{"id":"https://openalex.org/W7222475151","doi":"https://doi.org/10.3389/fneur.2026.1843264","title":"MCH-02, a synthetic macamide analog with in vitro FAAH-inhibitory activity, modulates hippocampal endocannabinoid system and BK channel expression without preventing PTZ-induced progressive seizure susceptibility in rats","display_name":"MCH-02, a synthetic macamide analog with in vitro FAAH-inhibitory activity, modulates hippocampal endocannabinoid system and BK channel expression without preventing PTZ-induced progressive seizure susceptibility in rats","publication_year":2026,"publication_date":"2026-10-16","ids":{"openalex":"https://openalex.org/W7222475151","doi":"https://doi.org/10.3389/fneur.2026.1843264","pmid":"https://pubmed.ncbi.nlm.nih.gov/42964122","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13719350"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1843264","doi":"https://doi.org/10.3389/fneur.2026.1843264","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1843264","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1843264/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1843264/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158932171","display_name":"Yessenia Yauri-Huaman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141205","display_name":"Universidad Andina del Cusco","ror":"https://ror.org/04jzwa923","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210141205"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Yessenia Yauri-Huaman","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco","institution_ids":["https://openalex.org/I4210141205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158895460","display_name":"Rodrigo Caceres-Robles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141205","display_name":"Universidad Andina del Cusco","ror":"https://ror.org/04jzwa923","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210141205"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Rodrigo Caceres-Robles","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco","institution_ids":["https://openalex.org/I4210141205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158876264","display_name":"Christell Becerra Flores","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141205","display_name":"Universidad Andina del Cusco","ror":"https://ror.org/04jzwa923","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210141205"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Christell Becerra Flores","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco","institution_ids":["https://openalex.org/I4210141205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158935202","display_name":"Miguel Garay-Malpartida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Miguel Garay-Malpartida","raw_affiliation_strings":["Multidisciplinary Research Center, School of Arts, Sciences and Humanities, University of S\u00e3o Paulo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Research Center, School of Arts, Sciences and Humanities, University of S\u00e3o Paulo","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093106585","display_name":"Carlos Medina-Saldivar","orcid":"https://orcid.org/0000-0001-9975-1282","observed_orcids":["https://orcid.org/0000-0001-9975-1282"]},"institutions":[{"id":"https://openalex.org/I4210141205","display_name":"Universidad Andina del Cusco","ror":"https://ror.org/04jzwa923","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210141205"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Carlos Medina-Saldivar","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco","institution_ids":["https://openalex.org/I4210141205"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5135936897","display_name":"Luis F. Pacheco\u2010Ot\u00e1lora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141205","display_name":"Universidad Andina del Cusco","ror":"https://ror.org/04jzwa923","country_code":"PE","type":"education","lineage":["https://openalex.org/I4210141205"]}],"countries":["PE"],"is_corresponding":true,"raw_author_name":"Luis F. Pacheco-Otalora","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Neurociencias, Instituto Cient\u00edfico, Universidad Andina del Cusco","institution_ids":["https://openalex.org/I4210141205"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5135936897"],"corresponding_institution_ids":["https://openalex.org/I4210141205"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74627619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1843264","last_page":"1843264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.24120000004768372,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fatty-acid-amide-hydrolase-inhibitors","display_name":"fatty acid amide hydrolase inhibitors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/endocannabinoid-system","display_name":"endocannabinoid