{"id":"https://openalex.org/W7222284694","doi":"https://doi.org/10.3389/fimmu.2026.1932850","title":"Glaucoma neurodegeneration: targeted modulation of intraocular immune pathways \u2013 a review of novel therapeutic advances","display_name":"Glaucoma neurodegeneration: targeted modulation of intraocular immune pathways \u2013 a review of novel therapeutic advances","publication_year":2026,"publication_date":"2026-10-15","ids":{"openalex":"https://openalex.org/W7222284694","doi":"https://doi.org/10.3389/fimmu.2026.1932850","pmid":"https://pubmed.ncbi.nlm.nih.gov/42959469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13717443"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1932850","doi":"https://doi.org/10.3389/fimmu.2026.1932850","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932850","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932850/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932850/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158822617","display_name":"Yunyun Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152237","display_name":"Wenzhou City People's Hospital","ror":"https://ror.org/04jmysw33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunyun Sun","raw_affiliation_strings":["Wenzhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158834715","display_name":"Keyun Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152237","display_name":"Wenzhou City People's Hospital","ror":"https://ror.org/04jmysw33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keyun Xue","raw_affiliation_strings":["Wenzhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019450154","display_name":"Congqin Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152237","display_name":"Wenzhou City People's Hospital","ror":"https://ror.org/04jmysw33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Congqin Wen","raw_affiliation_strings":["Wenzhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006287214","display_name":"Xinyan Ma","orcid":"https://orcid.org/0009-0005-1004-5629","observed_orcids":["https://orcid.org/0009-0005-1004-5629","https://orcid.org/0009-0008-1348-5840"]},"institutions":[{"id":"https://openalex.org/I4210152237","display_name":"Wenzhou City People's Hospital","ror":"https://ror.org/04jmysw33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152237"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyan Ma","raw_affiliation_strings":["Wenzhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152237"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101440533","display_name":"Xiaojie Hu","orcid":"https://orcid.org/0000-0002-7159-9917","observed_orcids":["https://orcid.org/0000-0002-7159-9917"]},"institutions":[{"id":"https://openalex.org/I4210152237","display_name":"Wenzhou City People's Hospital","ror":"https://ror.org/04jmysw33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152237"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaojie Hu","raw_affiliation_strings":["Wenzhou People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wenzhou People\u2019s Hospital","institution_ids":["https://openalex.org/I4210152237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101440533"],"corresponding_institution_ids":["https://openalex.org/I4210152237"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62429907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1932850","last_page":"1932850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/retinal-ganglion-cell-loss","display_name":"retinal ganglion cell death","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.8830000162124634},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8149999976158142},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tlr4-nf-kappab-signaling-pathway","display_name":"TLR4/NF-\u03baB signaling","score":0.9049999713897705},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.949999988079071},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8429999947547913},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.6960999965667725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6935999989509583},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6126000285148621},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.5810999870300293},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43209999799728394},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.42820000648498535},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4025999903678894},{"id":"https://openalex.org/C2991678113","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immune modulation","level":3,"score":0.3935999870300293},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3555000126361847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3537999987602234},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.35269999504089355},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.33230000734329224},{"id":"https://openalex.org/C2777624874","wikidata":"https://www.wikidata.org/wiki/Q927337","display_name":"Retinal ganglion cell","level":3,"score":0.3255000114440918},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.30399999022483826},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.2556999921798706}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005901","descriptor_name":"Glaucoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1932850","doi":"https://doi.org/10.3389/fimmu.2026.1932850","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932850","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932850/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13717443","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717443/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717443/pdf/fimmu-17-1932850.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42959469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42959469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9450421319624400ab25c2cb335e6787","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9450421319624400ab25c2cb335e6787","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1932850","doi":"https://doi.org/10.3389/fimmu.2026.1932850","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932850","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932850/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222284694.pdf","grobid_xml":"https://content.openalex.org/works/W7222284694.