{"id":"https://openalex.org/W7222825601","doi":"https://doi.org/10.64898/2026.10.12.26365031","title":"Evaluate epidemiologic burden, treatment patterns and treatment outcomes of advanced prostate cancer in Hong Kong using territory-wide electronic medical records","display_name":"Evaluate epidemiologic burden, treatment patterns and treatment outcomes of advanced prostate cancer in Hong Kong using territory-wide electronic medical records","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7222825601","doi":"https://doi.org/10.64898/2026.10.12.26365031"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.12.26365031","doi":"https://doi.org/10.64898/2026.10.12.26365031","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.12.26365031","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/14/2026.10.12.26365031.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/14/2026.10.12.26365031.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038133645","display_name":"Yuanshi Jiao","orcid":"https://orcid.org/0000-0002-0993-3830","observed_orcids":["https://orcid.org/0000-0002-0993-3830"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yuanshi Jiao","raw_affiliation_strings":["Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152373588","display_name":"Jiaqi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Jiaqi Wang","raw_affiliation_strings":["Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158966598","display_name":"Xue Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Xue Li","raw_affiliation_strings":["Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5158966598"],"corresponding_institution_ids":["https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.8759999871253967},{"id":"https://openalex.org/keywords/metastatic-hormone-sensitive-prostate-cancer","display_name":"metastatic hormone-sensitive prostate cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/treatment-patterns","display_name":"treatment patterns","score":0.8330000042915344},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.8090000152587891},{"id":"https://openalex.org/keywords/novel-hormonal-agents","display_name":"novel hormonal agents","score":0.953000009059906},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9800000190734863},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7080000042915344},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.7720000147819519},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/hong-kong","display_name":"Hong Kong","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9326000213623047},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8120999932289124},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6215000152587891},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.6018999814987183},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.532800018787384},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5268999934196472},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5103999972343445},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5087000131607056},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.47859999537467957},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4374000132083893},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4359000027179718},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39340001344680786},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.38519999384880066},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.37369999289512634},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.34709998965263367},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.3359000086784363},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3089999854564667},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.289000004529953},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.27869999408721924},{"id":"https://openalex.org/C2777899217","wikidata":"https://www.wikidata.org/wiki/Q4759439","display_name":"Androgen deprivation therapy","level":4,"score":0.27810001373291016},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.27239999175071716},{"id":"https://openalex.org/C3019952477","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Health records","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C2780664029","wikidata":"https://www.wikidata.org/wiki/Q5282120","display_name":"Disease burden","level":3,"score":0.25760000944137573},{"id":"https://openalex.org/C2987381348","wikidata":"https://www.wikidata.org/wiki/Q517656","display_name":"Electronic records","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C3020144179","wikidata":"https://www.wikidata.org/wiki/Q10871684","display_name":"Electronic health record","level":3,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.12.26365031","doi":"https://doi.org/10.64898/2026.10.12.26365031","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.12.26365031","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/14/2026.10.12.26365031.