system","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6940000057220459},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cb1-receptor","display_name":"CB1 receptor","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cnr1","display_name":"CNR1","score":0.6620000004768372},{"id":"https://openalex.org/keywords/pentylenetetrazole-kindling","display_name":"pentylenetetrazole kindling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7720000147819519},{"id":"https://openalex.org/keywords/seizure-susceptibility","display_name":"seizure susceptibility","score":0.7519999742507935},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.4650000035762787},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C46721173","wikidata":"https://www.wikidata.org/wiki/Q368952","display_name":"Endocannabinoid system","level":3,"score":0.8051999807357788},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.6722999811172485},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6480000019073486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6008999943733215},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5145999789237976},{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.49230000376701355},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.47450000047683716},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4603999853134155},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.4171000123023987},{"id":"https://openalex.org/C2779783865","wikidata":"https://www.wikidata.org/wiki/Q410228","display_name":"Anandamide","level":5,"score":0.4106000065803528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37459999322891235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37279999256134033},{"id":"https://openalex.org/C2781144285","wikidata":"https://www.wikidata.org/wiki/Q21113274","display_name":"Fatty acid amide hydrolase","level":5,"score":0.3619000017642975},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C2778302826","wikidata":"https://www.wikidata.org/wiki/Q1741970","display_name":"Kindling model","level":4,"score":0.3398999869823456},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.3359000086784363},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.32269999384880066},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.321399986743927},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C2778460930","wikidata":"https://www.wikidata.org/wiki/Q7447053","display_name":"Seizure threshold","level":4,"score":0.2816999852657318},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2750999927520752},{"id":"https://openalex.org/C14314382","wikidata":"https://www.wikidata.org/wiki/Q1943386","display_name":"Molecular Pharmacology","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.25540000200271606},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.25}],"mesh":[{"descriptor_ui":"D000099252","descriptor_name":"Fatty Acid Amide Hydrolases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007696","descriptor_name":"Kindling, Neurologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010433","descriptor_name":"Pentylenetetrazole","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063388","descriptor_name":"Endocannabinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fneur.2026.1843264","doi":"https://doi.org/10.3389/fneur.2026.1843264","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1843264","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1843264/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13719350","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719350/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13719350/pdf/fneur-17-1843264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurol","raw_type":"Text"},{"id":"pmid:42964122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42964122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neurology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8cbaccde3d074c5499c247953b6c6520","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8cbaccde3d074c5499c247953b6c6520","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neurology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1843264","doi":"https://doi.org/10.3389/fneur.2026.1843264","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1843264","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1843264/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320326614","display_name":"Consejo Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Tecnol\u00f3gica","ror":"https://ror.org/05c7j7r25"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222475151.pdf","grobid_xml":"https://content.openalex.org/works/W7222475151.