{"id":"https://openalex.org/W7222087481","doi":"https://doi.org/10.3389/fcvm.2026.1879657","title":"Advances and challenges in personalized cardiac modeling and simulation for predicting the risk of sudden death from malignant arrhythmias in post-myocardial infarction","display_name":"Advances and challenges in personalized cardiac modeling and simulation for predicting the risk of sudden death from malignant arrhythmias in post-myocardial infarction","publication_year":2026,"publication_date":"2026-10-15","ids":{"openalex":"https://openalex.org/W7222087481","doi":"https://doi.org/10.3389/fcvm.2026.1879657","pmid":"https://pubmed.ncbi.nlm.nih.gov/42959335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13717152"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2026.1879657","doi":"https://doi.org/10.3389/fcvm.2026.1879657","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1879657","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1879657/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1879657/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158789764","display_name":"Erwei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Erwei Zhao","raw_affiliation_strings":["Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158795441","display_name":"Liting Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liting Cheng","raw_affiliation_strings":["Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109743097","display_name":"Huanfu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanfu Liu","raw_affiliation_strings":["Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017775126","display_name":"Zefeng Wang","orcid":"https://orcid.org/0000-0002-0219-7180","observed_orcids":["https://orcid.org/0000-0002-0219-7180"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zefeng Wang","raw_affiliation_strings":["Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078054184","display_name":"Yongquan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongquan Wu","raw_affiliation_strings":["Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Capital Medical University Affiliated Anzhen Hospital","institution_ids":["https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017775126","https://openalex.org/A5078054184"],"corresponding_institution_ids":["https://openalex.org/I183519381"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59585561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1879657","last_page":"1879657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9359999895095825},{"id":"https://openalex.org/keywords/malignant-ventricular-arrhythmias","display_name":"malignant ventricular arrhythmias","score":0.8949999809265137},{"id":"https://openalex.org/keywords/personalized-cardiac-modeling","display_name":"personalized cardiac modeling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/digital-twin","display_name":"digital twin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7540000081062317},{"id":"https://openalex.org/keywords/implantable-cardioverter-defibrillator","display_name":"implantable cardioverter-defibrillator","score":0.8460000157356262},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.9570000171661377},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.871999979019165},{"id":"https://openalex.org/keywords/ion-channel-remodeling","display_name":"ion channel remodeling","score":0.7400000095367432},{"id":"https://openalex.org/keywords/anisotropic-conductivity","display_name":"anisotropic conductivity","score":0.925000011920929},{"id":"https://openalex.org/keywords/programmed-electrical-stimulation","display_name":"programmed electrical stimulation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6585000157356262},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6539000272750854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6521999835968018},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.5963000059127808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5418000221252441},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.43529999256134033},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.4277999997138977},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.38760000467300415},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.3799000084400177},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.37770000100135803},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.31139999628067017},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.29420000314712524},{"id":"https://openalex.org/C2776008845","wikidata":"https://www.wikidata.org/wiki/Q5038325","display_name":"Cardiac magnetic resonance imaging","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.2574000060558319},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25440001487731934},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2026.1879657","doi":"https://doi.org/10.3389/fcvm.2026.1879657","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1879657","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1879657/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13717152","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717152/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717152/pdf/fcvm-13-1879657.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmid:42959335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42959335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d057e5f1030a4f8299c202368afc6af5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d057e5f1030a4f8299c202368afc6af5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2026.1879657","doi":"https://doi.org/10.3389/fcvm.2026.1879657","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2026.1879657","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2026.1879657/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321496","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222087481.pdf","grobid_xml":"https://content.openalex.org/works/W7222087481.