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W141548993","https://openalex.org/W1571280146","https://openalex.org/W1963965212","https://openalex.org/W1972129424","https://openalex.org/W1983740408","https://openalex.org/W2003895213","https://openalex.org/W2016055211","https://openalex.org/W2033617297","https://openalex.org/W2034742711","https://openalex.org/W2062171726","https://openalex.org/W2071960951","https://openalex.org/W2081861923","https://openalex.org/W2096327192","https://openalex.org/W2115757439","https://openalex.org/W2117783087","https://openalex.org/W2120119175","https://openalex.org/W2122037893","https://openalex.org/W2122563776","https://openalex.org/W2127176298","https://openalex.org/W2134735862","https://openalex.org/W2160605010","https://openalex.org/W2247769468","https://openalex.org/W2274578880","https://openalex.org/W2317516423","https://openalex.org/W2545696695","https://openalex.org/W2590373630","https://openalex.org/W2607574901","https://openalex.org/W2608281831","https://openalex.org/W2728593064","https://openalex.org/W2741537813","https://openalex.org/W2808187480","https://openalex.org/W2886637733","https://openalex.org/W2911799682","https://openalex.org/W2916863386","https://openalex.org/W2918874988","https://openalex.org/W2963865669","https://openalex.org/W2969484883","https://openalex.org/W2998129640","https://openalex.org/W2998392755","https://openalex.org/W2999977624","https://openalex.org/W3005603369","https://openalex.org/W3005666955","https://openalex.org/W3012007736","https://openalex.org/W3037075657","https://openalex.org/W3080595528","https://openalex.org/W3081774080","https://openalex.org/W3082036436","https://openalex.org/W3083385516","https://openalex.org/W3089690790","https://openalex.org/W3096251629","https://openalex.org/W3102161185","https://openalex.org/W3113247268","https://openalex.org/W3119632507","https://openalex.org/W3123106292","https://openalex.org/W3123657625","https://openalex.org/W3126725218","https://openalex.org/W3132493147","https://openalex.org/W3194579551","https://openalex.org/W3196895587","https://openalex.org/W3201220696","https://openalex.org/W3207335649","https://openalex.org/W4200571393","https://openalex.org/W4206485229","https://openalex.org/W4220700460","https://openalex.org/W4221053075","https://openalex.org/W4291155391","https://openalex.org/W4301398089","https://openalex.org/W4308150510","https://openalex.org/W4321769506","https://openalex.org/W4328053694","https://openalex.org/W4362577190","https://openalex.org/W4366830027","https://openalex.org/W4367833860","https://openalex.org/W4372295798","https://openalex.org/W4376131206","https://openalex.org/W4377137936","https://openalex.org/W4385480681","https://openalex.org/W4386552811","https://openalex.org/W4386857262","https://openalex.org/W4386894288","https://openalex.org/W4387098638","https://openalex.org/W4387129996","https://openalex.org/W4387784461","https://openalex.org/W4388500819","https://openalex.org/W4391535908","https://openalex.org/W4392960558","https://openalex.org/W4394764710","https://openalex.org/W4395000449","https://openalex.org/W4395703978","https://openalex.org/W4399258819","https://openalex.org/W4400178424","https://openalex.org/W4401818014","https://openalex.org/W4401895746","https://openalex.org/W4401912842","https://openalex.org/W4403194069","https://openalex.org/W4404495663","https://openalex.org/W4404533072","https://openalex.org/W4405892623","https://openalex.org/W4407126519","https://openalex.org/W4411264354","https://openalex.org/W4411376372","https://openalex.org/W4411438124","https://openalex.org/W4413961409","https://openalex.org/W4414479799","https://openalex.org/W4414658672","https://openalex.org/W4416137393","https://openalex.org/W4416894416","https://openalex.org/W4416939351","https://openalex.org/W7124428793","https://openalex.org/W7125772910","https://openalex.org/W7128803077","https://openalex.org/W7134848276","https://openalex.org/W7152000559"],"related_works":["https://openalex.org/W4416894416","https://openalex.org/W7162545057","https://openalex.org/W2019547548","https://openalex.org/W4200092553","https://openalex.org/W2942297939","https://openalex.org/W4412538245","https://openalex.org/W7164801802","https://openalex.org/W4411988600","https://openalex.org/W2737162252","https://openalex.org/W1993968998"],"abstract_inverted_index":{"Glaucoma":[0],"is":[1],"the":[2,20,29,40,68,76,111],"leading":[3],"global":[4],"cause":[5],"of":[6,19,32,71,87],"irreversible":[7],"blindness,":[8],"with":[9,51],"its":[10],"pathogenesis":[11],"extending":[12],"far":[13],"beyond":[14,138],"elevated":[15],"intraocular":[16,21,45,139],"pressure.":[17],"Dysregulation":[18],"immune":[22,46],"system":[23],"plays":[24],"a":[25,52,125],"central":[26],"role":[27],"in":[28,48],"progressive":[30],"death":[31],"retinal":[33],"ganglion":[34],"cells.":[35,64],"This":[36],"review":[37,101],"systematically":[38],"examines":[39],"research":[41,116],"progress":[42],"on":[43,55],"key":[44],"pathways":[47],"glaucomatous":[49],"neurodegeneration,":[50],"primary":[53],"focus":[54],"immune-inflammatory":[56],"responses":[57],"mediated":[58],"by":[59],"microglia,":[60],"astrocytes,":[61],"and":[62,85,95,117,128],"T":[63],"It":[65],"delves":[66],"into":[67],"molecular":[69],"mechanisms":[70],"various":[72],"immunoregulatory":[73],"networks,":[74],"including":[75],"TLR4/nuclear":[77],"factor":[78],"kappa":[79],"B":[80],"(TLR4/NF-\u03baB),":[81],"Janus":[82],"kinase/signal":[83],"transducer":[84],"activator":[86],"transcription":[88],"(JAK/STAT),":[89],"mitogen-activated":[90],"protein":[91],"kinase":[92],"(MAPK),":[93],"complement,":[94],"T-cell":[96],"receptor":[97],"signaling":[98],"pathways.":[99,108],"The":[100],"analyzes":[102],"potential":[103],"therapeutic":[104],"strategies":[105],"targeting":[106],"these":[107],"By":[109],"integrating":[110],"latest":[112],"evidence":[113],"from":[114],"basic":[115],"translational":[118],"medicine,":[119],"this":[120],"article":[121],"aims":[122],"to":[123],"provide":[124],"theoretical":[126],"foundation":[127],"directional":[129],"guidance":[130],"for":[131],"developing":[132],"neuroprotective":[133],"immunomodulatory":[134],"therapies":[135],"that":[136],"go":[137],"pressure":[140],"reduction.":[141]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-16T00:00:00"}