{"id":"https://openalex.org/W7222287281","doi":"https://doi.org/10.64898/2026.10.07.755981","title":"Excitation-contraction coupling plasticity is revealed upon RyR2 depletion in adult mouse ventricular myocytes","display_name":"Excitation-contraction coupling plasticity is revealed upon RyR2 depletion in adult mouse ventricular myocytes","publication_year":2026,"publication_date":"2026-10-14","ids":{"openalex":"https://openalex.org/W7222287281","doi":"https://doi.org/10.64898/2026.10.07.755981"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.07.755981","doi":"https://doi.org/10.64898/2026.10.07.755981","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.755981","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.07.755981.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.07.755981.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018307902","display_name":"Erick B. R\u00edos P\u00e9rez","orcid":"https://orcid.org/0000-0002-2246-9112","observed_orcids":["https://orcid.org/0000-0002-2246-9112"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erick B. R\u00edos P\u00e9rez","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0000-0002-2246-9112","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126388432","display_name":"Achal M. Gowda","orcid":"https://orcid.org/0009-0001-1364-0387","observed_orcids":["https://orcid.org/0009-0001-1364-0387"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Achal M. Gowda","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0009-0001-1364-0387","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126392787","display_name":"Isabel Cecilia Garay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabel C. Garay","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126408407","display_name":"Sergio Estrada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Estrada","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033804025","display_name":"David W. Kingston","orcid":"https://orcid.org/0009-0008-0825-6066","observed_orcids":["https://orcid.org/0009-0008-0825-6066"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Kingston","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0009-0008-0825-6066","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039229335","display_name":"Francisco Alvarado","orcid":"https://orcid.org/0000-0003-0552-9029","observed_orcids":["https://orcid.org/0000-0003-0552-9029"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Francisco J. Alvarado","raw_affiliation_strings":["Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"],"raw_orcid":"https://orcid.org/0000-0003-0552-9029","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiovascular Medicine, Cardiovascular Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039229335"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ryanodine-receptor-2","display_name":"RyR2","score":0.921999990940094},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.7929999828338623},{"id":"https://openalex.org/keywords/homeostatic-plasticity","display_name":"homeostatic plasticity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-handling","display_name":"sarcoplasmic reticulum calcium handling","score":0.8199999928474426},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.7070000171661377},{"id":"https://openalex.org/keywords/l-type-calcium-current","display_name":"L-type calcium current","score":0.8230000138282776},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.6790000200271606},{"id":"https://openalex.org/keywords/serca2a","display_name":"SERCA2a","score":0.8840000033378601},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.5199999809265137},{"id":"https://openalex.org/keywords/autoregulation","display_name":"autoregulation","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C190712762","wikidata":"https://www.wikidata.org/wiki/Q18031341","display_name":"Ryanodine receptor 2","level":4,"score":0.9311000108718872},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.8314999938011169},{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.5764999985694885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5134999752044678},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5029000043869019},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4896000027656555},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.482699990272522},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.44839999079704285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44589999318122864},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.42590001225471497},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C2775953344","wikidata":"https://www.wikidata.org/wiki/Q24774223","display_name":"Calsequestrin","level":4,"score":0.3930000066757202},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.3864000141620636},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3734000027179718},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3707999885082245},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.365200012922287},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.358599990606308},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3458000123500824},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3352999985218048},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3073999881744385},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.30090001225471497},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.30079999566078186},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2858000099658966},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.266400009393692},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2778470358","wikidata":"https://www.wikidata.org/wiki/Q908761","display_name":"Fura-2","level":4,"score":0.25929999351501465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.10.07.755981","doi":"https://doi.org/10.64898/2026.10.07.755981","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.755981","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.07.755981.