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1859307504","https://openalex.org/W1911769041","https://openalex.org/W1977859104","https://openalex.org/W1989011699","https://openalex.org/W2003251032","https://openalex.org/W2033890512","https://openalex.org/W2036185068","https://openalex.org/W2036632357","https://openalex.org/W2039686430","https://openalex.org/W2047970481","https://openalex.org/W2048078392","https://openalex.org/W2060772678","https://openalex.org/W2061451182","https://openalex.org/W2061824317","https://openalex.org/W2070722083","https://openalex.org/W2072260252","https://openalex.org/W2081212418","https://openalex.org/W2090859123","https://openalex.org/W2091230218","https://openalex.org/W2097087273","https://openalex.org/W2106351593","https://openalex.org/W2110130810","https://openalex.org/W2111930564","https://openalex.org/W2112735350","https://openalex.org/W2115765852","https://openalex.org/W2116621000","https://openalex.org/W2123858305","https://openalex.org/W2130321115","https://openalex.org/W2155032388","https://openalex.org/W2158152768","https://openalex.org/W2168518074","https://openalex.org/W2313547185","https://openalex.org/W2320382602","https://openalex.org/W2367512715","https://openalex.org/W2549396322","https://openalex.org/W2566887259","https://openalex.org/W2583371454","https://openalex.org/W2589792216","https://openalex.org/W2769116429","https://openalex.org/W2955429761","https://openalex.org/W2968334567","https://openalex.org/W2996036235","https://openalex.org/W3005567406","https://openalex.org/W3007670977","https://openalex.org/W3010152544","https://openalex.org/W3096057463","https://openalex.org/W3111744997","https://openalex.org/W3144574636","https://openalex.org/W3176592881","https://openalex.org/W3193527872","https://openalex.org/W4205281484","https://openalex.org/W4291910163","https://openalex.org/W4292662920","https://openalex.org/W4361279281","https://openalex.org/W4363646955","https://openalex.org/W4383481092","https://openalex.org/W4383604386","https://openalex.org/W4384297296","https://openalex.org/W4387128694","https://openalex.org/W4387357427","https://openalex.org/W4390339624","https://openalex.org/W4391428302","https://openalex.org/W4391936221","https://openalex.org/W4392093351","https://openalex.org/W4394762712","https://openalex.org/W4395084655","https://openalex.org/W4398142314","https://openalex.org/W4399631381","https://openalex.org/W4401338126","https://openalex.org/W4402638107","https://openalex.org/W4403128023","https://openalex.org/W4409580797","https://openalex.org/W4410421958","https://openalex.org/W4412197038","https://openalex.org/W4412894402","https://openalex.org/W4413139067","https://openalex.org/W4414848838","https://openalex.org/W7204579142"],"related_works":["https://openalex.org/W2367512715","https://openalex.org/W4292590367","https://openalex.org/W2525243755","https://openalex.org/W4411640150","https://openalex.org/W4235066354","https://openalex.org/W4403210271","https://openalex.org/W4205281484","https://openalex.org/W7124854760","https://openalex.org/W1967344218","https://openalex.org/W4389543093"],"abstract_inverted_index":{"Sudden":[0],"cardiac":[1,79,127,138],"death":[2],"(SCD)":[3],"represents":[4],"a":[5,96],"major":[6],"global":[7],"public":[8],"health":[9],"challenge,":[10],"with":[11],"malignant":[12,33],"ventricular":[13,34,48],"arrhythmias":[14,220],"being":[15],"its":[16],"primary":[17],"cause.":[18],"This":[19,54,131,234],"review":[20],"focuses":[21],"specifically":[22],"on":[23,41,212],"post-myocardial":[24],"infarction":[25],"(post-MI)":[26],"ischemic":[27],"cardiomyopathy-the":[28],"most":[29],"prevalent":[30],"substrate":[31],"for":[32,51],"arrhythmias.":[35],"Current":[36],"clinical":[37,118,262],"practice":[38],"predominantly":[39],"relies":[40],"single":[42],"functional":[43],"indices,":[44],"such":[45],"as":[46],"left":[47],"ejection":[49],"fraction,":[50],"risk":[52],"stratification.":[53],"approach":[55],"suffers":[56],"from":[57,126,162],"significant":[58],"limitations":[59],"in":[60,66,92,111,198,255,261],"predictive":[61],"accuracy,":[62],"leading":[63],"to":[64,101,171,219],"dilemmas":[65],"the":[67,88,112,133,143,191,213,217,241,267],"prophylactic":[68],"application":[69,253],"of":[70,87,107,115,136,146,194,202,229],"implantable":[71],"cardioverter-defibrillators,":[72],"including":[73,186],"both":[74],"under-implantation":[75],"and":[76,81,149,167,196,226,265],"over-implantation.":[77],"Personalized":[78],"modeling":[80],"simulation":[82],"technology,":[83],"an":[84,230],"advanced":[85],"embodiment":[86],"digital":[89],"twin":[90],"concept":[91],"cardiovascular":[93],"medicine,":[94],"offers":[95],"highly":[97],"promising":[98],"non-invasive":[99],"solution":[100],"overcome":[102],"these":[103],"limitations.":[104],"The":[105],"core":[106,180],"this":[108,153],"technology":[109],"lies":[110],"deep":[113],"integration":[114],"personalized,":[116],"multi-modal":[117],"imaging":[119],"data,":[120],"particularly":[121],"late":[122],"gadolinium":[123],"enhancement":[124],"sequences":[125],"magnetic":[128],"resonance":[129],"imaging.":[130],"enables":[132],"precise":[134],"construction":[135],"individualized":[137],"anatomical":[139,154,247],"substrates":[140,248],"that":[141],"reflect":[142],"spatial":[144],"distribution":[145],"myocardial":[147,203],"fibrosis":[148],"scar.":[150],"Building":[151],"upon":[152],"foundation,":[155],"multi-scale":[156],"computational":[157,214],"models":[158,177],"are":[159],"established,":[160],"spanning":[161],"microscopic":[163],"ion":[164,188],"channel":[165,189],"kinetics":[166],"cellular":[168],"electrophysiological":[169],"activity":[170],"macroscopic":[172],"tissue":[173],"conduction":[174,200],"properties.":[175],"These":[176],"systematically":[178],"simulate":[179],"pro-arrhythmic":[181],"factors":[182],"under":[183],"pathological":[184],"conditions,":[185],"key":[187],"remodeling,":[190],"coupling":[192],"effects":[193],"non-myocytes,":[195],"alterations":[197],"anisotropic":[199],"properties":[201],"tissue.":[204],"Ultimately,":[205],"by":[206],"implementing":[207],"programmed":[208],"electrical":[209,243],"stimulation":[210],"protocols":[211],"heart":[215],"model,":[216],"susceptibility":[218],"is":[221],"dynamically":[222],"assessed,":[223],"achieving":[224],"quantitative":[225],"visual":[227],"stratification":[228],"individual's":[231],"SCD":[232],"risk.":[233],"technological":[235],"framework":[236],"not":[237],"only":[238],"non-invasively":[239],"reveals":[240],"dynamic":[242],"instability":[244],"underlying":[245],"static":[246],"but":[249],"also":[250],"demonstrates":[251],"broad":[252],"prospects":[254],"understanding":[256],"complex":[257],"arrhythmia":[258],"mechanisms,":[259],"assisting":[260],"therapeutic":[263],"decision-making,":[264],"advancing":[266],"shift":[268],"towards":[269],"precision":[270],"medicine":[271],"models.":[272]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2026-10-16T00:00:00"}