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1564854503","https://openalex.org/W1865383866","https://openalex.org/W1875008998","https://openalex.org/W1920696238","https://openalex.org/W1980805930","https://openalex.org/W1985249962","https://openalex.org/W2003646464","https://openalex.org/W2007860569","https://openalex.org/W2010425177","https://openalex.org/W2018991110","https://openalex.org/W2022981588","https://openalex.org/W2031180465","https://openalex.org/W2034375626","https://openalex.org/W2038933710","https://openalex.org/W2043033522","https://openalex.org/W2127586922","https://openalex.org/W2137070227","https://openalex.org/W2144673831","https://openalex.org/W2154135229","https://openalex.org/W2168499817","https://openalex.org/W2171313875","https://openalex.org/W2560441588","https://openalex.org/W2597981375","https://openalex.org/W2729040841","https://openalex.org/W2753608950","https://openalex.org/W2761862301","https://openalex.org/W2804921146","https://openalex.org/W2807928577","https://openalex.org/W2809388826","https://openalex.org/W2885509851","https://openalex.org/W2886541210","https://openalex.org/W2910544292","https://openalex.org/W2989864966","https://openalex.org/W3023279797","https://openalex.org/W3030173003","https://openalex.org/W3132662748","https://openalex.org/W3183518814","https://openalex.org/W4205179746","https://openalex.org/W4292323913","https://openalex.org/W4379473685","https://openalex.org/W4386062492","https://openalex.org/W4392463775","https://openalex.org/W4406472850"],"related_works":["https://openalex.org/W6950348110","https://openalex.org/W2976270996","https://openalex.org/W2729404278","https://openalex.org/W2073037861","https://openalex.org/W2096699623","https://openalex.org/W1983200388","https://openalex.org/W7154171924","https://openalex.org/W4406472850","https://openalex.org/W2989939721","https://openalex.org/W2194300967"],"abstract_inverted_index":{"Epilepsy":[0],"remains":[1],"a":[2,28,46,70,131,137,182],"major":[3],"neurological":[4],"disorder,":[5],"with":[6,199],"about":[7],"30%":[8],"of":[9,17,45,96,130,221,226],"patients":[10],"showing":[11],"drug":[12],"resistance":[13],"despite":[14],"the":[15,43,149,162,214,218,224],"availability":[16],"multiple":[18],"antiseizure":[19],"medications.":[20],"The":[21],"endocannabinoid":[22,201],"system":[23],"(ECS)":[24],"has":[25],"emerged":[26],"as":[27],"promising":[29],"therapeutic":[30,239],"target":[31],"due":[32],"to":[33,234],"its":[34],"role":[35],"in":[36,69,76,148,161,169,213,244],"regulating":[37],"neuronal":[38],"excitability.":[39,192],"This":[40],"study":[41],"examined":[42],"effects":[44],"new":[47],"macamide-derived":[48],"fatty":[49],"acid":[50],"amide":[51],"hydrolase":[52],"(FAAH)":[53],"inhibitor,":[54],"N":[55],"-(8Z-heptadecen-1-yl)-":[56],"O":[57],"-(3-pyridylmethyl)":[58],"carbamate":[59],"(MCH-02),":[60],"on":[61,134],"seizure":[62,110,115],"development,":[63],"cognition,":[64],"and":[65,85,89,93,99,112,125,144,156,167,184,190,203,231,238],"hippocampal":[66,200],"molecular":[67,90,138,175,196],"markers":[68],"chronic":[71,245],"pentylenetetrazol":[72],"(PTZ)":[73],"kindling":[74],"model":[75],"rats.":[77],"Behavioral":[78],"measures":[79],"(Racine":[80],"scale,":[81],"survival,":[82],"Barnes":[83],"maze,":[84],"novel":[86],"object":[87],"recognition)":[88],"analyses":[91],"(RT-qPCR":[92],"Western":[94],"blot":[95],"CA1,":[97],"CA3,":[98],"dentate":[100],"gyrus)":[101],"were":[102],"conducted.":[103],"MCH-02":[104,140,194],"did":[105,119],"not":[106,120,209],"prevent":[107],"PTZ-induced":[108],"progressive":[109],"susceptibility":[111],"initially":[113],"worsened":[114],"severity.":[116],"Survival":[117],"probability":[118],"differ":[121],"significantly":[122],"among":[123],"groups,":[124],"we":[126],"observed":[127],"no":[128],"evidence":[129],"protective":[132],"effect":[133],"survival.":[135],"On":[136],"level,":[139],"increased":[141],"FAAH,":[142],"Cnr1,":[143],"Napepld":[145],"mRNA":[146],"levels":[147,160],"CA1":[150],"region.":[151],"It":[152],"altered":[153],"CB1":[154],"receptor":[155],"BK\u03b11":[157],"subunit":[158],"protein":[159],"hippocampus,":[163],"suggesting":[164,181],"ECS":[165,188],"remodeling":[166,206],"changes":[168],"potassium":[170],"channel":[171,205],"regulation.":[172],"Despite":[173],"these":[174],"changes,":[176],"behavioral":[177],"protection":[178],"was":[179],"inconsistent,":[180],"complex":[183],"context-dependent":[185],"relationship":[186],"between":[187],"function":[189],"intrinsic":[191],"Overall,":[193],"modulates":[195],"pathways":[197],"associated":[198],"signaling":[202],"BK":[204],"but":[207],"does":[208],"demonstrate":[210],"antiepileptogenic":[211],"efficacy":[212],"PTZ-kindling":[215],"model.":[216],"However,":[217],"surprising":[219],"worsening":[220],"seizures":[222],"highlights":[223],"importance":[225],"further":[227],"research":[228],"incorporating":[229],"electrophysiological":[230],"pharmacokinetic":[232],"studies":[233],"determine":[235],"optimal":[236],"dosing":[237],"timing":[240],"for":[241],"FAAH":[242],"inhibitors":[243],"epilepsy":[246],"models.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-10-17T00:00:00"}
