{"id":"https://openalex.org/W7222599009","doi":"https://doi.org/10.48550/arxiv.2610.24728","title":"Evidence-informed dynamic modelling and intervention prioritisation in diabetic bone marrow","display_name":"Evidence-informed dynamic modelling and intervention prioritisation in diabetic bone marrow","publication_year":2026,"publication_date":"2026-10-16","ids":{"openalex":"https://openalex.org/W7222599009","doi":"https://doi.org/10.48550/arxiv.2610.24728"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2610.24728","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2610.24728","pdf_url":"https://arxiv.org/pdf/2610.24728","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2610.24728","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011359646","display_name":"Paolo Roberto Madeddu","orcid":"https://orcid.org/0000-0002-4718-9205","observed_orcids":["https://orcid.org/0000-0002-4718-9205"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Madeddu, Paolo","raw_affiliation_strings":["Bristol Medical School University of Bristol Bristol BS8 1TH United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Medical School University of Bristol Bristol BS8 1TH United Kingdom","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011359646"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.7250000238418579},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.7459999918937683},{"id":"https://openalex.org/keywords/dynamic-modeling","display_name":"dynamic modeling","score":0.5920000076293945},{"id":"https://openalex.org/keywords/intervention-prioritization","display_name":"intervention prioritization","score":0.9399999976158142},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7509999871253967},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oncostatin-m","display_name":"oncostatin M","score":0.9440000057220459},{"id":"https://openalex.org/keywords/p66shc","display_name":"p66Shc","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8342999815940857},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.4564000070095062},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4090999960899353},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4050000011920929},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3995000123977661},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3353999853134155},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3278000056743622},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31940001249313354},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26089999079704285}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:arXiv.org:2610.24728","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2610.24728","pdf_url":"https://arxiv.org/pdf/2610.24728","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2610.24728","doi":"https://doi.org/10.48550/arxiv.2610.24728","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2610.24728","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.23411562","doi":"https://doi.org/10.5281/zenodo.23411562","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23411562","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.23411563","doi":"https://doi.org/10.5281/zenodo.23411563","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.23411563","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2610.24728","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2610.24728","pdf_url":"https://arxiv.org/pdf/2610.24728","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222599009.pdf","grobid_xml":"https://content.openalex.org/works/W7222599009.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1970845955","https://openalex.org/W1980735247","https://openalex.org/W2069943416","https://openalex.org/W2102163501","https://openalex.org/W2105280584","https://openalex.org/W2133967407","https://openalex.org/W2142041241","https://openalex.org/W2210027779","https://openalex.org/W2394904421","https://openalex.org/W2796629168","https://openalex.org/W2799727388","https://openalex.org/W2802571930","https://openalex.org/W2934211558","https://openalex.org/W2937562729","https://openalex.org/W2949437761","https://openalex.org/W3016664799","https://openalex.org/W3118091656","https://openalex.org/W4280592992","https://openalex.org/W4387861288","https://openalex.org/W7221567475"],"related_works":["https://openalex.org/W2426580129","https://openalex.org/W6960280981","https://openalex.org/W4213415385","https://openalex.org/W7074693166","https://openalex.org/W2978408216","https://openalex.org/W4396933068","https://openalex.org/W6903784429","https://openalex.org/W2506336265","https://openalex.org/W7033415004","https://openalex.org/W7081649391"],"abstract_inverted_index":{"Aims.":[0],"Fragmented":[1],"understanding":[2],"of":[3,193,229],"how":[4],"diabetes":[5],"disrupts":[6],"interconnected":[7],"bone":[8],"marrow":[9,246],"niches":[10],"has":[11],"hindered":[12],"integrated":[13,101],"strategies":[14],"to":[15,29,39,56,210,215],"restore":[16],"function.":[17],"Building":[18],"on":[19,112],"a":[20,26,43,239],"previous":[21],"static":[22],"network,":[23],"we":[24],"developed":[25],"dynamic":[27],"model":[28],"simulate":[30],"intervention":[31,70],"responses.":[32],"Methods.":[33],"The":[34],"investigator":[35],"and":[36,46,62,83,103,155,198,200,227,231],"ChatGPT":[37],"dialogued":[38],"extract":[40],"evidence":[41],"from":[42],"frozen":[44],"corpus":[45],"develop":[47],"the":[48,129],"model.":[49],"A":[50,95],"Python":[51],"implementation":[52],"extended":[53],"Boolean":[54],"logic":[55],"three":[57,81,138],"ordinal":[58],"levels":[59],"(0,":[60],"1":[61,162],"2)":[63],"representing":[64],"biological":[65],"states":[66],"and,":[67],"where":[68],"applicable,":[69],"strength.":[71,94],"Under":[72],"high":[73,190],"metabolic":[74,115,207],"stress,":[75],"15":[76],"interventions":[77,135],"were":[78,90,118],"assessed":[79,108],"at":[80,92],"strengths":[82],"four":[84],"with":[85,173,219],"binary":[86],"settings;":[87],"171":[88],"pairs":[89],"tested":[91],"maximal":[93],"domain":[96],"balanced":[97],"score":[98,131],"(0":[99],"to100)":[100],"favourable":[102],"adverse":[104],"changes.":[105],"Staged":[106],"simulations":[107,237],"withdrawal;":[109],"regulatory":[110],"constraints":[111],"recovery":[113,226],"after":[114,204],"stress":[116,208],"reduction":[117],"examined":[119],"separately.":[120],"Results.":[121],"Endothelial":[122,141],"reactive":[123],"oxygen":[124],"species":[125],"(ROS)":[126],"suppression":[127,171],"achieved":[128],"highest":[130],"among":[132],"19":[133],"single":[134],"(24.2),":[136],"improving":[137],"functional":[139],"domains.":[140],"protein":[142,161],"kinase":[143],"B":[144],"(Akt)":[145],"augmentation":[146,197],"scored":[147,166,180],"15.2":[148],"(two":[149,168],"domains);":[150],"oncostatin":[151],"M":[152],"(OSM)":[153],"blockade":[154,176,202],"haematopoietic":[156],"66":[157],"kDa":[158],"SHC":[159],"transforming":[160],"(p66Shc)":[163],"loss":[164,179],"each":[165],"13.6":[167],"domains).":[169,183],"ROS":[170,194,199],"combined":[172],"either":[174],"OSM":[175,201],"or":[177],"p66Shc":[178],"37.9,":[181],"(five":[182],"No":[184],"pair":[185],"restored":[186,220],"all":[187],"functions":[188],"under":[189],"stress.":[191],"Benefits":[192],"suppression,":[195],"Akt":[196],"disappeared":[203],"withdrawal.":[205],"Reducing":[206],"led":[209],"variable":[211],"scores":[212],"(range":[213],"4.5":[214],"100),":[216],"increasing":[217],"mainly":[218],"endothelial":[221],"function,":[222],"followed":[223],"by":[224],"progenitor":[225],"interruption":[228],"inflammatory":[230],"adipocyte":[232],"stromal":[233],"signalling.":[234],"Conclusions.":[235],"These":[236],"offer":[238],"rule":[240],"based":[241],"framework":[242],"for":[243],"investigating":[244],"diabetic":[245],"recovery.":[247],"Experimental":[248],"studies":[249],"must":[250],"establish":[251],"whether":[252],"it":[253],"can":[254],"guide":[255],"targeted":[256],"therapy.":[257]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-17T00:00:00"}