{"id":"https://openalex.org/W7222018053","doi":"https://doi.org/10.18699/vjgb-26-90","title":"Whole genome sequencing identifies genetic variants associated with senescence-accelerated phenotype of OXYS rats","display_name":"Whole genome sequencing identifies genetic variants associated with senescence-accelerated phenotype of OXYS rats","publication_year":2026,"publication_date":"2026-10-13","ids":{"openalex":"https://openalex.org/W7222018053","doi":"https://doi.org/10.18699/vjgb-26-90","pmid":"https://pubmed.ncbi.nlm.nih.gov/42908879","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13683464"},"language":"en","primary_location":{"id":"doi:10.18699/vjgb-26-90","doi":"https://doi.org/10.18699/vjgb-26-90","is_oa":true,"landing_page_url":"https://doi.org/10.18699/vjgb-26-90","pdf_url":"https://vavilov.elpub.ru/jour/article/download/5296/2136","source":{"id":"https://openalex.org/S4210186544","display_name":"Vavilov Journal of Genetics and Breeding","issn_l":"1814-554X","issn":["1814-554X","1814-5558","2500-0462","2500-3259"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312839","host_organization_name":"Institute of Cytology and Genetics","host_organization_lineage":["https://openalex.org/P4310312839","https://openalex.org/P4310312755"],"host_organization_lineage_names":["Institute of Cytology and Genetics","Siberian Branch of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vavilov Journal of Genetics and Breeding","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://vavilov.elpub.ru/jour/article/download/5296/2136","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158821821","display_name":"V. M. Petrova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093196","display_name":"Sirius University of Science and Technology","ror":"https://ror.org/00n51jg89","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210093196"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. M. Petrova","raw_affiliation_strings":["Sirius University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sirius University of Science and Technology","institution_ids":["https://openalex.org/I4210093196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014640040","display_name":"Maria Protasova","orcid":"https://orcid.org/0000-0002-2422-1540","observed_orcids":["https://orcid.org/0000-0002-2422-1540"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210093196","display_name":"Sirius University of Science and Technology","ror":"https://ror.org/00n51jg89","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210093196"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. S. Protasova","raw_affiliation_strings":["Sirius University of Science and Technology","Vavilov Institute of General Genetics of the Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sirius University of Science and Technology","institution_ids":["https://openalex.org/I4210093196"]},{"raw_affiliation_string":"Vavilov Institute of General Genetics of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016800905","display_name":"Andrey Dmitrievich Manakhov","orcid":"https://orcid.org/0000-0002-5163-8747","observed_orcids":["https://orcid.org/0000-0002-5163-8747"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210093196","display_name":"Sirius University of Science and Technology","ror":"https://ror.org/00n51jg89","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210093196"]},{"id":"https://openalex.org/I4210148309","display_name":"Vavilov Institute of General Genetics","ror":"https://ror.org/05ermrg42","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210148309"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. D. Manakhov","raw_affiliation_strings":["Sirius University of Science and Technology","Vavilov Institute of General Genetics of the Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sirius University of Science and Technology","institution_ids":["https://openalex.org/I4210093196"]},{"raw_affiliation_string":"Vavilov Institute of General Genetics of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210148309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005719344","display_name":"Natalia A. Stefanova","orcid":"https://orcid.org/0000-0001-5127-5993","observed_orcids":["https://orcid.org/0000-0001-5127-5993"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. A. Stefanova","raw_affiliation_strings":["Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030568682","display_name":"Nataliya G. Kolosova","orcid":"https://orcid.org/0000-0003-2398-8544","observed_orcids":["https://orcid.org/0000-0003-2398-8544"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. G. Kolosova","raw_affiliation_strings":["Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051730671","display_name":"Evgeny Ivanovich Rogaev","orcid":"https://orcid.org/0000-0002-0351-8783","observed_orcids":["https://orcid.org/0000-0002-0351-8783"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. I. Rogaev","raw_affiliation_strings":["UMass Chan Medical School, Department of Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMass Chan Medical School, Department of Psychiatry","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67219292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"6","first_page":"883","last_page":"898"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxys-rats","display_name":"OXYS