{"id":"https://openalex.org/W7222497091","doi":"https://doi.org/10.64898/2026.10.14.26365508","title":"Restoring Physical Resilience: Consistent Functional and Sarcopenia Gains Across Two Vivifrail Cohorts","display_name":"Restoring Physical Resilience: Consistent Functional and Sarcopenia Gains Across Two Vivifrail Cohorts","publication_year":2026,"publication_date":"2026-10-16","ids":{"openalex":"https://openalex.org/W7222497091","doi":"https://doi.org/10.64898/2026.10.14.26365508"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.14.26365508","doi":"https://doi.org/10.64898/2026.10.14.26365508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.26365508","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/16/2026.10.14.26365508.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/16/2026.10.14.26365508.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104219560","display_name":"Javier Fern\u00e1ndez\u2010Ortega","orcid":"https://orcid.org/0000-0002-9236-9504","observed_orcids":["https://orcid.org/0000-0002-9236-9504"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Fern\u00e1ndez-Ortega","raw_affiliation_strings":["Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9236-9504","affiliations":[{"raw_affiliation_string":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158854483","display_name":"Javier Loza-Herbella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Loza-Herbella","raw_affiliation_strings":["Santo\u00f1a Town Council, Cantabria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santo\u00f1a Town Council, Cantabria, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158891324","display_name":"Juan A. Rangel-Garcia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan A. Rangel-Garc\u00eda","raw_affiliation_strings":["Santo\u00f1a Town Council, Cantabria, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Santo\u00f1a Town Council, Cantabria, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005949266","display_name":"Andr\u00e9s B. Fern\u00e1ndez Revelles","orcid":"https://orcid.org/0000-0002-8089-650X","observed_orcids":["https://orcid.org/0000-0002-8089-650X"]},"institutions":[{"id":"https://openalex.org/I173304897","display_name":"Universidad de Granada","ror":"https://ror.org/04njjy449","country_code":"ES","type":"education","lineage":["https://openalex.org/I173304897"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andr\u00e9s B. Fern\u00e1ndez-Revelles","raw_affiliation_strings":["Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8089-650X","affiliations":[{"raw_affiliation_string":"Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain","institution_ids":["https://openalex.org/I173304897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104219560"],"corresponding_institution_ids":["https://openalex.org/I173304897"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vivifrail","display_name":"Vivifrail","score":0.8519999980926514},{"id":"https://openalex.org/keywords/multicomponent-exercise","display_name":"multicomponent exercise","score":0.871999979019165},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7889999747276306},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fall-risk","display_name":"fall risk","score":0.8149999976158142},{"id":"https://openalex.org/keywords/short-physical-performance-battery","display_name":"Short Physical Performance Battery","score":0.8539999723434448},{"id":"https://openalex.org/keywords/handgrip-strength","display_name":"grip strength","score":0.906000018119812},{"id":"https://openalex.org/keywords/timed-up-and-go-test","display_name":"Timed Up and Go test","score":0.8539999723434448},{"id":"https://openalex.org/keywords/community-based-exercise","display_name":"community-based exercise","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.9395999908447266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6811000108718872},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6633999943733215},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4788999855518341},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4717999994754791},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4154999852180481},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.41519999504089355},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C3020255362","wikidata":"https://www.wikidata.org/wiki/Q747883","display_name":"Physical activity","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C3018086343","wikidata":"https://www.wikidata.org/wiki/Q3540864","display_name":"Balance test","level":3,"score":0.29350000619888306},{"id":"https://openalex.org/C79544238","wikidata":"https://www.wikidata.org/wiki/Q423243","display_name":"Activities of daily living","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C54183767","wikidata":"https://www.wikidata.org/wiki/Q10384","display_name":"Geriatrics","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C3018868096","wikidata":"https://www.wikidata.org/wiki/Q2693233","display_name":"Internal consistency","level":3,"score":0.2655999958515167},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C2988918651","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle strength","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C18747219","wikidata":"https://www.wikidata.org/wiki/Q620994","display_name":"Standard error","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C2776255841","wikidata":"https://www.wikidata.org/wiki/Q5647202","display_name":"Hand strength","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.14.26365508","doi":"https://doi.org/10.64898/2026.10.14.26365508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.26365508","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/16/2026.10.14.26365508.