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.12.26365031","doi":"https://doi.org/10.64898/2026.10.12.26365031","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.12.26365031","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/14/2026.10.12.26365031.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307285","display_name":"Impact Fund","ror":"https://ror.org/00jb20j87"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320329815","display_name":"Hong Kong Government","ror":"https://ror.org/034179816"},{"id":"https://openalex.org/F4320335055","display_name":"Health and Medical Research Fund","ror":"https://ror.org/03qh32912"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222825601.pdf","grobid_xml":"https://content.openalex.org/works/W7222825601.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2123553801","https://openalex.org/W2160840037","https://openalex.org/W2214621962","https://openalex.org/W2620798309","https://openalex.org/W2938589827","https://openalex.org/W3158318954","https://openalex.org/W3202674817","https://openalex.org/W4387828188","https://openalex.org/W4410884998","https://openalex.org/W7160503670"],"related_works":["https://openalex.org/W4391968991","https://openalex.org/W2890884375","https://openalex.org/W7128381912","https://openalex.org/W7168398733","https://openalex.org/W4380149743","https://openalex.org/W4303446324","https://openalex.org/W4416607119","https://openalex.org/W4407700150","https://openalex.org/W1904433804","https://openalex.org/W7162559208"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Prostate":[2],"cancer":[3,18,147,153,203],"(PCa)":[4],"is":[5,41],"the":[6,57,118,160,236],"most":[7],"common":[8],"urological":[9],"malignancy":[10],"globally":[11],"and":[12,34,47,61,78,94,135,149,155,169,190,211,232,262,280,291],"remains":[13],"a":[14,25,108,253,305],"major":[15],"cause":[16],"of":[17,28,59,63,188,230,235,257],"mortality":[19],"among":[20,83],"men.":[21],"In":[22],"Hong":[23,66,119,272],"Kong,":[24],"comprehensive":[26],"evaluation":[27],"disease":[29],"burden,":[30,277],"real-world":[31,81,278],"treatment":[32,76,161,170,176,260],"patterns,":[33,77],"outcomes":[35,82,177,281],"across":[36,282],"clinically":[37],"relevant":[38],"PCa":[39,60,130,276],"subgroups":[40],"essential":[42],"for":[43,201,243],"identifying":[44],"unmet":[45,296],"needs":[46],"optimising":[48],"care":[49,64],"delivery.":[50],"Objectives":[51],"This":[52,267,300],"study":[53,112,270],"aims":[54],"to":[55,180,197,205,209,214,223,294],"characterise":[56],"burden":[58],"patterns":[62,171],"in":[65],"Kong":[67,120],"by":[68,159,304],"(1)":[69],"estimating":[70],"annual":[71,166,217],"patient":[72,167],"load":[73,168],"(2)":[74],"describing":[75],"(3)":[79],"evaluating":[80],"patients":[84,127,142,247],"receiving":[85],"systemic":[86],"therapy":[87,242],"(chemotherapy":[88],"or":[89],"novel":[90,95,238],"hormonal":[91],"agents":[92,96],"[NHA])":[93],"(immunotherapy,":[97],"poly":[98],"ADP-ribose":[99],"polymerase":[100],"[PARP]":[101],"inhibitors,":[102],"radiation":[103],"therapy).":[104],"Methods":[105],"We":[106,174],"conducted":[107],"population-based":[109,268],"retrospective":[110,269],"cohort":[111,125],"using":[113],"electronic":[114],"medical":[115],"records":[116],"from":[117,178,221,307],"Hospital":[121],"Authority":[122],"(HA).":[123],"The":[124],"included":[126,141],"diagnosed":[128],"with":[129,143,246,249],"between":[131],"January":[132],"1,":[133],"2012":[134,179],"December":[136],"31,":[137],"2024.":[138],"Subgroup":[139],"analyses":[140,164],"metastatic":[144,150],"hormone-sensitive":[145],"prostate":[146,152,202],"(mHSPC)":[148],"castration-resistant":[151],"(mCRPC)":[154],"were":[156],"further":[157],"stratified":[158],"received.":[162],"Descriptive":[163],"summarised":[165],"over":[172],"2018-2022.":[173],"evaluated":[175],"2024,":[181],"including":[182,240],"overall":[183],"survival,":[184,186],"progression-free":[185],"number":[187,229],"hospitalisations,":[189,258],"main":[191],"adverse":[192],"events.":[193],"Results":[194],"From":[195],"2018":[196],"2022,":[198],"prevalence":[199],"increased":[200],"(12,014":[204],"15,610),":[206],"mHSPC":[207],"(1,188":[208],"1,779),":[210],"mCRPC":[212,218],"(167":[213],"290),":[215],"while":[216],"incidence":[219],"rose":[220],"125":[222],"274.":[224],"There":[225],"was":[226,302],"an":[227],"increasing":[228],"prevalent":[231],"new":[233],"users":[234],"investigated":[237],"treatment,":[239],"first-/second-/third-line":[241],"mCRPC.":[244],"Compared":[245],"treated":[248],"NHAs,":[250],"chemotherapy":[251],"showed":[252],"numerically":[254],"higher":[255,263],"rate":[256],"bone":[259],"initiation":[261],"hematologic":[264],"toxicity.":[265],"Conclusions":[266],"provides":[271],"Kong\u2013specific":[273],"evidence":[274],"on":[275],"management,":[279],"key":[283],"subgroups,":[284],"thereby":[285],"supporting":[286],"policy":[287],"planning,":[288],"formulary":[289],"evaluation,":[290],"targeted":[292],"strategies":[293],"address":[295],"clinical":[297],"needs.":[298],"Funding":[299],"work":[301],"supported":[303],"grant":[306],"Novartis.":[308]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-10-18T00:00:00"}