{"id":"https://openalex.org/W7222138776","doi":"https://doi.org/10.1002/cne.70217","title":"Age\u2010Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC","display_name":"Age\u2010Related Changes in Density, Arborization, and NMDA Receptor Expression in Somatostatin Interneurons of the Mouse mPFC","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7222138776","doi":"https://doi.org/10.1002/cne.70217","pmid":"https://pubmed.ncbi.nlm.nih.gov/42876423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13670132"},"language":"en","primary_location":{"id":"doi:10.1002/cne.70217","doi":"https://doi.org/10.1002/cne.70217","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cne.70217","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cne.70217","source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cne.70217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093196567","display_name":"Blanca S\u00e1nchez-Moreno","orcid":"https://orcid.org/0009-0002-7103-6548","observed_orcids":["https://orcid.org/0009-0002-7103-6548"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca S\u00e1nchez\u2010Moreno","raw_affiliation_strings":["Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"],"raw_orcid":"https://orcid.org/0009-0002-7103-6548","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045363010","display_name":"Yaiza Gramuntell","orcid":"https://orcid.org/0000-0003-2282-242X","observed_orcids":["https://orcid.org/0000-0003-2282-242X"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yaiza Gramuntell","raw_affiliation_strings":["Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA)  Valencia Spain","CIBERSAM, ISCIII Spanish National Network for Research in Mental Health  Madrid Spain","Institute of Biotechnology and Biomedicine (BIOTECMED) Universitat de Val\u00e8ncia  Burjassot Spain"],"raw_orcid":"https://orcid.org/0000-0003-2282-242X","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA)  Valencia Spain","institution_ids":[]},{"raw_affiliation_string":"CIBERSAM, ISCIII Spanish National Network for Research in Mental Health  Madrid Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Institute of Biotechnology and Biomedicine (BIOTECMED) Universitat de Val\u00e8ncia  Burjassot Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088343500","display_name":"Patrycja Klimczak","orcid":"https://orcid.org/0000-0002-2258-9691","observed_orcids":["https://orcid.org/0000-0002-2258-9691"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patrycja Klimczak","raw_affiliation_strings":["Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA)  Valencia Spain","CIBERSAM, ISCIII Spanish National Network for Research in Mental Health  Madrid Spain","Institute of Biotechnology and Biomedicine (BIOTECMED) Universitat de Val\u00e8ncia  Burjassot Spain"],"raw_orcid":"https://orcid.org/0000-0002-2258-9691","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA)  Valencia Spain","institution_ids":[]},{"raw_affiliation_string":"CIBERSAM, ISCIII Spanish National Network for Research in Mental Health  Madrid Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Institute of Biotechnology and Biomedicine (BIOTECMED) Universitat de Val\u00e8ncia  Burjassot Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158828340","display_name":"Evelina B\u00e4cker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Evelina B\u00e4cker","raw_affiliation_strings":["Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066244994","display_name":"Juan N\u00e1cher","orcid":"https://orcid.org/0000-0001-7599-3957","observed_orcids":["https://orcid.org/0000-0001-7599-3957"]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan N\u00e1cher","raw_affiliation_strings":["Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA)  Valencia Spain","CIBERSAM, ISCIII Spanish National Network for Research in Mental Health  Madrid Spain","Institute of Biotechnology and Biomedicine (BIOTECMED) Universitat de Val\u00e8ncia  Burjassot Spain"],"raw_orcid":"https://orcid.org/0000-0001-7599-3957","affiliations":[{"raw_affiliation_string":"Biomedical Research Institute of the Clinic Hospital of Valencia (INCLIVA)  Valencia Spain","institution_ids":[]},{"raw_affiliation_string":"CIBERSAM, ISCIII Spanish National Network for Research in Mental Health  Madrid Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Institute of Biotechnology and Biomedicine (BIOTECMED) Universitat de Val\u00e8ncia  Burjassot Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076725240","display_name":"Javier Gilabert\u2010Juan","orcid":"https://orcid.org/0000-0001-5187-3942","observed_orcids":["https://orcid.org/0000-0001-5187-3942"]},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Gilabert\u2010Juan","raw_affiliation_strings":["Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"],"raw_orcid":"https://orcid.org/0000-0001-5187-3942","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Histology and Neuroscience, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"PhD Program in Neuroscience Cajal\u2010UAM, School of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain","institution_ids":["https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5066244994","https://openalex.org/A5076725240"],"corresponding_institution_ids":["https://openalex.org/I16097986","https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I63634437"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":{"value":5450,"currency":"USD","value_usd":5450},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6870945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"534","issue":"10","first_page":"e70217","last_page":"e70217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9200000166893005},{"id":"https://openalex.org/keywords/somatostatin-interneurons","display_name":"somatostatin