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.10.07.755981","doi":"https://doi.org/10.64898/2026.10.07.755981","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.07.755981","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/14/2026.10.07.755981.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222287281.pdf","grobid_xml":"https://content.openalex.org/works/W7222287281.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130563798","https://openalex.org/W4223651210","https://openalex.org/W2111867044","https://openalex.org/W4390693994","https://openalex.org/W1614269731","https://openalex.org/W2059342097","https://openalex.org/W3021103183","https://openalex.org/W2032816757","https://openalex.org/W4387996294","https://openalex.org/W2228278740"],"abstract_inverted_index":{"ABSTRACT":[0],"Ryanodine":[1],"receptor":[2],"2":[3],"(RyR2)":[4],"is":[5,30,239,316],"central":[6],"to":[7,57,61,300,327],"cardiac":[8,63,77,103,215,235,290],"excitation-contraction":[9,236],"coupling":[10,237],"(ECC),":[11,238],"translating":[12],"electrical":[13],"signals":[14],"into":[15],"sarcoplasmic":[16],"reticulum":[17],"(SR)":[18],"Ca":[19,82,108,120,137,143,148,160,207,216,272],"2+":[20,83,109,121,138,144,208,217,273],"release":[21,127],"and":[22,80,99,105,114,129,135,150,164,173,210,219,261,297],"mechanical":[23],"contraction.":[24],"Although":[25],"constitutive":[26],"deletion":[27],"of":[28,159,179,229,285,311],"RyR2":[29,40,59,69,93,202,224,251,268,278,295,314],"lethal,":[31],"adult":[32,67,243],"hearts":[33,113,260],"can":[34,245],"withstand":[35],"a":[36,231,247,264,294,308],"significant":[37,248],"reduction":[38,249,266],"in":[39,111,155,250,267,319],"expression":[41,252,269,315],"without":[42,253],"overt":[43,254,283],"ECC":[44,49,151,198,287,302],"dysfunction.":[45,255],"We":[46,256],"hypothesized":[47],"that":[48,54,141,258],"possesses":[50],"intrinsic":[51,197],"homeostatic":[52,305],"plasticity":[53,306],"rapidly":[55],"adapts":[56],"acute":[58],"loss":[60],"maintain":[62,214,301],"performance.":[64],"Using":[65],"an":[66],"tamoxifen-inducible":[68],"conditional":[70],"knockout":[71],"(RyR2cKO)":[72],"mouse":[73,259],"model,":[74],"we":[75],"evaluated":[76],"structure,":[78],"electrophysiology,":[79],"intracellular":[81],"dynamics.":[84],"RyR2cKO":[85,156],"mice":[86],"survived":[87],"for":[88,234,276],"weeks":[89],"with":[90,263],"<10%":[91],"residual":[92],"protein":[94],"expression.":[95],"In":[96],"vivo":[97],"echocardiography":[98],"electrocardiography":[100],"revealed":[101],"normal":[102],"structure":[104],"function.":[106],"Confocal":[107],"imaging":[110,139],"intact":[112],"isolated":[115],"ventricular":[116],"myocytes":[117],"showed":[118],"preserved":[119,271],"transient":[122],"(CaT)":[123],"amplitude":[124],"but":[125],"slower":[126],"kinetics":[128],"elevated":[130,205],"SR":[131,190,206],"load.":[132],"Simultaneous":[133],"patch-clamp":[134],"confocal":[136],"established":[140],"L-type":[142],"current":[145],"(":[146],"I":[147],")":[149],"gain":[152],"were":[153],"maintained":[154],"myocytes.":[157],"Expression":[158],"V":[161],"1.2,":[162],"NCX,":[163],"phospholamban":[165],"remained":[166],"unchanged,":[167],"whereas":[168],"SERCA2a,":[169],"IP":[170,180],"3":[171,181],"receptor,":[172],"VMP1":[174],"levels":[175,279],"decreased.":[176],"Pharmacological":[177],"inhibition":[178],"receptors":[182],"did":[183],"not":[184,281,325],"suppress":[185],"CaT,":[186],"ruling":[187],"out":[188],"alternative":[189],"channel":[191,203,233],"compensation.":[192],"These":[193],"findings":[194],"reveal":[195],"remarkable":[196],"plasticity,":[199],"where":[200],"high":[201],"reserve,":[204],"load,":[209],"CaT":[211],"autoregulation":[212,299],"collectively":[213],"cycling":[218],"contractile":[220],"function":[221],"despite":[222],"profound":[223],"depletion.":[225],"KEY":[226],"POINTS":[227],"Deletion":[228],"RyR2,":[230],"critical":[232],"embryonically":[240],"lethal;":[241],"however,":[242,322],"cardiomyocytes":[244,262],"tolerate":[246],"show":[257,270],"90%":[265],"handling.":[274],"Compensation":[275],"reduced":[277],"does":[280],"involve":[282],"remodeling":[284],"the":[286,328],"machinery":[288],"or":[289],"structure.":[291],"Cardiomyocytes":[292],"have":[293],"reserve":[296],"employ":[298],"fidelity,":[303],"uncovering":[304],"as":[307],"regulatory":[309],"mechanism":[310],"ECC.":[312],"Reduced":[313],"often":[317],"observed":[318],"heart":[320],"disease;":[321],"it":[323],"may":[324],"contribute":[326],"pathology.":[329]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-16T00:00:00"}