rats","score":0.925000011920929},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.875},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.8389999866485596},{"id":"https://openalex.org/keywords/abcf1","display_name":"ABCF1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cic","display_name":"CIC","score":0.5429999828338623},{"id":"https://openalex.org/keywords/nqo2","display_name":"NQO2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cerkl","display_name":"CERKL","score":0.8889999985694885},{"id":"https://openalex.org/keywords/retinopathy","display_name":"retinopathy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cataract","display_name":"cataract","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9290000200271606},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.7739999890327454},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7982000112533569},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.7117000222206116},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6520000100135803},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5351999998092651},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5115000009536743},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.4456000030040741},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4131999909877777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.3499999940395355},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3255999982357025},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3244999945163727},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.30390000343322754},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.2973000109195709},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.2786000072956085},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.2605000138282776},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.2587999999523163}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18699/vjgb-26-90","doi":"https://doi.org/10.18699/vjgb-26-90","is_oa":true,"landing_page_url":"https://doi.org/10.18699/vjgb-26-90","pdf_url":"https://vavilov.elpub.ru/jour/article/download/5296/2136","source":{"id":"https://openalex.org/S4210186544","display_name":"Vavilov Journal of Genetics and Breeding","issn_l":"1814-554X","issn":["1814-554X","1814-5558","2500-0462","2500-3259"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312839","host_organization_name":"Institute of Cytology and Genetics","host_organization_lineage":["https://openalex.org/P4310312839","https://openalex.org/P4310312755"],"host_organization_lineage_names":["Institute of Cytology and Genetics","Siberian Branch of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vavilov Journal of Genetics and Breeding","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13683464","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683464/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13683464/pdf/VJGB-30-2690.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vavilovskii Zhurnal Genet Selektsii","raw_type":"Text"},{"id":"pmid:42908879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42908879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vavilovskii zhurnal genetiki i selektsii","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9bcd5d4f4d7c48b3ab125804c5c3476b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9bcd5d4f4d7c48b3ab125804c5c3476b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0412\u0430\u0432\u0438\u043b\u043e\u0432\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0433\u0435\u043d\u0435\u0442\u0438\u043a\u0438 \u0438 \u0441\u0435\u043b\u0435\u043a\u0446\u0438\u0438, Vol 30, Iss 6, Pp 883-898 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18699/vjgb-26-90","doi":"https://doi.org/10.18699/vjgb-26-90","is_oa":true,"landing_page_url":"https://doi.org/10.18699/vjgb-26-90","pdf_url":"https://vavilov.elpub.ru/jour/article/download/5296/2136","source":{"id":"https://openalex.org/S4210186544","display_name":"Vavilov Journal of Genetics and Breeding","issn_l":"1814-554X","issn":["1814-554X","1814-5558","2500-0462","2500-3259"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-c","ki-jl-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312839","host_organization_name":"Institute of Cytology and Genetics","host_organization_lineage":["https://openalex.org/P4310312839","https://openalex.org/P4310312755"],"host_organization_lineage_names":["Institute of Cytology and Genetics","Siberian Branch of the Russian Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vavilov Journal of Genetics and Breeding","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7222018053.pdf","grobid_xml":"https://content.openalex.org/works/W7222018053.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W131946804","https://openalex.org/W184703081","https://openalex.org/W851142300","https://openalex.org/W1509520361","https://openalex.org/W1534066500","https://openalex.org/W1748696921","https://openalex.org/W1972631980","https://openalex.org/W1982959887","https://openalex.org/W1989891419","https://openalex.org/W1991256183","https://openalex.org/W2003627315","https://openalex.org/W2009847113","https://openalex.org/W2018594419","https://openalex.org/W2021341670","https://openalex.org/W2021630037","https://openalex.org/W2040382817","https://openalex.org/W2054129051","https://openalex.org/W2060176013","https://openalex.org/W2083873656","https://openalex.org/W2098466396","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2105204727","https://openalex.org/W2108234281","https://openalex.org/W2109108939","https://openalex.org/W2112802413","https://openalex.org/W2116745204","https://openalex.org/W2119180969","https://openalex.org/W2121366725","https://openalex.org/W2123171788","https://openalex.org/W2129077731","https://openalex.org/W2133553247","https://openalex.org/W2134741353","https://openalex.org/W2150506261","https://openalex.org/W2152298001","https://openalex.org/W2161633633","https://openalex.org/W2164936271","https://openalex.org/W2171808845","https://openalex.org/W2263582186","https://openalex.org/W2297706130","