{"id":"https://openalex.org/W7222263901","doi":"https://doi.org/10.3389/fimmu.2026.1945662","title":"Case Report: A case of postneurosurgery Klebsiella pneumoniae meningitis with longitudinal CSF cytokine profiling and combined intrathecal therapy","display_name":"Case Report: A case of postneurosurgery Klebsiella pneumoniae meningitis with longitudinal CSF cytokine profiling and combined intrathecal therapy","publication_year":2026,"publication_date":"2026-10-15","ids":{"openalex":"https://openalex.org/W7222263901","doi":"https://doi.org/10.3389/fimmu.2026.1945662","pmid":"https://pubmed.ncbi.nlm.nih.gov/42959039","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13716629"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1945662","doi":"https://doi.org/10.3389/fimmu.2026.1945662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1945662","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1945662/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1945662/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100380607","display_name":"Zhu Li","orcid":"https://orcid.org/0009-0003-5073-2402","observed_orcids":["https://orcid.org/0009-0003-5073-2402","https://orcid.org/0000-0002-0331-4879"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]},{"id":"https://openalex.org/I4210160452","display_name":"Third People's Hospital of Yunnan Province","ror":"https://ror.org/0555qme52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhu","raw_affiliation_strings":["Department of Neurology, First Affiliated Hospital, Kunming Medical University","Department of Rehabilitation, The Third People\u2019s Hospital of Yunnan Province"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, First Affiliated Hospital, Kunming Medical University","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]},{"raw_affiliation_string":"Department of Rehabilitation, The Third People\u2019s Hospital of Yunnan Province","institution_ids":["https://openalex.org/I4210160452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618196","display_name":"Qian Wu","orcid":"https://orcid.org/0000-0003-3092-7598","observed_orcids":["https://orcid.org/0000-0003-3092-7598"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Wu","raw_affiliation_strings":["Department of Neurology, First Affiliated Hospital, Kunming Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, First Affiliated Hospital, Kunming Medical University","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158844802","display_name":"Jing Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Xu","raw_affiliation_strings":["Department of Neurology, First Affiliated Hospital, Kunming Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, First Affiliated Hospital, Kunming Medical University","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120618609","display_name":"Deshan Ge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deshan Ge","raw_affiliation_strings":["Department of Neurology, First Affiliated Hospital, Kunming Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, First Affiliated Hospital, Kunming Medical University","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068424093","display_name":"Shujuan Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shujuan Dai","raw_affiliation_strings":["Department of Neurology, First Affiliated Hospital, Kunming Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, First Affiliated Hospital, Kunming Medical University","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068424093"],"corresponding_institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76281836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1945662","last_page":"1945662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid-cytokines","display_name":"cerebrospinal fluid cytokines","score":0.8270000219345093},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8830000162124634},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intrathecal-therapy","display_name":"intrathecal therapy","score":0.7630000114440918},{"id":"https://openalex.org/keywords/polymyxin-b","display_name":"polymyxin B","score":0.8519999980926514},{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":0.996999979019165},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.996999979019165},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8059999942779541},{"id":"https://openalex.org/keywords/central-nervous-system-infection","display_name":"central nervous system infection","score":0.7549999952316284},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9186999797821045},{"id":"https://openalex.org/C2779862588","wikidata":"https://www.wikidata.org/wiki/Q7920329","display_name":"Ventriculitis","level":3,"score":0.7139000296592712},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6935999989509583},{"id":"https://openalex.org/C2780066322","wikidata":"https://www.wikidata.org/wiki/Q719444","display_name":"Lumbar puncture","level":3,"score":0.6764000058174133},{"id":"https://openalex.org/C2781026528","wikidata":"https://www.wikidata.org/wiki/Q48143","display_name":"Meningitis","level":2,"score":0.6388000249862671},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.5892000198364258},{"id":"https://openalex.org/C157820659","wikidata":"https://www.wikidata.org/wiki/Q1320251","display_name":"Intrathecal","level":2,"score":0.5022000074386597},{"id":"https://openalex.org/C2781304901","wikidata":"https://www.wikidata.org/wiki/Q4804182","display_name":"Aseptic