interneurons","score":0.9789999723434448},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nmda-receptor-subunits","display_name":"NMDA receptor subunits","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glun1","display_name":"GluN1","score":0.996999979019165},{"id":"https://openalex.org/keywords/glun2b","display_name":"GluN2B","score":1.0},{"id":"https://openalex.org/keywords/dendritic-branching","display_name":"dendritic branching","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuronal-density","display_name":"neuronal density","score":0.8669999837875366},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9760000109672546},{"id":"https://openalex.org/keywords/inhibitory-interneurons","display_name":"inhibitory interneurons","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7398999929428101},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.7358999848365784},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.694100022315979},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6891999840736389},{"id":"https://openalex.org/C2779296341","wikidata":"https://www.wikidata.org/wiki/Q1500732","display_name":"Interneuron","level":3,"score":0.6769000291824341},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6700999736785889},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.6115999817848206},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5428000092506409},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4528000056743622},{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.41429999470710754},{"id":"https://openalex.org/C2778437258","wikidata":"https://www.wikidata.org/wiki/Q2116409","display_name":"Pyramidal cell","level":3,"score":0.4120999872684479},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.37279999256134033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3325999975204468},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3075999915599823},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27810001373291016},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C32363146","wikidata":"https://www.wikidata.org/wiki/Q18031732","display_name":"Somatostatin receptor 3","level":5,"score":0.26080000400543213},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003712","descriptor_name":"Dendrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/cne.70217","doi":"https://doi.org/10.1002/cne.70217","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cne.70217","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cne.70217","source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-7657662/v1","doi":"https://doi.org/10.21203/rs.3.rs-7657662/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7657662/v1","pdf_url":"https://www.researchsquare.com/article/rs-7657662/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13670132","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13670132/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13670132/pdf/CNE-534-e70217.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Comp Neurol","raw_type":"Text"},{"id":"pmid:42876423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42876423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of comparative neurology","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.uam.es:10486/800800","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10486/800800","pdf_url":null,"source":{"id":"https://openalex.org/S4306400964","display_name":"Biblos-e Archivo (Universidad Aut\u00f3noma de Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63634437","host_organization_name":"Universidad Aut\u00f3noma de Madrid","host_organization_lineage":["https://openalex.org/I63634437"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1002/cne.70217","doi":"https://doi.org/10.1002/cne.70217","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cne.70217","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cne.70217","source":{"id":"https://openalex.org/S4210186231","display_name":"The Journal of Comparative Neurology","issn_l":"0021-9967","issn":["0021-9967","0092-7317","1096-9861","1550-7130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Comparative Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.781000018119812,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1855990336","display_name":null,"funder_award_id":".13039/501100011033","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2227127946","display_name":null,"funder_award_id":"PID2021-127595OB-I00","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2309174360","display_name":null,"funder_award_id":"10.13039","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G2660406951","display_name":null,"funder_award_id":"/ AEI/10","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G3518538256","display_name":null,"funder_award_id":"13039","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4045293325","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F7296444849","funder_display_name":"Ministerio de Universidades"},{"id":"https://openalex.org/G430777504","display_name":null,"funder_award_id":"10.13039/501100011033/","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4624099308","display_name":null,"funder_award_id":"PID2021-126258OA-I00","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G4925834383","display_name":null,"funder_award_id":"AEI/10.13039/501100011033","funder_id":"https://openalex.org/F7296444849","funder_display_name":"Ministerio de Universidades"},{"id":"https://openalex.org/G5421974903","display_name":null,"funder_award_id":"501100011033","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G6384254145","display_name":null,"funder_award_id":"10.13039/501100011033","funder_id":"https://openalex.org/F7296444849","funder_display_name":"Ministerio