https://openalex.org/W2410352126","https://openalex.org/W2417483443","https://openalex.org/W2525574633","https://openalex.org/W2613171628","https://openalex.org/W2619755875","https://openalex.org/W2788699100","https://openalex.org/W2794248168","https://openalex.org/W2801332034","https://openalex.org/W2949552933","https://openalex.org/W2953020344","https://openalex.org/W2990427812","https://openalex.org/W2999103376","https://openalex.org/W3006878337","https://openalex.org/W3033505922","https://openalex.org/W3043351512","https://openalex.org/W3082660797","https://openalex.org/W3091791644","https://openalex.org/W3112890076","https://openalex.org/W3131055609","https://openalex.org/W3138667949","https://openalex.org/W3164083435","https://openalex.org/W3164417432","https://openalex.org/W3212059340","https://openalex.org/W4200434959","https://openalex.org/W4224255802","https://openalex.org/W4254687493","https://openalex.org/W4294281202","https://openalex.org/W4303699561","https://openalex.org/W4306156582","https://openalex.org/W4309664456","https://openalex.org/W4315641052","https://openalex.org/W4318482981","https://openalex.org/W4380684774","https://openalex.org/W4386415301","https://openalex.org/W4390705303","https://openalex.org/W4396721167","https://openalex.org/W4396937326","https://openalex.org/W4404635460","https://openalex.org/W4405231264","https://openalex.org/W4407132167","https://openalex.org/W4408387644","https://openalex.org/W4411541839"],"related_works":["https://openalex.org/W4253610039","https://openalex.org/W2040382817","https://openalex.org/W4249094081","https://openalex.org/W4245496067","https://openalex.org/W2562113381","https://openalex.org/W2999103376","https://openalex.org/W1768795272","https://openalex.org/W2996606389","https://openalex.org/W7204277572","https://openalex.org/W7099915362"],"abstract_inverted_index":{"Age":[0],"is":[1],"the":[2,9,22,44,58,90,110,157,162,200,212,246,250,265,281,294,313],"primary":[3],"risk":[4],"factor":[5],"for":[6,24,120],"age-related":[7],"diseases,":[8],"early":[10,91,228,289],"onset":[11,92],"of":[12,47,78,85,93,165,203,267,296,315,332],"which":[13,61],"manifests":[14],"as":[15,115],"premature":[16,34,48,86,204],"aging,":[17],"whereas":[18],"delayed":[19],"development":[20,291],"forms":[21],"basis":[23],"healthy":[25],"aging":[26,35,49,87,205],"and":[27,36,50,105,127,132,167,169,178,215,224,230,239,249,263,269,278,305,310,320,323,329],"longevity.":[28],"Adverse":[29],"genetic":[30,45,137],"variants":[31,122,138,171,196,252,302],"contribute":[32,198],"to":[33,56,140,182,199,288],"its":[37],"diverse":[38],"manifestations,":[39],"including":[40,96],"increased":[41],"multimorbidity.":[42],"Identifying":[43],"underpinnings":[46],"developing":[51],"preventive":[52],"approaches":[53],"are":[54,144],"essential":[55],"extending":[57],"human":[59],"healthspan,":[60],"requires":[62],"fundamental":[63],"research":[64],"using":[65,109],"animal":[66],"models.":[67],"In":[68],"this":[69],"study,":[70],"we":[71,151],"performed":[72],"whole-genome":[73],"sequencing":[74],"(coverage":[75],"depth":[76],">25\u00d7)":[77],"OXYS":[79,141,207],"rats":[80,142],"-":[81,108],"a":[82,116,153],"unique":[83,139],"model":[84],"characterized":[88],"by":[89,233,259,292],"geriatric":[94],"disorders,":[95],"cataracts,":[97],"AMD-like":[98],"retinopathy,":[99],"Alzheimer's":[100],"disease-like":[101],"pathology,":[102],"osteoporosis,":[103],"sarcopenia,":[104],"hypertrophic":[106],"cardiomyopathy":[107,311],"parental":[111],"Wistar/Icgn":[112],"rat":[113,148],"strain":[114],"control.":[117],"The":[118,243],"screening":[119],"single-nucleotide":[121],"(SNVs),":[123],"short":[124],"insertions/deletions":[125],"(indels),":[126],"copy":[128],"number":[129],"variations":[130],"(CNVs)":[131],"comparative":[133],"genomic":[134],"analysis":[135,192],"revealed":[136],"that":[143,180,194],"absent":[145],"in":[146,156,161,172,186,206,211,221,245,253,284,303,317],"other":[147],"strains.":[149],"Specifically,":[150],"identified":[152],"large":[154],"deletion":[155,244],"Fat1":[158,213],"enhancer,":[159],"deletions":[160,210],"promoter":[163,248],"regions":[164],"Abcf1":[166,247],"Gsta6,":[168],"missense":[170,219,251,282,301],"Cic,":[173,222],"Akap6,":[174,223],"Nqo2,":[175,225],"Cerkl,":[176],"Bfsp1,":[177],"Cmya5":[179,304],"lead":[181],"amino":[183],"acid":[184],"substitutions":[185,220],"highly":[187],"conserved":[188],"protein":[189],"regions.":[190],"Bioinformatic":[191],"suggested":[193],"these":[195],"may":[197,226,255,307],"key":[201],"features":[202,258],"rats.":[208],"Notably,":[209],"enhancer":[214],"Gsta6":[216],"promoter,":[217],"alongside":[218],"drive":[227],"neurodegeneration":[229],"cognitive":[231],"deficits":[232],"disrupting":[234,260],"neurogenesis,":[235],"reducing":[236,293],"neuronal":[237],"survival,":[238],"impairing":[240],"antioxidant":[241],"defense.":[242],"Cerkl":[254],"induce":[256],"retinopathy":[257],"retinal":[261,270],"homeostasis":[262],"weakening":[264],"protection":[266],"photoreceptors":[268],"pigment":[271],"epithelium":[272],"(RPE)":[273],"cells":[274],"against":[275],"oxidative":[276],"stress":[277],"apoptosis.":[279],"Furthermore,":[280],"substitution":[283],"Bfsp1":[285],"likely":[286],"contributes":[287],"cataract":[290],"stability":[295],"lens":[297],"intermediate":[298],"filaments.":[299],"Finally,":[300],"Akap6":[306],"promote":[308],"sarcopenia":[309],"via":[312],"destabilization":[314],"myofibrils":[316],"skeletal":[318,326],"muscles":[319],"cardiomyocytes":[321,333],"(Cmya5)":[322],"through":[324],"impaired":[325],"muscle":[327],"regeneration":[328],"structural":[330],"disorganization":[331],"(Akap6).":[334]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-10-16T00:00:00"}
