{"id":"https://openalex.org/W7222673137","doi":"https://doi.org/10.64898/2026.10.09.758107","title":"Central platelet-rich plasma administration promotes weight loss in diet-induced obese mice","display_name":"Central platelet-rich plasma administration promotes weight loss in diet-induced obese mice","publication_year":2026,"publication_date":"2026-10-16","ids":{"openalex":"https://openalex.org/W7222673137","doi":"https://doi.org/10.64898/2026.10.09.758107"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.09.758107","doi":"https://doi.org/10.64898/2026.10.09.758107","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.758107","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/16/2026.10.09.758107.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/16/2026.10.09.758107.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086439049","display_name":"\u6768\u6653\u71d5","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaoyan Yang","raw_affiliation_strings":["Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China","Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China","institution_ids":["https://openalex.org/I4210139449"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158926795","display_name":"Xuefang Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuefang Hu","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087120463","display_name":"Xiaohua Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaohua Yang","raw_affiliation_strings":["Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China","Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Laboratory Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China","institution_ids":["https://openalex.org/I4210139449"]},{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158920726","display_name":"Qi Xu","orcid":"https://orcid.org/0009-0002-9850-8760","observed_orcids":["https://orcid.org/0009-0002-9850-8760"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Xu","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0009-0002-9850-8760","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067286899","display_name":"Marcos David Munoz","orcid":"https://orcid.org/0000-0002-4126-1720","observed_orcids":["https://orcid.org/0000-0002-4126-1720"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcos David Munoz","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-4126-1720","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158871198","display_name":"Mahilini Muthamilan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahilini Muthamilan","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158888933","display_name":"Dharshini Jayaprakash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dharshini Jayaprakash","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003773743","display_name":"Qi Wu","orcid":"https://orcid.org/0000-0003-0303-4065","observed_orcids":["https://orcid.org/0000-0003-0303-4065","https://orcid.org/0000-0001-9363-4114"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingwen Xu","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0001-9363-4114","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065079953","display_name":"Pei Luo","orcid":"https://orcid.org/0000-0002-8983-9229","observed_orcids":["https://orcid.org/0000-0002-8983-9229"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pei Luo","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-8983-9229","affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065079953"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":1.0},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.906000018119812},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6869999766349792},{"id":"https://openalex.org/keywords/energy-balance","display_name":"energy balance","score":0.7039999961853027},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/arcuate-nucleus","display_name":"arcuate nucleus","score":0.8939999938011169},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.6880000233650208},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.8360000252723694},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8389999866485596},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8194000124931335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8188999891281128},{"id":"https://openalex.org/C2780192938","wikidata":"https://www.wikidata.org/wiki/Q5275043","display_name":"Diet-induced obese","level":4,"score":0.7257000207901001},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.7245000004768372},{"id":"https://openalex.org/C2778458369","wikidata":"https://www.wikidata.org/wiki/Q253246","display_name":"Arcuate nucleus","level":3,"score":0.7213000059127808},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.5842000246047974},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5583999752998352},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5037000179290771},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.4666999876499176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41999998688697815},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.4065999984741211},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.391400009393692},{"id":"https://openalex.org/C138906646","wikidata":"https://www.wikidata.org/wiki/Q7507668","display_name":"Sickness behavior","level":3,"score":0.3871000111103058},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.3831999897956848},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.3831999897956848},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37630000710487366},{"id":"https://openalex.org/C2777423268","wikidata":"https://www.wikidata.org/wiki/Q3663116","display_name":"Energy balance","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3244999945163727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31940001249313354},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3174999952316284},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.29750001430511475},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.28630000352859497},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.2533999979496002}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.09.758107","doi":"https://doi.org/10.64898/2026.10.09.758107","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.758107","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/16/2026.10.09.758107.