de Universidades"},{"id":"https://openalex.org/G99296377","display_name":null,"funder_award_id":"/AEI/10.13039/ 501100011033","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320310220","display_name":"Fundaci\u00f3n Mutua Madrile\u00f1a","ror":"https://ror.org/00skv9577"},{"id":"https://openalex.org/F4320310221","display_name":"Fundaci\u00f3n Alicia Koplowitz","ror":"https://ror.org/036jhs482"},{"id":"https://openalex.org/F4320313831","display_name":"Comunidad de Madrid","ror":null},{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320322755","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38"},{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"},{"id":"https://openalex.org/F7296444849","display_name":"Ministerio de Universidades","ror":"https://ror.org/03zcny908"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222138776.pdf","grobid_xml":"https://content.openalex.org/works/W7222138776.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W623506756","https://openalex.org/W756325778","https://openalex.org/W1557485257","https://openalex.org/W1593904343","https://openalex.org/W1909450484","https://openalex.org/W1969997932","https://openalex.org/W1977340092","https://openalex.org/W1979369962","https://openalex.org/W1985241009","https://openalex.org/W1991762922","https://openalex.org/W1997165755","https://openalex.org/W1998855584","https://openalex.org/W2019249853","https://openalex.org/W2024380057","https://openalex.org/W2031534534","https://openalex.org/W2036619379","https://openalex.org/W2037200077","https://openalex.org/W2039490982","https://openalex.org/W2041405064","https://openalex.org/W2043686726","https://openalex.org/W2051519554","https://openalex.org/W2054118509","https://openalex.org/W2056590282","https://openalex.org/W2064501673","https://openalex.org/W2066886650","https://openalex.org/W2070524933","https://openalex.org/W2072969178","https://openalex.org/W2082703403","https://openalex.org/W2087809804","https://openalex.org/W2093872071","https://openalex.org/W2101151644","https://openalex.org/W2104260362","https://openalex.org/W2116657587","https://openalex.org/W2120535747","https://openalex.org/W2140268092","https://openalex.org/W2141284711","https://openalex.org/W2143699555","https://openalex.org/W2145877345","https://openalex.org/W2155754335","https://openalex.org/W2333325874","https://openalex.org/W2394842952","https://openalex.org/W2526401721","https://openalex.org/W2531096663","https://openalex.org/W2547648483","https://openalex.org/W2561291287","https://openalex.org/W2562545759","https://openalex.org/W2754326783","https://openalex.org/W2761818916","https://openalex.org/W2790140753","https://openalex.org/W2810608517","https://openalex.org/W2888837455","https://openalex.org/W2896362483","https://openalex.org/W2897952239","https://openalex.org/W2901883649","https://openalex.org/W2937581993","https://openalex.org/W2953277664","https://openalex.org/W2953757242","https://openalex.org/W2964824489","https://openalex.org/W2995488791","https://openalex.org/W3012964148","https://openalex.org/W3044840779","https://openalex.org/W3126762019","https://openalex.org/W3130160967","https://openalex.org/W3148916402","https://openalex.org/W3178168279","https://openalex.org/W3180200569","https://openalex.org/W4200290610","https://openalex.org/W4283695316","https://openalex.org/W4388839605","https://openalex.org/W4390665787","https://openalex.org/W4408135195","https://openalex.org/W4410098413"],"related_works":["https://openalex.org/W4415584213","https://openalex.org/W4200290610","https://openalex.org/W4365447680","https://openalex.org/W7213147681","https://openalex.org/W2887944244","https://openalex.org/W2521689126","https://openalex.org/W6945483492","https://openalex.org/W184952693","https://openalex.org/W2905028708","https://openalex.org/W4402956523"],"abstract_inverted_index":{"ABSTRACT":[0],"Aging":[1],"is":[2],"associated":[3],"with":[4,96,111],"progressive":[5],"alterations":[6],"in":[7,23,48,79,83,93,106,115,132],"cortical":[8],"circuits":[9],"that":[10],"compromise":[11],"cognitive":[12],"function.":[13],"Somatostatin\u2010positive":[14],"(SST+)":[15],"Martinotti":[16],"interneurons,":[17],"which":[18],"regulate":[19],"pyramidal":[20],"cell":[21],"activity":[22],"the":[24,133],"medial":[25],"prefrontal":[26],"cortex":[27],"(mPFC),":[28],"are":[29],"particularly":[30],"relevant":[31],"for":[32],"inhibitory":[33],"control,":[34],"yet":[35],"their":[36],"age\u2010related":[37],"vulnerability":[38],"remains":[39],"poorly":[40],"understood.":[41],"Here,":[42],"we":[43],"examined":[44],"GFP\u2010labeled":[45],"SST+":[46,80,130],"interneurons":[47,131],"mice":[49,89],"at":[50],"3,":[51],"9,":[52],"and":[53,64,71,108,123,126],"16":[54],"months":[55],"of":[56,66,99,129],"age,":[57],"focusing":[58],"on":[59],"neuronal":[60],"density,":[61],"dendritic":[62,94],"arborization,":[63],"expression":[65],"NMDA":[67,100],"receptor":[68,101],"subunits":[69],"GluN1":[70,107],"GluN2B.":[72],"Our":[73],"findings":[74,120],"reveal":[75,121],"a":[76,104],"significant":[77],"decline":[78],"interneuron":[81],"density":[82,110],"aged":[84],"male":[85],"mice,":[86],"whereas":[87],"female":[88],"displayed":[90],"an":[91],"increase":[92],"arborization":[95],"age.":[97],"Analysis":[98],"puncta":[102,113],"showed":[103],"reduction":[105],"GluN2B":[109],"increased":[112],"size":[114],"older":[116],"animals.":[117],"Together,":[118],"these":[119],"age\u2010":[122],"sex\u2010dependent":[124],"structural":[125],"molecular":[127],"remodeling":[128],"mPFC.":[134]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-10-16T00:00:00"}