meningitis","level":3,"score":0.46140000224113464},{"id":"https://openalex.org/C2776603314","wikidata":"https://www.wikidata.org/wiki/Q908292","display_name":"Neopterin","level":2,"score":0.4341000020503998},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40209999680519104},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.3898000121116638},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C2778134817","wikidata":"https://www.wikidata.org/wiki/Q193003","display_name":"Hydrocephalus","level":2,"score":0.32440000772476196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32330000400543213},{"id":"https://openalex.org/C33619753","wikidata":"https://www.wikidata.org/wiki/Q5014091","display_name":"CSF albumin","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.29660001397132874},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27639999985694885},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.27480000257492065},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.27379998564720154},{"id":"https://openalex.org/C2779473907","wikidata":"https://www.wikidata.org/wiki/Q886695","display_name":"Blood culture","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.25780001282691956},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2558000087738037}],"mesh":[{"descriptor_ui":"D000583","descriptor_name":"Amikacin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011112","descriptor_name":"Polymyxin B","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016920","descriptor_name":"Meningitis, Bacterial","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1945662","doi":"https://doi.org/10.3389/fimmu.2026.1945662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1945662","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1945662/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13716629","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13716629/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13716629/pdf/fimmu-17-1945662.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42959039","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42959039","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Case Reports"},{"id":"pmh:oai:doaj.org/article:fe4504a5e07742c8a7e8a4267c17158c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fe4504a5e07742c8a7e8a4267c17158c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1945662","doi":"https://doi.org/10.3389/fimmu.2026.1945662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1945662","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1945662/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G4950910588","display_name":null,"funder_award_id":"82160260","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322268","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222263901.pdf","grobid_xml":"https://content.openalex.org/works/W7222263901.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2300719632","https://openalex.org/W2588163058","https://openalex.org/W2775001823","https://openalex.org/W2964851761","https://openalex.org/W3005968613","https://openalex.org/W3128834624","https://openalex.org/W3167892113","https://openalex.org/W4224274633","https://openalex.org/W4385064130","https://openalex.org/W4388626278","https://openalex.org/W4391534226","https://openalex.org/W4392005701","https://openalex.org/W4392921964","https://openalex.org/W4405952447","https://openalex.org/W4406792861","https://openalex.org/W4410419443","https://openalex.org/W7161141977"],"related_works":["https://openalex.org/W7154898953","https://openalex.org/W2809772913","https://openalex.org/W2011124670","https://openalex.org/W4294199562","https://openalex.org/W4395689270","https://openalex.org/W2338983570","https://openalex.org/W2029741815","https://openalex.org/W1970341374","https://openalex.org/W2059399698","https://openalex.org/W4366782322"],"abstract_inverted_index":{"A":[0],"47-year-old":[1],"woman":[2],"with":[3,69],"poorly":[4],"controlled":[5],"diabetes":[6],"developed":[7],"acute":[8],"fever,":[9],"headache,":[10],"seizures,":[11],"and":[12,27,44,67,76,85,92,99,119,147],"progressive":[13],"confusion":[14],"during":[15],"an":[16],"admission":[17],"for":[18],"glycemic":[19],"management.":[20],"Neurological":[21],"examination":[22],"showed":[23],"mild":[24],"meningeal":[25],"signs,":[26],"brain":[28],"MRI":[29],"demonstrated":[30],"diffuse":[31],"linear":[32],"leptomeningeal":[33],"enhancement.":[34],"Lumbar":[35],"puncture":[36],"revealed":[37,61],"strikingly":[38],"viscous,":[39],"\u2018jelly-like\u2019":[40],"cerebrospinal":[41],"fluid":[42],"(CSF),":[43],"culture":[45],"identified":[46],"Klebsiella":[47,116],"pneumoniae":[48,117],".":[49],"Despite":[50],"systemic":[51,81],"antimicrobial":[52],"therapy,":[53],"central":[54,129],"inflammatory":[55,82,145],"activity":[56,146],"persisted.":[57],"Serial":[58],"CSF":[59,73,114,134],"analyses":[60],"pronounced":[62],"elevations":[63],"of":[64,95,112,124,143],"IL-1\u03b2,":[65],"IL-6,":[66],"IL-8,":[68],"IL-1\u03b2":[70,135],"closely":[71],"paralleling":[72],"leukocyte":[74],"dynamics":[75],"demonstrating":[77],"relative":[78],"independence":[79],"from":[80],"fluctuations.":[83],"Clinical":[84],"laboratory":[86],"improvement":[87],"occurred":[88],"after":[89],"combined":[90],"intravenous":[91],"intrathecal":[93,125],"administration":[94],"polymyxin":[96],"B,":[97],"amikacin,":[98],"dexamethasone,":[100],"leading":[101],"to":[102],"full":[103],"neurological":[104],"recovery.":[105],"This":[106],"case":[107],"highlights":[108],"the":[109,121],"diagnostic":[110],"significance":[111],"mucoid":[113],"in":[115,127,154],"meningitis":[118],"underscores":[120],"therapeutic":[122],"value":[123],"antibiotics":[126],"severe":[128],"nervous":[130],"system":[131],"infections.":[132],"Longitudinal":[133],"measurements":[136],"may":[137],"provide":[138],"a":[139],"potentially":[140],"useful":[141],"marker":[142],"intracranial":[144],"treatment":[148],"response,":[149],"although":[150],"this":[151],"requires":[152],"validation":[153],"larger":[155],"cohorts.":[156]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-16T00:00:00"}