798","https://openalex.org/W4311376272","https://openalex.org/W6958475648","https://openalex.org/W4312069973","https://openalex.org/W2930532753","https://openalex.org/W2066410157","https://openalex.org/W2372384822","https://openalex.org/W3203512811","https://openalex.org/W2159436311"],"abstract_inverted_index":{"Marine":[0],"actinomycetes":[1],"represent":[2],"a":[3,64,77,136,141,146],"promising":[4,137],"source":[5,139],"of":[6,125,140],"biologically":[7],"active":[8],"natural":[9],"pigments.":[10],"In":[11],"the":[12,22,85,89,95,105],"present":[13],"study,":[14],"isolate":[15],"MOE3,":[16],"recovered":[17],"from":[18],"mangrove":[19],"sediment":[20],"along":[21],"Egyptian":[23],"Red":[24],"Sea":[25],"coast,":[26],"was":[27],"provisionally":[28],"assigned":[29],"to":[30,49,84,104],"Streptomyces":[31,52],"lateritius":[32],"based":[33],"on":[34],"partial":[35],"16":[36],"S":[37],"rRNA":[38],"gene":[39],"sequencing":[40],"and":[41,59,144,152],"phylogenetic":[42],"analysis,":[43],"showing":[44],"approximately":[45,81,100],"99%":[46],"sequence":[47],"similarity":[48],"closely":[50],"related":[51],"taxa.":[53],"The":[54,108],"extracted":[55],"pigment":[56,109,143],"exhibited":[57,111],"UV-Visible":[58],"FTIR":[60],"characteristics":[61],"consistent":[62],"with":[63,122],"melanin-like":[65,142],"pigment,":[66],"including":[67],"an":[68,99,123],"absorption":[69],"maximum":[70,78],"at":[71],"255":[72],"nm.":[73],"Plackett-Burman":[74],"screening":[75],"produced":[76],"observed":[79,92],"response":[80,93],"1.65-fold":[82],"relative":[83,103],"basal":[86,106],"response,":[87],"while":[88],"highest":[90],"experimentally":[91],"within":[94],"Box-Behnken":[96],"design":[97],"represented":[98],"2.3-fold":[101],"increase":[102],"response.":[107],"also":[110],"concentration-dependent":[112],"in":[113],"vitro":[114],"cytotoxicity":[115],"against":[116],"A-431":[117],"human":[118],"epidermoid":[119],"carcinoma":[120],"cells,":[121],"IC\u2085\u2080":[124],"45.11":[126],"\u00b5g/mL":[127],"after":[128],"24":[129],"h.":[130],"These":[131],"findings":[132],"identify":[133],"MOE3":[134],"as":[135],"microbial":[138],"provide":[145],"basis":[147],"for":[148],"further":[149],"structural,":[150],"biological,":[151],"process-development":[153],"studies.":[154]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-10-18T00:00:00"}