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.09.758107","doi":"https://doi.org/10.64898/2026.10.09.758107","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.758107","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/16/2026.10.09.758107.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222673137.pdf","grobid_xml":"https://content.openalex.org/works/W7222673137.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1992304191","https://openalex.org/W2025131475","https://openalex.org/W2031632319","https://openalex.org/W2047685291","https://openalex.org/W2066038269","https://openalex.org/W2071470362","https://openalex.org/W2074625678","https://openalex.org/W2086773826","https://openalex.org/W2098259366","https://openalex.org/W2154696002","https://openalex.org/W2178881533","https://openalex.org/W2252857368","https://openalex.org/W2335162728","https://openalex.org/W2623177225","https://openalex.org/W2727793071","https://openalex.org/W2781516261","https://openalex.org/W2795396011","https://openalex.org/W2904584666","https://openalex.org/W2953574432","https://openalex.org/W2971465822","https://openalex.org/W3091097189","https://openalex.org/W3145152257","https://openalex.org/W3196760175","https://openalex.org/W3198875687","https://openalex.org/W3207791606","https://openalex.org/W4281753775","https://openalex.org/W4283330605","https://openalex.org/W4286254592","https://openalex.org/W4362698310","https://openalex.org/W4386194581","https://openalex.org/W4402244375","https://openalex.org/W4402908070","https://openalex.org/W4414443705"],"related_works":["https://openalex.org/W2772021754","https://openalex.org/W2795233762","https://openalex.org/W3127462604","https://openalex.org/W2609132562","https://openalex.org/W7171873779","https://openalex.org/W7135556210","https://openalex.org/W2047356396","https://openalex.org/W2419317691","https://openalex.org/W4390013726","https://openalex.org/W2110607315"],"abstract_inverted_index":{"Abstract":[0],"Aims":[1],"Platelet-rich":[2],"plasma":[3],"(PRP)":[4],"contains":[5],"diverse":[6],"bioactive":[7],"factors,":[8],"but":[9],"its":[10,219],"potential":[11,208],"role":[12],"in":[13,31,53,89,141,154,190],"central":[14,25,179,204],"regulation":[15],"of":[16,56,174,210],"energy":[17,67,119,211],"balance":[18,212],"remains":[19],"unexplored.":[20],"This":[21],"study":[22],"investigated":[23],"whether":[24],"PRP":[26,49,84,101,134,180,205],"administration":[27,181],"alters":[28],"metabolic":[29,157,188],"homeostasis":[30],"diet-induced":[32],"obese":[33,42],"(DIO)":[34],"mice":[35],"and":[36,43,47,58,69,77,113,125,131,156,162,186,198,213,222],"examined":[37],"associated":[38],"hypothalamic":[39,74,196],"responses":[40],"under":[41],"inflammatory":[44],"conditions.":[45],"Materials":[46],"Methods":[48],"was":[50],"administered":[51],"intracerebroventricularly":[52],"mouse":[54],"models":[55],"DIO":[57,90,130,191],"lipopolysaccharide":[59],"(LPS)-induced":[60],"systemic":[61],"inflammation.":[62,175],"Body":[63],"weight,":[64,112],"food":[65,105],"intake,":[66,106],"metabolism,":[68],"adiposity":[70],"were":[71],"assessed":[72],"alongside":[73],"microglial":[75,139,147,197],"morphology":[76],"transcriptomic":[78],"profiling.":[79],"Results":[80],"A":[81,177],"single":[82,178],"intracerebroventricular":[83],"injection":[85],"reduced":[86,135],"body":[87],"weight":[88,184],"mice,":[91,133,192],"with":[92],"the":[93,97,142],"effect":[94],"persisting":[95],"throughout":[96],"7-day":[98],"observation":[99],"period.":[100],"also":[102],"decreased":[103],"cumulative":[104],"relative":[107],"gonadal":[108],"white":[109],"adipose":[110],"tissue":[111],"fasting":[114],"glucose,":[115],"accompanied":[116,193],"by":[117,194],"increased":[118],"expenditure,":[120],"oxygen":[121],"consumption,":[122],"fat":[123],"utilization,":[124],"physical":[126],"activity.":[127],"In":[128],"both":[129],"LPS-treated":[132],"IBA1-positive":[136],"area":[137],"per":[138],"cell":[140],"arcuate":[143],"nucleus":[144],"without":[145],"altering":[146],"number.":[148],"Hypothalamic":[149],"RNA":[150],"sequencing":[151],"revealed":[152],"changes":[153,189],"immune":[155],"signaling,":[158],"extracellular":[159],"matrix":[160],"organization,":[161],"growth-related":[163],"pathways,":[164],"suggesting":[165],"a":[166,207,215],"complex":[167],"transcriptional":[168,199],"response":[169],"rather":[170],"than":[171],"uniform":[172],"suppression":[173],"Conclusions":[176],"induces":[182],"sustained":[183],"loss":[185],"favorable":[187],"region-specific":[195],"responses.":[200],"These":[201],"findings":[202],"identify":[203],"as":[206],"modulator":[209],"provide":[214],"basis":[216],"for":[217],"investigating":[218],"active":[220],"components":[221],"underlying":[223],"mechanisms.":[224]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-17T00:00:00"}