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.14.26365508","doi":"https://doi.org/10.64898/2026.10.14.26365508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.14.26365508","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/10/16/2026.10.14.26365508.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222497091.pdf","grobid_xml":"https://content.openalex.org/works/W7222497091.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1541923384","https://openalex.org/W1968399062","https://openalex.org/W1993056843","https://openalex.org/W2006074288","https://openalex.org/W2073862763","https://openalex.org/W2096657471","https://openalex.org/W2101897425","https://openalex.org/W2102236934","https://openalex.org/W2142514031","https://openalex.org/W2159296038","https://openalex.org/W2809033846","https://openalex.org/W2946278828","https://openalex.org/W2968962647","https://openalex.org/W2979340990","https://openalex.org/W2981414419","https://openalex.org/W3191864380","https://openalex.org/W4280521333","https://openalex.org/W4389786035","https://openalex.org/W4399772605","https://openalex.org/W4403584833","https://openalex.org/W4408400553","https://openalex.org/W4414380165","https://openalex.org/W7161848370","https://openalex.org/W7163354704","https://openalex.org/W7172272864"],"related_works":["https://openalex.org/W4211012689","https://openalex.org/W3083355973","https://openalex.org/W4405965154","https://openalex.org/W4412732756","https://openalex.org/W4405957853","https://openalex.org/W4388865396","https://openalex.org/W7164824269","https://openalex.org/W4286209419","https://openalex.org/W3192714068","https://openalex.org/W2985544290"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"To":[2],"evaluate":[3],"change":[4,31],"in":[5,110,132,218,224],"physical":[6,219],"function":[7,220],"and":[8,24,54,84,92,104,159,179,221],"probable":[9,98,225],"sarcopenia":[10,99,150,226],"following":[11],"a":[12,105,117,222],"36-week":[13,207],"community":[14],"multicomponent":[15,208],"exercise":[16,209],"programme":[17,210],"(Vivifrail":[18],"model)":[19],"across":[20,227],"two":[21,228],"consecutive":[22],"cycles,":[23],"to":[25,154,200],"assess":[26],"the":[27,143,182,191],"consistency":[28],"of":[29,119],"this":[30],"between":[32,174],"cohorts.":[33,112,230],"Study":[34],"design":[35,233],"Quasi-experimental,":[36],"single-arm,":[37],"repeated-measures":[38],"service":[39],"evaluation.":[40],"Ninety-two":[41],"older":[42],"adults":[43],"(2025\u20132026":[44],"cohort;":[45],"mean":[46,118],"age":[47],"75.9":[48],"years,":[49],"88.0%":[50],"women)":[51],"completed":[52],"baseline":[53],"post-intervention":[55],"assessments;":[56],"an":[57],"independent":[58,229],"2024\u20132025":[59],"cohort":[60],"(n":[61,69],"=":[62,70,124,157,203],"86)":[63],"was":[64,185,211],"analysed":[65],"jointly":[66],"for":[67,176,187],"replication":[68],"178).":[71],"Main":[72],"outcome":[73],"measures":[74],"Short":[75],"Physical":[76],"Performance":[77],"Battery":[78],"(SPPB)":[79],"score":[80],"(primary);":[81],"Timed":[82],"Up":[83],"Go":[85],"(TUG),":[86],"handgrip":[87,178],"strength,":[88],"6-metre":[89,180],"walk":[90],"time":[91],"Mini-Mental":[93],"State":[94],"Examination":[95],"(MMSE)":[96],"(secondary);":[97],"(EWGSOP2),":[100],"SPPB-based":[101],"frailty":[102,160],"category,":[103],"fall-risk":[106],"indicator":[107],"computed":[108],"identically":[109],"both":[111],"Results":[113],"SPPB":[114],"improved":[115],"by":[116],"1.33":[120],"points":[121],"(Cohen\u2019s":[122],"d":[123],"0.96;":[125],"p":[126],"<":[127,139,168],".001),":[128],"with":[129,213],"concordant":[130],"improvement":[131,217],"all":[133],"four":[134],"secondary":[135],"outcomes":[136],"(all":[137],"q":[138],".005).":[140],"72.8%":[141],"reached":[142],"substantial":[144],"minimal":[145],"clinically":[146,214],"important":[147],"difference.":[148],"Probable":[149],"fell":[151,197],"from":[152,198],"17.4%":[153],"5.4%":[155],"(p":[156,167,202],".006),":[158],"category":[161],"shifted":[162],"toward":[163],"higher":[164],"functional":[165],"levels":[166],".001).":[169],"Effect":[170],"sizes":[171],"were":[172],"consistent":[173],"cohorts":[175],"SPPB,":[177],"walk;":[181],"Time\u00d7Cohort":[183],"interaction":[184],"significant":[186],"TUG":[188],"only.":[189],"In":[190],"pooled":[192],"sample,":[193],"elevated":[194],"fall":[195],"risk":[196],"19.7%":[199],"11.2%":[201],".002).":[204],"Conclusions":[205],"A":[206],"associated":[212],"meaningful,":[215],"reproducible":[216],"reduction":[223],"The":[231],"single-arm":[232],"precludes":[234],"causal":[235],"inference.":[236]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-17T00:00:00"}
